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公开(公告)号：US20180140304A1
公开(公告)日：2018-05-24
申请号：US15575896
申请日：2016-05-25
发明人： Sayyeda Marziya Hasan , Jennifer Nicole Rodriguez , Pooja Singhal , Thomas Stephen Wilson , Duncan J. Maitland
CPC分类号： A61B17/12113 , A61B17/12131 , A61B17/1219 , A61B2017/00526 , A61B2017/00871 , A61B2090/3966 , A61L31/128 , A61L31/14 , A61L31/146 , A61L31/18 , A61L2400/12 , A61L2400/16 , A61M31/002 , C08L2201/12
摘要： The invention relates to radiopaque shape memory foam compositions and methods of using the compositions. In certain embodiments, the compositions are used in neurovascular occlusion applications.
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公开(公告)号：US20180009932A1
公开(公告)日：2018-01-11
申请号：US15548212
申请日：2016-02-02
IPC分类号： C08G18/32 , C08G18/67 , C08G18/75 , B29K105/04
CPC分类号： C08G18/3206 , B29K2105/04 , C08G18/3212 , C08G18/6715 , C08G18/675 , C08G18/73 , C08G18/758 , C08L75/04 , C08L75/16 , C08L81/02
摘要： An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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43.发明申请ULTRA LOW DENSITY BIODEGRADABLE SHAPE MEMORY POLYMER FOAMS WITH TUNABLE PHYSICAL PROPERTIES 有权超低密度可生物降解形状记忆聚合物具有可调物理特性公开(公告)号：US20170002130A1
公开(公告)日：2017-01-05
申请号：US15269516
申请日：2016-09-19
CPC分类号： C08G18/6622 , A61B17/0057 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , C08G18/10 , C08G18/14 , C08G18/165 , C08G18/73 , C08G63/00 , C08G63/6852 , C08G71/04 , C08G2101/005 , C08G2101/0083 , C08G2230/00 , C08G2280/00 , C08J9/00 , C08J2375/06
摘要： Compositions and/or structures of degradable shape memory polymers (SMPs) ranging in form from neat/unfoamed to ultra low density materials of down to 0.005 g/cc density. These materials show controllable degradation rate, actuation temperature and breadth of transitions along with high modulus and excellent shape memory behavior. A method of making extremely low density foams (up to 0.005 g/cc) via use of combined chemical and physical blowing agents, where the physical blowing agents may be a single compound or mixtures of two or more compounds, and other related methods, including of using multiple co-blowing agents of successively higher boiling points in order to achieve a large range of densities for a fixed net chemical composition. Methods of optimization of the physical properties of the foams such as porosity, cell size and distribution, cell openness etc. of these materials, to further expand their uses and improve their performance.
摘要翻译： 范围从纯/未发泡到超低密度材料形式的可降解形状记忆聚合物（SMP）的组合物和/或结构，其浓度低至0.005g / cc。 这些材料显示可控的降解速率，致动温度和转变幅度以及高模量和优异的形状记忆行为。 通过使用组合的化学和物理发泡剂制造极低密度泡沫（高达0.005g / cc）的方法，其中物理发泡剂可以是单一化合物或两种或更多种化合物的混合物，以及其它相关方法，包括 使用多个连续较高沸点的共发泡剂，以实现固定净化学成分的大范围密度。 优化泡沫物理性能的方法，如孔隙度，孔径，分布，细胞开放度等，进一步扩大使用范围，提高其性能。
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公开(公告)号：US20240008875A1
公开(公告)日：2024-01-11
申请号：US18469671
申请日：2023-09-19
发明人： Thomas S. Wilson , Ward Small, IV , William J. Benett , Jason M. Ortega , Duncan J. Maitland , Jonathan Hartman
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2310/00071
摘要： An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.
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公开(公告)号：US11786641B2
公开(公告)日：2023-10-17
申请号：US16652588
申请日：2018-10-10
CPC分类号： A61L31/06 , A61B17/12113 , A61B17/12118 , A61B17/12181 , A61F2/07 , A61L31/146 , A61L31/148 , A61L31/18 , A61L2300/606 , A61L2400/16 , A61L2430/36
摘要： An embodiment includes an apparatus comprising: a shape memory polymer (SMP) foam having an outside surface; and a membrane that encapsulates at least 50% of the outside surface of the SMP foam; wherein (a) the SMP foam includes a thermoset SMP, and (b) the membrane includes a thermoplastic polymer. Other embodiments are addressed herein.
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公开(公告)号：US20230200822A1
公开(公告)日：2023-06-29
申请号：US18167107
申请日：2023-02-10
CPC分类号： A61B17/12195 , A61B17/12113 , A61B17/12181 , A61B17/12186 , A61B90/39 , A61M29/00 , A61B2017/00867 , A61B2017/12072
摘要： An embodiment includes a system comprising: a catheter; an optic fiber having a long axis and a short axis that is orthogonal to the long axis; first and second radiopaque elements coupled to the optic fiber; a first wire coupled to the optic fiber and extending from the first radiopaque element to the second radiopaque element; a fluid; wherein (a)(i) the first wire wraps at least partially around an exterior surface of the optic fiber; (a)(ii) an outer diameter of the first wire and an outer diameter of the optic fiber are collectively less than an inner diameter of the catheter, and (a)(iii) the first wire is configured to center the optic fiber within the catheter within a plane orthogonal to the long axis.
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公开(公告)号：US20220395615A1
公开(公告)日：2022-12-15
申请号：US17847426
申请日：2022-06-23
摘要： An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
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公开(公告)号：US11459439B2
公开(公告)日：2022-10-04
申请号：US16984370
申请日：2020-08-04
发明人： Landon D. Nash , Duncan J. Maitland , Nicole Docherty , Thomas S. Wilson , Ward Small, IV , Jason Ortega , Pooja Singhal
IPC分类号： C08J9/36 , B29C59/14 , B32B27/06 , B32B5/18 , A61L31/14 , A61L31/06 , A61L24/00 , A61L24/04 , B05D1/00 , B05D3/14 , B05D7/02 , B29K33/04 , B29C44/56 , B29K69/00 , B29K75/00 , B29K77/00
摘要： An embodiment includes a system comprising: a monolithic shape memory polymer (SMP) foam having first and second states; wherein the SMP foam includes: (a) polyurethane, (b) an inner half portion having inner reticulated cells defined by inner struts, (c) an outer half portion, having outer reticulated cells defined by outer struts, surrounding the inner portion in a plane that provides a cross-section of the SMP foam, (d) hydroxyl groups chemically bound to outer surfaces of both the inner and outer struts. Other embodiments are discussed herein.
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公开(公告)号：US11345067B2
公开(公告)日：2022-05-31
申请号：US16870094
申请日：2020-05-08
IPC分类号： B29C44/56 , C08J9/38 , A61L31/06 , A61L31/14 , C08G18/73 , B32B5/18 , B32B5/32 , C08G18/32 , C08L75/04 , B29K75/00 , C08G101/00 , B29K105/04
摘要： Polymeric based closed cell foams, such as shape memory polymer foams, contain bubbles. Making these bubbles continuous is called reticulation. Disclosed are embodiments of a device and method to controllably reticulate polymer-based closed cell foams by puncturing the membranes of these polymer-based closed cell foams.
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公开(公告)号：US20220016310A1
公开(公告)日：2022-01-20
申请号：US17395116
申请日：2021-08-05
IPC分类号： A61L24/00 , A61L24/04 , C08G18/10 , C08G18/73 , C08G18/83 , C08J9/36 , A61L15/26 , A61L27/50 , A61L31/14 , A61L31/16 , A61L15/46 , A61L27/18 , A61L27/56 , A61L15/42 , A61L31/06 , A61L27/54
摘要： An embodiment includes a system comprising a thermoset polyurethane shape memory polymer (SMP) foam that includes at least one antimicrobial agent. The antimicrobial agent may include at least one phenolic acid that is a pendent group chemically bonded to a polyurethane polymer chain of the SMP foam. Other embodiments are described herein.
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