Abstract:
Provided herein are monomeric variants of Sandercyanin fluorescent protein (SFP) including those monomeric SFP variants set forth in SEQ ID NO:2-6 and SFP variants with increased brightness. Also provided herein are methods of making and using fluorescent probes comprising such monomeric variants, where the fluorescent probes have specificity for desired targets.
Abstract:
An apparatus for musculoskeletal stimulation allows a restoring element communicating with the limb support to provide a restoring force to the limb support that is dependent on displacement of the limb support from a neutral positions. The restoring force may be applied by a weight or a spring.
Abstract:
A cup for use with those having muscular tremors provides a battery-operated gyroscope stabilizing the cup body as supported by a handle communicating with the cup body through one or more pivot joints. The cup body may also be weighted to be naturally stabilized in a vertical orientation.
Abstract:
A composition is provided that, when utilized in combination with a coumarin anticoagulant, greatly improves the anticoagulant effects of the anticoagulant in mammalian subjects. The composition is a compound having a naphthohydroquinone ring system substantially similar to the ring system of the reduced form of vitamin K1 and has the general formula: where n is 1 or 2, where R1 and R4 are hydrogen or acyl, R2 is a hydrogen or saturated or unsaturated alkyl group with up to 6 carbons, and R3 is a hydrogen or saturated or unsaturated alkyl group with up to 6 carbons, or R2 and R3 are part of a cyclic or polycyclic ring system.
Abstract:
A field emission transistor uses carbon nanotubes positioned to extend along a substrate plane rather than perpendicularly thereto. The carbon nanotubes may be pre-manufactured and applied to the substrate and then may be etched to create a gap between the carbon nanotubes and an anode through which electrons may flow by field emission. A planar gate may be positioned beneath the gap to provide a triode structure.
Abstract:
A building technique uses standard shipping containers as buttresses to support a truss system that may extend between the shipping containers to provide a roof. A sliding connector system attaches the trusses to the shipping containers to accommodate variations in separation of the shipping containers presenting a versatile framing system that is insensitive to site-related variations.
Abstract:
A prefabricated sprue assembly provides attachment to independently-produced investment casting molds to substantially reduce the need for pattern material. Installable connections between the prefabricated sprue assembly and the investment mold allow substantial reduction of scrap loss caused by errors in production of individual investment molds by culling defective molds before installation to the sprue assembly.
Abstract:
An apparatus for musculoskeletal stimulation allows independent electronic control of vibration parameters and overall biasing force so that an optimum combination of these parameters may be obtained regardless of the user's weight and without the need for adjustment of mechanical weights or springs.
Abstract:
An investment casting method involves producing a casting shell by applying a hardenable refractory material to a sacrificial pattern. The casting shell having a plurality of phosphate bonds in the hardenable refractory material, which provide increased structural integrity during casting and improved frangibility during shell removal. The casting shell may also have a plurality of gaseous pockets suspended in the refractory material, which do not degrade the structural integrity during casting and provide improved frangibility during shell removal.
Abstract:
A three-dimensional (3D) printer system includes a nozzle that can passively align fibers being deposited with resin while creating fiber-reinforced composite components. The nozzle may include a nozzle body with main bore that directs material axially through a nozzle body, toward an alignment duct that provides the nozzle's outlet. The alignment duct may provide a passage in which the fibers are urged into a different orientation aligns the fibers generally parallel to each other in a different direction than the axial flow direction through the nozzle. The alignment duct's passage may be radially asymmetric, such as a tapering rectangular slot(s), which may provide guide surfaces to impart the reorientation of the flowing fibers.