Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof
    41.
    发明申请
    Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof 有权
    可用作甲酰肽受体如1受体的配体的组合物及其使用方法

    公开(公告)号:US20060034863A1

    公开(公告)日:2006-02-16

    申请号:US11175003

    申请日:2005-07-05

    IPC分类号: A61K39/02 A61K38/10

    摘要: The inventors have discovered that a CKβ8-1 truncation variant, CKβ8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKβ8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKβ8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKβ8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1. This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.

    摘要翻译: 本发明人已经发现CKbeta8-1截短变体CKbeta8-1(25-116)是两种不同GPCR,趋化因子受体CCR1和甲酰肽受体1(FPRL1)的双功能配体。 因此,本发明人发现除了CCR1的功能活性外,CKbeta8-1(25-116)也是通过募集单核细胞和嗜中性粒细胞参与炎症反应和先天免疫的GPCR受体FPRL1的功能性配体。 此外,本发明人已经发现了称为SHAAGTIDE的CKbeta8-1的可变剪接外显子。 SHAAGTIDE与其母体趋化因子CKbeta8-1(25-116)一起在已知表达FPRL1的单核细胞和嗜中性粒细胞上完全起作用。 本申请一般涉及增强免疫应答。 这种免疫应答可以通过疫苗施用引起。 提供了诱导或增强对抗原的免疫应答的组合物和方法。 组合物和方法可用于治疗和预防用途(免疫)和产生抗体的疫苗制剂。

    2Bit/cell architecture for floating gate flash memory product and associated method
    48.
    发明授权
    2Bit/cell architecture for floating gate flash memory product and associated method 有权
    2Bit /单元架构的浮栅闪存产品及相关方法

    公开(公告)号:US06570211B1

    公开(公告)日:2003-05-27

    申请号:US10180673

    申请日:2002-06-26

    IPC分类号: H01L2976

    摘要: The invention relates to a flash memory devices and a method associated therewith in which combined source/drain regions are shared by more than two memory cells. For example, source/drain regions can be shared by four adjacent memory cells. Such sharing can be accomplished by providing memory cells along main branches of word lines and additional memory cells along dead end branches extending off the main branches. Another aspect of the invention relates to a flash memory device wherein the memory cells are arrayed and a first portion of the memory cells are read with source and drain regions sharing a row of the array and a second portion of the memory cells are read with source and drain regions sharing a column of the array.

    摘要翻译: 本发明涉及一种闪存器件及其相关方法,其中组合的源/漏区由两个以上的存储单元共享。 例如,源/漏区可由四个相邻的存储单元共享。 这样的共享可以通过沿着主线的主分支提供存储器单元并且沿着从主分支延伸的死端分支的附加存储器单元来实现。 本发明的另一方面涉及一种闪速存储器件,其中存储器单元被排列并且存储单元的第一部分被读取,源区和漏区共享阵列的一行,并且存储单元的第二部分被读取 并且漏极区域共享阵列的列。

    DEVICE AND METHOD FOR REALIZING PREFIX CODE CONSTRUCTION
    49.
    发明申请
    DEVICE AND METHOD FOR REALIZING PREFIX CODE CONSTRUCTION 有权
    用于实现前缀代码构造的设备和方法

    公开(公告)号:US20110299624A1

    公开(公告)日:2011-12-08

    申请号:US13202189

    申请日:2009-12-21

    IPC分类号: H04L27/00

    CPC分类号: H03M7/40

    摘要: The present invention provides a device and method for realizing prefix code construction. The device includes a sort indexer, a generator and a sequence regulator. The sort indexer is used to sort a group of received code lengths to obtain a group of sorted code lengths, and record the position correspondence relationship. The generator receives the sorted code lengths and orderly generates the prefix codes. Except that the first prefix code is preconfigured, the generator generates a current prefix code by adding one to the adjacently previous prefix code and then shifting left by a certain number of bits. When the current prefix code is generated, the generator simultaneously judges whether the adjacently previous prefix code is identical to the current prefix code from the high bit, if yes, the error information is outputted; otherwise the prefix codes corresponding to the sorted code lengths are generated. The sequence regulator is used to receive the prefix codes corresponding to the sorted code lengths, and regulates the sequence of the prefix codes corresponding to the sorted code lengths according to the position correspondence relationship recorded by the sort indexer to obtain the prefix codes corresponding to the code lengths. The solution can report error in time.

    摘要翻译: 本发明提供一种实现前缀码构造的装置和方法。 该设备包括分类索引器,发生器和序列调节器。 分类索引器用于对一组接收到的代码长度进行排序以获得一组排序的代码长度,并记录位置对应关系。 生成器接收排序的代码长度,并有序地生成前缀代码。 除了第一个前缀代码被预先配置之外,生成器通过将相加的前一个前缀代码相加,然后向左移动一定数量的位来生成当前前缀代码。 当产生当前前缀码时,发生器同时判断相邻的前缀码是否与来自高位的当前前缀码相同,如果是,则输出错误信息; 否则生成与排序后的码长对应的前缀码。 序列调节器用于接收与分类码长相对应的前缀码,并且根据由分类索引器记录的位置对应关系来调节与分类码长相对应的前缀码序列,以获得对应于 代码长度 解决方案可以及时报告错误。

    METHOD AND APPARATUS FOR COMMAND SYNCHRONIZATION
    50.
    发明申请
    METHOD AND APPARATUS FOR COMMAND SYNCHRONIZATION 有权
    用于命令同步的方法和装置

    公开(公告)号:US20100145477A1

    公开(公告)日:2010-06-10

    申请号:US12513156

    申请日:2006-11-06

    IPC分类号: G05B11/01

    摘要: Method and apparatus for command synchronization is described. In some embodiments, a remote system system may set up a user interactive session with a local device according to a user interaction protocol. The remote system may insert a predetermined execution time into a first command and send the first command to a local device according to the user interaction protocol. The first command, when executed on the local device, causes a second command compliant with the user interaction protocol to execute on the local device at the predetermined execution time.

    摘要翻译: 描述了用于命令同步的方法和装置。 在一些实施例中,远程系统系统可以根据用户交互协议来建立与本地设备的用户交互式会话。 远程系统可以将预定的执行时间插入到第一命令中,并且根据用户交互协议将第一命令发送到本地设备。 第一命令在本地设备上执行时,使得符合用户交互协议的第二命令在预定执行时间在本地设备上执行。