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322 条记录 (耗时 0.046 秒)

    Cyclopentenone derivative
    44.
    发明授权
    Cyclopentenone derivative 失效
    环戊烯酮衍生物

    公开(公告)号：US6136854A

    公开(公告)日：2000-10-24

    申请号：US359069

    申请日：1999-07-21

    申请人： Nobuto Koyama ,  Katsushige Ikai ,  Eiji Kobayashi ,  Ikunoshin Kato

    发明人： Nobuto Koyama ,  Katsushige Ikai ,  Eiji Kobayashi ,  Ikunoshin Kato

    IPC分类号： C07C69/013 ,  A61K31/235 ,  C07C69/52 ,  C07C69/76

    CPC分类号： C07C69/013

    摘要： Cyclopentenone derivative having a structure of 5-(R.sub.1 COO--)-4-(R.sub.2 COO--)--substituted 2-cyclopenten-1-one (R.sub.1 and R.sub.2 are some or different and each is alkyl group, alkenyl group or aryl group) or an optically active substance thereof; a method for the manufacture of the cyclopentenone derivative by the reaction of 4,5-dihydroxy-2-cyclopenten-1-one with the corresponding carboxylic acid or a reactive derivative thereof; and anticancer agent, apoptosis-inducing agent and antibacterial agent containing said derivative.

    摘要翻译： 具有5-（R 1 COO - ） - 4-（R 2 COO - ） - 取代的2-环戊烯-1-酮的结构的环戊烯酮衍生物（R 1和R 2有一些或不同，各自为烷基，烯基或芳基）或 其光学活性物质; 通过4,5-二羟基-2-环戊烯-1-酮与相应的羧酸或其活性衍生物的反应制备环戊烯酮衍生物的方法; 和抗癌剂，凋亡诱导剂和含有所述衍生物的抗菌剂。

    Remedies
    45.
    发明申请
    Remedies 审中-公开
    补救措施

    公开(公告)号：US20060199774A1

    公开(公告)日：2006-09-07

    申请号：US11408946

    申请日：2006-04-24

    申请人： Hiromu Ohnogi ,  Masahiro Shiraga ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Masahiro Shiraga ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K31/366 ,  A61K31/7048

    CPC分类号： A61K31/7048 ,  A23K20/116 ,  A23K20/163 ,  A23L33/105 ,  A61K31/366 ,  A61K31/37 ,  C07H17/04 ,  C07H17/075

    摘要： The present invention relates to a medicament, a food, a beverage or a feed, each comprising as an effective ingredient a compound having an enhancing action for NGF production, which is effective for a treatment, an amelioration of symptom, prevention or the like of a disease requiring enhancement of NGF production, wherein the compound has a coumarin and/or chroman backbone. Since no toxicity is especially found in the effective ingredient of the present invention, and there is no risk of incidence of adverse actions, the treatment or the like of the above disease can be safely and appropriately carried out.

    摘要翻译： 本发明涉及一种药物，食品，饮料或饲料，其各自包含作为有效成分的具有NGF生产增强作用的化合物，其有效治疗，改善症状，预防等 需要增强NGF生产的疾病，其中所述化合物具有香豆素和/或色胺骨架。 由于在本发明的有效成分中没有特别的毒性，并且不存在不良反应的发生风险，所以可以安全，适当地进行上述疾病的治疗等。

    Remedy
    48.
    发明申请
    Remedy 审中-公开
    补救

    公开(公告)号：US20060051316A1

    公开(公告)日：2006-03-09

    申请号：US10537333

    申请日：2003-12-05

    申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K31/74 ,  A61K31/737 ,  A61K31/727 ,  A61K31/715

    CPC分类号： A61K36/02 ,  A23L33/10 ,  A61K31/216 ,  A61K31/737 ,  A61K31/78

    摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring enhancement of bone morphogenetic protein production or promotion of osteogenesis; an agent for enhancement of bone morphogenetic protein production or an agent for promotion of osteogenesis, a food, beverage or feed for enhancement of bone mornhogenetic protein production or promotion of osteogenesis, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of (a) an acidic saccharide, (b) a polyacrylic acid, (c) chlorogenic acid and (d) an oxidation processed product of chlorogenic acid, or an extract derived from algae.

    摘要翻译： 本发明涉及需要增强骨形态发生蛋白产生或促进成骨的疾病的治疗剂或预防剂; 用于增强骨形态发生蛋白质产生的药物或用于促进成骨的药剂，用于增强骨发生蛋白质产生或促进成骨的食品，饮料或饲料，其特征在于，每种药物包含作为有效成分的至少一种选自 由（a）酸性糖，（b）聚丙烯酸，（c）绿原酸和（d）绿原酸的氧化加工产物或源自藻类的提取物组成的组。

    Food beverage or feed for the promotion of osteogenesis comprising umbelliferae, liliaceae or compositae plant species
    50.
    发明申请
    Food beverage or feed for the promotion of osteogenesis comprising umbelliferae, liliaceae or compositae plant species 审中-公开
    用于促进成骨的食物饮料或饲料，包括伞形花序，百合科或合成植物物种

    公开(公告)号：US20080008773A1

    公开(公告)日：2008-01-10

    申请号：US11819441

    申请日：2007-06-27

    申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K36/886 ,  A61K36/00 ,  A61P19/00 ,  A61K36/28

    CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/23 ,  A61K36/232 ,  A61K36/282 ,  A61K36/8967 ,  A23V2200/306 ,  A23V2250/21

    摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.

    摘要翻译： 本发明涉及需要促进骨形成发生或增强骨形态发生蛋白质生成的疾病的治疗剂或预防剂，促进成骨的药剂或增强骨形态发生蛋白质生产的药剂，以及食品，饮料或饲料 用于促进成骨或增强骨形态发生蛋白质的生成，其特征在于，每种都包含作为有效成分的来自植物的加工产品。 另外，本发明涉及骨形态发生蛋白质生成增强作用的测定方法，骨形态发生蛋白质生成增强作用物质的筛选方法以及骨形态发生增强作用物质的制备方法 蛋白质生产，每种方法使用指定的细胞。