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公开(公告)号：US07060248B2
公开(公告)日：2006-06-13
申请号：US10645272
申请日：2003-08-21
IPC分类号： A61K49/00
CPC分类号： A61K49/00 , A61K38/00 , A61K49/0002 , A61K49/085 , A61K49/10 , A61K49/223 , A61K51/0497 , C07F9/6527 , C07K5/06026 , C07K5/06078 , C07K5/06191
摘要： Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties; a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to the diagnostic metal. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in diagnosis of diseases associated with MMPs.
摘要翻译： 因此，本发明描述了包含诊断金属和化合物的诊断剂，其中所述化合物包含：1-10个靶向部分; 螯合剂 和靶向部分和螯合剂之间的0-1个连接基团; 其中靶向部分是基质金属蛋白酶抑制剂; 并且其中螯合剂能够与诊断金属共轭。 本发明还提供本发明化合物，试剂盒及其在诊断与MMP相关的疾病中的用途的新组合物。
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公开(公告)号：US06656448B1
公开(公告)日：2003-12-02
申请号：US09783249
申请日：2001-02-14
IPC分类号： A61K4900
CPC分类号： A61K49/00 , A61K38/00 , A61K49/0002 , A61K49/085 , A61K49/10 , A61K49/223 , A61K51/0497 , C07F9/6527 , C07K5/06026 , C07K5/06078 , C07K5/06191
摘要： Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties;a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to the diagnostic metal. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in diagnosis of diseases associated with MMPs.
摘要翻译： 因此，本发明描述了包含诊断金属和化合物的诊断剂，其中所述化合物包含：1-10个靶向部分;螯合剂; 和靶向部分和螯合剂之间的0-1个连接基团; 其中靶向部分是基质金属蛋白酶抑制剂; 并且其中螯合剂能够与诊断金属共轭。 本发明还提供本发明化合物，试剂盒及其在诊断与MMP相关的疾病中的用途的新组合物。
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43.发明授权Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders 失效放射性标记的血小板GPIIb / IIIa受体拮抗剂作为诊断血栓栓塞障碍的显像剂
公开(公告)号：US6022523A
公开(公告)日：2000-02-08
申请号：US999400
申请日：1997-12-29
申请人： William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
发明人： William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
IPC分类号： A61K38/12 , A61K49/04 , A61K51/00 , A61K51/04 , A61K51/08 , C07B59/00 , C07D213/82 , C07D257/00 , C07D259/00 , C07D277/60 , C07D401/00 , C07D401/12 , C07D401/14 , C07D413/12 , C07K5/10 , C07K5/103 , C07K7/64 , C07K14/75 , C07K17/02
CPC分类号： C07K14/75 , A61K51/04 , A61K51/0482 , A61K51/082 , A61K51/088 , C07B59/008 , C07D213/82 , C07D401/12 , C07D401/14 , A61K2123/00
摘要： This invention provides novel radiopharmaceuticals that are radiolabeled cyclic compounds containing carbocyclic or heterocyclic ring systems which act as antagonists of the platelet glycoprotein IIb/IIIa complex; to methods of using said radiopharmaceuticals as imaging agents for the diagnosis of arterial and venous thrombi; to novel reagents for the preparation of said radiopharmaceuticals; and to kits comprising said reagents.
摘要翻译： 本发明提供新的放射性药物，其是放射性标记的环状化合物，其含有作为血小板糖蛋白IIb / IIIa复合物拮抗剂的碳环或杂环系统; 使用所述放射性药物作为诊断动脉和静脉血栓的显像剂的方法; 用于制备所述放射性药物的新型试剂; 以及包含所述试剂的试剂盒。
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公开(公告)号：US5879657A
公开(公告)日：1999-03-09
申请号：US218861
申请日：1994-03-28
申请人： William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
发明人： William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
IPC分类号： A61K38/12 , A61K49/04 , A61K51/00 , A61K51/04 , A61K51/08 , C07B59/00 , C07D213/82 , C07D257/00 , C07D259/00 , C07D277/60 , C07D401/00 , C07D401/12 , C07D401/14 , C07D413/12 , C07K5/10 , C07K5/103 , C07K7/64 , C07K14/75 , C07K17/02 , A61M36/14
CPC分类号： C07K14/75 , A61K51/04 , A61K51/0482 , A61K51/082 , A61K51/088 , C07B59/008 , C07D213/82 , C07D401/12 , C07D401/14 , A61K2123/00
摘要： This invention provides novel radiopharmaceuticals that are radiolabeled cyclic compounds containing carbocyclic or heterocyclic ring systems which act as antagonists of the platelet glycoprotein IIb/IIIa complex; to methods of using said radiopharmaceuticals as imaging agents for the diagnosis of arterial and venous thrombi; to novel reagents for the preparation of said radiopharmaceuticals; and to kits comprising said reagents.
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45.发明授权Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels 有权生物相容性N，N-二取代磺酰胺荧光染料标记公开(公告)号：US09574085B2
公开(公告)日：2017-02-21
申请号：US12065387
申请日：2006-09-01
IPC分类号： A61K49/00 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C09B23/08 , C07D209/14 , C09B23/01 , G01N33/533 , G01N33/537 , G01N33/58
CPC分类号： C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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46.发明授权Methods and compositions for identifying subjects at risk of developing stent thrombosis 有权用于识别发生支架血栓形成危险的受试者的方法和组合物公开(公告)号：US08864821B2
公开(公告)日：2014-10-21
申请号：US12625264
申请日：2009-11-24
申请人： Farouc Jaffer , Milind Rajopadhye
发明人： Farouc Jaffer , Milind Rajopadhye
CPC分类号： A61B5/0071 , A61B1/043 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/061 , A61B5/066 , A61B5/4851 , A61B5/7275 , A61B90/20 , A61B2576/02 , A61F2/82 , A61K49/0034 , A61K49/0097
摘要： The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.
摘要翻译： 本发明提供了用于确定含有固定在血管中的支架的受试者是否具有无症状的支架内血栓形成或具有发展为临床症状性支架内血栓形成的风险的方法和组合物。 在一种方法中，该方法涉及使用包含荧光染料（例如近红外荧光染料）的探针对含有支架的血管的区域成像，以及结合指示存在无症状的分子标记的靶向部分 支架血栓形成或症状性支架血栓形成的发展。 在受试者显示一种或多种这样的标记物的程度上，探针结合标记并增加探针在支架附近的局部浓度。 成像方法识别那些在支架附近显示较高密度的标记物的患者。 因此，可以监测和/或治疗这些患者以防止症状性支架内血栓形成。
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公开(公告)号：US20120321562A1
公开(公告)日：2012-12-20
申请号：US13450003
申请日：2012-04-18
IPC分类号： C09B23/08 , C12N5/071 , C12N5/09 , C12N5/04 , C12N5/0783 , C12N5/078 , C12N5/07 , A61K49/00 , C12N1/20
CPC分类号： A61K49/0032 , A61K49/0021 , C07D401/06 , C07D401/14 , C07D417/06 , C09B23/0008 , C09B23/083
摘要： This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，包括含有羧基或羰基官能化的吡啶部分的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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公开(公告)号：US08173819B2
公开(公告)日：2012-05-08
申请号：US12065391
申请日：2006-09-01
IPC分类号： C07D401/06
CPC分类号： A61K49/0032 , A61K49/0021 , C07D401/06 , C07D401/14 , C07D417/06 , C09B23/0008 , C09B23/083
摘要： This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，包括含有羧基或羰基官能化的吡啶部分的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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49.发明申请Methods and Compositions for Identifying Subjects at Risk of Developing Stent Thrombosis 有权识别发生支架血栓风险的受试者的方法和组成公开(公告)号：US20100268070A1
公开(公告)日：2010-10-21
申请号：US12625264
申请日：2009-11-24
申请人： Farouc Jaffer , Milind Rajopadhye
发明人： Farouc Jaffer , Milind Rajopadhye
CPC分类号： A61B5/0071 , A61B1/043 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/061 , A61B5/066 , A61B5/4851 , A61B5/7275 , A61B90/20 , A61B2576/02 , A61F2/82 , A61K49/0034 , A61K49/0097
摘要： The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.
摘要翻译： 本发明提供了用于确定含有固定在血管中的支架的受试者是否具有无症状的支架内血栓形成或具有发展为临床症状性支架内血栓形成的风险的方法和组合物。 在一种方法中，该方法涉及使用包含荧光染料（例如近红外荧光染料）的探针对含有支架的血管的区域成像，以及结合指示存在无症状的分子标记的靶向部分 支架血栓形成或症状性支架血栓形成的发展。 在受试者显示一种或多种这样的标记物的程度上，探针结合标记并增加探针在支架附近的局部浓度。 成像方法识别那些在支架附近显示较高密度的标记物的患者。 因此，可以监测和/或治疗这些患者以防止症状性支架内血栓形成。
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50.发明申请Biocompatible N, N-Disubstituted Sulfonamide-Containing Fluorescent Dye Labels 有权生物相容的N，N-二取代的含磺酰胺的荧光染料标签公开(公告)号：US20090130024A1
公开(公告)日：2009-05-21
申请号：US12065387
申请日：2006-09-01
IPC分类号： A61K49/00 , C07D403/12 , C07D401/14 , C07D403/06 , C07D403/14
CPC分类号： C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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