-
公开(公告)号：US06368814B1
公开(公告)日：2002-04-09
申请号：US09747809
申请日：2000-12-22
申请人： Mitali Ghoshal , Jane S. C. Tsai , Stephen Vitone
发明人： Mitali Ghoshal , Jane S. C. Tsai , Stephen Vitone
IPC分类号： G01N33535
CPC分类号： C07D403/12 , C07D207/46 , C07K16/44 , G01N33/94 , Y10S436/815
摘要： The present invention is directed to novel tricyclic antidepressant drug derivatives synthesized for covalent attachment to proteins or polypeptide antigens for use in the preparation of antibodies or receptors to tricyclic antidepressant drugs and tricyclic antidepressant metabolites. The new derivatives are characterized by a saturated double bond on the amitriptyline portion of the molecule and are represented by the structure where R1 is a saturated or unsaturated, substituted or unsubstituted, straight or branched chain of 0-10 carbon or heteroatoms, X is a linker group consisting of 0-2 substituted or unsubstituted aromatic rings, and Y is an activated ester or NH—Z, where Z is a poly(amino acid). The novel tricyclic antidepressant activated hapten derivatives are useful for preparing tracers and conjugates for tricyclic antidepressant immunoassays, including an enzyme immunoassay and a microparticle capture inhibition assay using an antibody produced from the novel immunogen with a conjugate derivatized either at the N-1 position of imipramine or at the C-2 position of dihydroamitriptyline.
摘要翻译： 本发明涉及用于共价连接蛋白质或多肽抗原的新型三环抗抑郁药物衍生物，用于制备三环抗抑郁药物和三环抗抑郁药代谢物的抗体或受体。 新衍生物的特征在于分子的阿米替林部分上具有饱和双键并且由其中R 1是饱和或不饱和的，取代或未取代的0-10个碳原子或杂原子的直链或支链的结构表示，X是连接基 由0-2个取代或未取代的芳环组成的基团，Y是活化酯或NH-Z，其中Z是聚（氨基酸）。 新型三环抗抑郁药活化的半抗原衍生物可用于制备用于三环抗抑郁药免疫测定的示踪剂和缀合物，包括酶免疫测定和使用由新型免疫原产生的抗体的微粒捕获抑制测定与在丙咪嗪的N-1位衍生的缀合物 或在二氢阿米替林的C-2位置。
-
公开(公告)号：US5986094A
公开(公告)日：1999-11-16
申请号：US844488
申请日：1997-04-18
IPC分类号： G01N33/542 , C07D493/10 , G01N21/78 , G01N33/533 , C07D405/14
CPC分类号： C07D493/10 , G01N33/533
摘要： The present invention relates to a novel class of tracer compounds for fluorescence polarization imunoassays. The novel 4'-methyl fluorescein derivatives are conjugated to ligands via cyclic linkers.
摘要翻译： 本发明涉及一类用于荧光偏振免疫测定的示踪剂化合物。 新型4'-甲基荧光素衍生物通过环状连接体与配体缀合。
-
43.发明授权公开(公告)号：US08008037B2
公开(公告)日：2011-08-30
申请号：US12056473
申请日：2008-03-27
IPC分类号： C12Q1/32
CPC分类号： C12Q1/006 , C12Q1/004 , G01N2333/904
摘要： A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.
摘要翻译： 用于测定生物流体中分析物浓度的化学基质包括葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺。 化学基质与电化学生物传感器一起使用以确定在生物传感器内发生反应后分析物的浓度，此时完成分析以确定浓度。 使用葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺的化学基质测定分析物的浓度的方法是描述的另一方面。 该方法还进一步具有5秒或更短的测试时间。 利用新化学基质的方法可以容易地确定分析物，例如浓度为约20-600mg / dL的分析物，pH为约6.5至约8.5。
-
公开(公告)号：US5741715A
公开(公告)日：1998-04-21
申请号：US452742
申请日：1995-05-30
IPC分类号： G01N33/53 , A61K39/395 , C07D453/04 , C07D493/10 , C07D519/00 , C07K14/435 , C07K14/47 , C07K14/76 , C07K14/765 , C07K14/77 , C07K16/00 , C07K16/44 , G01N33/94 , G01N33/542 , G01N33/533 , G01N33/577
CPC分类号： G01N33/9453 , C07D453/04 , Y10S436/815 , Y10S530/807
摘要： Novel quinidine derivatives are provided which can be used in an improved immunoasssay for the detection of quinidine and quinidine metabolites.
摘要翻译： 提供了新的奎尼丁衍生物，其可用于改进的免疫测定中用于检测奎尼丁和奎尼丁代谢物。
-
45.发明授权Methods for electrochemical analysis using matrix compositions with alkylphenazine quaternary salt and a nitrosoaniline 有权使用烷基吩嗪季盐和亚硝基苯胺的基质组成的电化学分析方法公开(公告)号：US08535511B2
公开(公告)日：2013-09-17
申请号：US13208420
申请日：2011-08-12
CPC分类号： C12Q1/006 , C12Q1/004 , G01N2333/904
摘要： A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.
摘要翻译： 用于测定生物流体中分析物浓度的化学基质包括葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺。 化学基质与电化学生物传感器一起使用以确定在生物传感器内发生反应后分析物的浓度，此时完成分析以确定浓度。 使用葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺的化学基质测定分析物的浓度的方法是描述的另一方面。 该方法还进一步具有5秒或更短的测试时间。 利用新化学基质的方法可以容易地确定分析物，例如浓度为约20-600mg / dL的分析物，pH为约6.5至约8.5。
-
公开(公告)号：US08293904B2
公开(公告)日：2012-10-23
申请号：US13236838
申请日：2011-09-20
CPC分类号： G01N33/5306 , C07F15/002 , C07F15/0026 , C12Q1/004 , G01N33/5438 , G01N2458/30
摘要： The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.
-
公开(公告)号：US08288544B2
公开(公告)日：2012-10-16
申请号：US10555138
申请日：2004-07-01
申请人： Eric R. Diebold , Mitali Ghoshal , David Z. Deng , Jane S.C. Tsai
发明人： Eric R. Diebold , Mitali Ghoshal , David Z. Deng , Jane S.C. Tsai
CPC分类号： G01N33/5306 , C07F15/002 , C07F15/0026 , C12Q1/004 , G01N33/5438 , G01N2458/30
摘要： The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.
摘要翻译： 本发明提供用于使用免疫学技术检测多种分析物的新型锇基电化学物质。 本发明还提供了可与锇基电化学物质一起使用的支持电极结构的诊断试剂盒和测试传感器。 可以制造测试传感器以支持指数的电极阵列，其被设计为提供期望分析可能以低浓度存在的分析物的电信号放大的放大。
-
公开(公告)号：US20090215993A1
公开(公告)日：2009-08-27
申请号：US12257704
申请日：2008-10-24
申请人： Mitali Ghoshal , Raymond Hui , Shaker Rashid
发明人： Mitali Ghoshal , Raymond Hui , Shaker Rashid
IPC分类号： C07K16/44 , C07K14/765 , C07D405/12 , C07K14/47
CPC分类号： C07D307/88
摘要： Described are immunogenic compounds useful for generation of antibodies which are highly specific for mycophenolic acid which do not react or have substantially no cross-reactivity with the glucuronide metabolites of mycophenolic acid, especially the acyl-glucuronide metabolite.
摘要翻译： 描述了可用于产生对麦考酚酸具有高度特异性的抗体的免疫原性化合物，其不与麦考酚酸，特别是酰基 - 葡糖苷酸代谢物的葡糖苷酸代谢物反应或基本上不具有交叉反应性。
-
公开(公告)号：US07566549B2
公开(公告)日：2009-07-28
申请号：US11639707
申请日：2006-12-14
IPC分类号： G01N33/53 , G01N33/532 , G01N33/533 , G01N33/535
CPC分类号： C07D457/06 , C07K16/44 , G01N33/946 , Y10S436/815 , Y10S436/901 , Y10T436/13
摘要： The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. The resulting haptens can then be further modified at this functionalized position for linking to appropriate immunogenic or labeling groups to provide reagents for immunoassays having substantially equal specificity for both LSD and 2-oxo-3-hydroxy-LSD.
摘要翻译： 本发明提供了可用于制备用于免疫测定用于检测LSD和2-氧代-3-羟基LSD的抗原，抗体和试剂的半抗原衍生物。 在本发明中，将2-氧基LSD核从吲哚氮中衍生出氨基烷基衍生物。 然后可以在该官能化位置进一步修饰所得的半抗原，以连接到合适的免疫原性或标记基团，以提供对LSD和2-氧代-3-羟基-LDD具有基本相同特异性的免疫测定试剂。
-
公开(公告)号：US07465797B2
公开(公告)日：2008-12-16
申请号：US11683496
申请日：2007-03-08
IPC分类号： C07D489/00 , C07K1/00
CPC分类号： C07D489/02 , A61K47/542 , A61K47/646 , C07K16/44 , Y10S530/807
摘要： Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.
摘要翻译： 描述了6-单乙酰吗啡（6-MAM）的类似物。 这些包括在分子的C-3位，C-6位或非位置衍生的类似物。 这些类似物允许用官能团如活化酯终止的接头进行阐述，所述官能团可用于将分子连接到其它实体如蛋白质，多糖和报告基团。
-
-
-
-
-
-
-
-
-
搜索结果
51 条记录 (耗时 0.044 秒)
