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    Stealth Polymeric Particles For Delivery Of Bioactive Or Diagnostic Agents
    42.
    发明申请
    Stealth Polymeric Particles For Delivery Of Bioactive Or Diagnostic Agents 有权
    用于递送生物活性或诊断剂的隐形聚合物颗粒

    公开(公告)号：US20140274929A1

    公开(公告)日：2014-09-18

    申请号：US14292314

    申请日：2014-05-30

    Applicant: HOWARD UNIVERSITY

    Inventor： Emmanuel Oyekanmi Akala ,  Oluyomi Modupe Okunola

    IPC: A61K9/16 ,  C08F220/68 ,  A61K31/704 ,  A61K31/337 ,  A61K31/135

    CPC classification number: A61K9/1641 ,  A61K9/5146 ,  A61K31/135 ,  A61K31/337 ,  A61K31/704 ,  C08F8/00 ,  C08F8/30 ,  C08F220/68 ,  C08F290/062 ,  Y10T428/2982 ,  C08F120/14 ,  C08F220/18 ,  C08F222/00

    Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alkylene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.

    Abstract translation: 本发明涉及交联聚合物颗粒或非交联聚合物颗粒，其中交联聚合物颗粒包含由至少一种可水解单体或交联剂交联的聚（亚烷基二醇 - 接枝 - 丙烯酸酯）的共聚物。 本发明还涉及包含交联聚合物颗粒的聚合物颗粒，其是起始材料的产物，其包含（a）亲水性单体，（b）疏水性单体和（c）可水解交联剂（交联剂可以 在非交联颗粒的情况下不存在）。 本发明还涉及包含交联共聚物的聚合物颗粒，其中交联共聚物包括如说明书中所定义的由式（I），（II）和（III）表示的结构。 本发明的其它实施方案还包括制备聚合物颗粒的方法。

    C-terminal fragment of tetanus toxin (HC) for treatment of depression
    44.
    发明授权
    C-terminal fragment of tetanus toxin (HC) for treatment of depression 有权

    公开(公告)号：US12168035B2

    公开(公告)日：2024-12-17

    申请号：US17729502

    申请日：2022-04-26

    Applicant: HOWARD UNIVERSITY

    Inventor： Yousef Tizabi

    IPC: A61K38/16 ,  A61K9/00

    Abstract: C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.

    HYBRID PUBLIC-KEY AND PRIVATE-KEY CRYPTOGRAPHIC SYSTEMS BASED ON ISO-RSA ENCRYPTION SCHEME
    45.
    发明申请
    HYBRID PUBLIC-KEY AND PRIVATE-KEY CRYPTOGRAPHIC SYSTEMS BASED ON ISO-RSA ENCRYPTION SCHEME 有权

    公开(公告)号：US20240380586A1

    公开(公告)日：2024-11-14

    申请号：US18291148

    申请日：2022-07-21

    Applicant: HOWARD UNIVERSITY

    Inventor： Mamadou I. WADE

    IPC: H04L9/30 ,  H04L9/08

    Abstract: Systems, methods and apparatus for secure encryption and decryption of a file may be provided which may include generating, by a first processor, a plurality of encryption isokeys, wherein the plurality of encryption isokeys include a first public isokey, a second public isokey, and a private isounit; and encrypting, by the first processor, ciphertext associated with a message based on the plurality of encryption isokeys. The approach may also include receiving, by a second processor, the ciphertext associated with the message; generating, by the second processor, a plurality of decryption isokeys, wherein the plurality of decryption isokeys include the private isounit, a private decryption isokey, and the first public isokey; and decrypting, by the second processor, the message associated with the ciphertext based on the plurality of decryption isokeys.

    SMALL COMPLEMENTARY NUCLEIC ACIDS, COMPOSITIONS CONTAINING THE SAME, AND METHODS FOR USE AS ANTIVIRALS
    46.
    发明公开
    SMALL COMPLEMENTARY NUCLEIC ACIDS, COMPOSITIONS CONTAINING THE SAME, AND METHODS FOR USE AS ANTIVIRALS 审中-公开

    公开(公告)号：US20240263180A1

    公开(公告)日：2024-08-08

    申请号：US18564938

    申请日：2022-05-27

    Applicant: HOWARD UNIVERSITY

    Inventor： Qiyi TANG ,  Hua ZHU

    IPC: C12N15/113 ,  A61P31/22

    CPC classification number: C12N15/1131 ,  A61P31/22 ,  C12N2310/11 ,  C12N2320/33

    Abstract: The present disclosure provides small complementary RNAs (scRNAs), compositions containing the same, and methods for using such small complementary RNAs as antivirals. The present disclosure provides, in more specific embodiments, scRNAs that are single-stranded and which are about 20-30 nucleotides (nt) long, and which are complementary to the intron of an essential viral gene, such as the major immediate early (MIE) gene of human cytomegalovirus (HCMV). Also provided herein are pharmaceutical compositions additionally containing a pharmaceutically acceptable carrier system, wherein the carrier system includes a cationic polymer which releases the scRNA in response to endosomal pH.

    Hybrid public-key and private-key encryption system
    49.
    发明授权
    Hybrid public-key and private-key encryption system 有权

    公开(公告)号：US11728984B2

    公开(公告)日：2023-08-15

    申请号：US17125300

    申请日：2020-12-17

    Applicant: Howard University

    Inventor： Mamadou Ibra Wade ,  Tepper Gill

    IPC: H04L9/08 ,  H04L9/14 ,  H04L9/30 ,  G06F21/60

    CPC classification number: H04L9/0869 ,  G06F21/602 ,  H04L9/14 ,  H04L9/30

    Abstract: A method, computer program, and computer system is provided for encrypting data or information represented by bits, numbers, used to encode images, text, or audio. For the case of an RGB image encryption applications, the data may be separated into its constituent channels before encryption. In addition to the standard encryption keys, another encryption isokey is generated based on an isounit using an algebraic isofield having a multiplicative identity value different than the number one. On the sender side, each of the channels is encrypted using the standard keys and the generated isokey. On the receiver side, each encrypted channel is decrypted before combining them to obtain the recovered RGB image. In addition to images, the cryptographic algorithm can also be used the encrypt data related to text, audio, and other file types.

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