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41.发明申请公开(公告)号：US20110242533A1
公开(公告)日：2011-10-06
申请号：US13020935
申请日：2011-02-04
IPC分类号： G01J3/28
CPC分类号： G01J3/32 , G01J3/44 , G01N21/359 , G01N33/0057
摘要： A system and method for MWIR hyperspectral imaging to detect hazardous agents including explosive agents. A system comprising an illumination source, a tunable filter, and an imaging detector configured for MWIR hyperspectral imaging of a target comprising an unknown material. A method comprising illuminating a target comprising an unknown material, passing interacted photons through a tunable filter, and generating a MWIR hyperspectral image of the target. Algorithms and chemometric techniques may be applied to assess the MWIR hyperspectral image to identify the unknown material as comprising an explosive agent or a non-explosive agent. A video imaging device may also be configured to provide a video image of an area of interest, which may be assessed to identify a target for interrogation using MWIR hyperspectral imaging.
摘要翻译： 用于MWIR高光谱成像检测危险物质（包括爆炸物质）的系统和方法。 一种包括照明源，可调谐滤光器和被配置用于包含未知材料的靶的MWIR高光谱成像的成像检测器的系统。 一种方法，包括照射包括未知材料的靶，通过可调滤波器传递相互作用的光子，以及生成目标的MWIR高光谱图像。 可以应用算法和化学计量技术来评估MWIR高光谱图像，以将未知材料识别为包括爆炸剂或非爆炸剂。 视频成像设备还可以被配置为提供感兴趣区域的视频图像，其可以被评估以使用MWIR高光谱成像识别用于询问的目标。
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公开(公告)号：US20070263290A1
公开(公告)日：2007-11-15
申请号：US11744797
申请日：2007-05-04
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer , Ryan Smith
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer , Ryan Smith
CPC分类号： G02B6/06 , A61B1/00165 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0227 , G01J3/024 , G01J3/0256 , G01J3/0262 , G01J3/0286 , G01J3/44 , G01J2003/1213
摘要： A fiberscope device is disclosed which is suitable for video imaging, laser Raman spectroscopy and laser Raman spectroscopic (i.e. chemical) imaging. The fiberscope design minimizes fiber background interference arising from the laser delivery fiber optic and the coherent fiber optic light gathering bundle while maintaining high light throughput efficiency through the use of integrated spectral filters. In the fiberscope design, the laser delivery fiber optic is offset from the coherent fiber optic light gathering bundle. The laser delivery field is captured entirely by the light gathering field of view of the coherent fiber bundle. The fiberscope incorporates spectral filter optical elements that provide environmental insensitivity, particularly to temperature and moisture. The fiberscope is suited to the analysis of a wide range of condensed phase materials (solids and liquids), including the analysis of biological materials such as breast tissue lesions and arterial plaques, in such a manner to delineate abnormal from normal tissues.
摘要翻译： 公开了适用于视频成像，激光拉曼光谱和激光拉曼光谱（即化学）成像的纤维内窥镜装置。 纤维镜设计可以最大限度地减少激光传输光纤和相干光纤采集光束产生的光纤背景干扰，同时通过使用集成光谱滤波器保持高光通量效率。 在纤维镜设计中，激光传输光纤与相干光纤聚光束偏移。 激光输送场完全由相干光纤束的聚光场捕获。 纤维镜包含光谱滤光器光学元件，其提供环境不敏感性，特别是对温度和湿度。 纤维内窥镜适用于分析各种凝聚相材料（固体和液体），包括分析生物材料如乳房组织损伤和动脉斑块，以便从正常组织中描绘异常。
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公开(公告)号：US20070145258A1
公开(公告)日：2007-06-28
申请号：US11640197
申请日：2006-12-18
申请人： Matthew Nelson , Patrick Treado
发明人： Matthew Nelson , Patrick Treado
IPC分类号： G01D18/00
CPC分类号： G01J3/28 , A61B5/0059 , A61B2560/0223 , G01J2003/2866
摘要： The disclosure generally relates to a method and apparatus for automated spectral calibration of a spectroscopy device. In one embodiment, the disclosure relates to a method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.
摘要翻译： 本发明一般涉及一种用于光谱设备的自动光谱校准的方法和装置。 在一个实施方案中，本公开涉及通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱。
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公开(公告)号：US20060192956A1
公开(公告)日：2006-08-31
申请号：US11257219
申请日：2005-10-24
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01J3/28
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.
摘要翻译： 提供使用近红外辐射显微镜的化学成像系统。 该系统包括使用近红外辐射波长的光和可见波长的光来照射样品的区域的照明源。 收集来自样品的照射区域的透射，反射，发射或散射的近红外波长辐射光的多个空间解析光谱，并从其中产生准直光束。 提供近红外成像光谱仪用于选择准直光束的近红外辐射图像。 滤波后的图像由检测器收集以进一步处理。 同时检测来自样品的照射区域的可见波长的光，提供样品的同时可见和近红外化学成像分析。 提供了三维近红外化学成像显微镜的两种有效手段。
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公开(公告)号：US20060151702A1
公开(公告)日：2006-07-13
申请号：US11366129
申请日：2006-03-02
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01N21/35
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.
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公开(公告)号：US20060049354A1
公开(公告)日：2006-03-09
申请号：US11257139
申请日：2005-10-24
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01J5/02
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.
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公开(公告)号：US20060036181A1
公开(公告)日：2006-02-16
申请号：US11204196
申请日：2005-08-09
申请人： Patrick Treado , Matthew Nelson
发明人： Patrick Treado , Matthew Nelson
CPC分类号： A61B5/0091 , A61B5/4312 , G01N21/65
摘要： Apparatus and methods for spatially resolved Raman chemical imaging of breast tissue is disclosed. A region of breast tissue is illuminated with monochromatic light. A spatially organized area of endogenous molecules in the tissue is then detected in the region by detecting a Raman shifted light signal. The Raman shifted light signal is spatially resolved in at least one direction and is thus useful for examining breast tissue, especially to detect malignant tissue.
摘要翻译： 公开了用于乳腺组织的空间分辨拉曼化学成像的装置和方法。 乳腺组织区域用单色光照射。 然后通过检测拉曼移动的光信号在该区域中检测组织中的内分子的空间有组织的区域。 拉曼移动的光信号在至少一个方向上被空间分辨，因此可用于检查乳腺组织，特别是用于检测恶性组织。
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公开(公告)号：US08687177B2
公开(公告)日：2014-04-01
申请号：US12899055
申请日：2010-10-06
申请人： Jeff Beckstead , Matthew Nelson , Patrick Treado
发明人： Jeff Beckstead , Matthew Nelson , Patrick Treado
IPC分类号： G01N21/00
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/10 , G01J3/28 , G01J3/36 , G01J3/44 , G01J3/443 , G01N21/65 , G01N21/718 , G01N2201/0221 , G01N2201/06113 , G01N2201/0833 , G01N2201/0846
摘要： A system and method for detection and identification of unknown samples using a combination of Raman and LIBS detection techniques. A first region of a sample and a second region of a sample are illuminated using structured illumination to thereby generate a first plurality of interacted photons and a second plurality of interacted photons. This first plurality and second plurality of interacted photons may be passed through a fiber array spectral translator device. Said first plurality of interacted photons are assessed using Raman spectroscopy to thereby generate a Raman data set. Said second plurality of interacted photons are assessed using LIBS spectroscopy to thereby generate LIBS data set. These data sets may be analyzed to identify the sample. These data sets may also be fused for further analysis.
摘要翻译： 一种使用拉曼和LIBS检测技术的组合检测和识别未知样品的系统和方法。 使用结构照明来照射样品的第一区域和样品的第二区域，从而产生第一多个相互作用的光子和第二多个相互作用的光子。 该第一多个和第二多个相互作用的光子可以通过光纤阵列光谱转换器装置。 使用拉曼光谱来评估所述第一多个相互作用的光子，从而产生拉曼数据集。 使用LIBS光谱来评估所述第二多个相互作用的光子，从而生成LIBS数据集。 可以分析这些数据集以识别样品。 这些数据集也可以融合进一步分析。
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49.发明申请公开(公告)号：US20120145906A1
公开(公告)日：2012-06-14
申请号：US12802649
申请日：2010-06-11
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/26 , G01J3/28 , G01J3/2823 , G01J3/44 , G01N21/31 , G01N21/6456 , G01N21/65 , G01N2021/3155 , G01N2021/6423 , G01N2201/0221 , G01N2201/129
摘要： A portable device for detecting explosives and other target materials using SWIR spectroscopic imaging, including hyperspectral imaging. The device may comprise a lens, a tunable filter, and a detector. The device may use solar radiation, or may comprise an illumination source such as a laser, to illuminate at target material and thereby produce interacted photons. The device may utilize multi-conjugate liquid crystal filter technology to filter interacted photons. The disclosure also provides for a method for using the portable device comprising illuminating a target material to produce interacted photons. The interacted photons are used to form a SWIR spectroscopic image, which may be a hyperspectral image. This image is analyzed to thereby identify the target material. This analysis may comprise comparing at least one spectrum or image representative of the target material to a reference spectrum or image. This comparison may be accomplished using a chemometric technique.
摘要翻译： 一种使用SWIR光谱成像检测爆炸物和其他目标材料的便携式设备，包括高光谱成像。 该装置可以包括透镜，可调滤光器和检测器。 该装置可以使用太阳辐射，或者可以包括诸如激光器的照明源，以在目标材料上照射，从而产生相互作用的光子。 该器件可以利用多重共轭液晶滤波技术来过滤相互作用的光子。 本公开还提供了一种使用该便携式设备的方法，包括照射目标材料以产生相互作用的光子。 相互作用的光子用于形成SWIR光谱图像，其可以是高光谱图像。 分析该图像，从而识别目标材料。 该分析可以包括将表示目标材料的至少一个光谱或图像与参考光谱或图像进行比较。 该比较可以使用化学计量技术来完成。
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公开(公告)号：US20120038908A1
公开(公告)日：2012-02-16
申请号：US13209688
申请日：2011-08-15
CPC分类号： G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0272 , G01J3/28 , G01J3/44 , G01J3/443 , G01N21/35 , G01N21/6402 , G01N21/6456 , G01N21/65 , G01N21/658 , G01N21/718 , G01N2021/6423 , G01N2201/0221 , G01N2201/06113 , G01N2201/08 , G01N2201/101 , G01N2201/1087
摘要： A system and method for locating and identifying unknown samples. A targeting mode may be utilized to scan regions of interest for potential unknown materials. This targeting mode may interrogate regions of interest using SWIR and/or fluorescence spectroscopic and imaging techniques. Unknown samples detected in regions of interest may be further interrogated using a combination of Raman and LIBS techniques to identify the unknown samples. Structured illumination may be used to interrogate an unknown sample. Data sets generated during interrogation may be compared to a reference database comprising a plurality of reference data sets, each associated with a known material. The system and method may be used to identify a variety of materials including: biological, chemical, explosive, hazardous, concealment, and non-hazardous materials.
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