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公开(公告)号：US20130080082A1
公开(公告)日：2013-03-28
申请号：US13697739
申请日：2011-06-14
Applicant: Grant C. Howes , Collin A. Rich
Inventor： Grant C. Howes , Collin A. Rich
CPC classification number: G01F1/00 , G01F25/0007 , G01N15/14 , G01N35/00871 , G06F17/00 , G06F19/28
Abstract: A system for creating a flow cytometer network includes: a flow cytometer with an interrogation zone and a fixed gain detection system that collects sample data from the interrogation zone; a flow cytometer data center that stores and manages sample- related data from the flow cytometer; and a network communication module that communicates sample-related data between the flow cytometer and the data center. The system may include a second flow cytometer and a second network communication module, where the first and second flow cytometers are calibrated to have substantially identical fixed gain settings. A method for creating a flow cytometer network includes: calibrating first and second flow cytometers with a calibration solution; collecting sample data with a fixed gain detection system; uploading data to a flow cytometer data center; retrieving data from the data center; and performing data analysis on the retrieved data.
Abstract translation: 用于产生流式细胞仪网络的系统包括：具有询问区的流式细胞仪和从询问区收集样本数据的固定增益检测系统; 流式细胞仪数据中心，用于存储和管理来自流式细胞仪的样品相关数据; 以及在流式细胞仪和数据中心之间传送样本相关数据的网络通信模块。 该系统可以包括第二流式细胞仪和第二网络通信模块，其中第一和第二流式细胞仪被校准以具有基本相同的固定增益设置。 创建流式细胞仪网络的方法包括：用校准溶液校准第一和第二流式细胞仪; 用固定增益检测系统收集样本数据; 将数据上传到流式细胞仪数据中心; 从数据中心检索数据; 并对所检索的数据执行数据分析。
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公开(公告)号：US08262990B2
公开(公告)日：2012-09-11
申请号：US12857405
申请日：2010-08-16
Applicant: Nathaniel C. Bair , Collin A. Rich
Inventor： Nathaniel C. Bair , Collin A. Rich
CPC classification number: F04B23/04 , F04B43/0081 , F04B43/12 , F04B2201/1201 , F04B2205/09 , G01N15/1404 , G01N2015/1413 , G05D7/0682 , Y10T137/0352 , Y10T137/0379 , Y10T137/0402 , Y10T137/85986 , Y10T436/115831 , Y10T436/117497
Abstract: The fluidic system with an unclogging feature of the preferred embodiment includes a flow channel, a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The pump and controller cooperate to propagate a pulsation through the flow channel from the pump if the flow channel is clogged. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.
Abstract translation: 具有优选实施例的不记录特征的流体系统包括流动通道，用于将护套流体从鞘容器泵送到询问区域的护套泵以及将废液从询问区泵送到废物容器中的废水泵。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 如果流道被堵塞，泵和控制器协同传播来自泵的流动通道的脉动。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。
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公开(公告)号：US07981661B2
公开(公告)日：2011-07-19
申请号：US11736412
申请日：2007-04-17
Applicant: Collin A. Rich
Inventor： Collin A. Rich
CPC classification number: G01N15/1404 , G01N2015/1409 , Y10T436/115831
Abstract: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, a sheath volume measurement device to measure the fluid in the sheath container, a waste pump to pump the sheath fluid and a sample fluid as waste fluid from the interrogation zone into a waste container, and a waste volume measurement device to measure the fluid in the waste container. The system also includes a controller connected to the sheath pump, the waste pump, and the volume measurement devices. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone, which functions to provide a location for the fluidic system and an optical system of the flow cytometer to cooperatively facilitate the analysis of the sample fluid.
Abstract translation: 优选实施例的流体系统包括鞘套泵，以将护套流体从护套容器泵送到询问区域中;护套体积测量装置，用于测量护套容器中的流体;泵送护套流体的废泵和样品流体 作为从询问区到废物容器的废液，以及用于测量废物容器中的流体的废物体积测量装置。 该系统还包括连接到护套泵，废水泵和体积测量装置的控制器。 护套泵和/或废液泵将样品流体从样品容器抽入询问区，其功能是提供流体系统的位置和流式细胞计数器的光学系统，以便协调地促进样品流体的分析。
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公开(公告)号：US20110058163A1
公开(公告)日：2011-03-10
申请号：US12939836
申请日：2010-11-04
Applicant: Collin A. Rich
Inventor： Collin A. Rich
IPC: G01N1/10
CPC classification number: G01N15/1434 , G01N15/1459 , G02B27/141 , G02B27/145
Abstract: The optical system of the preferred embodiments includes a first light source that creates a first beam of a first wavelength, a first collimating element that collimates the first beam, a second light source 102 that creates a second beam of a second wavelength, a second collimating element that collimates the second beam, a beam combining element that combines the collimated beams, and a focusing element that focuses the combined collimated beam to a single point.
Abstract translation: 优选实施例的光学系统包括产生第一波长的第一光束的第一光源，准直第一光束的第一准直元件，产生第二波长的第二光束的第二光源102，第二准直 对第二光束进行准直的元件，组合准直光束的光束组合元件以及将组合的准直光束聚焦到单个点的聚焦元件。
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45.发明申请公开(公告)号：US20110008816A1
公开(公告)日：2011-01-13
申请号：US12792536
申请日：2010-06-02
Applicant: Jack T. Ball , Grant C. Howes , Collin A. Rich
Inventor： Jack T. Ball , Grant C. Howes , Collin A. Rich
CPC classification number: G01N33/5094 , G01N15/1012 , G01N15/14 , G01N15/1404 , G01N15/1459 , G01N33/56972 , G01N2015/1006 , G01N2015/1018 , G01N2015/1486 , G01N2333/70514 , Y10T436/10 , Y10T436/101666
Abstract: A system and method for a flow cytometer system including a prepared sample fluid with reference beads; an interrogation zone that analyzes the prepared sample fluid; a peristaltic pump system that draws the sample fluid through the interrogation zone; and a processor that monitors a measured volume of sample fluid sampled by the peristaltic pump system and an expected sample volume based on data generated by the analysis of the sample fluid. A system and method is additionally described using an alternative volume sensing fluidic system.
Abstract translation: 一种用于流式细胞仪系统的系统和方法，其包括具有参比珠的制备的样品流体; 一个询问区，分析制备的样品液; 蠕动泵系统，通过询问区抽取样品液; 以及处理器，其基于通过对样品流体的分析产生的数据监测由蠕动泵系统采样的样品流体的测量体积和预期样品体积。 使用替代的体积感测流体系统另外描述系统和方法。
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Patent Agency Ranking
公开(公告)号：US20100302536A1
公开(公告)日：2010-12-02
申请号：US12476877
申请日：2009-06-02
Applicant: Jack T. Ball , Collin A. Rich , Rogers E. Clare
Inventor： Jack T. Ball , Collin A. Rich , Rogers E. Clare
IPC: G01J3/30
CPC classification number: G01J3/4406
Abstract: A system for a flow cytometer that collects data for a sample prepared with a plurality of fluorochromes that includes a fixed gain detection system that collects data for a plurality of fluorescence channels, fluorochrome compensation factors for a plurality of fluorochromes types, and a computer system that has an interface that gathers fluorochrome information of the sample and an analysis program that compensates for spectral spillover in the collected data. The fixed gain detection system preferably has a wide dynamic range. A fluorochrome compensation factor preferably remains constant for a fixed gain detection system. The analysis program preferably uses the fluorochrome compensation factors to compensate for spectral spillover.
Abstract translation: 一种用于流式细胞计数器的系统，其收集由多个荧光染料制备的样品的数据，所述荧光染料包括收集多个荧光通道的数据的固定增益检测系统，用于多个荧光染料类型的荧光染料补偿因子，以及计算机系统， 具有收集样品的荧光染料信息的界面和补偿收集的数据中的光谱外溢的分析程序。 固定增益检测系统优选具有宽的动态范围。 对于固定增益检测系统，荧光染料补偿因子优选保持恒定。 分析程序优选使用荧光染料补偿因子来补偿光谱溢出。
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公开(公告)号：US07780916B2
公开(公告)日：2010-08-24
申请号：US11735456
申请日：2007-04-14
Applicant: Nathaniel C. Bair , Collin A. Rich
Inventor： Nathaniel C. Bair , Collin A. Rich
CPC classification number: F04B23/04 , F04B43/0081 , F04B43/12 , F04B2201/1201 , F04B2205/09 , G01N15/1404 , G01N2015/1413 , G05D7/0682 , Y10T137/0352 , Y10T137/0379 , Y10T137/0402 , Y10T137/85986 , Y10T436/115831 , Y10T436/117497
Abstract: The fluidic system with an unclogging feature of the preferred embodiment includes a flow channel, a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The pump and controller cooperate to propagate a pulsation through the flow channel from the pump if the flow channel is clogged. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.
Abstract translation: 具有优选实施例的不记录特征的流体系统包括流动通道，用于将护套流体从鞘容器泵送到询问区域的护套泵以及将废液从询问区泵送到废物容器中的废水泵。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 如果流道被堵塞，泵和控制器协同传播来自泵的流动通道的脉动。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。
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公开(公告)号：US20100118298A1
公开(公告)日：2010-05-13
申请号：US12514052
申请日：2007-11-07
Applicant: Nathaniel C. Bair , Collin A. Rich , Mark Robert Eadie , Rebecca Ann Lehrmann
Inventor： Nathaniel C. Bair , Collin A. Rich , Mark Robert Eadie , Rebecca Ann Lehrmann
CPC classification number: G01N15/1404 , G01N2015/1413 , Y10T29/49826 , Y10T137/0352 , Y10T137/0379 , Y10T137/0419 , Y10T436/115831 , Y10T436/117497
Abstract: The flow cytometer system of the preferred embodiment includes a flow cell body that functions to contain, protect, and align the components of the flow cytometer system; a flow channel, coupled to the flow cell body, that functions to conduct and focus sample fluid through an interrogation zone; and a sample injection probe, removably coupled to the flow cell body, that functions to provide a uniform flow of sample fluid to the flow channel. The flow cytometer system is preferably designed for the flow cytometer field. The flow cytometer system, however, may be alternatively used in any suitable environment and for any suitable reason.
Abstract translation: 优选实施例的流式细胞仪系统包括流动池主体，其用于容纳，保护和对准流式细胞仪系统的部件; 耦合到流动池主体的流动通道，其用于将样品流体引导和聚焦通过询问区; 以及可移除地耦合到流动池主体的样品注入探针，其用于提供样品流体到流动通道的均匀流动。 流式细胞仪系统优选设计用于流式细胞仪领域。 然而，流式细胞仪系统可以替代地在任何合适的环境中用于任何合适的原因。
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公开(公告)号：US07520300B2
公开(公告)日：2009-04-21
申请号：US11958278
申请日：2007-12-17
Applicant: Collin A. Rich , Steven M. Martin
Inventor： Collin A. Rich , Steven M. Martin
IPC: F16L55/04
CPC classification number: F15B1/021 , F04B43/12 , F15B1/10 , F15B21/008 , F15B2201/205 , F15B2201/215 , F15B2201/3151 , G01N15/1404 , Y10T137/3118 , Y10T137/7792
Abstract: A pulsation attenuator for a fluidic system with a fluidic pump. The pulsation attenuator includes a fluidic channel, a first fluidic device adapted to attenuate pulsations with a shallow rolloff slope, and a second fluidic device adapted to attenuate pulsations with a shallow rolloff slope. The first fluidic device and the second fluidic device are connected to the fluidic channel such that they cooperatively attenuate pulsations with a steep rolloff slope. Preferably, the first fluidic device includes a first fluidic resistor and a first fluidic capacitor, and the second fluidic device includes a second fluidic resistor and a second fluidic capacitor. Preferably, the pulsation attenuator is arranged, similar a second-order low-pass filter, in the following order: (1) first fluidic resistor, (2) first fluidic capacitor, (3) second fluidic resistor, and (4) second fluidic capacitor.
Abstract translation: 一种具有流体泵的流体系统的脉动衰减器。 脉动衰减器包括流体通道，适于衰减具有浅滚降斜率的脉动的第一流体装置，以及适于以浅滚降斜率衰减脉动的第二流体装置。 第一流体装置和第二流体装置连接到流体通道，使得它们以陡峭的滚降斜率协同地衰减脉动。 优选地，第一流体装置包括第一流体电阻器和第一流体电容器，并且第二流体装置包括第二流体电阻器和第二流体电容器。 优选地，按照以下顺序将脉动衰减器类似于二阶低通滤波器：（1）第一流体电阻器，（2）第一流体电容器，（3）第二流体电阻器，和（4）第二流体电阻器 电容器。
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公开(公告)号：US20080152542A1
公开(公告)日：2008-06-26
申请号：US11872676
申请日：2007-10-15
Applicant: Jack T. Ball , Collin A. Rich
Inventor： Jack T. Ball , Collin A. Rich
CPC classification number: G01N15/1404 , Y10T137/85978
Abstract: The fluidic system 10 of the preferred embodiment includes a sheath pump 12 to pump sheath fluid 14 from a sheath container 16 through a sample port 34 into an interrogation zone 18 and a waste pump 20 to pump the sheath fluid 14 and a sample fluid 26 as waste fluid 22 from the interrogation zone 18 into a waste container 24, and a processor 30 to calculate a time window based on the flow rate of the sample fluid 26. Preferably the processor 30 also calculates a time window for the sample fluid to reach the interrogation zone 18 from the sample port 34 based on the flow rate of the sample fluid 26. The interrogation zone 18 functions to provide a location for the fluidic system 10 and an optical analysis system 32 of the flow cytometer to cooperatively facilitate the analysis of the sample fluid 26.
Abstract translation: 优选实施例的流体系统10包括护套泵12，其将护套流体14从鞘容器16通过样品端口34泵送到询问区域18和废水泵20，以将鞘液14和样品流体26泵送为 从询问区18到废物容器24的废液22以及基于样品流体26的流速计算时间窗的处理器30.优选地，处理器30还计算样品流体到达的时间窗口 询问区18基于样品流体26的流速从采样端口34询问。询问区18用于提供流体系统10的位置和流式细胞计数器的光学分析系统32，以便协调地促进对 样品流体26。
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