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75 条记录 (耗时 0.04 秒)

    Electroerosion recording medium fabrication method
    42.
    发明授权
    Electroerosion recording medium fabrication method 失效
    电解记录介质制造方法

    公开(公告)号：US4606937A

    公开(公告)日：1986-08-19

    申请号：US705388

    申请日：1985-01-30

    申请人： Manfred Rossler ,  Gerhard Winter ,  Hermann Stiltz

    发明人： Manfred Rossler ,  Gerhard Winter ,  Hermann Stiltz

    IPC分类号： B41M5/24 ,  B05D5/12 ,  B32B5/16 ,  G01D15/34 ,  G03C1/76

    CPC分类号： B41M5/245 ,  Y10S428/913 ,  Y10S430/102 ,  Y10S430/136 ,  Y10S430/162 ,  Y10T428/25 ,  Y10T428/253 ,  Y10T428/254 ,  Y10T428/256

    摘要： A track recording support for recording devices is suggested with a support (10) made of paper or plastic on which a metallic coating (12) is mounted by means of evaporation and being able to be burned off by means of recording electrodes, in particular an aluminum coating. A lubricant in a finely dispersed form is added to contrast coating (11) for reducing of scratching and grinding traces on the surface of metal coating (12) which reaches metal coating (12) and the freely exposed surface thereof by means of diffusion. Preferably, the lubricant is fed to the contrast substance in a powdery form before the processing of the same. On the one hand, it acts in a physical point of view by a reduction of the slide friction on the surface and, on the other hand, in a chemical point of view in that it substantially prevents the build up of combustion residues from the contrast layer on the recording electrodes.

    摘要翻译： PCT No.PCT / DE84 / 00157 Sec。 371日期1985年1月30日 102（e）日期1985年1月30日PCT提交1984年7月24日PCT公布。 第WO85 / 01019号公报 日期：1985年3月14日。记录装置的轨道记录载体由具有纸或塑料的支撑件（10）提出，其上通过蒸发安装金属涂层（12）并且能够通过手段 的记录电极，特别是铝涂层。 加入精细分散形式的润滑剂用于对比涂料（11），用于减少通过扩散到达金属涂层（12）和其自由暴露表面的金属涂层（12）的表面上的划痕和研磨痕迹。 优选地，润滑剂在加工之前以粉末形式供给到对比物质。 一方面，它通过减少表面上的滑动摩擦而从物理角度起作用，另一方面，在化学观点上，其基本上防止燃烧残余物与对比物的积聚 记录电极上的层。

    Silk particles for controlled and sustained delivery of compounds
    44.
    发明授权
    Silk particles for controlled and sustained delivery of compounds 有权
    用于控制和持续输送化合物的丝粒

    公开(公告)号：US09233067B2

    公开(公告)日：2016-01-12

    申请号：US13512789

    申请日：2010-11-30

    申请人： Andreas Lammel ,  Thomas Scheibel ,  Martin Schwab ,  Gerhard Winter ,  Markus Hofer ,  Julia Myschik

    发明人： Andreas Lammel ,  Thomas Scheibel ,  Martin Schwab ,  Gerhard Winter ,  Markus Hofer ,  Julia Myschik

    IPC分类号： A61K9/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/245 ,  A61K31/285 ,  A61K31/40 ,  A61K31/485 ,  C07K14/435 ,  A61K38/00

    CPC分类号： A61K9/0002 ,  A61K31/137 ,  A61K31/138 ,  A61K31/245 ,  A61K31/285 ,  A61K31/40 ,  A61K31/485 ,  A61K38/00 ,  C07K14/43518

    摘要： The present invention relates to a method of producing and loading silk particles, preferably spider silk particles, with a compound. In particular, the present invention provides a novel two step method for loading silk particles, preferably spider silk particles, with small and water-soluble compounds. Also disclosed are silk particles, preferably spider silk particles, loaded with at least one compound which are eminently suited as carriers for controlled and sustained delivery applications. Furthermore, the invention relates to pharmaceutical or cosmetic compositions comprising said silk particles, preferably spider silk particles, and a pharmaceutically active compound or cosmetic compound for controlled and sustained release. The present invention is also directed to silk particles, preferably spider silk particles, loaded with a compound obtainable by the method according to the invention.

    摘要翻译： 本发明涉及一种用化合物生产和加载丝粒子，优选蜘蛛丝粒子的方法。 特别地，本发明提供了一种用于将丝状颗粒，优选蜘蛛丝颗粒加载到小的和水溶性化合物的新颖的两步法。 还公开了装载有至少一种非常适合用作控制和持续递送应用的载体的化合物的丝粒子，优选蜘蛛丝粒子。 此外，本发明涉及包含所述丝粒，优选蜘蛛丝颗粒的药物或化妆品组合物，以及用于受控和持续释放的药学活性化合物或化妆品化合物。 本发明还涉及装有可通过本发明方法获得的化合物的丝粒子，优选蜘蛛丝粒子。

    Method for the controlled intracellular delivery of nucleic acids
    45.
    发明申请
    Method for the controlled intracellular delivery of nucleic acids 审中-公开
    核酸控制细胞内递送的方法

    公开(公告)号：US20140371292A1

    公开(公告)日：2014-12-18

    申请号：US14125914

    申请日：2012-08-10

    申请人： Ahmed Besheer ,  Matthaus Noga ,  Gerhard Winter ,  Ernst Wagner ,  Daniel Edinger

    发明人： Ahmed Besheer ,  Matthaus Noga ,  Gerhard Winter ,  Ernst Wagner ,  Daniel Edinger

    IPC分类号： A61K47/36 ,  A61K31/713

    CPC分类号： A61K47/36 ,  A61K31/713 ,  A61K47/59 ,  A61K47/61

    摘要： The present invention relates to a method for the controlled intracellular delivery of nucleic acid molecules into one or more target cells, in particular tumor cells, the method comprising: providing a polymeric complex formed between one or more nucleic acid molecules to be delivered and one or more cationic carrier molecules, wherein at least a part of the one or more carrier molecules in the polymeric complex are covalently attached to hydroxyalkyl starch, and wherein the hydroxyalkyl starch is shielding the polymeric complex; allowing the shielded polymeric complex to get into contact with the one or more target cells; deshielding the polymeric complex by removing the hydroxyalkyl starch; and allowing the deshielded polymeric complex to internalize into the one or more target cells. Removal of the hydroxyalkyl starch can be accomplished enzymatically by exposing the polymeric complex to amylase. The invention also concerns the use of such method for the prevention and/or treatment of a condition selected from the group consisting of cancer, immune diseases, cardiovascular diseases, neuronal diseases, infections, and inflammatory diseases.

    摘要翻译： 本发明涉及将核酸分子受控的细胞内递送到一个或多个靶细胞，特别是肿瘤细胞中的方法，所述方法包括：提供在待递送的一个或多个核酸分子之间形成的聚合物复合物， 更多的阳离子载体分子，其中聚合物络合物中的一个或多个载体分子的至少一部分共价连接到羟烷基淀粉上，并且其中羟烷基淀粉屏蔽聚合复合物; 允许屏蔽聚合物复合物与一个或多个靶细胞接触; 通过除去羟烷基淀粉去除聚合物复合物; 并且允许未屏蔽的聚合物络合物内化到一个或多个靶细胞中。 可以通过将聚合物复合物暴露于淀粉酶来酶促去除羟烷基淀粉。 本发明还涉及使用这种方法来预防和/或治疗选自癌症，免疫疾病，心血管疾病，神经元疾病，感染和炎性疾病的病症。

    Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof
    49.
    发明授权
    Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof 失效
    以微粒形式的含多肽的药物给药形式及其制备方法

    公开(公告)号：US06346274B1

    公开(公告)日：2002-02-12

    申请号：US08894796

    申请日：1998-01-05

    申请人： Hans Koll ,  Gerhard Winter ,  Thomas Kissel ,  Michael Morlock

    发明人： Hans Koll ,  Gerhard Winter ,  Thomas Kissel ,  Michael Morlock

    IPC分类号： A61K916

    CPC分类号： A61K9/1652 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1658 ,  A61K38/1816

    摘要： The invention concerns parenteral pharmaceutical forms of administration containing polypeptide in the form of microparticles and a process for the production thereof. The microparticles according to the invention contain as a biodegradable polymer an ABA triblock copolymer the A block of which is a copolymer of lactic and glycolic acid and the B block of which represents a polyethylene glycol chain, together with additives that are selected from the group comprising serum proteins, polyamino acids, cyclodextrins, cyclodextrin derivatives, saccharides, amino sugars, amino acids, detergents or carboxylic acids as well as mixtures of these additives. The microparticles according to the invention continuously release the polypeptide over a relatively long time period even when the amounts of polypeptide they include are small or susceptible to aggregation.

    摘要翻译： 本发明涉及含有微粒形式的多肽的肠胃外药物给药形式及其生产方法。 根据本发明的微粒包含作为生物可降解聚合物的ABA三嵌段共聚物，其中A嵌段是乳酸和乙醇酸的共聚物，其B嵌段代表聚乙二醇链，以及选自以下的添加剂： 血清蛋白，聚氨基酸，环糊精，环糊精衍生物，糖，氨基糖，氨基酸，去污剂或羧酸，以及这些添加剂的混合物。 根据本发明的微粒在相对长的时间段内连续地释放多肽，即使它们包括的多肽的量很小或易于聚集。