公开(公告)号：US20090028877A1

公开(公告)日：2009-01-29

申请号：US10575114

申请日：2004-10-08

申请人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Takabe ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

发明人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Takabe ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/06 ,  A61P31/00 ,  C12P21/04

CPC分类号： C07K16/3084 ,  A61K2039/505 ,  C07K2317/52 ,  C07K2317/732

摘要： An anti-ganglioside GM2 antibody composition having enhanced effector function which is useful as a medicament has been desired. The present invention provides an antibody composition comprising an antibody molecule which specifically binds to ganglioside GM2 and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

摘要翻译： 已经需要可用作药物的具有增强的效应子功能的抗神经节苷脂GM2抗体组合物。 本发明提供一种抗体组合物，其包含特异性结合神经节苷脂GM2并且在Fc区中具有复合型N-糖苷连接的糖链的抗体分子，其中复合型N-糖苷连接的糖链具有其中岩藻糖 在糖链的还原末端不与N-乙酰氨基葡萄糖结合; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

公开(公告)号：US20130059318A1

公开(公告)日：2013-03-07

申请号：US13519696

申请日：2010-12-28

申请人： Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

发明人： Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

IPC分类号： C07K16/42 ,  C12N5/12 ,  C12N15/63 ,  G01N33/577 ,  C12N1/19 ,  C12N5/10 ,  C12P21/08 ,  C12N15/13 ,  C12N1/21

CPC分类号： C07K16/4283 ,  C07K2317/34 ,  C07K2317/92 ,  G01N2800/34

摘要： An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

摘要翻译： 本发明的目的是提供一种单克隆抗体，该单克隆抗体对于诊断IgA肾病是有效的，并特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区 半乳糖不结合。 根据本发明，可以提供特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区的单克隆抗体或其抗体片段 使用抗体或其抗体片段提供诊断剂，并提供包含抗体或其抗体片段的治疗剂作为活性成分。

公开(公告)号：US09023999B2

公开(公告)日：2015-05-05

申请号：US12494827

申请日：2009-06-30

申请人： Katsuhiro Mori ,  Naoko Hiura ,  Tsuguo Kubota ,  Akiko Furuya ,  Yutaka Kanda ,  Mitsuo Satoh

发明人： Katsuhiro Mori ,  Naoko Hiura ,  Tsuguo Kubota ,  Akiko Furuya ,  Yutaka Kanda ,  Mitsuo Satoh

IPC分类号： C07K16/00 ,  C12P19/00 ,  G01N33/53 ,  G01N33/574 ,  C07K16/28 ,  C12R1/91 ,  G01N33/68

CPC分类号： G01N33/57484 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/734 ,  C07K2317/92 ,  C12R1/91 ,  G01N33/6863 ,  G01N2333/70578 ,  G01N2400/02 ,  G01N2800/347

摘要： The present invention provides a monoclonal antibody which specifically recognizes CD27 containing an O-linked sugar chain to which galactose is not bound and binds to its extracellular region, or a method for using the same.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which specifically recognizes a polypeptide encoded by CD27 gene containing an O-linked sugar chain to which galactose is not bound, and binds to its extracellular region; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

摘要翻译： 本发明提供一种单克隆抗体，其特异性识别含有O-连接的糖链的CD27，其中半乳糖不结合并结合到其胞外区域，或其使用方法。 本发明可以提供一种单克隆抗体或其抗体片段，该单克隆抗体或其抗体片段特异性识别由含有O-连接的糖链的CD27基因编码的多肽，其中半乳糖未结合到其上并结合其胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及包含该抗体或其抗体片段作为有效成分的诊断剂或治疗剂。

公开(公告)号：US07749753B2

公开(公告)日：2010-07-06

申请号：US10409600

申请日：2003-04-09

申请人： Yutaka Kanda ,  Mitsuo Satoh ,  Katsuhiro Mori

发明人： Yutaka Kanda ,  Mitsuo Satoh ,  Katsuhiro Mori

IPC分类号： C12P21/02 ,  C07H21/04

CPC分类号： C12N15/8245 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/732

摘要： A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition.

摘要翻译： 与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的活性比其亲本细胞更多地减少或缺失的细胞; 使用该细胞产生抗体组合物的方法; 转基因非人动物或植物或其后代，其中基因组被修饰以具有与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的降低或缺失的活性; 从动物或植物制备抗体组合物的方法; 和包含该抗体组合物的药物。

公开(公告)号：US20070134759A1

公开(公告)日：2007-06-14

申请号：US10575096

申请日：2004-10-08

申请人： Harue Nishiya ,  Mitsuo Satoh ,  Katsuhiro Mori

发明人： Harue Nishiya ,  Mitsuo Satoh ,  Katsuhiro Mori

IPC分类号： C07K16/40 ,  C07H21/04 ,  C12P21/06 ,  C12N9/10

CPC分类号： C12N15/1137 ,  C07K16/00 ,  C07K2317/72 ,  C12N2310/111 ,  C12N2310/14 ,  C12Y204/01068

摘要： The present invention provides a process for producing an antibody composition using a cell, which comprises using a cell into which an RNA having activity of suppressing the function of an enzyme relating to the modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex type N-glycoside-linked sugar chain is introduced; the RNA used in the production process; a DNA corresponding to the RNA; a cell in which the RNA or DNA is introduced or expressed; a process for producing the cell; and a method for suppressing the enzyme.

摘要翻译： 本发明提供一种使用细胞的抗体组合物的制造方法，其包括使用具有抑制与其中1位的岩藻糖结合的糖链的修饰相关的酶的功能的活性的RNA的细胞 通过复合型N-糖苷连接的糖链中的α-键引入还原末端的N-乙酰葡糖胺的6-位; 生产过程中使用的RNA; 对应于RNA的DNA; 引入或表达RNA或DNA的细胞; 一种生产细胞的方法; 和抑制酶的方法。

公开(公告)号：US20100291628A1

公开(公告)日：2010-11-18

申请号：US12782782

申请日：2010-05-19

申请人： Yutaka KANDA ,  Mitsuo Satoh ,  Katsuhiro Mori

发明人： Yutaka KANDA ,  Mitsuo Satoh ,  Katsuhiro Mori

IPC分类号： C12P21/04

CPC分类号： C12N15/8245 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/732

摘要： A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition.

公开(公告)号：US08361751B2

公开(公告)日：2013-01-29

申请号：US12782782

申请日：2010-05-19

申请人： Yutaka Kanda ,  Mitsuo Satoh ,  Katsuhiro Mori

发明人： Yutaka Kanda ,  Mitsuo Satoh ,  Katsuhiro Mori

IPC分类号： C12P21/08 ,  C12N5/10 ,  C12N5/0781

CPC分类号： C12N15/8245 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/732

摘要： A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition.

摘要翻译： 与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的活性比其亲本细胞更多地减少或缺失的细胞; 使用该细胞产生抗体组合物的方法; 转基因非人动物或植物或其后代，其中基因组被修饰以具有与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的降低或缺失的活性; 从动物或植物制备抗体组合物的方法; 和包含该抗体组合物的药物。

公开(公告)号：US20060223147A1

公开(公告)日：2006-10-05

申请号：US11196503

申请日：2005-08-04

申请人： Harue Nishiya ,  Mitsuo Satoh ,  Katsuhiro Mori

发明人： Harue Nishiya ,  Mitsuo Satoh ,  Katsuhiro Mori

IPC分类号： C12P19/28 ,  C07H21/04 ,  C12P21/06 ,  C12N9/04 ,  C12N9/10

CPC分类号： C12P21/005 ,  C12N9/1051 ,  C12N9/88

摘要： The present invention relates to a cell into which an RNA capable of suppressing the function of an enzyme catalyzing a reaction which converts GDP-mannose into GDP-4-keto,6-deoxy-GDP-mannose is introduced; a process for producing a glycoprotein using the cell; a cell into which an RNA capable of suppressing the function of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in the complex type N-glycoside-linked sugar chain, and an RNA capable of suppressing the function of an enzyme relating to synthesis of an intracellular sugar nucleotide, GDP-fucose, or an RNA capable of suppressing the function of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body are introduced; a process for producing a glycoprotein composition using the cell; and the like.

摘要翻译： 本发明涉及能够抑制催化将GDP-甘露糖转化成GDP-4-酮，6-脱氧-GG-甘露糖的反应的酶的功能的RNA的细胞; 使用该细胞产生糖蛋白的方法; 能够抑制与糖链的修饰相关的酶的功能的RNA的细胞，其中岩藻糖的1位通过复合型中的α-键与还原末端的N-乙酰葡糖胺的6-位结合 N-糖苷连接的糖链，以及能够抑制与胞内糖核苷酸GDP-岩藻糖合成相关的酶的功能的RNA，或能够抑制与细胞内糖的运输有关的蛋白质的功能的RNA 核苷酸，GDP-岩藻糖，到高尔基体; 使用该细胞产生糖蛋白组合物的方法; 等等。

公开(公告)号：US4236800A

公开(公告)日：1980-12-02

申请号：US59701

申请日：1979-07-23

申请人： Mitsuo Satoh

发明人： Mitsuo Satoh

IPC分类号： G03B1/00 ,  G03B1/14 ,  G03B1/62 ,  G03B17/00 ,  G03B17/42

CPC分类号： G03B1/62 ,  G03B1/14

摘要： A film stop position adjusting mechanism with a stop lever (3) having a stop pawl (3a) engaged with a ratchet gear (2) and adapted to stop the feeding of a film. A ratchet releasing lever (7) holds the stop lever (3) at a release position, with the ratchet releasing lever having a bent portion (7a) and an extended portion (7b). A locking lever (11) has a step (11a) which engages the bent portion (7a) of the ratchet releasing lever to lock the ratchet releasing lever (7). A detection lever has a protrusion (15a) which is inserted into a perforation of the film to detect a film stop position, and an arm (15b) having a straight edge substantially perpendicular to a film feeding direction. The locking lever (11) is provided with an eccentric pin (10) whose position can be adjusted by rotation. The eccentric pin (10) is engaged with an arm (15b) of the detection lever adapted to detect a film stop position by inserting the protrusion (15a) into a film perforation. The film stop position is adjusted by changing the timing at which the step (11a) is disengaged from the bent portion (7a).

摘要翻译： 一种具有止动杆（3）的胶片停止位置调节机构，其具有与棘轮（2）接合并适于停止胶片馈送的止动爪（3a）。 棘轮释放杆（7）将止动杆（3）保持在释放位置，棘轮释放杆具有弯曲部分（7a）和延伸部分（7b）。 锁定杆（11）具有与棘轮释放杆的弯曲部分（7a）接合以锁定棘轮释放杆（7）的台阶（11a）。 检测杆具有插入到胶片的穿孔中以检测胶片停止位置的突起（15a）和具有与胶片输送方向基本垂直的直边缘的臂（15b）。 锁定杆（11）设置有偏心销（10），其位置可以通过旋转来调节。 偏心销（10）与检测杆的臂（15b）接合，适于通过将突起（15a）插入薄膜穿孔中来检测胶片停止位置。 通过改变步骤（11a）与弯曲部分（7a）脱离的时间来调整胶片停止位置。

公开(公告)号：US20060281179A1

公开(公告)日：2006-12-14

申请号：US10495567

申请日：2002-11-14

申请人： Yoshiki Sasai ,  Hiroo Iwata ,  Yoshinobu Murakami ,  Mitsuo Satoh ,  Masato Kobori ,  Keiichi Yano

发明人： Yoshiki Sasai ,  Hiroo Iwata ,  Yoshinobu Murakami ,  Mitsuo Satoh ,  Masato Kobori ,  Keiichi Yano

IPC分类号： C12N5/08 ,  C12N15/09 ,  C07K14/475

CPC分类号： G01N33/5073 ,  A61K35/12 ,  A61K35/48 ,  A61K38/1709 ,  C12N5/0603 ,  C12N5/0619 ,  C12N2501/415 ,  C12N2501/90 ,  C12N2501/91 ,  C12N2502/13 ,  C12N2503/02 ,  C12N2506/02 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5058 ,  G01N33/6896

摘要： A method for obtaining a solution having activity to induce differentiation of an embryonic stem cell into an ectodermal cell or ectoderm-derived cell, which comprises culturing a stromal cell in a culture comprising a polyanionic compound and recovering the culture; a solution having activity to induce differentiation of an embryonic stem cell into an ectodermal cell or ectoderm-derived cell, which is obtainable by the method; and an agent for inducing differentiation of an embryonic stem cell into an ectodermal cell or ectoderm-derived cell.

摘要翻译： 一种获得具有诱导胚胎干细胞分化为外胚层细胞或外胚层衍生细胞的活性的溶液的方法，其包括在包含聚阴离子化合物的培养物中培养基质细胞并回收培养物; 具有诱导胚胎干细胞分化为外胚层细胞或外胚层衍生细胞的活性的溶液，其可通过该方法获得; 以及用于诱导胚胎干细胞分化为外胚层细胞或外胚层衍生细胞的药剂。