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公开(公告)号:US09175027B2
公开(公告)日:2015-11-03
申请号:US13364967
申请日:2012-02-02
申请人: Nian Wu
发明人: Nian Wu
IPC分类号: A61K31/7032 , A61K31/231 , A61K31/25 , A61K31/325 , A61K31/4188 , A61K31/223 , A61K31/575 , C07H1/00 , A61K31/05 , A61K47/26 , C07H15/04 , C08G65/329 , C07J41/00 , A61K9/00 , A61K9/20
CPC分类号: C07H1/00 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K9/0095 , A61K9/2013 , A61K31/05 , A61K31/223 , A61K31/231 , A61K31/25 , A61K31/325 , A61K31/4188 , A61K31/575 , A61K31/7032 , A61K47/26 , C07H15/04 , C07J41/0061 , C08G65/329 , C08L2203/02
摘要: The invention comprises compounds, methods of making, and methods of using. The compounds may have a backbone and three appended functional groups: one lipid, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. A variety of linkers between the backbone and functional groups may also be selected to optimize performance.
摘要翻译: 本发明包括化合物,制备方法和使用方法。 化合物可以具有主链和三个附加的官能团:一种脂质,一种亲水聚合物和一种碳水化合物。 可以在配制药物,化妆品,营养品等中的特定应用中选择特定的官能团。 骨架和功能组之间的各种接头也可以被选择以优化性能。
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公开(公告)号:US09168291B2
公开(公告)日:2015-10-27
申请号:US14453829
申请日:2014-08-07
申请人: The United States of America, as represented by the Secretary, Department of Health and Human Service , The University of Birmingham, of Edgbaston
IPC分类号: A61K39/00 , C07H15/04 , A61K31/7004 , A61K45/06
CPC分类号: A61K31/7032 , A61K31/7004 , A61K38/2013 , A61K39/00 , A61K39/0011 , A61K45/06 , A61K2039/585 , C07H15/04 , C07H15/06
摘要: β-mannosylceramides or salts or solvates thereof in a pharmaceutically acceptable carrier, for use as a Type I NKT cell agonist in conjunction with a therapeutically effective amount of α-galactosylceramide or a salt or a solvate thereof, and/or at least one or more T-cell co-stimulatory molecules, disclosed. Compositions comprising β-mannosylceramide, as well as methods of treatment of tumors are also provided.
摘要翻译: - 甘露糖基神经酰胺或其盐或溶剂化物在药学上可接受的载体中,用作I型NKT细胞激动剂与治疗有效量的α-半乳糖神经酰胺或其盐或溶剂化物,和/或至少一种或 更多的T细胞共刺激分子。 还提供了包含β-甘露糖基神经酰胺的组合物以及治疗肿瘤的方法。
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公开(公告)号:US20150259371A1
公开(公告)日:2015-09-17
申请号:US13696248
申请日:2011-05-06
IPC分类号: C07H15/203 , C07H15/04
CPC分类号: C07H15/203 , A61K31/382 , A61K31/70 , A61K31/7008 , A61K31/7024 , A61K31/7034 , A61K31/7072 , C07H13/04 , C07H15/04 , C07H19/10
摘要: The invention provides, in part, compounds that are capable of inhibiting a glycosyltransferase, such as a uridine diphospho-N-acetylglucosamine:polypeptide β N-acetylglucosaminyltransferase, an N-acetylgalactosaminyltransferase, a fucosyltransferase, a xylotransferase or a sialyltransferase. The invention also provides methods for using the compounds.
摘要翻译: 本发明部分提供能够抑制糖基转移酶的化合物,例如尿苷二磷酸-N-乙酰葡糖胺:多肽&bgr; N-乙酰葡糖胺基转移酶,N-乙酰半乳糖胺基转移酶,岩藻糖基转移酶,木糖转移酶或唾液酸转移酶。 本发明还提供了使用该化合物的方法。
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公开(公告)号:US20150252400A1
公开(公告)日:2015-09-10
申请号:US14430930
申请日:2013-09-25
申请人: GLYCOM A/S
发明人: Pauline Peltier-Pain , Gyula Dekany , Christophe Pain , Pierre Chassagne , Nicolas Fierfort , Dóra Molnàr-Gàbor
摘要: The invention relates to a method for producing a glycoconjugate comprising an oligosaccharide part covalently linked to a non-sugar moiety selected from the group consisting of amino acids, peptides, proteins, lipids, longer alkyl groups, polyethylene glycols, α,β-unsaturated amido group and polyvinyl alcohols, using a genetically modified cell.
摘要翻译: 本发明涉及一种制备糖缀合物的方法,其包含与非糖部分共价连接的寡糖部分,所述寡糖部分选自氨基酸,肽,蛋白质,脂质,较长的烷基,聚乙二醇,α,β-不饱和 酰胺基和聚乙烯醇,使用转基因细胞。
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公开(公告)号:US09120838B2
公开(公告)日:2015-09-01
申请号:US14112830
申请日:2012-04-18
IPC分类号: C07H15/04 , A61K9/00 , A61K47/06 , A61K47/12 , A61K9/06 , A61K47/32 , A61K47/38 , A61K9/20 , A61K47/02 , A61K47/10 , A61K9/48
CPC分类号: C07H15/04 , A61K9/0014 , A61K9/0019 , A61K9/008 , A61K9/06 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/38
摘要: The invention provides a series of novel Lipid A analogs that are structually simple, synthetically accessible, and capable of blocking the cellular receptor within the signal transduction pathway. The novel Lipid A analogs can include a monosaccharide core with hydrophobic side chains and amino acid ionic motif. The invention further provides methods of using the compounds and compositions thereof in various therapeutic methods.
摘要翻译: 本发明提供了一系列新颖的脂质A类似物,其结构简单,合成可及,并能够阻断信号转导途径内的细胞受体。 新型脂质A类似物可以包括具有疏水侧链和氨基酸离子基序的单糖核心。 本发明还提供了在各种治疗方法中使用该化合物及其组合物的方法。
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公开(公告)号:US20150239826A1
公开(公告)日:2015-08-27
申请号:US14627613
申请日:2015-02-20
IPC分类号: C07C227/18
CPC分类号: C09K11/06 , B82Y20/00 , B82Y40/00 , C01B32/15 , C07C215/08 , C07C227/18 , C07C231/02 , C07C235/74 , C07H15/04 , C09K9/02 , C09K11/65 , C09K2208/10 , C09K2211/10 , E21B47/1015 , E21B49/00 , E21B49/008 , Y10S977/773 , Y10S977/774 , Y10S977/896 , Y10S977/95 , Y10T428/2982
摘要: The present invention relates to carbon-based fluorescent nano-agent tracers for analysis of oil reservoirs. The carbon-based fluorescent nano-agents may be used in the analysis of the porosity of a formation. The nanoagents are suitable for injection into a petroleum reservoir and may be recovered from the reservoir for the determination of hydrocarbon flow rates and retention times.
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公开(公告)号:US09107930B2
公开(公告)日:2015-08-18
申请号:US14316652
申请日:2014-06-26
申请人: Rhamnopharma Inc.
发明人: Anton Leighton
IPC分类号: A01N43/04 , A61K31/70 , A61K31/715 , A61K31/7028 , A61K8/60 , A61Q19/06 , C07H15/04
CPC分类号: A61K31/7028 , A61K8/602 , A61Q19/06 , C07H15/04
摘要: The present invention is directed to methods for treating obesity, reducing excessive body weight, treating an obesity-related condition, treating unwanted localized fat deposits, and treating areas of cellulite. The method comprises the steps of first identifying a subject in need thereof, and administering to the subject an effective amount of rhamnolipids. A pharmaceutical composition comprising rhamnolipids can be applied by any accepted mode of administration including oral, intranasal, subcutaneous, percutaneous, intravenous, or intracutaneous administration.
摘要翻译: 本发明涉及治疗肥胖症,减少体重过多,治疗肥胖相关病症,治疗不需要的局部脂肪沉积物以及治疗脂肪团区域的方法。 该方法包括以下步骤:首先鉴定有需要的受试者,并向受试者施用有效量的鼠李糖脂。 包含鼠李糖脂的药物组合物可以通过任何接受的给药方式施用,包括口服,鼻内,皮下,经皮,静脉内或皮内给药。
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公开(公告)号:US20150225439A1
公开(公告)日:2015-08-13
申请号:US14425602
申请日:2013-09-05
发明人: Phillip Martin Rendle , Steven Toms
IPC分类号: C07H15/04 , C07C229/06 , C07C229/38
CPC分类号: C07H15/04 , A61K47/32 , A61K47/48192 , A61K47/59 , A61K49/0021 , A61K49/0054 , A61K49/124 , C07C229/06 , C07C229/10 , C07C229/38 , C07C233/18 , C07C237/08
摘要: This invention relates to certain dendrimer compounds. In particular, this invention relates to novel dendrimer compounds that can be elaborated to give increasingly large and complex compounds. These elaborated compounds can be attached to, or can encapsulate within, active agent(s) so as to beneficially modify the characteristics of that active agent. Alternatively, the elaborated compounds can themselves be beneficially modified into therapeutic agents by the attachment of inactive agents.
摘要翻译: 本发明涉及某些树枝状大分子化合物。 特别地,本发明涉及新颖的树枝状大分子化合物,其可以被精心制备以产生越来越大的和复杂的化合物。 这些精制化合物可以附着于活性剂或可以包封在活性剂中,以有利地改变该活性剂的特性。 或者,精制的化合物本身可以通过无活性剂的附着而有益地修饰成治疗剂。
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公开(公告)号:US20150218196A1
公开(公告)日:2015-08-06
申请号:US14409604
申请日:2013-06-20
发明人: Adriaan Jacobus Minnaard , Manuel Jäger , Aditya Lakshmi Narasimha Raju Gottumukkala , Johannes Gerardus de Vries , Andreas Alexander Bastian , Andreas Herrmann
CPC分类号: C07H15/222 , C07H1/00 , C07H3/02 , C07H3/04 , C07H3/06 , C07H5/06 , C07H15/04 , C07H15/18 , C07H15/22 , C07H15/224 , C07H15/226 , C07H15/228 , C07H15/23 , C07H15/232 , C07H15/234 , C07H17/04 , C07H23/00
摘要: The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, comprising contacting the carbohydrate substrate in a solvent in the presence of a transition metal catalyst complex with an oxidizing agent to yield a mono-oxidized carbohydrate.
摘要翻译: 本发明涉及碳水化合物化学领域。 提供了一种用于区域选择性氧化包含两个或更多个次级羟基官能团的碳水化合物底物的单次级羟基官能团的方法,包括在过渡金属催化剂配合物与氧化剂存在下使碳水化合物底物在溶剂中接触,得到 单氧化碳水化合物。
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公开(公告)号:US20150191503A1
公开(公告)日:2015-07-09
申请号:US14417487
申请日:2013-07-26
发明人: Benjamin Jason Compton , Colin Malcolm Hayman , Ian Francis Hermans , David Samuel Larsen , Gavin Frank Painter , Regan J. Anderson
CPC分类号: C07H15/04 , A61K39/39 , A61K2039/55511 , C07H15/06
摘要: This invention relates to sphingoglycolipid analogues, compositions comprising these compounds, processes for preparing the compounds, and methods of treating or preventing diseases or conditions using the compounds, such as diseases or conditions relating to infection, atopic disorders, autoimmune disease, diabetes or cancer.
摘要翻译: 本发明涉及鞘糖脂类似物,包含这些化合物的组合物,制备该化合物的方法,以及使用该化合物治疗或预防疾病或病症的方法,例如与感染,特应性障碍,自身免疫性疾病,糖尿病或癌症有关的疾病或病症。
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