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93 条记录 (耗时 0.039 秒)

    Flexural plate wave sensor and array
    42.
    发明授权
    Flexural plate wave sensor and array 有权
    弯曲板波传感器和阵列

    公开(公告)号：US07266990B2

    公开(公告)日：2007-09-11

    申请号：US11357911

    申请日：2006-02-17

    申请人： Brian T. Cunningham ,  John R. Williams

    发明人： Brian T. Cunningham ,  John R. Williams

    IPC分类号： G01N29/02

    CPC分类号： G01N29/022 ,  G01N29/22 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106 ,  Y10T29/42 ,  Y10T29/49007

    摘要： A method for manufacturing a flexural plate wave sensor includes the steps of depositing an etch-stop layer over a substrate, depositing a membrane layer over the etch stop layer, depositing a piezoelectric layer over the membrane layer, forming a transducer on the piezoelectric layer, etching a cavity through the substrate, the cavity having substantially parallel interior walls, and removing the portion of the etch stop layer between the cavity and the membrane layer to expose a portion of the membrane layer.

    摘要翻译： 制造弯曲板波传感器的方法包括以下步骤：在衬底上沉积蚀刻停止层，在蚀刻停止层上沉积膜层，在膜层上沉积压电层，在压电层上形成换能器， 通过衬底蚀刻空腔，空腔具有基本上平行的内壁，并且去除腔和膜层之间的蚀刻停止层的部分以暴露膜层的一部分。

    External cavity laser biosensor arrangements
    46.
    发明授权
    External cavity laser biosensor arrangements 有权

    公开(公告)号：US09829435B2

    公开(公告)日：2017-11-28

    申请号：US13433619

    申请日：2012-03-29

    申请人： Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

    发明人： Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

    IPC分类号： G01N21/64 ,  H01S3/1055 ,  H01S5/14

    CPC分类号： G01N21/6428 ,  G01N21/6458 ,  G01N2021/6421 ,  H01S3/1055 ,  H01S5/141 ,  H01S5/142

    摘要： A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.

    Discrete frequency spectroscopy and instrumentation
    47.
    发明授权
    Discrete frequency spectroscopy and instrumentation 有权
    离散频谱和仪器仪表

    公开(公告)号：US08593630B2

    公开(公告)日：2013-11-26

    申请号：US12900172

    申请日：2010-10-07

    申请人： Rohit Bhargava ,  Brian T. Cunningham

    发明人： Rohit Bhargava ,  Brian T. Cunningham

    IPC分类号： G01J3/40

    CPC分类号： G01J3/12 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0275 ,  G01J3/0286 ,  G01J3/0289 ,  G01N21/35

    摘要： Described herein are spectrometers comprising one or more wavelength-selective filters, such as guided mode resonance filters. Some of the spectrometers described herein are configured for obtaining absorbance spectra in a discrete fashion by measuring absorbances of a sample at multiple discrete wavelengths or wavelength bands. In another aspect, methods are also provided for obtaining spectra, images and chemical maps of samples in a discrete fashion.

    摘要翻译： 这里描述的是包括一个或多个波长选择性滤波器的光谱仪，例如导模谐振滤波器。 这里描述的一些光谱仪被配置为通过测量在多个离散波长或波长带上的样品的吸光度以离散的方式获得吸收光谱。 在另一方面，还提供了用于以离散方式获得样品的光谱，图像和化学图谱的方法。

    Multi-color fluorescence enhancement from a photonic crystal surface
    48.
    发明授权
    Multi-color fluorescence enhancement from a photonic crystal surface 有权
    光子晶体表面的多色荧光增强

    公开(公告)号：US08344333B2

    公开(公告)日：2013-01-01

    申请号：US13135246

    申请日：2011-06-28

    申请人： Meng Lu ,  Stephen C. Shulz ,  Brian T. Cunningham ,  Anusha Pokhriyal

    发明人： Meng Lu ,  Stephen C. Shulz ,  Brian T. Cunningham ,  Anusha Pokhriyal

    IPC分类号： G01N21/64

    CPC分类号： G01N21/648 ,  G01N21/6428 ,  G01N21/7743

    摘要： A photonic crystal substrate exhibiting resonant enhancement of multiple fluorophores has been demonstrated. The device, which can be fabricated uniformly from plastic materials over a ˜3×5 in2 surface area by nanoreplica molding, features a 1-D periodic grating structure which utilizes two distinct resonant modes to enhance electric field stimulation of a first dye excited by a first laser (e.g., λ=632.8 nm laser exciting cyanine-5) and a second dye excited by a second laser (e.g., λ=532 nm laser exciting cyanine-3). The first and second lasers could be replaced by a single variable wavelength (tunable) laser. Resonant coupling of the laser excitation to the photonic crystal surface is obtained for each wavelength at a distinct incident angle θ. The photonic crystal is capable of amplifying the output of any fluorescent dye with an excitation wavelength in a given wavelength range (e.g., the range 532 nm

    摘要翻译： 已经证明了表现出多个荧光团的共振增强的光子晶体衬底。 可以通过纳米尺寸成型在〜3×5 in2表面积上由塑料材料均匀地制造的器件具有1-D周期性光栅结构，其利用两种不同的谐振模式来增强第一染料激发的电场刺激 第一激光（例如，λ= 632.8nm激光花青-5）和由第二激光器激发的第二染料（例如，λ= 532nm激光花青-3）。 第一和第二激光器可以由单个可变波长（可调谐）激光器代替。 获得激光激发与光子晶体表面的共振耦合，每个波长处于不同的入射角。 通过选择适当的入射角，光子晶体能够通过给定波长范围（例如，532nm <λ<660nm）的激发波长放大任何荧光染料的输出。 该装置可用于在单个成像区域内利用多种荧光染料的生物测定法，例如基因表达微阵列。

    Surface Enhanced Raman Spectroscopy Nanodome Biosensors and Methods of Manufacturing the Same
    49.
    发明申请
    Surface Enhanced Raman Spectroscopy Nanodome Biosensors and Methods of Manufacturing the Same 有权
    表面增强拉曼光谱纳米体生物传感器及其制造方法

    公开(公告)号：US20120309080A1

    公开(公告)日：2012-12-06

    申请号：US13438950

    申请日：2012-04-04

    申请人： Brian T. Cunningham ,  Charles J. Choi ,  Alysia R. Watkins

    发明人： Brian T. Cunningham ,  Charles J. Choi ,  Alysia R. Watkins

    IPC分类号： G01N21/65 ,  B05D3/12 ,  C12M1/34 ,  B82Y15/00

    CPC分类号： G02B1/005 ,  G01N21/658

    摘要： Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring.

    摘要翻译： 诸如透明塑料一次性管道或玻璃管的管道包括形成在管道中或放置在管道内的光子传感器。 光子传感器可以采用光子晶体传感器，分布式反馈激光传感器和表面增强拉曼光谱（SERS）传感器的形式，包括光子晶体增强型SERS传感器。 描述传感器的检测装置。 本发明具有许多应用，包括在医院护理中使用的管道（例如，导尿管，静脉输液管道，透析中使用的管，例如肝素管线或血管套件），食品制造，药物制造，水质监测和环境监测。