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    Parallel Separation System
    44.
    发明申请
    Parallel Separation System 有权

    公开(公告)号：US20220016547A1

    公开(公告)日：2022-01-20

    申请号：US17488046

    申请日：2021-09-28

    Applicant: Cytiva BioProcess R&D AB

    Inventor： Klaus Gebauer

    IPC: B01D15/18 ,  G01N30/46 ,  G01N30/32

    Abstract: A separation system may include a number of parallel fluid paths. Each parallel fluid path may include a separation module, and an adjustable flow restrictor. Each adjustable flow restrictor is operable sequentially and operable such that the hydraulic resistance of all the parallel fluid paths is substantially the same and is equal to or higher than the hydraulic resistance of a fluid path identified to have the highest hydraulic resistance. The system includes a pressure sensor that measures pressure loss over the whole separation system. The system is operable such that the hydraulic resistances of the respective separation modules are synchronised, and such that when operated in parallel and at substantially the same time, the respective modules have substantially the same time residence times. The system may include a control system for automated operation.

    Mutated Immunoglobulin-Binding Polypeptides
    46.
    发明申请
    Mutated Immunoglobulin-Binding Polypeptides 有权

    公开(公告)号：US20210162319A1

    公开(公告)日：2021-06-03

    申请号：US17153015

    申请日：2021-01-20

    Applicant: CYTIVA BIOPROCESS R&D AB

    Inventor： Sophia Hober

    IPC: B01D15/38 ,  B01J20/286 ,  B01J20/32 ,  C07K1/22 ,  C07K16/06 ,  C07K14/31 ,  C07K14/195 ,  B01J20/24 ,  B01J20/289 ,  C07K14/00

    Abstract: The present invention relates to an immunoglobulin-binding protein, wherein at least one asparagine residue has been mutated to an amino acid other than glutamine or aspartic acid, which mutation confers an increased chemical stability at pH-values of up to about 13-14 compared to the parental molecule. The protein can for example be derived from a protein capable of binding to other regions of the immunoglobulin molecule than the complementarity determining regions (CDR), such as protein A, and preferably the B-domain of Staphylococcal protein A. The invention also relates to a matrix for affinity separation, which comprises an immunoglobulin-binding protein as ligand coupled to a solid support, in which protein ligand at least one asparagine residue has been mutated to an amino acid other than glutamine.

    Method in Bioprocess System
    49.
    发明申请
    Method in Bioprocess System 有权

    公开(公告)号：US20210057049A1

    公开(公告)日：2021-02-25

    申请号：US17045775

    申请日：2019-04-24

    Applicant: Cytiva BioProcess R&D AB

    Inventor： Gunnar Malmquist ,  Per Liden

    IPC: G16C20/30 ,  G01N30/88

    Abstract: The present invention relates to a method for estimating performance of a bioprocess material when used in a bioprocess system. The bioprocess material comprising at least two ingredients, each having data properties. The method comprises: i) obtaining (81) the data properties for the at least two ingredients used to produce the bioprocess material; ii) defining (82) procedures to process the at least two ingredients; iii) processing (83) the at least two ingredients according to the defined process parameters to obtain at least a product; iv) measuring (84) data properties of each product, v) calculating (85) data properties of each product based on the measured data properties of each product and/obtain or data properties from the at least two ingredients, and vi)if the product is the bioprocess material, processing (88) the measured and calculated data properties to estimate the impact of the bioprocess material on a target product in the bioprocess system, or vii) if the product is not the bioprocess material, treating the product as an intermediate material and repeating (87) steps iii)-vi) with each product as one of the at least two ingredients.

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