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公开(公告)号：US20230341408A1
公开(公告)日：2023-10-26
申请号：US18008535
申请日：2021-06-08
IPC: G01N33/574
CPC classification number: G01N33/57492 , G01N33/57407 , G01N2333/924
Abstract: The present disclosure provides a method of diagnosing cancer in a subject comprising contacting a blood sample from the subject with an hyaluronidase 2-binding agent and detecting a level of hyaluronidase 2-positive myeloid cells in the blood sample, wherein an elevated level of hyaluronidase 2-positive myeloid cells in the blood sample identifies the subject as suffering from cancer. Methods comprising administering a cancer therapy to a subject identified as suffering from cancer are also provided.
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公开(公告)号：US20230339023A1
公开(公告)日：2023-10-26
申请号：US18216985
申请日：2023-06-30
Inventor： Wei David Wei , Yueming Zhai
CPC classification number: B22F9/24 , B82Y5/00 , C22B11/04 , C30B7/14 , C30B29/66 , B22F1/054 , B22F1/0553 , B22F1/056 , B82Y30/00
Abstract: In one aspect, the present disclosure pertains to methods of making various noble metal nanoprisms, e.g., gold nanoprisms. In various aspects, the methods can comprise incubating, under dark conditions, a growth solution comprising: (a) a plurality of gold seed structures; (b) a gold precursor, and (c) a photocatalytic intermediary, such that during the incubating step multiply-twinned gold seed structures in the growth solution are preferentially enlarged. The disclosed methods can comprise separating the multiply-twinned gold seed structures from the growth solution based upon the size of the gold seed structures to produce an enriched growth solution. In some aspects, the methods comprise irradiating the enriched growth solution to produce the gold nanoprisms. In some aspects, the disclosed nanoprisms comprise silver.
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公开(公告)号：US11797667B2
公开(公告)日：2023-10-24
申请号：US16913850
申请日：2020-06-26
Inventor： Prabhat Kumar Mishra , Thelijjagoda S N Charles , Yangdi Lyu
IPC: G06F21/55
CPC classification number: G06F21/552 , G06F2221/034
Abstract: Various examples are provided related to software and hardware architectures that enable lightweight and real-time Denial-of-Service (DoS) and Distributed Denial-of-Service (DDoS) attack detection. In one example, among others, a method for detection and localization of denial-of-service (DoS) attacks includes detecting, by a router of an intellectual property (IP) core in a network-on-chip (NoC) based system-on-chip (SoC) architecture, a compromised packet stream based at least in part upon a packet arrival curve (PAC) associated with the router; identifying, by the IP core, a candidate IP core in the NoC as a potential attacker based at least in part upon a destination packet latency curve (DLC) associated with the IP core; and transmitting, by the router, a notification message indicating that the candidate IP core is the potential attacker to a router of the candidate IP core.
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44.发明公开公开(公告)号：US20230324417A1
公开(公告)日：2023-10-12
申请号：US18190623
申请日：2023-03-27
Applicant: University of Florida Research Foundation, Inc. , The Regents of the University of Colorado
Inventor： Damon Ghetmiri , Amor Menezes , Mitchell Cohen
CPC classification number: G01N33/86 , G01N33/4905 , G16B5/00 , G16H20/00 , G01N2333/974
Abstract: The present disclosure presents systems and methods for administering blood products having a personalized concentration of coagulation factors. One such method includes obtaining measured coagulation factor concentrations from a blood sample of a subject; generating a clotting prediction for the subject based on the measured blood factor concentrations of the subject; determining one or more coagulation factor concentrations to be administered to the subject based on the clotting prediction; iteratively generating a new clotting prediction for the subject based on the determined coagulation factors; iteratively determining additional coagulation factor concentrations to be administered to the subject based on the new clotting prediction until the subject’s coagulation factor concentrations are predicted to equilibrate at a predefined normal range; and/or outputting a recommended set of coagulation factor concentrations to be administered to the subject based on the determined coagulation factor concentrations. Other methods and systems are also provided.
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公开(公告)号：US11781206B2
公开(公告)日：2023-10-10
申请号：US17661054
申请日：2022-04-28
Applicant: University of Florida Research Foundation, Inc. , United States Of America As Represented By The Administrator of NASA
Inventor： Michele Viola Manuel , Charles Robert Fisher , Maria Clara Wright
IPC: C22C21/02 , C22F1/00 , C22C21/14 , B32B15/20 , C22C1/04 , C22C49/14 , C22C1/10 , C22C49/06 , B22F1/00 , B22D19/00 , B22D21/00 , C22F1/043 , C22F1/057
CPC classification number: C22F1/006 , B22D19/00 , B22D21/007 , B22F1/00 , B32B15/20 , C22C1/0416 , C22C1/1036 , C22C1/1084 , C22C21/02 , C22C21/14 , C22C49/06 , C22C49/14 , C22F1/043 , C22F1/057 , B22F2301/15 , B32B2307/54
Abstract: Disclosed herein is a composite comprising a metal alloy matrix; where the metal alloy matrix comprises aluminum in an amount greater than 50 atomic percent; a first metal and a second metal; where the first metal is different from the second metal; and where the metal alloy matrix comprises a low temperature melting phase and a high temperature melting phase; where the low temperature melting phase melts at a temperature that is lower than the high temperature melting phase; and a contracting constituent; where the contracting constituent exerts a compressive force on the metal alloy matrix at a temperature between a melting point of the low temperature melting phase and a melting point of the high temperature melting phase or below the melting points of the high and low temperature melting phases.
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Patent Agency Ranking
46.发明授权公开(公告)号：US11775693B1
公开(公告)日：2023-10-03
申请号：US17543034
申请日：2021-12-06
Inventor： Prabhat Kumar Mishra , Jennifer Marie Sheldon , Zhixin Pan
IPC: G06F21/76 , G06F21/54 , G06F30/333 , G06F21/55 , G06N3/08
CPC classification number: G06F21/76 , G06F21/54 , G06F21/554 , G06F21/556 , G06F30/333 , G06N3/08
Abstract: The present disclosure describes systems and methods for test pattern generation to detect a hardware Trojan using delay-based analysis. One such method comprises determining a set of initial test patterns to activate the hardware Trojan within an integrated circuit design; and generating a set of succeeding test patterns to activate the hardware Trojan within the integrated circuit design using a reinforcement learning model. The set of initial test patterns can be applied as an input to the reinforcement learning model. Further, the reinforcement learning model can be trained with a stochastic learning scheme to increase a probability of triggering one or more rare nodes in the integrated circuit design and identify optimal test vectors to maximize delay-based side-channel sensitivity when the hardware Trojan is activated in the integrated circuit design. Other methods and systems are also provided.
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公开(公告)号：US11771665B2
公开(公告)日：2023-10-03
申请号：US17824235
申请日：2022-05-25
Inventor： Anuj Chauhan , Phillip J. Dixon
CPC classification number: A61K31/145 , A45C11/005 , A61F9/0008 , A61K9/0048 , A61K47/22 , A61K47/42
Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.
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公开(公告)号：US20230279329A1
公开(公告)日：2023-09-07
申请号：US18013359
申请日：2021-07-01
Inventor： Jack E. FAMIGLIETTI , Sean R. NIEMI , Wallace G. SAWYER , Ryan A. SMOLCHEK , Kylie E. VAN METER
CPC classification number: C12M33/04 , B25J7/00 , C12M21/08 , C12M25/04 , C12M29/10 , C12M41/36 , G02B21/32
Abstract: Disclosed herein are systems and methods relating to in-situ servo-hydraulic biomanipulators. In-situ servo-hydraulic bio-manipulators as described herein have the advantages over existing systems and methods at least by having a lower cost, interchangeable and/or disposal displacement devices coupled to the extrusion head, and mounting of the displacement head along the optical axis of a microscope for enhanced visibility and well clearance.
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公开(公告)号：US20230277873A1
公开(公告)日：2023-09-07
申请号：US18132570
申请日：2023-04-10
Inventor： Sanjiv Singh Samant , Jyothier Nimmagadda , James Edward Baciak , Thomas S.S. Samant , Andreas Jon Enqvist
IPC: A61N5/10
CPC classification number: A61N5/1049 , A61N5/1071 , A61N2005/1054 , A61N2005/1087
Abstract: A particle portal imaging (PPI) system and method are provided that can be used to provide a “beam’s eye view” of a patient’s anatomy as a charged particle beam is delivered to a target region of the patient’s body. The PPI system is capable of performing real-time image acquisition and in-situ dose monitoring using at least exit neutrons generated within the patient. The PPI system can perform charged particle treatment (PT) monitoring to monitor the particle beam being used for PT.
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公开(公告)号：US20230272327A1
公开(公告)日：2023-08-31
申请号：US18013200
申请日：2021-07-02
Inventor： Wallace Gregory SAWYER , Ryan A. SMOLCHEK , Juan Manuel URUEÑA VARGAS , Jack E. FAMIGLIETTI , Duy T. NGUYEN
Abstract: Provided herein are injection molded perfusion-enabled bioreactors and systems including said bioreactors. The bioreactor can include a lid, a frame comprising an an-ay of sample wells, a membrane adhered to a bottom of the frame beneath the array of sample wells, and a skirt adhered to a bottom of the frame, such that the membrane is located between the frame and the skirt. The skirt can include a plurality of channels corresponding to the sample wells. When the sample wells are filled with a 3D cell culture support matrix, a pressure above the 3D cell culture support matrix is atmospheric pressure and a pressure below the membrane is less than atmospheric, thereby perfusing a fluid along a vertical fluid flow path from the sample wells through the
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