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    Protein crystallization apparatus, method of protein crystallization, protein crystallizing agent and process for preparing the same
    42.
    发明申请
    Protein crystallization apparatus, method of protein crystallization, protein crystallizing agent and process for preparing the same 审中-公开
    蛋白质结晶装置，蛋白质结晶方法，蛋白质结晶剂及其制备方法

    公开(公告)号：US20070181058A1

    公开(公告)日：2007-08-09

    申请号：US10567666

    申请日：2004-08-10

    Applicant: Isao Tanaka ,  Nobuhisa Watanabe ,  Hiroshi Takeuchi ,  Takayuki Iseki ,  Nozomu Shibuya ,  Chiharu Nishijima

    Inventor： Isao Tanaka ,  Nobuhisa Watanabe ,  Hiroshi Takeuchi ,  Takayuki Iseki ,  Nozomu Shibuya ,  Chiharu Nishijima

    IPC: C30B15/26 ,  C30B11/00

    CPC classification number: C30B7/00 ,  C07K1/306 ,  C30B29/58 ,  Y10T117/1004 ,  Y10T117/1024

    Abstract: The invention provides a protein crystallizing device capable of performing a protein crystallization experiment or screening of crystallization conditions rapidly and economically with a high reliability, and a protein crystallizing agent capable of performing the operation of protein crystallization by a simpler method. The protein crystallizing device of the present invention comprises a protein crystallizing microarray having at least two crystallizing agent holding parts which hold a protein crystallizing agent and a plate laminated on the protein crystallizing microarray, wherein the plate has crystallizing sections corresponding to the crystallizing agent holding parts and capable of being filled with a protein-containing sample and recessed parts provided between the crystallizing sections. The protein crystallizing agent of the present invention is evenly held in a gel by gelatinizing a solution containing a protein precipitant and an unsaturated monomer.

    Abstract translation: 本发明提供能够以高可靠性快速且经济地进行蛋白质结晶实验或筛选结晶条件的蛋白质结晶装置，以及能够通过更简单的方法进行蛋白质结晶操作的蛋白质结晶剂。 本发明的蛋白质结晶装置包括蛋白结晶微阵列，其具有至少两个结晶剂保持部分，其保持蛋白质结晶剂和层压在蛋白质结晶微阵列上的板，其中该板具有对应于结晶剂保持部分的结晶部分 并且能够填充含蛋白质的样品和设置在结晶部之间的凹部。 通过将含有蛋白质沉淀剂和不饱和单体的溶液凝胶化，将本发明的蛋白质结晶剂均匀地保持在凝胶中。

    Benzimidazole compound
    44.
    发明申请
    Benzimidazole compound 有权
    苯并咪唑化合物

    公开(公告)号：US20070010542A1

    公开(公告)日：2007-01-11

    申请号：US11520838

    申请日：2006-09-14

    Applicant: Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    Inventor： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    IPC: A61K31/4747 ,  A61K31/4439 ,  C07D405/14

    CPC classification number: C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

    Abstract: An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

    Abstract translation: 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。

    Microprocessor with improved instruction cycle using time-compressed fetching
    46.
    发明授权
    Microprocessor with improved instruction cycle using time-compressed fetching 失效
    微处理器使用时间压缩的提取改进了指令周期

    公开(公告)号：US06484252B1

    公开(公告)日：2002-11-19

    申请号：US08488082

    申请日：1995-06-07

    Applicant: Nobuhisa Watanabe

    Inventor： Nobuhisa Watanabe

    IPC: G06F930

    CPC classification number: G06F9/3802 ,  G06F9/321 ,  G06F9/383

    Abstract: A microcomputer includes an instruction decoder and a program counter. The instruction decoder decodes fetched instructions and outputs a control signal ordering execution of the fetched instruction. The control signal from the instruction decoder includes a component controlling fetch cycles which triggers a fetch cycle at the beginning of each instruction cycle to fetch the operand for the instruction currently being executed and midway through each instruction cycle to fetch the OP code for the next instruction. The program counter is responsive to the triggering of each fetch cycle to increment its counter value so as to keep the counter value consistent with the address being accessed in each fetch cycle.

    Abstract translation: 微型计算机包括指令解码器和程序计数器。 指令译码器解码取出的指令，并输出排序执行取指令的控制信号。 来自指令解码器的控制信号包括控制读取周期的部件，其触发在每个指令周期开始时的获取周期，以获取当前正在执行的指令的操作数，并在每个指令周期的中途获取下一个指令的OP代码 。 程序计数器响应于每个读取周期的触发以递增其计数器值，以便使计数值与每个读取周期中被访问的地址保持一致。

    Monochromator and method of manufacturing the same
    48.
    发明授权
    Monochromator and method of manufacturing the same 失效
    单色器及其制造方法

    公开(公告)号：US06229874B1

    公开(公告)日：2001-05-08

    申请号：US09439283

    申请日：1999-11-15

    Applicant: Noriyoshi Sakabe ,  Nobuhisa Watanabe

    Inventor： Noriyoshi Sakabe ,  Nobuhisa Watanabe

    IPC: G21K106

    CPC classification number: G21K1/06 ,  G21K2201/067

    Abstract: A base member obtained by cutting a cylindrical body having a center axial line at a maximum asymmetric angle &agr;0 with respect to a plane orthogonal to the center axial line of cylindrical body is prepared. Next, the thus obtained ellipsoidal asymmetric cut surface of the base member is shaped along a peripheral surface of an imaginary cylindrical body having a radius R0, into an asymmetric cut curved-surface. Then, a monochromator Si crystal is bonded to the asymmetric cut curved-surface of the base member. Both the asymmetric angle and the radius of curvature for a desired wavelength within a wide wavelength range can be simultaneously tuned only by the &phgr;-axis rotation.

    Abstract translation: 准备通过切割具有相对于与圆柱体的中心轴线正交的平面的具有最大不对称角α0的中心轴线的圆柱体获得的基底构件。 接下来，将如此获得的基体的椭圆形不对称切割面沿着具有半径R 0的假想圆筒体的周面成形为非对称切割曲面。 然后，将单色器Si晶体结合到基体的非对称切割曲面上。 在宽波长范围内的所需波长的不对称角和曲率半径都可以仅通过旋转旋转来同时调谐。

    Data bus arrangement with improved speed and timing
    50.
    发明授权
    Data bus arrangement with improved speed and timing 失效
    数据总线布置与改进的速度和时序

    公开(公告)号：US5157772A

    公开(公告)日：1992-10-20

    申请号：US192362

    申请日：1988-05-10

    Applicant: Nobuhisa Watanabe

    Inventor： Nobuhisa Watanabe

    IPC: G06F15/78 ,  G06F13/40

    CPC classification number: G06F13/4077 ,  G06F13/4027

    Abstract: To speed up data transfer, one embodiment of the invention features a transmission gate arrangement which pre-charges and transfers data in internal and external buses with the same timing and which further initializes the internal bus and a device such as an ALU, every bus cycle. A second embodiment speeds the data transfer in the buses by providing two data transfer paths through the interconnected buses and reducing the combined resistances of the internal and external buses.

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