公开(公告)号：US20120093720A1

公开(公告)日：2012-04-19

申请号：US13274093

申请日：2011-10-14

Applicant: Robert Jones ,  Thomas Beck

Inventor： Robert Jones ,  Thomas Beck

IPC: A61K49/00 ,  A61K51/06 ,  C08G65/34

CPC classification number: A61K49/0002 ,  A61K51/06 ,  A61K51/1244 ,  C08G65/329 ,  C08L71/02 ,  C08L2203/02

Abstract: The invention described herein provides biocompatible molecularly imprinted polymers (MIPs) that are non-toxic, water soluble, small molecular weight, and degradable in a living body. The MIPs are capable of binding to all or a portion of a specific target macromolecule associated with a disease located within the living body and they are derivatized for stealth for in vivo applications to avoid the reticuloendothelial system. The MIPs of the invention are functionalized to an amine or carboxyl group and are derivatized with an imaging and/or therapeutic agent for taking images of the disease and/or for providing therapy. The macromolecule can be selected from a group consisting of proteins, glycoproteins, lipoproteins, peptidoglycans, peptides, polypeptides, polynucleotides, and polysaccharides. The invention described herein also provides methods and kits wherein MIPs of the invention can be employed as targeted imaging and therapeutic agents.

Abstract translation: 本文描述的本发明提供了生物相容性分子印迹聚合物（MIP），其在生物体中是无毒的，水溶性的，小分子量的和可降解的。 MIP能够结合与位于生物体内的疾病相关的特定目标大分子的全部或一部分，并且它们被衍生化用于隐形以用于体内应用以避免网状内皮系统。 本发明的MIP被官能化为胺或羧基，并且用成像和/或治疗剂衍生以获取疾病图像和/或用于提供治疗。 大分子可以选自蛋白质，糖蛋白，脂蛋白，肽聚糖，肽，多肽，多核苷酸和多糖。 本文所述的发明还提供了本发明的MIP可用作靶向成像和治疗剂的方法和试剂盒。

公开(公告)号：US20120091106A9

公开(公告)日：2012-04-19

申请号：US12223204

申请日：2007-01-05

Applicant: Thomas Beck ,  Silke Settegast

Inventor： Thomas Beck ,  Silke Settegast

IPC: B23K26/38 ,  B23K26/06 ,  B23K26/42

CPC classification number: B23K26/0648 ,  B23K26/0622 ,  B23K26/064 ,  B23K26/0665 ,  B23K26/389

Abstract: There is described a method for producing a hole using e.g. a lasers, wherein short laser pulse durations are used. The laser pulse durations are varied, short laser pulse durations being utilized only in the area to be removed in which an influence on the penetration behavior and discharge behavior is noticeable while longer pulse durations of >0.4 ms are used. This is the case for the inner surface of a diffuser of a hole, for example, which can be produced very accurately by means of short laser pulse durations.

Abstract translation: 描述了使用例如制造孔的方法。 激光器，其中使用短激光脉冲持续时间。 激光脉冲持续时间是变化的，短激光脉冲持续时间仅在要去除的区域中被使用，其中在使用> 0.4ms的较长脉冲持续时间时，对穿透行为和放电行为的影响是显着的。 这是孔的扩散器的内表面的情况，例如，可以通过短的激光脉冲持续时间非常精确地制造。

公开(公告)号：US20110262020A1

公开(公告)日：2011-10-27

申请号：US13092999

申请日：2011-04-25

Applicant: Miriam Bauer ,  Thomas Beck ,  Dominik Bernhardt ,  Christina Biermann

Inventor： Miriam Bauer ,  Thomas Beck ,  Dominik Bernhardt ,  Christina Biermann

IPC: G06K9/00

CPC classification number: A61B6/504 ,  A61B5/055 ,  A61B6/03 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/487 ,  A61B6/5235 ,  A61B6/5247 ,  G06F19/00 ,  G06T7/12 ,  G06T7/149 ,  G06T7/33 ,  G06T2207/10081 ,  G06T2207/30101 ,  G16H50/20 ,  G16H50/50

Abstract: A method and a computer system are disclosed for automatic vectorization of the profile of a vessel tree and at least one of its properties on the basis of tomographic images of an examined patient. In at least one embodiment, using previously established location probabilities of landmarks in the vessel tree, there is an automatic determination of a plurality of distinctive landmarks in the current tomographic image data record of the patient, a registration of the current tomographic image data record to the statistical vessel model, an automatic determination of previously unidentified landmarks in the registered tomographic image data record using characteristic identification features of the previously unidentified landmarks from the statistical vessel model and the statistical location probability thereof, and a determination of at least one current vessel model using the identified landmarks and at least one vessel property at and/or between the identified landmarks.

Abstract translation: 公开了一种方法和计算机系统，用于基于检查的患者的断层图像自动矢量化血管树的轮廓和其属性中的至少一个。 在至少一个实施例中，使用先前建立的血管树中的地标的位置概率，存在对患者的当前断层图像数据记录中的多个独特地标的自动确定，将当前断层图像数据记录登记到 统计血管模型，使用来自统计血管模型的先前未识别的地标的特征识别特征及其统计位置概率来自动确定登记的断层图像数据记录中的先前未识别的地标，以及确定至少一个当前血管模型 在所识别的地标之间和/或之间使用所识别的地标和至少一个船只属性。

公开(公告)号：US20110114557A2

公开(公告)日：2011-05-19

申请号：US11722411

申请日：2005-12-19

Applicant: Warren Johnson ,  Thomas Beck ,  Rebecca Yeo

Inventor： Warren Johnson ,  Thomas Beck ,  Rebecca Yeo

IPC: B01D65/02

CPC classification number: B01D65/02 ,  B01D63/02 ,  B01D2315/06 ,  B01D2321/16 ,  B01D2321/162 ,  B01D2321/164 ,  B01D2321/168 ,  C02F1/444

Abstract: A method of cleaning permeable, hollow membranes (6) in an arrangement of the type wherein a pressure differential is applied across the walls (15) of the permeable, hollow membranes (6) immersed in a liquid suspension, the liquid suspension being applied to the outer surface of the porous hollow membranes (6) to induce and sustain filtration through the membrane walls (15) wherein some of the liquid suspension passes through the walls (15) of the membranes (6) to be drawn off as clarified liquid or permeate from the hollow membrane lumens (7), and at least some of the solids are retained on or in the hollow membranes (6) or otherwise as suspended solids within the liquid surrounding the membranes (6). The method of cleaning comprises the steps of applying a cleaning solution (14) to one side of the membrane wall (15); applying a pressure differential across the membrane wall (15) to cause flow of the cleaning solution (14) through the wall (15) from the one side of the membrane wall (15) to the other side of the membrane wall (15) and applying a reverse pressure differential across the membrane wall (15) to cause flow of the cleaning solution (14) through the wall (15) from the other side of the membrane wall (15) back to the one side of the membrane wall (15). A method of determining the amount of chemical cleaning solution required is also disclosed.

Abstract translation: 一种以这种类型布置的可清洁的中空膜（6）的清洁方法，其中在穿过液体悬浮液的可渗透的中空膜（6）的壁（15）上施加压力差，该液体悬浮液被施加到 多孔中空膜（6）的外表面通过膜壁（15）诱导和维持过滤，其中一些液体悬浮液通过膜（6）的壁（15）被作为澄清的液体或者 从中空膜腔（7）渗透，并且至少一些固体保留在中空膜（6）上或其中，作为悬浮固体保留在膜（6）周围的液体中。 清洗方法包括以下步骤：将清洁溶液（14）施加到膜壁（15）的一侧; 在所述膜壁（15）上施加压力差以使所述清洁溶液（14）从所述膜壁（15）的一侧到所述膜壁（15）的另一侧通过所述壁（15）流动，并且 在所述膜壁（15）上施加反向压力差以使所述清洁溶液（14）从所述膜壁（15）的另一侧通过所述壁（15）流回所述膜壁（15）的一侧 ）。 还公开了确定所需化学清洗溶液量的方法。

公开(公告)号：US20090221480A1

公开(公告)日：2009-09-03

申请号：US11931665

申请日：2007-10-31

Applicant: Henry Blair ,  Thomas Beck ,  Robert C. Ladner

Inventor： Henry Blair ,  Thomas Beck ,  Robert C. Ladner

IPC: A61K38/17 ,  A61P7/00

CPC classification number: A61K38/55 ,  A61K31/195 ,  A61K38/57 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

公开(公告)号：US07521926B2

公开(公告)日：2009-04-21

申请号：US10525026

申请日：2003-08-01

Applicant: Thomas Beck ,  Ralph Reiche ,  Rolf Wilkenhöner

Inventor： Thomas Beck ,  Ralph Reiche ,  Rolf Wilkenhöner

IPC: G01N27/72

CPC classification number: F01D5/005 ,  G01N27/902 ,  G01N27/9046

Abstract: The invention relates to a method for the nondestructive testing of a component, in which corrosion regions close to the surface, composed of oxidized carbides or sulfided base material close to the surface, are determined by means of an eddy current measurement. This allows the blades or vanes to be ground down and/or separated out in particular prior to a complex process of cleaning and coating the gas turbine blade or vane.

Abstract translation: 本发明涉及一种组件的非破坏性测试方法，其中通过涡流测量来确定由靠近表面的氧化碳化物或硫化基材组成的靠近表面的腐蚀区域。 这允许叶片或叶片在清洁和涂覆燃气轮机叶片或叶片的复杂过程之前被特别地磨碎和/或分离。

公开(公告)号：US20090001061A1

公开(公告)日：2009-01-01

申请号：US12087720

申请日：2006-12-29

Applicant: Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

Inventor： Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

IPC: B23K26/00

CPC classification number: B23K15/085 ,  B23K26/384 ,  B23K26/389 ,  B23K2101/001 ,  F01D5/186 ,  F05D2230/13 ,  Y02T50/67 ,  Y02T50/676 ,  Y10T29/49341

Abstract: There are a multiplicity of methods of making through-holes. In particular in the production of a multiplicity of film-cooling holes, as in gas turbine blades or combustion chamber elements, small time advantages are also important when making a hole. The method according to the invention, to make the hole close to the final contour in each case in sections in a top and a bottom region in order to then produce the final contour with other laser parameters, achieves time advantages.

Abstract translation: 有多种形成通孔的方法。 特别是在制造多个薄膜冷却孔时，如在燃气轮机叶片或燃烧室元件中，小的时间优点在制造孔时也是重要的。 根据本发明的方法，为了使其在顶部和底部区域中的每一种情况下，使得孔接近于最终轮廓，以便随后用其他激光参数产生最终轮廓，这实现了时间优点。

公开(公告)号：US20080200360A1

公开(公告)日：2008-08-21

申请号：US11995138

申请日：2006-08-21

Applicant: Thomas Beck ,  Irene Kubitza ,  Hans-Jurgen Schreier ,  Gerhard Steinberger

Inventor： Thomas Beck ,  Irene Kubitza ,  Hans-Jurgen Schreier ,  Gerhard Steinberger

IPC: C11D7/32 ,  C11D7/50

CPC classification number: H05K3/26 ,  C11D7/261 ,  C11D7/3218 ,  C11D7/5013 ,  C11D7/5022 ,  C11D11/0047 ,  G03F7/40 ,  G03F7/405 ,  G03F7/425 ,  H05K3/244 ,  H05K3/28 ,  H05K2201/0761 ,  H05K2203/122

Abstract: To reduce ionic contaminants on printed circuit boards that are at least partially covered with a solder resist mask and are provided with top layers on the copper structures, an aqueous cleaning solution is used, which contains at least one ethanolamine compound and/or the salt thereof, at least one alcoholic solvent and, at need, at least one guanidine compound and/or the salt thereof.

Abstract translation: 为了减少至少部分地被阻焊掩模覆盖的印刷电路板上的离子污染物，并且在铜结构上设置有顶层，使用含水清洗溶液，其含有至少一种乙醇胺化合物和/或其盐 ，至少一种醇溶剂和需要的至少一种胍化合物和/或其盐。

公开(公告)号：US07311720B2

公开(公告)日：2007-12-25

申请号：US10789372

申请日：2004-02-26

Applicant: Gottfried Mueller ,  Thomas Beck ,  Manfred Dworschak ,  Sven Eggerstedt

Inventor： Gottfried Mueller ,  Thomas Beck ,  Manfred Dworschak ,  Sven Eggerstedt

IPC: A61B17/08 ,  A61B17/04

CPC classification number: A61B17/0057 ,  A61B2017/00637 ,  A61B2017/00659

Abstract: In a closure device for an opening in a layer of tissue comprising a plurality of wings which provide and/or hold bearing areas on tissue surrounding the opening, the wings are held by means of respective joints for swivelling movement on a base part.

Abstract translation: 在用于组织层中的开口的封闭装置中，其包括提供和/或保持围绕开口的组织上的支承区域的多个翼，所述翼通过各自的关节保持，用于在基部上的旋转运动。

公开(公告)号：US07306670B2

公开(公告)日：2007-12-11

申请号：US10729201

申请日：2003-12-05

Applicant: Thomas Beck ,  Georg Bostanjoglo ,  Nigel-Philip Cox ,  Rolf Wilkenhöner

Inventor： Thomas Beck ,  Georg Bostanjoglo ,  Nigel-Philip Cox ,  Rolf Wilkenhöner

IPC: C30B13/00

CPC classification number: B23K15/0093 ,  B23K26/0732 ,  B23K26/0736 ,  B23K26/0738 ,  B23K26/32 ,  B23K26/342 ,  B23K2101/001 ,  B23K2103/02 ,  B23K2103/26 ,  B23K2103/50 ,  C30B11/00 ,  C30B13/00 ,  C30B13/24 ,  C30B29/52 ,  Y10S117/904 ,  Y10S117/905

Abstract: In the case of the epitaxial growth according to the prior art, a number o strips often have to be produced in a plane in order to restore an area to be repaired. This leads to overlapping and misorientation of the crystalline structures. In the case of the method according to the invention, the strip is of such a width that no overlapping occurs, since the width is adapted to the contour of the area to be repaired.

Abstract translation: 在根据现有技术的外延生长的情况下，为了恢复要修复的区域，通常必须在平面中生产数个带。 这导致晶体结构的重叠和取向偏差。 在根据本发明的方法的情况下，条带具有不会发生重叠的宽度，因为宽度适应待修补区域的轮廓。