摘要:
The inventors have discovered that a CKβ8-1 truncation variant, CKβ8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKβ8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKβ8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKβ8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1. This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.
摘要:
DNA encoding a polypeptide capable of catalyzing the deacetylation and sulfation of a glycosaminoglycan; production and isolation of recombinant and synthetic polypeptides capable of catalyzing the deacetylation, sulfation or both the deacetylation and sulfation of a glycosaminoglycan; antibodies to the polypeptides of the invention; and therapeutic uses of these compounds are disclosed.
摘要:
The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific migration blockers.
摘要:
The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of a chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.
摘要:
The invention relates to a flash memory devices and a method associated therewith in which combined source/drain regions are shared by more than two memory cells. For example, source/drain regions can be shared by four adjacent memory cells. Such sharing can be accomplished by providing memory cells along main branches of word lines and additional memory cells along dead end branches extending off the main branches. Another aspect of the invention relates to a flash memory device wherein the memory cells are arrayed and a first portion of the memory cells are read with source and drain regions sharing a row of the array and a second portion of the memory cells are read with source and drain regions sharing a column of the array.
摘要:
The present invention provides a device and method for realizing prefix code construction. The device includes a sort indexer, a generator and a sequence regulator. The sort indexer is used to sort a group of received code lengths to obtain a group of sorted code lengths, and record the position correspondence relationship. The generator receives the sorted code lengths and orderly generates the prefix codes. Except that the first prefix code is preconfigured, the generator generates a current prefix code by adding one to the adjacently previous prefix code and then shifting left by a certain number of bits. When the current prefix code is generated, the generator simultaneously judges whether the adjacently previous prefix code is identical to the current prefix code from the high bit, if yes, the error information is outputted; otherwise the prefix codes corresponding to the sorted code lengths are generated. The sequence regulator is used to receive the prefix codes corresponding to the sorted code lengths, and regulates the sequence of the prefix codes corresponding to the sorted code lengths according to the position correspondence relationship recorded by the sort indexer to obtain the prefix codes corresponding to the code lengths. The solution can report error in time.
摘要:
Method and apparatus for command synchronization is described. In some embodiments, a remote system system may set up a user interactive session with a local device according to a user interaction protocol. The remote system may insert a predetermined execution time into a first command and send the first command to a local device according to the user interaction protocol. The first command, when executed on the local device, causes a second command compliant with the user interaction protocol to execute on the local device at the predetermined execution time.