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    REPORTER VECTOR FOR USE IN EVALUATION OF CYP1A2 INDUCTION
    41.
    发明申请
    REPORTER VECTOR FOR USE IN EVALUATION OF CYP1A2 INDUCTION 有权
    用于评估CYP1A2诱导的记录载体

    公开(公告)号：US20090317800A1

    公开(公告)日：2009-12-24

    申请号：US11995398

    申请日：2006-07-12

    申请人： Rika Ueda ,  Kazutomi Kusano ,  Yasushi Yamazoe ,  Kiyoshi Nagata

    发明人： Rika Ueda ,  Kazutomi Kusano ,  Yasushi Yamazoe ,  Kiyoshi Nagata

    IPC分类号： C12Q1/68 ,  C12N15/63 ,  C12N5/00

    CPC分类号： C12N15/1086

    摘要： A reporter vector which can evaluate the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 and a method for evaluation of the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 by using the reporter vector. A reporter system which can evaluate the ability of a drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 is completed by constructing a reporter vector having a reporter gene linked to the 3′ end of a region between CYP1A1 and CYP1A2 or a reporter vector having different reporter genes linked to the both ends of the region, respectively, so as to sandwich the region, and a reporter vector having a deletion mutation in the region, and confirming that the expression of a reporter molecule is increased by the drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 in the reporter system using the reporter vector.

    摘要翻译： 可以评估药物诱导CYP1A2或CYP1A1和CYP1A2两者的能力的报告载体，以及通过使用报道载体评价药物诱导CYP1A2或CYP1A1和CYP1A2两者能力的方法。 可以通过构建具有与CYP1A1和CYP1A2之间的区域的3'末端连接的报道基因的报道载体或具有CYP1A1和CYP1A2两者的报道载体的报道载体来完成能够评价能够诱导CYP1A2或CYP1A1和CYP1A2两者的药物的能力的报道体系， 分别与区域两端连接的不同的报道基因以夹持该区域，以及在该区域具有缺失突变的报道载体，并证实报告分子的表达由能诱导的药物增加 CYP1A2或两者CYP1A1和CYP1A2在报告系统中使用报告载体。

    New utilities of amide compounds
    44.
    发明申请
    New utilities of amide compounds 有权
    酰胺化合物的新用途

    公开(公告)号：US20080221112A1

    公开(公告)日：2008-09-11

    申请号：US12081662

    申请日：2008-04-18

    申请人： Teruo Yamamori ,  Kiyoshi Nagata ,  Natsuki Ishizuka ,  Katsunori Sakai

    发明人： Teruo Yamamori ,  Kiyoshi Nagata ,  Natsuki Ishizuka ,  Katsunori Sakai

    IPC分类号： A61K31/498 ,  A61K31/4402 ,  A61P9/10

    CPC分类号： C07D213/75 ,  A61K31/165 ,  A61K31/47 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

    摘要： Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments.Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.

    摘要翻译： 提供具有增强载脂蛋白A表达活性的化合物，其用作药物。 式（I）的化合物：其中环A和Ar 1独立地是单环或双环芳族碳环基或芳族杂环基，其各自可以被任选取代;等等; R为氢等; Z是氧等; Y 1和Y 2是氢，低级烷基等; n为0〜2的整数， 虚线是存在或不存在债券; 并且波浪线表示相对于双键的顺式或反式几何异构体; 被披露。

    Method of measuring human CYP3A inducibility
    45.
    发明申请
    Method of measuring human CYP3A inducibility 审中-公开
    测定人CYP3A诱导率的方法

    公开(公告)号：US20060194248A1

    公开(公告)日：2006-08-31

    申请号：US11414189

    申请日：2006-05-01

    申请人： Yasushi Yamazoe ,  Kiyoshi Nagata

    发明人： Yasushi Yamazoe ,  Kiyoshi Nagata

    IPC分类号： C12Q1/68 ,  C12N15/86

    CPC分类号： C12Q1/6897 ,  C12Q1/02 ,  C12Q1/26 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5067 ,  G01N2333/90245 ,  G01N2333/90251 ,  G01N2500/04 ,  G01N2500/10

    摘要： A method for measuring human CYP3A inducibility upon administration of a test drug, characterized in that a non-human animal to which a test drug is administered or a population of human cells cultured in a medium containing a test drug is infected with viruses (A) and (B); virus (A) being an adenovirus which is used as a vector and engineered by incorporating thereto a detectable reporter gene and at least 3 human PXR binding regions falling within an untranslated region of a human CYP3A gene, and virus (B) being an adenovirus which is used as a vector and engineered by incorporating thereto a human PXR cDNA; and subsequently expression level of the reporter gene is determined in the non-human animal or the cultured human cells. The present invention ensures convenient and accurate evaluation of human CYP3A inducibility upon administration of a test drug to a human subject, providing accurate evaluation in terms of the efficacy of the test drug, occurrence of side effects, disappearance of the drug effect, etc.

    摘要翻译： 一种在给药试验药物时测量人CYP3A诱导率的方法，其特征在于，在含有试验药物的培养基中培养的非人动物或受试药物培养的人群受病毒感染（A） 和（B）; 病毒（A）是腺病毒，其用作载体并通过掺入可检测的报道基因和位于人CYP3A基因的非翻译区内的至少3个人PXR结合区域而工程化，并且病毒（B）是腺病毒， 用作载体并通过掺入人PXR cDNA而工程化; 并且随后在非人动物或培养的人细胞中测定报道基因的表达水平。 本发明确保了将人体受试者给药后的人CYP3A诱导率的方便，准确的评价，在试验药物的功效，副作用的发生，药物作用的消失等方面提供准确的评价。

    Fuel feed apparatus having sub tank and jet pump
    46.
    发明授权
    Fuel feed apparatus having sub tank and jet pump 有权

    公开(公告)号：US06981490B2

    公开(公告)日：2006-01-03

    申请号：US10793039

    申请日：2004-03-05

    申请人： Kiyoshi Nagata ,  Masaaki Konishi

    发明人： Kiyoshi Nagata ,  Masaaki Konishi

    IPC分类号： F02M37/00

    CPC分类号： F02M37/106 ,  F02M37/025 ,  Y10T137/86187

    摘要： A fuel feed apparatus including a sub-tank is received in a fuel tank having multiple tank sections. Multiple jet pumps respectively transfers fuel received in the tank sections into the sub-tank. Therefore, even if a fuel amount received in a single tank section decreases, fuel can be steadily supplied from another tank section. Intermediately pressurized fuel in a fuel pump is supplied to the jet pumps, so that fuel can be steadily supplied to the jet pumps regardless of fuel consumption amount in an engine. Fuel is drawn from an upstream side of a pressure regulator, and supplied to the jet pump. The pressure regulator has an urging unit, and controls fuel pressure without using a diaphragm. Therefore, the pressure regulator is simplified and downsized.

    Fuel feed apparatus having vibration damping structure
    47.
    发明授权
    Fuel feed apparatus having vibration damping structure 有权
    具有减震结构的燃料供给装置

    公开(公告)号：US06854451B2

    公开(公告)日：2005-02-15

    申请号：US10722541

    申请日：2003-11-28

    申请人： Yoshio Ebihara ,  Kiyoshi Nagata ,  Katsuhisa Yamada ,  Kouji Izatani ,  Tatsuo Sakai ,  Kunihiro Umetsu

    发明人： Yoshio Ebihara ,  Kiyoshi Nagata ,  Katsuhisa Yamada ,  Kouji Izatani ,  Tatsuo Sakai ,  Kunihiro Umetsu

    IPC分类号： F02M37/00 ,  F02M37/10 ,  F02M37/22 ,  F02M37/04

    CPC分类号： F02M37/106

    摘要： A fuel feed apparatus accommodates a sub tank. The sub tank includes a pump module The pump module generates vibration, and is supported by a supporting member and a suction filter. The suction filter is covered with a nonwoven fabric. The nonwoven fabric is used as an additional filter for removing debris in fuel drawn by the pump module. The supporting member and the nonwoven fabric have resilience. The pump module is mounted on the sub tank via the supporting member and the non woven fabric. Therefore, vibration of the pump module is not apt to be transmitted to the sub tank. Additionally, the supporting member need not to be rigidly formed, so that the supporting member can be manufactured easily.

    摘要翻译： 燃料供给装置容纳副罐。 副油箱包括泵模块泵模块产生振动，并由支撑构件和吸力过滤器支撑。 吸尘过滤器被无纺织物覆盖。 非织造织物用作用于去除由泵模块吸取的燃料中的碎屑的附加过滤器。 支撑构件和无纺布具有弹性。 泵模块通过支撑构件和非织造织物安装在副罐上。 因此，泵模块的振动不易于向副罐传送。 此外，支撑构件不需要刚性地形成，从而可以容易地制造支撑构件。

    Fuel supply device and method of assembling same
    49.
    发明授权
    Fuel supply device and method of assembling same 失效
    燃油供应装置及其组装方法

    公开(公告)号：US5356272A

    公开(公告)日：1994-10-18

    申请号：US755006

    申请日：1991-09-05

    申请人： Kiyoshi Nagata ,  Takeshi Matsuda

    发明人： Kiyoshi Nagata ,  Takeshi Matsuda

    IPC分类号： F02M37/08 ,  F04D13/06 ,  H02K5/08 ,  H02K5/12 ,  H02K5/128 ,  H02K5/22 ,  H02K11/00 ,  F04B17/00

    CPC分类号： F04D13/064 ,  F02M37/08 ,  H02K11/33 ,  H02K5/12 ,  H02K5/128 ,  H02K5/225 ,  F05C2201/046 ,  H02K2203/03 ,  H02K2211/03 ,  H02K5/08

    摘要： A fuel pump for a vehicle includes a brushless motor for operating this fuel pump, and a control circuit for the brushless motor is contained in the fuel pump. Difficulties such as a cutting of the wiring due to an electrolytic corrosion of electrically-conductive portions, and a short-circuiting thereof, are prevented. A pump portion, a motor portion and a discharge portion are provided in a housing of the fuel pump. The motor portion includes a rotor and a stator portion. The stator portion is molded by a resin material into a cylindrical shape with a closed bottom. The stator portion supports a shaft of the rotor. Stator coils are molded in a peripheral wall portion of the stator portion, and a container containing the control circuit is molded in the bottom wall portion of the stator portion. The stator coils, copper wires extending therefrom, and terminals from the control circuit are completely molded in the above resin material. With this arrangement, the stator coils, the control circuit, and the electrically-conductive portions extending between the control circuit and the stator coils are not exposed to the fuel at all, and therefore the above difficulties are prevented.

    摘要翻译： 用于车辆的燃料泵包括用于操作该燃料泵的无刷电动机，并且用于无刷电动机的控制电路容纳在燃料泵中。 防止了由于导电部分的电解腐蚀导致的布线的切割及其短路等困难。 泵部分，马达部分和排放部分设置在燃料泵的壳体中。 马达部分包括转子和定子部分。 定子部分由树脂材料模制成具有封闭底部的圆柱形形状。 定子部分支撑转子的轴。 定子线圈被模制在定子部分的周壁部分中，并且在定子部分的底壁部分中模制容纳控制电路的容器。 定子线圈，从其延伸的铜线和来自控制电路的端子在上述树脂材料中完全模制。 通过这种布置，定子线圈，控制电路和在控制电路和定子线圈之间延伸的导电部分根本不暴露于燃料，因此防止了上述困难。

    Stereoscopic color television system with lenticular screen
    50.
    发明授权
    Stereoscopic color television system with lenticular screen 失效
    立体彩色电视系统带透镜屏

    公开(公告)号：US4164748A

    公开(公告)日：1979-08-14

    申请号：US783628

    申请日：1977-04-01

    申请人： Kiyoshi Nagata

    发明人： Kiyoshi Nagata

    IPC分类号： H01J31/22 ,  H04N13/00 ,  H04N15/00 ,  H04N9/60

    CPC分类号： H04N13/0409 ,  H04N13/0404

    摘要： A stereoscopic color television system in which operation of a plurality of color television cameras photographing the same object is switched over in turn per period of a color synchronization subcarrier to send forth video outputs from the plural color television cameras in succession. A stereoscopic color television picture tube includes a lenticular lens assembly whose lenticular lenses are each formed with an equal width to the horizontal pitch of apertures of a shadow mask or meshy focusing grid, and which is positioned between the shadow mask and face plate and also provided with a phosphor screen on the focal plane of the lenticular lens assembly, the phosphor screen being formed of a plurality of sets of red, green and blue phosphor stripes formed with an equal width to the vertical pitch of apertures of the shadow mask or meshy focusing grid. The color television picture tube further includes vertically arranged red, green and blue electron guns. The electron guns are provided in the same number of groups as the television cameras used, and operation of the groups of the electron guns is changed over successively, each time the operation of the color television cameras is switched over. Or, the color television picture tube includes one set of vertically arranged electron guns and electrostatic deflection electrodes or an electromagnetic deflection device arranged so as to horizontally shift electron beams from the set of electron guns, each time the operation of the plural color television cameras is changed over.

    摘要翻译： 拍摄相同物体的多个彩色电视摄像机的操作在彩色同步副载波的每个周期依次切换的立体彩色电视系统，以连续从多个彩色电视摄像机发出视频输出。 立体彩色电视显像管包括双凸透镜组件，其双凸透镜各自形成为与荫罩或网状聚焦网格的孔的水平间距相等的宽度，并且位于荫罩和面板之间，并且还提供 在双凸透镜组件的焦平面上具有荧光屏，荧光屏由多组红色，绿色和蓝色荧光体条形成，其形成与荫罩或网状聚焦的孔的垂直间距相等的宽度 格。 彩色电视显像管还包括垂直布置的红色，绿色和蓝色电子枪。 电子枪设置在与所使用的电视摄像机相同数量的组中，并且每次电视摄像机的操作被切换时，电子枪组的操作被连续地改变。 或者，彩色电视显像管包括一组垂直布置的电子枪和静电偏转电极或电磁偏转装置，其被布置成水平移动来自该组电子枪的电子束，每次多个彩色电视摄像机的操作是 换了