摘要:
The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.
摘要:
A speaker is provided in the present disclosure. The speaker includes a membrane, a voice coil connected to the membrane, and a vibration part attached on the membrane. The membrane includes a main body and a periphery portion surrounding the main body. One of the vibration part and the main body includes a protrusion protruding away from the voice coil, and the other one of the vibration part and the main body includes a recess portion recessed towards the voice coil and corresponding to the protrusion.
摘要:
A recommender system uses an activity decision tree to model the changes in a user's behavior according to a plurality of time-related features. The system determines historical activities for the user, and generates a decision tree for the user's historical activities. Each leaf node of the decision tree is associated with an activity-prediction model that computes a probability for a corresponding activity. The system selects a path of the decision tree from a root node to a leaf node of the decision tree based on a target time. The selected path traverses two or more non-leaf nodes that are each associated with a temporal decision model that compares the target time against a temporal classifier. The system then determines a probability for a user activity based on an activity-prediction model of the selected path.
摘要:
A method is described for efficiently determining total end-to-end distortion of a pre-compressed data stream, such as video streams or other media streams, at the time of delivery over a lossy-network, and for providing adaptive error-resilient delivery schemes based on distortion estimates. The methods can be utilized with single or multilayer packet streams and are particularly well suited for video streams. By way of example, distortion estimates are performed by generating side-information at the time of data stream compression, wherein the side-information is used in conjunction with information about the network status to determine an estimated distortion for the group of packets when the data stream is transported over the network to a destination end. This estimation may be utilized within described resiliency techniques in which the error correction mechanism is selected in response to the estimated distortion, which may be additionally refined in reference to cost factors.
摘要:
The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要:
A MEMS microphone includes a silicon substrate, a diaphragm connected to the silicon substrate, a backplate opposed from the diaphragm for forming an air gap. The backplate defines a plurality of first through holes and a plurality of second through holes surrounded by the first through holes, each of the first through holes being formed by a straight boundary and an arc boundary, the radius of the second boundary being greater than half the width of the first boundary.
摘要:
In one embodiment, a process determines a size of a video unit (e.g., frame) to transmit from a sender to a receiver across a communication channel for an associated video stream, and also determines an updated packet loss rate on the channel. In response, the process may dynamically determine both a number N of video data packets and a number M of forward error correction (FEC) packets to transmit for the video unit based on the size of the video unit, the updated packet loss rate on the channel, and an error resilience requirement for the video stream. In an illustrative embodiment, N and M are determined during transmission of the video stream through a look-up operation into a table indexed by the size of the video unit and the updated packet loss rate as co-indices, the co-indices co-indexing a pre-determined N and M pair.
摘要:
Provided are probes featuring multiple electrodes, which probes have diameters in the nanometer range and may be inserted into cells or other subjects so as to monitor an electrical characteristic of the subject. The probes may also include a conductive coating on at least one probe element to improve the probes' performance. The probes may also be used to inject a fluid or other agent into the subject and simultaneously monitor changes in the subject's electrical characteristics in response to the injection. Related methods of fabricating and of using the inventive probes are also provided.
摘要:
Embodiments of the invention relate to dynamic power management of storage volumes and disk arrays in a storage subsystem to mitigate loss of performance resulting from the power management. The volumes and arrays are prioritized, and in real-time power is selectively reduced in response to both the prioritization and an energy savings goal. A feedback loop is provided to dynamically measure associated power gain based upon a lowering of power consumption, and device selection may be adjusted based upon received feedback.
摘要:
An automatic calendar-managing system automatically updates a user's schedule in response to schedule-modifying events. During operation, the system can detect a schedule-modifying event, which can include an event that is likely to require the user to modify a set of scheduled activities. The system then generates a schedule modification, which includes at least one change to the user's set of scheduled activities, to account for the schedule-modifying event. The system can reschedule the user's set of scheduled activities to accommodate the schedule modification.