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公开(公告)号：US08986928B2
公开(公告)日：2015-03-24
申请号：US12757789
申请日：2010-04-09
Applicant: Stephen Turner , Benjamin Flusberg , Mathieu Foquet , Hans Callebaut , Robert Sebra , Bidhan Chaudhuri , Jon Sorenson , Keith Bjornson , Adrian Fehr , Jonas Korlach , Robin Emig
Inventor： Stephen Turner , Benjamin Flusberg , Mathieu Foquet , Hans Callebaut , Robert Sebra , Bidhan Chaudhuri , Jon Sorenson , Keith Bjornson , Adrian Fehr , Jonas Korlach , Robin Emig
IPC: C12Q1/68 , G01N27/447 , G01N33/487 , G01N33/50
CPC classification number: G01N33/48721 , B82Y5/00 , B82Y15/00 , C12Q1/6869 , C12Q1/6874 , C12Q2565/631 , G01N27/447 , G01N27/44791 , C12Q2563/116 , C12Q2527/113
Abstract: The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed.
Abstract translation: 本发明涉及纳米孔测序的装置和方法。 本发明包括纳入电子电路的纳米孔阵列，例如在CMOS中。 在一些情况下，纳米孔阵列包括用于隔离电子信号的电阻开口以改善测序。 公开了通过纳米孔控制易位的方法。
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公开(公告)号：US08906831B2
公开(公告)日：2014-12-09
申请号：US12384097
申请日：2009-03-30
Applicant: John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig , Jeremy Gray , Robert Sebra , Lei Sun , Stephen Dudek
Inventor： John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig , Jeremy Gray , Robert Sebra , Lei Sun , Stephen Dudek
CPC classification number: B01J19/0046 , B01J2219/00596 , C12N2310/50 , C12N2310/51 , C12Q1/6869 , C12Q2535/122 , C40B40/06 , G01N33/54313 , G01N33/54366
Abstract: Methods for non-random loading of single analyte molecules into array structures are provided. The methods allow for distribution of a population of target molecules into a plurality of size confined regions such as wells. Sizing moieties are linked to individual target molecules. The sizing moieties are of sufficient size, relative to the size-confined reaction or observation regions, such that only a selected number of sizing moieties will fit into the size confined regions. The confined regions and the sizing moieties or target molecules comprise a selected charge that allow for controlling the loading of the sizing moities.
Abstract translation: 提供了将单一分析物分子非随机加载到阵列结构中的方法。 所述方法允许将目标分子群体分配到多个尺寸的限制区域例如孔中。 上限部分与单独的靶分子连接。 尺寸部分相对于尺寸限制的反应或观察区域具有足够的尺寸，使得只有选定数量的施胶部分将适合尺寸限制区域。 限制区域和施胶部分或靶分子包括允许控制施胶剂的载荷的选定的电荷。
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公开(公告)号：US08802600B2
公开(公告)日：2014-08-12
申请号：US11731748
申请日：2007-03-29
Applicant: David R. Rank , Jeffery Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ron Cicero
Inventor： David R. Rank , Jeffery Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ron Cicero
IPC: C40B99/00
CPC classification number: C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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44.发明授权Articles having localized molecules disposed thereon and methods of producing same 有权具有位于其上的局部分子的制品及其制备方法公开(公告)号：US08772202B2
公开(公告)日：2014-07-08
申请号：US13487978
申请日：2012-06-04
Applicant: David R. Rank , Jeffrey Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ronald L. Cicero
Inventor： David R. Rank , Jeffrey Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ronald L. Cicero
IPC: C40B99/00
CPC classification number: C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
Abstract translation: 通过使用底物的元素来辅助活性化学基团在基底的所需区域中的定位来制备具有选定的活性化学区域的基底的方法。 所述方法可以包括用于沉积，去除，激活和/或去活衬底的选定区域中的化学基团的光学，化学和/或机械方法，以提供衬底的选择性活性区域。
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45.发明授权公开(公告)号：US08658365B2
公开(公告)日：2014-02-25
申请号：US12537130
申请日：2009-08-06
Applicant: Keith Bjornson , Harold Ray Lee , Jonas Korlach
Inventor： Keith Bjornson , Harold Ray Lee , Jonas Korlach
CPC classification number: C12Q1/6869 , C12Q1/6874 , C12Q2527/125 , C12Q2527/119 , C12Q2527/101 , C12Q2565/1015 , C12Q2527/137 , C12Q2521/101
Abstract: The Application relates to compositions, kits, methods, and systems for nucleotide sequencing comprising producing polymerase reactions that comprise both catalytic and non-catalytic divalent metal ions. Effective ratios and amounts of catalytic and non-catalytic divalent metal ions are described.
Abstract translation: 本申请涉及用于核苷酸测序的组合物，试剂盒，方法和系统，其包括产生包含催化和非催化二价金属离子的聚合酶反应。 描述了催化和非催化二价金属离子的有效比例和量。
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Patent Agency Ranking
公开(公告)号：US20130183663A1
公开(公告)日：2013-07-18
申请号：US13688667
申请日：2012-11-29
Applicant: Jeffrey Wegener , Jonas Korlach
Inventor： Jeffrey Wegener , Jonas Korlach
IPC: C12Q1/68
CPC classification number: C07H21/00 , C07H19/10 , C07H19/20 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , C12Q2563/107
Abstract: Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated.
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公开(公告)号：US20130109577A1
公开(公告)日：2013-05-02
申请号：US13652172
申请日：2012-10-15
Applicant: Jonas Korlach , Stephen Turner , Lei Sun
Inventor： Jonas Korlach , Stephen Turner , Lei Sun
IPC: G01N27/00
CPC classification number: C12Q1/6869 , B82Y15/00 , C12Q1/001 , C12Q2521/543 , C12Q2563/113 , C12Q2565/607 , C40B60/10 , G01N27/00 , G01N27/3277 , G01N27/3278 , C12Q2563/155
Abstract: Real time redox sequencing methods, devices, and systems are described. Arrays of redox devices comprising one or two electrodes are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the electrode(s). A sequencing reaction mixture comprising nucleotide analogs comprising redox labels is introduced to the array of redox devices under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by electrochemically identifying the redox labels of the nucleotide analogs that are incorporated into the growing strand.
Abstract translation: 描述了实时氧化还原测序方法，设备和系统。 使用包含一个或两个电极的氧化还原装置的阵列来提供关于靠近电极的聚合酶 - 模板复合物中的模板核酸的序列信息。 将包含氧化还原标记的核苷酸类似物的测序反应混合物在聚合酶介导的核酸合成的条件下引入到氧化还原装置阵列中。 通过电化学鉴定掺入生长链中的核苷酸类似物的氧化还原标记来确定核苷酸类似物的掺入时间序列。
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公开(公告)号：US08354252B2
公开(公告)日：2013-01-15
申请号：US13115288
申请日：2011-05-25
Applicant: Jeffrey Wegener , Jonas Korlach
Inventor： Jeffrey Wegener , Jonas Korlach
CPC classification number: C07H21/00 , C07H19/10 , C07H19/20 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , C12Q2563/107
Abstract: Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated.
Abstract translation: 标记的反应物组合物和特别标记的核酸反应组合物包括结构成分，其维持足够远离分子的反应物部分的潜在的有害的标记组分，使得标记基团对其它反应组分如酶的损害作用降低 ，最小化和/或消除。
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公开(公告)号：US20110311964A1
公开(公告)日：2011-12-22
申请号：US13115288
申请日：2011-05-25
Applicant: Jeffrey Wegener , Jonas Korlach
Inventor： Jeffrey Wegener , Jonas Korlach
IPC: C12Q1/68
CPC classification number: C07H21/00 , C07H19/10 , C07H19/20 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , C12Q2563/107
Abstract: Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated.
Abstract translation: 标记的反应物组合物和特别标记的核酸反应组合物包括结构成分，其维持足够远离分子的反应物部分的潜在的有害的标记组分，使得标记基团对其它反应组分如酶的损害作用降低 ，最小化和/或消除。
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公开(公告)号：US07968702B2
公开(公告)日：2011-06-28
申请号：US12403090
申请日：2009-03-12
Applicant: Jeffrey Wegener , Jonas Korlach
Inventor： Jeffrey Wegener , Jonas Korlach
CPC classification number: C07H21/00 , C07H19/10 , C07H19/20 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , C12Q2563/107
Abstract: Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated.
Abstract translation: 标记的反应物组合物和特别标记的核酸反应组合物包括结构成分，其维持足够远离分子的反应物部分的潜在的有害的标记组分，使得标记基团对其它反应组分如酶的损害作用降低 ，最小化和/或消除。
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