摘要:
The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
摘要:
A tensioning device (10) for a seat belt, in particular in a motor vehicle, having a gas generator (17) and a piston (21) guided in a tube (16) that closes a pressure space (20) in the tube (16), whereas the pressure space (20) can be pressurized by the gas generator (17), as a result of which the piston (21) can be driven to perform a tensioning operation which can be transmitted to the seat belt by means of the force transmission means. The piston (21) having a closed or constricted opening (1, 1a), and the opening (1, 1a) can be enlarged and/or opened by the material erosion caused by the pressure and/or pressure conditions in the pressure space (20).
摘要:
According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of Aβ42 and hence are useful in treatment of Alzheimer's disease and related conditions.
摘要:
A monolithic catalyst system for the cleavage of water into hydrogen and oxygen comprises a first photoactive material capable by itself or together with an auxiliary material and/or an auxiliary catalyst when irradiated with light having a wavelength ≧420 nm of generating oxygen and protons from water, and a second photoactive material capable by itself or together with an auxiliary material and/or an auxiliary catalyst when irradiated with light having a wavelength ≧420 nm of reducing protons in water to hydrogen. The first and second photoactive materials are in electrical contact via an electron-conducting material.
摘要:
The invention encompasses 2-[4-(imidazolyl)-phenyl]vinyl-heterocycle derivatives which selectively attenuate production of Abeta(1-42) and are useful in the treatment of Alzheimer's disease. Pharmaceutical compositions and methods of use are also encompassed.
摘要:
A description is given of a process for the production of a disinfectant by electrochemical activation (ECA) of water, in that to the water to be disinfected is added an electrolytic solution, particularly a sodium or potassium chloride solution and the water to which the electrolytic solution has been added in the form of a dilute water/electrolytic solution is supplied with an electrical current in an electrolytic reactor with a cathode compartment having a cathode and with an anode compartment having an anode separated spatially from the cathode compartment by applying a d.c. voltage to the electrodes, in order to bring the water/electrolytic solution into a metastable state suitable for disinfection. To bring about a reliable disinfecting action of the electrochemically activated water and with high reproducibility, the invention proposes that the pH-value of the dilute water/electrolytic solution in the reactor anode compartment is controlled to a value between 2.5 and 3.5, particularly approximately 3, so that the potential of the anodic oxidation is controlled (potential-controlled anodic oxidation or PAO). The invention also relates to a disinfectant produced in this way and the use thereof.
摘要:
This invention relates to a door such as a balcony or patio door, featuring a threshold which, to accommodate handicapped traffic, is partly retractable, automatically dropping from its normal base position into its transit position, while by the actuation of a control mechanism it is restorable from the transit position to its normal base position, in a manner whereby in its transit position it permits unimpeded passage for handicapped persons from the inside to the outside and vice versa.
摘要:
The invention relates to a window, door, facade element or conservatory whose insulating glass pane (3) is bonded to the casement frame (1) on the base (1a) of which an all-round sealing lip is provided, projecting to the front side of the insulating glass pane and which may have a predetermined fold with which the holding space (1b) for the adhesive (1c) is limited.
摘要:
A suction tube with a switching element for longitudinal adjustment of different tube sections (16), particularly a suction tube having a drum switch (12). The invention provides for sealing strips (29) or sealing rings (17) which are supported inside the suction tube casing (14). This results in a relative movement between the drum switch (12) and the sealing elements fixed to the casing. The positioning of the sealing elements in the suction tube casing (14) is advantageous for assembly and allows for better compensation of tolerances in the sealing gap between the drum switch (12) and the suction tube casing (14).
摘要:
An air intake device for an internal combustion engine, in which the device includes at least one collecting vessel (10) as well as a plurality of intake ducts which extend separately toward different cylinders in the engine. The intake ducts extend into the collecting vessel and are formed from a flexible tube (16), such as a synthetic resin tube.