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41.发明公开公开(公告)号：US20240295477A1
公开(公告)日：2024-09-05
申请号：US18574682
申请日：2023-03-29
Inventor： Xiancheng ZHANG , Shantung TU , Liqiang LIU , Jianping TAN , Binhan SUN , Junmiao SHI , Runzi WANG , Ji WANG
IPC: G01N3/08
CPC classification number: G01N3/08 , G01N2203/0069 , G01N2203/0228
Abstract: A system for testing fatigue performance of material in low-temperature liquid hydrogen environment, which relates to the technical field of mechanical property test platforms, includes a jacket cover. A hydrogen sensor is provided at the top of and within the jacket cover; a rack, a liquid hydrogen tank and a liquid nitrogen tank are provided in the jacket cover; a loading mechanism and a liquid hydrogen containing mechanism are provided on the rack, the loading mechanism is connected to the rack, and the bottom of the loading mechanism extends into the liquid hydrogen containing mechanism; the liquid hydrogen tank and the liquid nitrogen tank both communicate with the liquid hydrogen containing mechanism; and the loading mechanism is configured for providing tension or pressure to a sample. The liquid hydrogen containing mechanism is provided with a cooling channel located around a sealing gasket, the cooling channel communicates with a thermostat.
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公开(公告)号：US20240287017A1
公开(公告)日：2024-08-29
申请号：US18569830
申请日：2022-06-14
Inventor： Jinghong ZHOU , Xiaofeng XU , Yueqiang CAO , Wei LI
IPC: C07D319/12 , C07C67/02
CPC classification number: C07D319/12 , C07C67/02
Abstract: This invention provides a method for synthesizing glycolide using methyl glycolate as a raw material, comprising two steps as illustrated in the following reaction formulas:
wherein, the ROH represents a straight/branched chain alcohol, acid or ester containing 18-30 carbons and at least one hydroxyl group. The method for glycolide synthesis disclosed in the present invention manages to maintain a low viscosity within the reaction system by introducing a high-boiling alcohol into the reaction system to form a larger alkoxy glycolate exhibiting a significantly lower molecular weight compared to the typical glycolic acid oligomers utilized in the conventional process. Thus the challenges of coking and inefficient heat transfer encountered in traditional glycolide synthesis routes are effectively addressed.-
43.发明公开公开(公告)号：US20240104482A1
公开(公告)日：2024-03-28
申请号：US18227069
申请日：2023-07-27
Inventor： Mingliang ZHU , Fuzhen XUAN , Gang ZHU , Shan-Tung TU
IPC: G06Q10/0639 , G05B23/02 , G06Q10/067 , G06Q50/04 , G06Q50/26
CPC classification number: G06Q10/06395 , G05B23/0283 , G06Q10/067 , G06Q50/04 , G06Q50/265
Abstract: An anti-fatigue and safety control method for ultra-long life service structures under extreme environment, comprising: judge the fatigue fracture mode in the long life stage of the service structure; according to the interaction principle of defect-matrix, obtain the internal defect induced fatigue cracking mechanism in ultra-high cycle regime under the service environment; considering the environmental factors, clarify the internal defect-matrix-environment interaction mechanism under service conditions and obtain the environmental weakening coefficient; considering the environmental factors, establish a fatigue life prediction model based on defect-load-life correlation under service conditions in ultra-high cycle regime; the process parameters of material metallurgy and manufacturing, design parameters of structural strength, structural service stress and environmental parameters are regulated based on the concept of integrated design/manufacturing.
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公开(公告)号：US11905369B2
公开(公告)日：2024-02-20
申请号：US17058739
申请日：2019-06-13
Inventor： Runhui Liu , Yueming Wu
CPC classification number: C08G69/10 , C08G69/16 , C08G69/20 , C07K1/00 , C07K14/001
Abstract: The present invention relates to a strong base-initiated N-carboxyanhydride rapid ring-opening polymerisation method. Specifically, the method comprises steps of: performing a polymerisation reaction with one or more amino acid N-carboxyanhydride monomers in an organic solvent in the presence of an initiator, so as to form an amino acid polymer, wherein the initiator is selected from the following group: LiHMDS, NaHMDS, KHMDS, or a combination thereof. The method significantly increases the speed of traditional NCA polymerisation and prepares a long-chain polymer, and the prepared amino acid polymer may be used as an anti-bacterial material, an anti-tumour material, a tissue engineering scaffold or a self-assembling material.
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45.发明公开公开(公告)号：US20230414837A1
公开(公告)日：2023-12-28
申请号：US18005114
申请日：2021-11-16
Inventor： Runhui Liu , Haodong Lin , Yueming Wu
CPC classification number: A61L27/48 , A61L27/56 , A61L2300/404 , A61L2430/02
Abstract: Disclosed are a polypeptide polymer-doped bone marrow cavity filler and the use thereof in the treatment of osteomyelitis, wherein the polypeptide polymer is used for being doped in a bone marrow cavity filler or preparing a bone marrow cavity filling antibacterial material for treating osteomyelitis, has efficient antibacterial activity on common staphylococcus aureus, etc., in osteomyelitis, is not easy to induce bacteria to generate drug resistance, has good biocompatibility in environments such as bone marrow and blood, has good stability, and still keeps activity after forming heat release and even the autoclaving of bone cement.
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Patent Agency Ranking
46.发明公开公开(公告)号：US20230414262A1
公开(公告)日：2023-12-28
申请号：US17905561
申请日：2021-03-02
Inventor： Changsheng LIU , Yulin LI , Wei LUO , Can CHEN
IPC: A61B17/86 , A61L27/12 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/12 , B29B9/12 , B29C71/02 , B29C45/77 , B29C45/78 , B29C48/92
CPC classification number: A61B17/86 , A61L27/12 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/127 , B29B9/12 , B29C71/02 , B29C45/77 , B29C45/78 , B29C48/92 , B29K2067/046
Abstract: The present invention relates to a high-strength absorbable composite active internal fixation device and a preparation method therefor. Specifically, the present invention discloses the internal fixation device and its preparation method, which possess excellent biological activity and mechanical properties.
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47.发明公开公开(公告)号：US20230406728A1
公开(公告)日：2023-12-21
申请号：US18245625
申请日：2020-09-17
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI HUACHANG ENVIRONMENTAL PROTECTION CO., LTD , SINOPEC GUANGZHOU ENGINEERING CO., LTD.
Inventor： Wenjie LV , Hualin WANG , Jiangi CHEN , Yu LIU , Lei SHI , Ligong QIAO , Jie ZHANG , Guoping CHANG , Bing LIU , Xin CUI , Weichi SANG , Jinsong WANG , Hongpeng MA , Wei YUAN , Yujie JI
CPC classification number: C02F1/40 , C02F1/16 , C02F2209/03 , C02F2301/066 , C02F2209/40 , C02F2301/046 , C02F2209/02 , C02F2209/105 , C02F2301/026 , C02F2303/24
Abstract: The present disclosure relates to a method and apparatus for prolonging a continuous operation period of a methanol-to-olefins water washing process. The method may perform micro cyclone treatment on methanol-to-olefins washing water. The method may also deliver the washing water subjected to micro cyclone treatment and oil removal to a fluidized bed separator for treatment. The method may also adjust the backwash flow to release the intercepted catalyst powder and empty the dirt holding capacity of a pore. The method may also perform three-phase separation on a gas-liquid-solid mixture subjected to backwash, returning the obtained filter media to a particle bed layer, and respectively discharging a backwashing liquid a backwashing gas which comprise a catalyst. The method may also switch the fluidized bed separator to a normal working state, completing the active regeneration of the particle bed layer, and continuing to operate.
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48.发明公开公开(公告)号：US20230310333A1
公开(公告)日：2023-10-05
申请号：US18043594
申请日：2021-08-23
Inventor： Weiping ZHU , Yun FU , Yufang XU , Xuhong QIAN
CPC classification number: A61K9/5115 , A61K38/28 , A61K9/0021
Abstract: A mesoporous silica nanoparticle controlled release system, a preparation method thereof and an application thereof, and specifically provides a mesoporous silica nanomaterial that can be used for controlled release is disclosed. The mesoporous silica nanomaterial that can be used for controlled release comprises a mesoporous silica nanoparticle functionalized by means of a polyhydroxy compound and a nanoparticle plugging agent functionalized by means of a phenylboronic acid compound. When substrate concentration is relatively low, the nanomaterial achieves “zero early release”; when substrate concentration is relatively high, mesoporous pores blocked by the plugging agent are opened and active ingredients are released. The nanomaterial can be loaded into microneedles and microneedle array patches used to treat diabetes or to control blood sugar levels in patients.
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公开(公告)号：US20230296617A1
公开(公告)日：2023-09-21
申请号：US17904503
申请日：2021-02-09
Inventor： Yi Yang , Yuzheng Zhao , Chenxia Zhang , Li Huang , Yejun Zou , Xie Li , Shuning Liu
CPC classification number: G01N33/6812 , G01N33/582 , C12N15/63
Abstract: Disclosed is a tryptophan optical probe, a preparation method therefor and the use thereof. Disclosed is an optical probe, comprising a tryptophan-sensitive polypeptide or a functional variant thereof and an optically active polypeptide or a functional variant thereof, wherein the optically active polypeptide or the functional variant thereof is located in the sequence of the tryptophan-sensitive polypeptide or the functional variant thereof. Furthermore, disclosed are a method for preparing the above-mentioned probe and the use thereof in the detection of tryptophan.
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公开(公告)号：US20230296616A1
公开(公告)日：2023-09-21
申请号：US17904498
申请日：2021-02-09
IPC: G01N33/68 , G01N33/533 , C07K14/00
CPC classification number: G01N33/6812 , G01N33/533 , C07K14/001
Abstract: Provided is an arginine fluorescent probe, comprising a polypeptide B that responds to arginine and a fluorescent protein A that expresses arginine; the fluorescent protein A is inserted into the polypeptide B, B is divided into an upper structural part and a lower structural part, B1 and B2, and a probe structure represented by the formula B1-A-B2 is formed; optimized mutants are likewise obtained by truncation and site-directed mutagenesis at different positions, and specific binding of the polypeptide B and arginine leads to a change in the fluorescence signal of the fluorescent protein A; and the polypeptide B is an arginine binding protein or a mutant thereof. The arginine fluorescent probe provided by the present invention has a relatively small protein molecular weight, is easy to express, experiences large dynamic changes in fluorescence, has good specificity, can be expressed, by means of genetic manipulation, in different subcellular organelles of cells, and can be used for the high-throughput, quantitative detection of arginine inside and outside of cells.
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