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公开(公告)号:US12104114B2
公开(公告)日:2024-10-01
申请号:US16917758
申请日:2020-06-30
Inventor: Colin Nuckolls , Jingjing Yang , Alexander D. Christodoulides , Boyuan Zhang , Qizhi Xu , Amirali Zangiabadi , Christine McGinn , Samuel Peurifoy , Lingyun Dai , Elena Meirzadeh , Michael Steigerwald , Xavier Roy , Ioannis Kymissis , Jonathan A. Malen
Abstract: Ionic superatomic materials that can be solution-processed into completely amorphous and homogeneous thin films are disclosed herein. The amorphous materials disclosed herein have tunable compositions and have electrical conductivities of up to 300 siemens per meter, thermal conductivities of 0.05 watt per meter per degree Kelvin, and optical transparencies of up to 92%. Application of these thin-films are also provided herein.
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公开(公告)号:US12100121B2
公开(公告)日:2024-09-24
申请号:US17347948
申请日:2021-06-15
Inventor: Jia Guo , Scott A. Small
CPC classification number: G06T5/00 , G06T5/50 , G16H30/20 , G16H30/40 , G16H50/20 , G16H50/50 , G06T2207/10096 , G06T2207/20081 , G06T2207/20084 , G06T2207/30016
Abstract: An exemplary system, method, and computer-accessible medium for detection of structural disorder(s) of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the structural disorder(s) of the patient(s) based on a GD contrast of the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map. The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), or (ii) a Gd-free MRI scan(s). The Gd contrast can be generated in the Gd enhanced map(s) using a T2-weighted MRI image of the portion(s). Structural disorder(s) can include Stroke, tumor, trauma, infection, Multiple sclerosis and/or other inflammatory disease.
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公开(公告)号:US12084696B2
公开(公告)日:2024-09-10
申请号:US18501966
申请日:2023-11-03
Inventor: Henry M. Colecraft , Scott Kanner
IPC: C12N9/64 , A61K38/00 , C12N15/85 , C12Q1/6883
CPC classification number: C12N9/6472 , C12N15/85 , C12Q1/6883 , C12Y304/22 , A61K38/00 , C12Q2600/156
Abstract: The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.
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公开(公告)号:US12079345B2
公开(公告)日:2024-09-03
申请号:US17511253
申请日:2021-10-26
Inventor: Salvatore J. Stolfo , Preetam Kumar Dutta
IPC: G06F21/57 , H04L67/306 , H04L67/50
CPC classification number: G06F21/577 , H04L67/306 , H04L67/535 , G06F2221/034
Abstract: Methods, systems, and media for testing insider threat detection systems are provided. In some embodiments, the method comprises: receiving, using a hardware processor, a first plurality of actions in a computing environment that are associated with one of a plurality of user accounts; generating a plurality of models of user behavior based at least in part on the first plurality of actions, wherein each of the plurality of models of user behavior is associated with each of the plurality of user accounts; selecting a model of user behavior from the plurality of models of user behavior, wherein the model of user behavior is associated with a malicious user type; generating a simulated user bot based on the selected model of user behavior; executing the simulated user bot in the computing environment, wherein the simulated user bot injects a second plurality of actions in the computing environment; determining whether an insider threat detection system executing within the computing environment identifies the simulated user bot as a malicious user; and transmitting a notification indicating an efficacy of the insider threat detection system based on the determination.
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公开(公告)号:US12076590B2
公开(公告)日:2024-09-03
申请号:US17690523
申请日:2022-03-09
Inventor: Elisa E. Konofagou , Fabrice Marquet , Yao-Sheng Tung
CPC classification number: A61N7/00 , A61B8/0808 , A61B8/481 , A61B17/2258 , A61B2017/00106 , A61B2017/22008 , A61B2017/22089 , A61B90/10 , A61B2090/378 , A61B2503/40 , A61N2007/0039
Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.
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公开(公告)号:US20240285701A1
公开(公告)日:2024-08-29
申请号:US18635627
申请日:2024-04-15
Inventor: Virginia Cornish , Amirhossein JAFARIYAN
IPC: A61K36/064 , A61K9/00 , A61K9/06 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/39 , A61K38/55 , A61K45/06 , A61K47/36 , A61P17/00 , A61P17/02 , A61P17/06
CPC classification number: A61K36/064 , A61K9/0014 , A61K9/06 , A61K38/1808 , A61K38/1841 , A61K38/1866 , A61K38/195 , A61K38/2026 , A61K38/39 , A61K38/55 , A61K45/06 , A61K47/36 , A61P17/00 , A61P17/02 , A61P17/06
Abstract: The disclosed subject matter provides for genetically modified cells, e.g., fungal cells, that autonomously generates and/or secretes one or more skin therapeutics, and methods of use thereof. In certain embodiments, the present disclosure provides genetically-engineered fungal cells that generate and secrete growth factors, protease inhibitors, cytokines and/or chemokines and methods of use thereof, e.g., for treating skin conditions.
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47.
公开(公告)号:US20240285227A1
公开(公告)日:2024-08-29
申请号:US18425030
申请日:2024-01-29
Inventor: CHRISTINE HENDON , HAIQIU YANG , ARIELLE JOASIL , AIDAN THERIEN
IPC: A61B5/00
CPC classification number: A61B5/4325 , A61B5/0075 , A61B5/0086
Abstract: Exemplary embodiments of the present disclosure are directed to systems, methods, and devices for determining at least one structure or at least one characteristic of a uterus. Exemplary embodiments of the present disclosure may include a probe, such as an endoscope, that includes a fiber bundle which includes a group of fibers which transmit one or more first electro-magnetic (EM) radiation to at least one portion of a uterus, and another group of fibers which receive one or more second EM radiations exiting the at least one portion which are based on the first EM radiations and a hyperspectral imaging camera obtaining at least one image data associated with the second EM radiations to determine the at least one of the structure or the at least one of the characteristic.
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48.
公开(公告)号:US20240266013A1
公开(公告)日:2024-08-08
申请号:US18417066
申请日:2024-01-19
Inventor: Shreyas BHAVE , Adler PEROTTE
IPC: G16H10/60
CPC classification number: G16H10/60
Abstract: Modeling exemplary EHR data can be useful in a broad range of applications including prediction of future conditions or building latent representations of patient history. Exemplary embodiments of the present disclosure can model the full longitudinal history of a patient using a generative multivariate point process that (optionally simultaneously) can, e.g., (1) model irregularly sampled events probabilistically without discretization or interpolation; (2) have a closed-form likelihood, making training straightforward; (3) encode dependence between times and events with an approach inspired by competing risk models; and (4) facilitate a direct sampling. The exemplary embodiments can provide an improved performance on next-event prediction compared to existing approaches.
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公开(公告)号:US20240252541A1
公开(公告)日:2024-08-01
申请号:US18357976
申请日:2023-07-24
Inventor: Erik J. WOODS , Brian H. JOHNSTONE , Dongsheng GU , Aubrey Marie SHERRY , Kelsey Gwen MUSALL , Kazuhiko YAMADA , Megan SYKES
CPC classification number: A61K35/28 , A61K31/44 , A61K45/06 , A61P37/06 , C07K16/26 , C07K16/2806 , C07K16/2875
Abstract: Described herein are methods of cell therapies. Also described herein are methods of establishing a mixed chimerism, and/or preventing a rejection of a donor organ in a subject wherein said subject has received an organ transplant, the method comprising administering to said subject a population of hematopoietic cells, wherein said organ transplant comprises a heart transplant.
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公开(公告)号:US20240252155A1
公开(公告)日:2024-08-01
申请号:US18466349
申请日:2023-09-13
Inventor: Anjali Saqi , Keith Yeager
CPC classification number: A61B10/0096 , A61B10/02 , A61M1/34 , A61M1/3403 , B01L3/502 , B01L3/5021 , G01N1/4077 , B01L2300/0618 , B01L2300/0681 , B01L2300/0851 , G01N2001/4088
Abstract: A medical apparatus having an elongate tubular body with a proximal end, an opening at the proximal end, and a distal end defining an interior space therebetween and the distalmost end of the elongate tubular body is configured to matingly engage a filter assembly; a filter assembly configured to matingly engage the distal portion of the elongate tubular body and to provide a seal with the interior space thereof, the filter assembly comprising a filter membrane and a border that is sectionable for mounting on a slide for analysis on a microscope; and a base member configured to releasably engage the distalmost end of the elongate tubular body and to receive the filter assembly therein.
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