公开(公告)号：US4784116A

公开(公告)日：1988-11-15

申请号：US79766

申请日：1987-07-29

Applicant: John L. Russell, Jr. ,  David N. Coggins

Inventor： John L. Russell, Jr. ,  David N. Coggins

IPC: A61K51/00 ,  A61K9/00 ,  A61K47/00 ,  A61K47/02 ,  A61M36/12 ,  A61N5/10 ,  A61P35/00 ,  G21G4/08

CPC classification number: G21G4/08 ,  A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024 ,  Y10S977/928

Abstract: A seed for implanting radioactive material within the living body of a recipient which contains radioactive material which emits therapeutic radiation to treat a specific localized area of the recipient's body. A capsule, which sealingly encloses the radioactive material, preventing contact with the recipient's body fluid and tissue, includes a generally cylindrical body portion having a pair of open ends. End members of a wall thickness substantially that of the cylindrical body close the open ends, and include an end wall and a generally tubular skirt portion extending therefrom. The skirt portion and the ends of the cylindrical body are deformably joined together by welding, crimping, peening or other cold flow metal treatment, to form a hermetic seal between the end cap and cylindrical body. Also disclosed is a cylindrical plug-like coupling member which joins the pair of seeds in end-to-end coaxial relationship. Each end of the coupling member is received in a socket-like cavity formed in the hollow interior of one end member.

Abstract translation: 用于将放射性物质植入到接受者生物体内的种子，其包含放射性物质，其放射治疗辐射以治疗受体身体的特定局部区域。 密封地包围放射性物质的胶囊防止与受体的体液和组织的接触，包括具有一对开口端的大致圆柱形主体部分。 基本上为圆柱形主体的壁厚的端部构件关闭开口端，并且包括从其延伸的端壁和大致管状的裙部。 圆筒体的裙部和端部通过焊接，压接，喷丸或其它冷流金属处理而可变形地连接在一起，以在端盖和圆柱体之间形成气密密封。 还公开了一种圆柱形塞状联接构件，其以端对端同轴关系连接该对种子。 联接构件的每个端部容纳在形成在一个端部构件的中空内部中的套筒状空腔中。

公开(公告)号：US4402308A

公开(公告)日：1983-09-06

申请号：US203320

申请日：1980-11-03

Applicant: Walter P. Scott

Inventor： Walter P. Scott

IPC: A61B17/34 ,  A61M5/00 ,  A61N5/10 ,  A61N5/00

CPC classification number: A61M37/0069 ,  A61B17/3468 ,  A61N5/1007 ,  A61N2005/1011 ,  A61N2005/1023 ,  A61N5/1001

Abstract: An injector for implanting materials comprising a hollow tubular sheath with a sharpened point suitable for injecting into human tissue and a slotted needle slidably and rotatably mounted inside said sheath, the sheath being retractable to expose any portion or all of the slotted needle, and the needle being rotatable within the sheath. This device is employed for implanting radioactive seeds in human tissue for treatment thereof.

Abstract translation: 一种用于植入材料的注射器，其包括具有适于注入人体组织的锐化点的中空管状护套和可滑动地且可旋转地安装在所述护套内的开槽针，所述护套可收缩以暴露所述开槽针的任何部分或全部，并且所述针 可在护套内旋转。 该装置用于将放射性种子植入人体组织进行处理。

公开(公告)号：US20180050134A2

公开(公告)日：2018-02-22

申请号：US15492293

申请日：2017-04-20

Applicant: Microspherix LLC

Inventor： Edward J. Kaplan

IPC: A61L31/16 ,  A61L31/02 ,  A61L31/04 ,  A61L31/14 ,  A61L31/18 ,  A61K41/00 ,  A61K49/00 ,  A61B90/00 ,  A61N5/10

CPC classification number: A61L31/16 ,  A61B5/064 ,  A61B90/39 ,  A61B2090/3966 ,  A61K41/0038 ,  A61K47/6957 ,  A61K49/00 ,  A61K49/0409 ,  A61K51/1282 ,  A61L31/02 ,  A61L31/04 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L31/18 ,  A61L2300/44 ,  A61L2300/45 ,  A61N5/1007 ,  A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

Abstract: A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.

公开(公告)号：US20170209601A1

公开(公告)日：2017-07-27

申请号：US15328711

申请日：2015-07-27

Applicant: Northeastern University ,  The Brigham and Women's Hospital, Inc. ,  Dana-Farber Cancer Institute, Inc.

Inventor： Rajiv KUMAR ,  Srinivas SRIDHAR ,  Wilfred NGWA ,  Robert CORMACK ,  Gerassimos MAKRIGIORGOS

IPC: A61K49/00 ,  A61L31/06 ,  A61L31/16 ,  A61B5/00 ,  A61L31/18 ,  A61K49/04 ,  A61B90/00 ,  A61N5/10 ,  A61K31/337 ,  A61L31/14

CPC classification number: A61K49/0065 ,  A61B5/4887 ,  A61B90/39 ,  A61B2090/3966 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/337 ,  A61K45/06 ,  A61K49/0054 ,  A61K49/04 ,  A61K49/0423 ,  A61L31/042 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2400/12 ,  A61N5/1027 ,  A61N2005/1023 ,  A61P35/04 ,  C08L67/04 ,  C08L71/02 ,  C08L33/26 ,  C08L5/08 ,  A61K2300/00

Abstract: A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor cells. Nanoparticles bound to the tumor cells that have migrated out of the region can be detected by various imaging modalities. The implant can be in the shape of a brachytherapy spacer or radiotherapy fiducial maker or can be a coating on a brachytherapy spacer or fiducial marker. A method of treating cancer is provided by implanting one or more brachytherapy spacers or fiducial markers including the matrix material and an anti-cancer therapeutic agent dispersed within the matrix material.

公开(公告)号：US20170049590A1

公开(公告)日：2017-02-23

申请号：US15237147

申请日：2016-08-15

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： JOHN A. HINGSTON ,  CLAUDE O. CLERC

IPC: A61F2/88 ,  B29C33/48 ,  B29C53/60 ,  B29C37/00 ,  A61F2/844 ,  B65H54/10

CPC classification number: A61F2/88 ,  A61F2/844 ,  A61F2/90 ,  A61F2210/0076 ,  A61F2210/0095 ,  A61F2240/001 ,  A61N5/1001 ,  A61N5/1002 ,  A61N5/1014 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1008 ,  A61N2005/1023 ,  B29C33/485 ,  B29C37/0025 ,  B29C53/60 ,  B29K2027/18 ,  B29K2083/00 ,  B29K2995/0037 ,  B29L2031/7532 ,  B65H54/10

Abstract: This disclosure provides design, material, preparation methods, and use alternatives for medical devices. An example stent includes an expandable framework and a plurality of tubular members disposed along the expandable framework. Each of the plurality of tubular members include a lumen extending therein. The example stent also include a coating, wherein the coating is applied directly to both the plurality of tubular members and the expandable framework.

Abstract translation: 本公开提供用于医疗设备的设计，材料，制备方法和使用替代物。 示例性支架包括可膨胀框架和沿着可膨胀框架设置的多个管状构件。 多个管状构件中的每一个包括在其中延伸的内腔。 示例性支架还包括涂层，其中涂层直接施加到多个管状构件和可膨胀框架两者。

公开(公告)号：US20150010470A1

公开(公告)日：2015-01-08

申请号：US14473159

申请日：2014-08-29

Applicant: Microspherix, LLC

Inventor： Edward J. Kaplan

IPC: A61K51/12 ,  A61B5/06 ,  A61N5/10 ,  A61L31/14

CPC classification number: A61L31/16 ,  A61B5/064 ,  A61B90/39 ,  A61B2090/3966 ,  A61K41/0038 ,  A61K47/6957 ,  A61K49/00 ,  A61K49/0409 ,  A61K51/1282 ,  A61L31/02 ,  A61L31/04 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L31/18 ,  A61L2300/44 ,  A61L2300/45 ,  A61N5/1007 ,  A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

Abstract: A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.

Abstract translation: 包括成像标记物和/或治疗性，诊断性或预防性药物的柔性或弹性近距离放射线束，所述治疗剂，诊断或预防剂例如生物相容性载体中的药物，其可以通过近距离放射治疗植入针的孔植入受试者后递送至受试者， 已经开发 链条可以形成为链条或连续的种子阵列，直到50厘米或更长，具有或不具有间隔物材料，松弛剂，刚性或柔性的。

公开(公告)号：US20130190549A1

公开(公告)日：2013-07-25

申请号：US13733272

申请日：2013-01-03

Applicant: THERAGENICS CORPORATION

Inventor： DAVID SCHREIBER ,  JACK C. WHITE ,  DAVID WESLEY STEPHENS ,  HENRY C. GOODE ,  NATHAN CHRISTOPHER GRIFFITH ,  MING K. TAI

IPC: A61N5/10

CPC classification number: A61N5/1001 ,  A61N2005/1009 ,  A61N2005/1023

Abstract: A point-of-care seed stranding device for automating assembly of brachytherapy seed strands for implantation in patients. The device includes a number of features to reduce the potential for mistakes by the user, as well as to reduce the potential for damaging the radioactive seeds during the stranding process. Tactile feedback may be provided to prevent exertion of too much force in the packing step of the stranding process, as well as to indicate that the seed and/or strand cartridges are empty and need to be replaced. The device may also include a mechanism for holding seeds or spacers in place to allow automated packing of seeds or spacers having corresponding geometries. The device may also be provided with a seed counter which can be employed to preset the number of seeds in a strand and which disables the device from dispensing or packing additional seeds once the preset number of seeds has been packed into the strand. Also, methods for automated assembly of seed strands including the steps of setting the number of seeds, dispensing seeds and spacers, packing seeds and spacers and transferring assembled strands to another device.

Abstract translation: 一种用于自动装配近距离放射治疗种子股的护理种子绞合装置，用于植入患者。 该装置包括许多特征，以减少使用者的错误的可能性，以及减少在绞合过程中损坏放射性种子的可能性。 可以提供触觉反馈以防止在绞合过程的包装步骤中施加过大的力，并且指示种子和/或线束筒是空的并且需要更换。 该装置还可以包括用于将种子或间隔物保持在适当位置以允许自动包装具有相应几何形状的种子或间隔物的机构。 该装置还可以具有种子计数器，该种子计数器可用于预定股线中的种子数量，并且一旦预定数量的种子已经被包装到股线中，该种子计数器就禁止装置分配或包装额外的种子。 此外，种子股线的自动装配的方法包括以下步骤：设定种子数量，分配种子和间隔物，包装种子和间隔物并将组装的股转移到另一装置。

公开(公告)号：US08366597B2

公开(公告)日：2013-02-05

申请号：US13025669

申请日：2011-02-11

Applicant: Axel Hentrich ,  Christoph Lederer

Inventor： Axel Hentrich ,  Christoph Lederer

IPC: A61M36/00 ,  A61M36/04

CPC classification number: A61N5/1001 ,  A61N5/1007 ,  A61N5/1027 ,  A61N2005/1009 ,  A61N2005/1023

Abstract: A device is proposed for assembling chain components to a chain, wherein at least two chain components include radioactive radiation sources. The device includes a housing, a working channel which extends along a first axis of the housing, a loading unit connected to the working channel and having at least two receiving devices for chain component magazines, wherein at least one receiving device is configured to receive a radiation source magazine, as well as at least one means for ejecting the chain components received from the magazines, and an joining unit for joining chain components. The at least two receiving devices are positioned so that the magazines for chain components received therein are spaced along the first axis and positioned vertically above the working channel.

Abstract translation: 提出了将链组件组装到链上的装置，其中至少两个链组分包括放射性辐射源。 该装置包括壳体，沿着壳体的第一轴线延伸的工作通道，连接到工作通道并具有至少两个用于链条部件杂志的接收装置的加载单元，其中至少一个接收装置被配置为接收 辐射源盒，以及至少一个用于喷射从杂志接收的链条组件的装置，以及用于连接链组件的接合单元。 所述至少两个接收装置被定位成使得容纳在其中的链条部件的盒子沿着第一轴线间隔开并且垂直地位于工作通道上方。

公开(公告)号：US08323171B2

公开(公告)日：2012-12-04

申请号：US11867625

申请日：2007-10-04

Applicant: Gail S. Lebovic ,  George D. Hermann

Inventor： Gail S. Lebovic ,  George D. Hermann

IPC: A61N5/00

CPC classification number: A61N5/1027 ,  A61N2005/1011 ,  A61N2005/1023 ,  A61N2005/1094

Abstract: Apparatus, systems and methods are provided for delivering brachytherapy to a target tissue region of a human or other mammalian body. In some embodiments, a flexible brachytherapy device is implanted that includes a therapy delivery portion having one or more radioactive sources securely retained thereto, and a tail portion extending from the therapy delivery portion. Once implanted, the tail portion may extend outside the body, where it may be folded and secured flat against the skin. The device may be removed at therapy completion. Other embodiments of the invention are directed to systems and methods for delivering brachytherapy devices to the body.

Abstract translation: 提供装置，系统和方法用于将近距离放射治疗递送至人或其他哺乳动物身体的靶组织区域。 在一些实施例中，植入柔性近距离放射治疗装置，其包括具有一个或多个可靠地保持在其上的放射源的治疗递送部分和从治疗递送部分延伸的尾部。 一旦植入，尾部可以延伸到身体的外部，在那里它可以被折叠并且平坦地固定在皮肤上。 在治疗完成时可以移除该装置。 本发明的其它实施例涉及用于将近距离放射治疗装置输送到身体的系统和方法。

公开(公告)号：US08192345B2

公开(公告)日：2012-06-05

申请号：US12357329

申请日：2009-01-21

Applicant: Gary A. Lamoureux ,  James Matons ,  Warren W. Johnston ,  Matthew Bouffard ,  Warren Rice

Inventor： Gary A. Lamoureux ,  James Matons ,  Warren W. Johnston ,  Matthew Bouffard ,  Warren Rice

IPC: A61M36/00

CPC classification number: A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

Abstract: In an embodiment, a brachytherapy device includes a cartridge adapted for use with a brachytherapy applicator. A plurality of therapeutic members are stacked parallel to one another within the cartridge. Each therapeutic member includes a radioactive seed that is at least partially encapsulated by a polymeric material. Additionally, each therapeutic member can include at least one protrusion on an outer surface of the encapsulating polymeric material to reduce a tendency for the therapeutic member to migrate and rotate within a patient's body after the therapeutic member is implanted.

Abstract translation: 在一个实施例中，近距离放射治疗装置包括适于与近距离放射治疗仪一起使用的筒。 多个治疗构件在筒内彼此平行地堆叠。 每个治疗成员包括至少部分地被聚合物材料包封的放射性种子。 此外，每个治疗构件可以包括在封装聚合物材料的外表面上的至少一个突起，以减少施用构件在植入治疗构件之后在患者体内迁移和旋转的趋势。