公开(公告)号：US20110212086A1

公开(公告)日：2011-09-01

申请号：US12087852

申请日：2007-01-19

申请人： Srinivas Shankara ,  Bruce Roberts

发明人： Srinivas Shankara ,  Bruce Roberts

IPC分类号： A61K39/395 ,  C12N5/09 ,  C12N5/16 ,  G01N33/566 ,  A61P35/00

CPC分类号： C07K16/2878 ,  C07K2317/734 ,  G01N33/5011

摘要： The present invention provides compositions and methods for inhibiting the growth of a GITR-expressing cancer cell which cells may include, but are not limited to cells of epithelial origin such as NSCLC, prostate cancer, breast cancer, colon cancer and ovarian cancer and to treat or ameliorate the symptoms associated with the presence of these cells in a subject. Suitable compositions for use in these methods are antibodies that selectively recognize and bind to GITR (Glucocorticoid-induced TNFR-related protein) present on these cancer cells. The antibodies can be either polyclonal or monoclonal antibodies.

摘要翻译： 本发明提供用于抑制表达GITR的癌细胞生长的组合物和方法，所述细胞可以包括但不限于上皮来源的细胞如NSCLC，前列腺癌，乳腺癌，结肠癌和卵巢癌，并且治疗 或改善与受试者中这些细胞存在相关的症状。 用于这些方法的合适的组合物是选择性识别和结合存在于这些癌细胞上的GITR（糖皮质激素诱导的TNFR相关蛋白）的抗体。 抗体可以是多克隆抗体或单克隆抗体。

公开(公告)号：US07800291B2

公开(公告)日：2010-09-21

申请号：US11746425

申请日：2007-05-09

申请人： William W. Beers ,  Gary R. Allen ,  Bruce Roberts ,  Gregory Brown

发明人： William W. Beers ,  Gary R. Allen ,  Bruce Roberts ,  Gregory Brown

IPC分类号： H01J1/62

CPC分类号： H01J61/72 ,  H01J61/20

摘要： A low-wattage mercury vapor discharge fluorescent lamp is provided. The lamp has a discharge sustaining fill of mercury vapor and an inert gas having 1-100 mole % xenon, balance comprising a rare gas or rare gas mixture, such as krypton or argon. The fill gas has a total pressure of 0.5-4 torr, and the lamp being adapted to operate below 10 watts per foot of arc length.

摘要翻译： 提供了一个低瓦数汞蒸汽放电荧光灯。 该灯具有放电维持填充的汞蒸气和具有1-100摩尔％氙的惰性气体，余量包含稀有气体或稀有气体混合物，例如氪或氩。 填充气体的总压力为0.5-4乇，灯适用于每英尺弧长低于10瓦特。

公开(公告)号：US20090147176A1

公开(公告)日：2009-06-11

申请号：US11952196

申请日：2007-12-07

申请人： Jonathan Kron ,  Bruce Roberts ,  Laszlo S. Ilyes

发明人： Jonathan Kron ,  Bruce Roberts ,  Laszlo S. Ilyes

IPC分类号： G02F1/1335 ,  G09G5/10

CPC分类号： G09G3/342 ,  G09G2310/024 ,  G09G2310/08 ,  G09G2320/0261 ,  G09G2320/064

摘要： In a scanning backlight for an LCD display, several backlights (101, 102, 103, 10n) provide a precisely positioned dimming pulse corresponding to a transition point of the LCD screen. The dimming pulse must be variable with video synchronization frequency and dimming duty cycle, which is a performance intensive calculation. One microcontroller performing this operation is limited in scope. By using several ballast controllers (141, 142, 143, 14n), the solution is scalable, in that it is flexible if the number of backlights (101, 102, 103, 10n) changes. Additionally, by using several controllers (141, 142, 143, 14n), added functions can be performed by the ballast controllers (141, 142, 143, 14n).

摘要翻译： 在用于LCD显示器的扫描背光中，几个背光源（101,102,103,10n）提供对应于LCD屏幕的转变点的精确定位的调光脉冲。 调光脉冲必须随着视频同步频率和调光占空比而变化，这是一个性能密集的计算。 执行此操作的一个微控制器的范围有限。 通过使用几个镇流器控制器（141,142,143,14n），解决方案是可扩展的，因为如果背光（101,102,103,10n）的数量改变，则灵活。 另外，通过使用多个控制器（141,142,143,14n），可以由镇流器控制器（141,142,143,14n）执行附加功能。

公开(公告)号：US20080225504A1

公开(公告)日：2008-09-18

申请号：US11724063

申请日：2007-03-14

申请人： Virgil A. Chichernea ,  Bruce Roberts

发明人： Virgil A. Chichernea ,  Bruce Roberts

IPC分类号： H05K9/00

CPC分类号： H05K9/0045

摘要： In an igniter module housing (F) of an automotive headlamp assembly, an improved EMI shielding includes a thin coating (12) on the housing. This arrangement eliminates the need for separate EMI shielding components. The coating is electrically conductive, typically a metal such as aluminum, and may be sputtered, painted, or dipped onto the plastic substrate at a thickness of approximately 3 microns or less. The total weight of the aluminum coating is on the order of 1 milligram.

摘要翻译： 在汽车前照灯组件的点火器模块外壳（F）中，改进的EMI屏蔽包括在外壳上的薄涂层（12）。 这种布置消除了对单独的EMI屏蔽部件的需要。 涂层是导电的，通常是诸如铝的金属，并且可以以大约3微米或更小的厚度溅射，涂漆或浸在塑料基材上。 铝涂层的总重量约为1毫克。

公开(公告)号：US07420336B2

公开(公告)日：2008-09-02

申请号：US11063079

申请日：2005-02-22

申请人： Timothy Chen ,  Wei Xiong ,  Bruce Roberts

发明人： Timothy Chen ,  Wei Xiong ,  Bruce Roberts

IPC分类号： H05B37/00

CPC分类号： H05B41/295 ,  H02M2001/0006 ,  H05B41/2988

摘要： The embodiment disclosed herein relates to systems and methods to provide improvements to power delivery systems employed with lamps in general and fluorescent lamps in particular. In accordance with one exemplary embodiment, cathode current is controlled to a maximum level to quickly bring the cathode temperature up to thermionic emission temperature. After lamp ignition, a cathode voltage reduction circuit is employed to reduce voltage of the external cathode heating. Power is supplied to a power factor correction circuit via an IC, in accordance with a second exemplary embodiment. Finally, a third disclosed embodiment addresses desensitizing the lamp from various deleterious parasitic capacitive effects associated with the power delivery to one or more lamps.

摘要翻译： 本文公开的实施例涉及提供对通常使用的灯和特别是荧光灯所采用的功率输送系统的改进的系统和方法。 根据一个示例性实施例，阴极电流被控制到最大电平以快速使阴极温度达到热离子发射温度。 在点灯后，使用阴极电压降低电路来降低外部阴极加热的电压。 根据第二示例性实施例，通过IC将功率提供给功率因数校正电路。 最后，第三个公开的实施例解决了从与一个或多个灯的功率输送相关联的各种有害的寄生电容效应来使灯脱敏。

公开(公告)号：US20080055879A1

公开(公告)日：2008-03-06

申请号：US11513777

申请日：2006-08-31

申请人： Viktor K. Varga ,  Bruce Roberts

发明人： Viktor K. Varga ,  Bruce Roberts

IPC分类号： H01F27/02 ,  H05K7/00

CPC分类号： H01F27/022 ,  F21V23/02 ,  H01F27/027 ,  H01F27/06 ,  H01F38/08 ,  H01F41/005 ,  H01F2027/065

摘要： Disclosed is a lamp transformer and method of assembling a lamp transformer within an igniter module or housing. The lamp transformer comprising a potted bar core transformer; and a carrier attached to the potted bar core transformer, the carrier adapted to position the potted bar core transformer on a pc board at a predetermined location.

摘要翻译： 公开了一种灯变压器和将灯变压器组装在点火器模块或壳体内的方法。 灯变压器包括盆棒式变压器; 以及附接到所述盆棒式变压器的载体，所述载体适于将所述盆棒式变压器定位在预定位置的印刷电路板上。

公开(公告)号：US20070259417A1

公开(公告)日：2007-11-08

申请号：US11745199

申请日：2007-05-07

申请人： Robert Ladner ,  Sonia Guterman ,  Bruce Roberts ,  William Markland ,  Arthur Ley ,  Rachel Kent

发明人： Robert Ladner ,  Sonia Guterman ,  Bruce Roberts ,  William Markland ,  Arthur Ley ,  Rachel Kent

IPC分类号： C12N1/08

CPC分类号： C40B40/02 ,  A61K8/64 ,  A61K38/00 ,  A61K2800/57 ,  A61Q11/00 ,  C07K1/047 ,  C07K14/43522 ,  C07K14/8114 ,  C07K14/8117 ,  C12N7/00 ,  C12N15/1037 ,  C12N2795/18111

摘要： In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained. In one embodiment, the first family of potential binding domains is related to bovine pancreatic trypsin inhibitor, the genetic package is M13 phage, and the protein includes the outer surface transport signal of the M13 gene III protein.

摘要翻译： 为了获得针对所选靶标的新型结合蛋白，每个编码包含相似潜在结合结构域的家族之一的蛋白质的DNA分子和要求在选择的细菌细胞的外表面上显示蛋白质的结构信号 ，细菌孢子或噬菌体（遗传包装）被引入到遗传包装中。 蛋白质被表达，并且潜在的结合结构域显示在包装的外表面上。 分离和扩增具有识别靶分子的结合域的细胞或病毒。 然后表征成功的结合结构域。 将这些成功结合结构域中的一个或多个用作设计新的潜在结合结构域家族的模型，并重复该过程，直到获得对靶分子具有所需亲和力的新结合结构域。 在一个实施方案中，第一潜在结合域家族与牛胰蛋白酶抑制剂有关，遗传包是M13噬菌体，蛋白质包括M13基因III蛋白的外表面转运信号。

公开(公告)号：US20060134087A1

公开(公告)日：2006-06-22

申请号：US11253176

申请日：2005-10-18

申请人： Arthur Ley ,  Sonia Guterman ,  William Markland ,  Rachel Kent ,  Bruce Roberts ,  Robert Ladner

发明人： Arthur Ley ,  Sonia Guterman ,  William Markland ,  Rachel Kent ,  Bruce Roberts ,  Robert Ladner

IPC分类号： A61K38/54 ,  C12N9/99

CPC分类号： A61K38/57 ,  C07K14/8114

摘要： Mutants of Kunitz domain 1 (ITI-D1) of human inter-α-trypsin inhibitor (ITI), are useful as inhibitors of human neutrophil elastase. Mutants characterized by one or more of the following substitutions (numbered to correspond to bovine pancreatic trypsin inhibitor, the archetypal Kunitz domain) are of particular interest: (a) Val15 or Ile15, (b) Ala16, (c) Phe18, (d) Pro19, (e) Arg1, (f) Pro2, and/or (g) Phe4.

公开(公告)号：US06988136B2

公开(公告)日：2006-01-17

申请号：US10000190

申请日：2001-10-19

申请人： Stephen J. Sicola ,  Bruce Sardeson ,  Dennis Spicher ,  Bruce Roberts ,  Bill Pagano ,  Richard Lary ,  William K. Miller ,  Mark J. Conrad

发明人： Stephen J. Sicola ,  Bruce Sardeson ,  Dennis Spicher ,  Bruce Roberts ,  Bill Pagano ,  Richard Lary ,  William K. Miller ,  Mark J. Conrad

IPC分类号： G06F15/173

CPC分类号： G06F3/0601 ,  G06F2003/0697

摘要： A multi-cabinet mass storage system with unified management features. The system includes a first reporting group and a second reporting group each having enclosure with processors, such as an environmental monitoring units (EMUs), for generating and transmitting environmental messages pertaining to the particular enclosures. The enclosures are positioned on shelves within cabinets. A bus or cabinet cable links each enclosure to facilitate broadcasting the environmental messages. The environmental messages identify the sending device's reporting group and its physical location within the system. Additional enclosures are included in this reporting group with enclosures of each reporting group located all in one cabinet, in two or more cabinets, and each cabinet may house one, two, or more reporting groups. A network links all of the cabinets to concurrently broadcast the environmental messages throughout the system and allows enclosures in a single reporting group to be positioned in differing cabinets.

公开(公告)号：US20050175297A1

公开(公告)日：2005-08-11

申请号：US11095637

申请日：2005-03-30

申请人： William Mazotti ,  Peter Deane ,  Luu Nguyen ,  Ken Pham ,  Bruce Roberts ,  Jia Liu ,  Yongseon Koh ,  John Briant ,  Roger Clarke ,  Michael Nelson ,  Christopher Smith ,  Janet Townsend

发明人： William Mazotti ,  Peter Deane ,  Luu Nguyen ,  Ken Pham ,  Bruce Roberts ,  Jia Liu ,  Yongseon Koh ,  John Briant ,  Roger Clarke ,  Michael Nelson ,  Christopher Smith ,  Janet Townsend

IPC分类号： G02B6/42 ,  H05K1/02 ,  H05K1/18 ,  H05K3/40 ,  G02B6/36

CPC分类号： G02B6/4201 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48465 ,  H05K1/0219 ,  H05K1/189 ,  H05K3/403 ,  H05K2201/0715 ,  H05K2201/09236 ,  H05K2201/10121 ,  H01L2924/00014 ,  H01L2924/00

摘要： Concepts for conveniently arranging devices for the transduction of signals to and from voltage and current domains to infrared radiation domains is described. Specifically, optoelectronic components and methods of making the same are described. In one aspect, the optoelectronic component includes a base substrate having a pair of angled (or substantially perpendicular) faces with electrical traces extending therebetween. A semiconductor chip assembly is mounted on the first face of the base substrate and a photonic device is mounted on the second face. Both the semiconductor chip assembly and the photonic device are electrically connected to traces on the base substrate. The semiconductor chip assembly is generally arranged to be electrically connected to external devices. The photonic devices are generally arranged to optically communicate with one or more optical fibers. The described structure may be used with a wide variety of photonic devices. In some embodiments the base substrate is formed from a ceramic material having the electrical traces formed thereon. In other implementations the substrate includes a backing block having a flexible printed circuit substrate adhered thereto.

摘要翻译： 描述了用于方便地布置用于将电压和电流域的信号传导到红外辐射域的装置的概念。 具体地说，描述了光电子元件及其制造方法。 在一个方面，光电子部件包括具有一对成角度（或基本上垂直）的表面的基底基板，其间延伸有电迹线。 半导体芯片组件安装在基底基板的第一面上，并且光子器件安装在第二面上。 半导体芯片组件和光子器件都与基底衬底上的迹线电连接。 半导体芯片组件通常被布置成电连接到外部装置。 光子器件通常布置成与一根或多根光纤光学通信。 所描述的结构可以与各种各样的光子器件一起使用。 在一些实施例中，基底由具有形成在其上的电迹线的陶瓷材料形成。 在其它实施方式中，基板包括具有粘附到其上的柔性印刷电路基板的背衬块。