公开(公告)号：US11169125B2

公开(公告)日：2021-11-09

申请号：US16384272

申请日：2019-04-15

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Curt Devlin ,  Theodore A. Dourdeville ,  Jacob N. Fairchild ,  Geoff C. Gerhardt ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: G01N30/00 ,  G01N30/72

Abstract: Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：US20210319995A1

公开(公告)日：2021-10-14

申请号：US17230793

申请日：2021-04-14

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Sylvain Gilles Cormier

IPC: H01J49/04 ,  G01N30/72 ,  H01J49/16 ,  H01J49/00

Abstract: Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS). The valve may be positioned remotely on a branch that has a junction with the path leading form the source of the mobile phase flow to the ion source. Alternatively, the valve may be positioned in line on the flow path from the source of the mobile phase flow to the ion source of the MS. A novel five port valve design may be employed. With this valve design, a first position of the valve allows a sample loop for the calibrant to be filled. In a second position, the calibrant is added coaxially to the flow from the source of the mobile phase to the MS. In a third position of the valve, diversion of or infusion to a post-source flow is enabled.

公开(公告)号：US11020687B2

公开(公告)日：2021-06-01

申请号：US15948666

申请日：2018-04-09

Applicant: Waters Technologies Corporation

Inventor： Jason F. Hill ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Joshua A. Shreve ,  Abhijit Tarafder

IPC: B01D15/40 ,  G01N30/32 ,  G01N30/86 ,  B01D15/16 ,  G01N30/60 ,  G01N30/30 ,  G01N30/02

Abstract: Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile. In some such methods, a length, an area, and a particle size of a first column in the first system and a flow rate in the first separation procedure are identifiable. Some such methods also involve selecting a combination of a length, an area, and a particle size of a second column in the second system and a flow rate for the second separation procedure. These methods may involve calculating a target length, a target area, or a target particle size for the second column in the second system or a target flow rate for the second separation procedure.

公开(公告)号：US20210132012A1

公开(公告)日：2021-05-06

申请号：US17084998

申请日：2020-10-30

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Mark J. Basile ,  Jeffrey Musacchio ,  Michael O. Fogwill ,  Sebastien Besner ,  Joseph D. Michienzi ,  Wade P. Leveille

IPC: G01N30/74 ,  G01N30/30

Abstract: Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.

公开(公告)号：US10996204B2

公开(公告)日：2021-05-04

申请号：US15948653

申请日：2018-04-09

Applicant: Waters Technologies Corporation

Inventor： Joseph D. Michienzi ,  Joshua A. Shreve ,  Jason F. Hill ,  Abhijit Tarafder ,  Michael O. Fogwill ,  Keith Fadgen

IPC: B01D15/40 ,  G01N30/32 ,  G01N30/46 ,  G01N30/38 ,  B01D15/16 ,  G01N30/86

Abstract: Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column. One technique involves leveraging experimental chromatography to develop a correction factor that is a function of at least one correction coefficient and at least one ratio of the differential analyte retention time to the retention time in the reference system. Another technique involves leveraging other experimental measurements of tubing pressure drops under various condition to develop a lookup table that can be used to identify likely tubing pressure drops in the target system. A third technique leverages knowledge of the separation procedure and the target system and the likely nature of the relevant flow to calculate tubing pressure drops in the target system.

公开(公告)号：US20200309743A1

公开(公告)日：2020-10-01

申请号：US16826667

申请日：2020-03-23

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Joseph D. Michienzi

IPC: G01N30/20 ,  G01N30/38 ,  G01N30/32

Abstract: Described is a dual mode sample manager for a liquid chromatography system. The dual mode sample manager includes a sample needle, a sample loop, a metering pump, a needle seat and first and second valves. Each valve is configurable in two valve states to enable two modes of operation. In one mode, sample acquired and stored in the sample needle is injected into a chromatography system flow and, in the other mode, sample acquired through the sample needle and stored in the sample loop is injected into the chromatography system flow. The automated switching of the sample manager between the two modes of operation avoids the need for maintaining two separate liquid chromatography systems or manual reconfiguration of a chromatography system for users desiring the capability of both modes of operation.

公开(公告)号：US10465808B2

公开(公告)日：2019-11-05

申请号：US16323637

申请日：2017-08-07

Applicant: Waters Technologies Corporation

Inventor： Jeffrey Musacchio ,  Joseph D. Michienzi ,  Keith Fadgen

IPC: F16K15/14 ,  F04B53/10 ,  G01N30/02 ,  G01N30/20 ,  F16J15/3212

Abstract: A check valve includes a first valve body having a chamber in which second and third valve bodies are located. The check valve also includes a spring-energized seal disposed in the chamber. The spring-energized seal includes a compliant seal body having an annular shape and a resilient member, such as a cantered spring or O-ring, disposed in a pocket of the seal body. The resilient member applies a force to portions of the seal body to prevent the passage of fluid from a valve inlet port to a valve outlet port unless the differential fluid exceeds the cracking pressure of the check valve.

公开(公告)号：US20190317062A1

公开(公告)日：2019-10-17

申请号：US16384272

申请日：2019-04-15

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Curt Devlin ,  Theodore A. Dourdeville ,  Jacob N. Fairchild ,  Geoff C. Gerhardt ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: G01N30/72

Abstract: Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：US20180321198A1

公开(公告)日：2018-11-08

申请号：US15967752

申请日：2018-05-01

Applicant: Waters Technologies Corporation

Inventor： Abhijit Tarafder ,  Michael O. Fogwill ,  Joshua A. Shreve ,  Joseph D. Michienzi ,  Steven J. Ciavarini

IPC: G01N30/28 ,  B01D15/10

CPC classification number: G01N30/28 ,  B01D15/10 ,  B01D15/16 ,  B01D15/40 ,  G01N30/32

Abstract: The present disclosure relates generally to a system and a method for improving performance of a chromatography system using a highly-compressible fluid based mobile phase (e.g., CO2). In particular, the present disclosure relates to a system that uses a conduit, such as a convergent-divergent nozzle, for reducing pressure noise in a chromatography system using a highly-compressible fluid based mobile phase. The chromatography system can include a conduit, such as a convergent-divergent nozzle, disposed downstream of the column to reduce or prevent the propagation of pressure or density pulses from a back pressure regulator.

公开(公告)号：US20180252685A1

公开(公告)日：2018-09-06

申请号：US15909275

申请日：2018-03-01

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joshua A. Shreve ,  Michael Eggertson ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Abhijit Tarafder

IPC: G01N30/32 ,  G01N30/34 ,  G01N30/72

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/40 ,  G01N30/34 ,  G01N30/7233 ,  G01N2030/326

Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO2-based chromatography system. A first pressure control element is located downstream of a CO2-based chromatography system and is disposed to control pressure within the column. A split restrictor is located downstream of the primary pressure control element and is disposed to divert a portion of the mobile phase flow to a detector. A second pressure control element is located downstream of the split restrictor and is disposed to control pressure at the restrictor. While the first pressure control element executes a pressure-controlled gradient separation, the second pressure control element maintains a constant pressure at the restrictor. During a composition-programmed gradient separation, the second control element maintains a constant pressure at the split restrictor while the first pressure control element maintains a constant average density across the column.