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61 条记录 (耗时 0.058 秒)

    FINGER GUIDED SUTURE FIXATION SYSTEM
    41.
    发明申请
    FINGER GUIDED SUTURE FIXATION SYSTEM 有权
    手指引导固定系统

    公开(公告)号：US20110092985A1

    公开(公告)日：2011-04-21

    申请号：US12817198

    申请日：2010-06-17

    申请人： Allen Gaynor ,  Michael K. Luk ,  Steven McClurg ,  Michael M. Witzmann ,  Ying Zheng

    发明人： Allen Gaynor ,  Michael K. Luk ,  Steven McClurg ,  Michael M. Witzmann ,  Ying Zheng

    IPC分类号： A61B17/10 ,  A61B17/04

    CPC分类号： A61B17/0482 ,  A61B17/0483 ,  A61B17/0625 ,  A61B2017/00438

    摘要： A suture fixation system includes a suture assembly having an anchor, an introducer, and a delivery device. The introducer is attachable to a finger of a person and includes a platform attached to an exterior of the introducer and a zip line attached to the platform. The delivery device is movable along the zip line and configured to removably retain the anchor. The introducer allows the finger to identify a target landmark within a patient and the delivery device is movable along the zip line and attachable to the platform to position the anchor for insertion to the target landmark.

    摘要翻译： 缝合线固定系统包括具有锚固件，导引器和输送装置的缝合线组件。 引导器可附接到人的手指，并且包括附接到导引器的外部的平台和附接到平台的拉链线。 输送装置可沿着拉链线移动并且构造成可移除地保持锚固件。 引导器允许手指识别患者内的目标地标，并且输送装置可沿着拉链线移动并且可附接到平台以将锚定位置以插入目标地标。

    BIOMARKERS FOR TRICHOGENICITY
    42.
    发明申请
    BIOMARKERS FOR TRICHOGENICITY 审中-公开
    生物标志物的生物多样性

    公开(公告)号：US20100291580A1

    公开(公告)日：2010-11-18

    申请号：US12808623

    申请日：2008-12-18

    申请人： Satish Parimoo ,  Honghua Yang ,  Ying Homan ,  Wei Chen ,  Ying Zheng ,  Kurt Stenn

    发明人： Satish Parimoo ,  Honghua Yang ,  Ying Homan ,  Wei Chen ,  Ying Zheng ,  Kurt Stenn

    IPC分类号： C12Q1/68 ,  G01N33/566 ,  C12N15/79

    CPC分类号： C12Q1/6881 ,  C12Q2600/178 ,  G01N33/6881 ,  G01N33/6893 ,  G01N2500/10

    摘要： Biomarkers for identifying trichogenic cells have been identified. The biomarkers include microRNA as wells as mRNA and proteins. Certain biomarkers are upregulated in trichogenic cells compared to non-trichogenic cells; whereas, other biomarkers are down-regulated in trichogenic cells compared to non-trichogenic cells. The cells can be dermal cells, epidermal cells, or a combination thereof. Preferably the cells are mammalian, more preferably the cells are human. One embodiment provides a method for selecting trichogenic cells by assaying the cells for expression of one or more biomarkers for trichogenicity, and selecting the cells having increased expression of the one or more biomarkers relative to a control, wherein increased expression of the a biomarker in the cells is indicative of trichogenicity. Preferably, the one or more biomarkers are selected from the group consisting of hsa-miR-200c, hsa-miR-205, hsa-miR-200a*, hsa-miR-200a, hsa-miR-141, hsa-miR-182, DEPDC1, hFLEG1, ESM1, TOME-1, THBD and combinations thereof.

    摘要翻译： 已鉴定出用于鉴定发生细胞的生物标志物。 生物标志物包括微RNA作为mRNA和蛋白质的孔。 与非致毛细胞相比，某些生物标志物在致毛细胞中上调; 而与非致毛细胞相比，其他生物标志物在发育细胞中下调。 细胞可以是真皮细胞，表皮细胞或其组合。 优选地，细胞是哺乳动物，更优选细胞是人。 一个实施方案提供了一种用于通过测定细胞用于表达一种或多种针刺性生物标志物的细胞并选择相对于对照而增加一种或多种生物标志物表达的细胞的方法，其中所述生物标志物在 细胞表示毛发性。 优选地，一种或多种生物标志物选自hsa-miR-200c，hsa-miR-205，hsa-miR-200a *，hsa-miR-200a，hsa-miR-141，hsa-miR-182 ，DEPDC1，hFLEG1，ESM1，TOME-1，THBD及其组合。

    Tool cabinet
    46.
    发明申请
    Tool cabinet 失效
    工具柜

    公开(公告)号：US20070007867A1

    公开(公告)日：2007-01-11

    申请号：US11480861

    申请日：2006-07-06

    申请人： Ying Zheng

    发明人： Ying Zheng

    IPC分类号： A47B97/00

    CPC分类号： A47B47/0075 ,  A47B43/00

    摘要： The present invention relates to a tool cabinet including an upper cover, a bottom board, a case body and a shelf accessory. The case body includes rotatably interconnected case boards, which are foldable with each other. The upper cover and the bottom board are loosely rabbeted into the case body. Without disconnecting each case board, each case board can be folded only by pulling out the pin in the upper cover, turning over the upper cover, then taking out the shelf and the upright column, releasing the block rabbeting, and folding the case boards. It is done after the shelf and the upright column are placed into a predetermined space of the right board and back board during the folding process. It is very simple and convenient. Hence, it is convenient to carry the tool cabinet after it is folded.

    摘要翻译： 本发明涉及一种包括上盖，底板，壳体和货架附件的工具柜。 壳体包括彼此可折叠的可旋转地互连的壳体板。 上盖和底板松动地拉入箱体。 每个外壳板不要断开，每个外壳板只能通过拉出上盖中的销钉，翻转上盖，然后取出架子和立柱，释放挡板拉出，并折叠机箱。 在折叠过程中，搁板和直立柱被放置在右板和后板的预定空间中之后完成。 这是非常简单和方便。 因此，工具柜折叠后方便携带。

    Organogenesis from dissociated cells
    47.
    发明申请
    Organogenesis from dissociated cells 审中-公开
    解离细胞的器官发生

    公开(公告)号：US20060062770A1

    公开(公告)日：2006-03-23

    申请号：US11203804

    申请日：2005-08-15

    申请人： Ying Zheng ,  Xiaobing Du ,  Wei Wang ,  Marylene Boucher ,  Satish Parimoo ,  Kurt Stenn

    发明人： Ying Zheng ,  Xiaobing Du ,  Wei Wang ,  Marylene Boucher ,  Satish Parimoo ,  Kurt Stenn

    IPC分类号： A61K35/36

    CPC分类号： A61K35/36 ,  A61K8/02 ,  A61K8/985 ,  A61K35/12 ,  A61Q7/00 ,  C12N5/0627

    摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate “infundibular cysts”. From the “infundibular cysts” hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the “infundibular cysts” by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.

    摘要翻译： 公开了一种用于从解离的上皮和间充质细胞中快速和可重复地产生毛囊的方法测定法。 该方法既用于测量细胞的致毛体（即毛发生长诱导）性质和用于研究解离的细胞用于组装器官的机制。 在这种方法中，从新生小鼠皮肤分离的解离的细胞被注射到成年小鼠的截肢皮肤中，形成毛囊。 该过程涉及上皮细胞的聚集以形成通过凋亡而雕刻以产生“漏斗状囊肿”的簇。 从“漏斗状囊肿”毛发细胞形式，然后是滤泡芽，然后是不对称生长的分离成循环成熟的皮脂状结构的栓。 使用各种技术，通过穿刺，刺穿或刮伤皮肤暴露“漏斗状囊肿”，并且在使用产生流出毛囊的伤口敷料材料覆盖暴露的囊肿的方法中。

    Silicone hydrogel contact lenses
    50.
    发明授权
    Silicone hydrogel contact lenses 有权
    硅胶水凝胶隐形眼镜

    公开(公告)号：US09121998B2

    公开(公告)日：2015-09-01

    申请号：US13983578

    申请日：2012-02-23

    申请人： Charlie Chen ,  Yuwen Liu ,  Yuan Xu ,  Ying Zheng ,  Junhao Ge ,  Li Yao ,  Arthur Back

    发明人： Charlie Chen ,  Yuwen Liu ,  Yuan Xu ,  Ying Zheng ,  Junhao Ge ,  Li Yao ,  Arthur Back

    IPC分类号： C08L101/14 ,  C08L83/04 ,  G02C7/04 ,  G02B1/04

    CPC分类号： G02B1/043 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

    摘要： Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group, 10 to 50 unit parts by weight of 2-hydroxyethyl methacrylate (HEMA), and a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof, where the total amount of siloxane monomer(s) present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

    摘要翻译： 描述了硅酮水凝胶隐形眼镜。 透镜衍生自可聚合组合物，其包含30-60单位重量份的具有一个N-乙烯基的亲水性单体，10-50单位重量份的甲基丙烯酸2-羟乙酯（HEMA）和第一个硅氧烷 单体组分，其包含本文所述的式（1）的硅氧烷单体或本文所述的式（2）的硅氧烷单体或本文所述的式（3）的硅氧烷单体或其任何组合，其中硅氧烷单体的总量 存在于聚合性组合物中的重量比为15〜40单位份。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。