公开(公告)号：US06265016B1

公开(公告)日：2001-07-24

申请号：US09531925

申请日：2000-03-21

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: B05D302

CPC classification number: C08J7/047 ,  A61L29/085 ,  A61L31/10 ,  C08G18/10 ,  C08G18/283 ,  C08G2230/00 ,  C08J7/04 ,  C08J2475/00 ,  Y10T428/31554 ,  Y10T428/31562 ,  Y10T428/31565 ,  Y10T428/31569 ,  Y10T428/31587 ,  Y10T428/31678 ,  A61L31/145 ,  A61L29/145 ,  C08L75/04 ,  C08G18/307 ,  C08G18/3225

Abstract: A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

公开(公告)号：US6120536A

公开(公告)日：2000-09-19

申请号：US663518

申请日：1996-06-13

Applicant: Ni Ding ,  Michael N. Helmus

Inventor： Ni Ding ,  Michael N. Helmus

IPC: A61F2/00 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61L27/00 ,  A61L27/22 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/10 ,  A61F2/06

CPC classification number: A61L33/0011 ,  A61L27/227 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L2300/236 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/622

Abstract: A coating and method for implantable open lattice metallic stent prostheses are disclosed. The coating includes a relatively thin layer of biostable elastomeric material containing an amount of biologically active material, particularly heparin, dispersed in the coating in combination with a non-thrombogenic surface. In one embodiment, the surface is provided with sites of high electronegativity species by coating with fluorosilicone which aid in controlling elution, particularly the initial release rate, and reduced thrombogenic activity. Other non-thrombogenic outer layers for heparin such as covalently bound polyethylene glycol (PEG) are also disclosed.

Abstract translation: 公开了一种用于可植入的开放格子金属支架假体的涂层和方法。 涂层包括相对薄的生物稳定的弹性材料层，其中含有一定数量的生物活性材料，特别是肝素，其与非血栓形成的表面组合分散在涂层中。 在一个实施方案中，通过用有助于控制洗脱，特别是初始释放速率和有助于降低血栓形成活性的氟硅氧烷来涂覆高电负性物质的表面。 还公开了用于肝素的其它非血栓形成外层，例如共价结合的聚乙二醇（PEG）。

公开(公告)号：US6030656A

公开(公告)日：2000-02-29

申请号：US126375

申请日：1998-03-24

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/08 ,  A61L31/10 ,  C08G18/10 ,  C08G18/28 ,  C08J7/04 ,  B05D7/14

CPC classification number: C08J7/047 ,  A61L29/085 ,  A61L31/10 ,  C08G18/10 ,  C08G18/283 ,  C08J7/04 ,  C08G2230/00 ,  C08J2475/00 ,  Y10T428/31554 ,  Y10T428/31562 ,  Y10T428/31565 ,  Y10T428/31569 ,  Y10T428/31587 ,  Y10T428/31678

Abstract: A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

公开(公告)号：US08821473B2

公开(公告)日：2014-09-02

申请号：US12632612

申请日：2009-12-07

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M31/00 ,  A61K31/7088 ,  A61K9/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

公开(公告)号：US08551446B2

公开(公告)日：2013-10-08

申请号：US11857362

申请日：2007-09-18

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61K51/00 ,  A61M36/14

CPC classification number: A61K31/573 ,  A61K31/436 ,  A61K47/6957 ,  Y10T428/31855

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a polyacetal-based polymer.

Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层包括聚缩醛基聚合物。

公开(公告)号：US08263170B2

公开(公告)日：2012-09-11

申请号：US12683404

申请日：2010-01-06

Applicant: Eugene T. Michal ,  Ni Ding ,  Christopher Buchko

Inventor： Eugene T. Michal ,  Ni Ding ,  Christopher Buchko

IPC: A61L33/00 ,  B05D3/00 ,  A61F2/06

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L33/0029 ,  A61L33/0088 ,  A61L2300/42 ,  A61L2420/08

Abstract: The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.

Abstract translation: 本发明涉及一种具有用于固定抗血栓形成材料如肝素的聚合底涂层的医疗装置。 粘合涂层由各种化学官能团组成，它们是稳定的并允许将抗血栓形成材料固定在其上。 还提供了将抗凝血栓塞材料固定在医疗装置表面上的底涂层内的方法。

公开(公告)号：US08048442B1

公开(公告)日：2011-11-01

申请号：US12211726

申请日：2008-09-16

Applicant: Syed F. A. Hossainy ,  Ni Ding

Inventor： Syed F. A. Hossainy ,  Ni Ding

IPC: A61F2/04 ,  A61K31/727 ,  B05D1/36

CPC classification number: A61F2/82 ,  A61F2250/0067 ,  A61K31/727 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2420/08

Abstract: Systems comprising modified heparin-based coatings to form coatings on medical devices are provided. The systems improve the suitability of the heparin-based coatings.

Abstract translation: 提供了包括改进的基于肝素的涂层以在医疗装置上形成涂层的系统。 该系统改善了肝素基涂层的适用性。

公开(公告)号：US08017142B2

公开(公告)日：2011-09-13

申请号：US12476987

申请日：2009-06-02

Applicant: Charles D. Claude ,  Ni Ding ,  Yeung Siu Yu

Inventor： Charles D. Claude ,  Ni Ding ,  Yeung Siu Yu

IPC: A61F2/00 ,  A61K47/00 ,  A61K47/30

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/606 ,  C08L81/06

Abstract: A polymeric composition comprising a polysulfone polymer and an elastomeric polymer for use as a coating composition for coating an implantable device, such as a DES, and methods of making and using the implantable device are provided.

Abstract translation: 提供了一种聚合物组合物，其包含聚砜聚合物和用作涂覆可植入装置（例如DES）的涂料组合物的弹性体聚合物，以及制造和使用可植入装置的方法。

公开(公告)号：US07989018B2

公开(公告)日：2011-08-02

申请号：US11395014

申请日：2006-03-31

Applicant: Andrew F. McNiven ,  Thomas D. Esbeck ,  Ni Ding ,  Stephen Pacetti ,  Syed F. A. Hossainy

Inventor： Andrew F. McNiven ,  Thomas D. Esbeck ,  Ni Ding ,  Stephen Pacetti ,  Syed F. A. Hossainy

IPC: B05D3/10 ,  B05D3/04 ,  A61F2/06

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  B05D3/107

Abstract: A method for modifying a polymeric coating on an implantable medical device, such as a stent, is disclosed. The method includes application of a fluid to a wet or dry polymeric coating with and without drugs.

Abstract translation: 公开了一种用于修改可植入医疗装置（例如支架）上的聚合物涂层的方法。 该方法包括将液体施用于具有和不具有药物的湿或干燥聚合物涂层。

公开(公告)号：US07959659B2

公开(公告)日：2011-06-14

申请号：US11027822

申请日：2004-12-29

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61F2/06 ,  C07K14/00

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61K38/1709 ,  A61L31/10 ,  A61L2300/252 ,  A61L2300/416

Abstract: An implantable medical device is disclosed comprising a high-density lipoprotein (HDL), recombinant HDL, high-density lipoprotein mimics (HDLm), or a combination thereof. Method are also disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.

Abstract translation: 公开了一种植入式医疗装置，其包括高密度脂蛋白（HDL），重组HDL，高密度脂蛋白模拟物（HDLm）或其组合。 还公开了局部和全身给药HDL，重组HDL或HDLm用于预防，治疗或改善血管疾病，疾病或闭塞如再狭窄或易损斑块的方法。