Abstract:
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Abstract:
A model-free adaptive controller is disclosed, which uses a dynamic artificial neural network with a learning algorithm to control any single-variable or multivariable open-loop stable, controllable, and consistently direct-acting or reverse-acting industrial process without requiring any manual tuning, quantitative knowledge of the process, or process identifiers. The need for process knowledge is avoided by substituting 1 for the actual sensitivity function .differential.y(t)/.differential.u(t) of the process.
Abstract:
The present invention relates to a high-hardenability, medium-carbon, low-alloy round steel for fasteners, the chemical constituents by mass percentage are as follows: C: 0.36˜0.44%, Si: 0.15˜0.40%, Mn: 0.80˜1.00%, Cr: 1.00˜1.15%, Mo: 0.05˜0.25%, Ni: 0.05˜0.25%, Cu: 0.05˜0.25%, Al: 0.015˜0.050%, B: 0.0010˜0.0050%, Ti: 0.020˜0.050%, the balance is Fe; the maximum diameter of the round steel is 65 mm. The manufacturing process are as follows: the raw materials are processed, in sequence, by converter smelting, LF refining, RH/VD degassing to obtain molten steel, feeding Ti wires and ferroboron, continuous casting, rolling into the bar, obtaining the quenched and tempered round steel after quenching and tempering treatment; the quenched and tempered round steel is able to be directly used in processing fasteners which meet ISO 898-1 standard for grade 10.9, such as bolts and the like.
Abstract:
Polypeptides, polynucleotides, reassortant viruses, immunogenic compositions and vaccines comprising influenza hemagglutinin and neuraminidase variants and method using thereof are provided.
Abstract:
An arrangement for use in connection with an air handling unit includes a controller and a processing circuit. The controller is configured to control a device within an air handler unit, which includes at least a first coil. The processing circuit is configured to receive first information representative of a maximum liquid flow rate through the first coil and second information representative of a maximum air flow rate of the first coil. The processing circuit is further configured to generate a time constant estimate, based on the first information and second information, for use in the controller in performing control of the device.
Abstract:
The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.
Abstract:
Polypeptides, polynucleotides, reassortant viruses, immunogenic compositions and vaccines comprising influenza hemagglutinin and neuraminidase variants and method using thereof are provided.
Abstract:
Compounds of formulae I, or pharmaceutically acceptable salts thereof: wherein R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
Abstract:
Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein X, R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
Abstract:
A method of fabricating a device including imprinting a mold having a protrusion against a substrate having a resist layer such that the protrusion engages the resist layer. The mold further has a mask member positioned generally adjacent the resist layer. Radiation energy is then transmitted through the mold and into the resist layer; however, the mask member substantially prevents transmission of the radiation energy therethrough, thereby defining an unexposed area in the resist layer. Once the mold is removed from the substrate, which consequently forms a first feature from nanoimprinting, the unexposed area of resist layer is removed through dissolving in a developer solution.