Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
    42.
    发明授权
    Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries 失效
    可用于合成多糖,天然产物和组合文库的保护基团

    公开(公告)号:US06693178B2

    公开(公告)日:2004-02-17

    申请号:US10146711

    申请日:2002-05-15

    IPC分类号: C07H1700

    摘要: One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

    摘要翻译: 本发明的一个方面涉及任选取代的卤代苄基卤化物等。 这些化合物可用作各种官能团的卤代苄基醚基保护基。 本发明的另一方面涉及所述保护基团在正交保护基团策略中用于合成包含多个合适官能团的复合分子的用途。 本发明的另一方面涉及带有本发明的各种保护基阵列的糖类。 本发明的另一方面涉及寡糖或糖缀合物的合成方法,其包括以下步骤:使用具有本发明的至少一个保护基团的糖糖基化第二分子以得到包含所述糖的产物; 并从所述产品中除去本发明的保护基团。

    Replacement solvents for use in chemical synthesis
    43.
    发明授权
    Replacement solvents for use in chemical synthesis 失效
    用于化学合成的替代溶剂

    公开(公告)号:US06231783B1

    公开(公告)日:2001-05-15

    申请号:US08748457

    申请日:1996-11-13

    IPC分类号: C09K300

    摘要: Replacement solvents for use in chemical synthesis include polymer-immobilized solvents having a flexible polymer backbone and a plurality of pendant groups attached onto the polymer backbone, the pendant groups comprising a flexible linking unit bound to the polymer backbone and to a terminal solvating moiety. The polymer-immobilized solvent may be dissolved in a benign medium. Replacement solvents for chemical reactions for which tetrahydrofuran or diethyl may be a solvent include substituted tetrahydrofurfuryl ethers and substituted tetrahydro-3-furan ethers. The replacement solvents may be readily recovered from the reaction train using conventional methods.

    摘要翻译: 用于化学合成的替代溶剂包括具有柔性聚合物主链和连接到聚合物主链上的多个侧基的聚合物固定化溶剂,所述侧基包含与聚合物主链结合的柔性连接单元和末端溶剂化部分。 聚合物固定的溶剂可以溶解在良性介质中。 用于其中四氢呋喃或二乙基可以是溶剂的化学反应的替代溶剂包括取代的四氢糠基醚和取代的四氢-3-呋喃醚。 使用常规方法可以容易地从反应装置中回收替代溶剂。