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公开(公告)号：US20120109537A1
公开(公告)日：2012-05-03
申请号：US13278015
申请日：2011-10-20
Applicant: Alexander Alekseevich MAKAROV
Inventor： Alexander Alekseevich MAKAROV
IPC: G06F19/00
CPC classification number: H01J49/0036 , G06F19/70 , H01J49/027 , H01J49/38
Abstract: A method is disclosed for generating a mass spectrum, e.g. for Fourier transform mass spectrometry, having improved resolving power. The method includes steps of acquiring a plurality of mass spectra from a mass spectrometer using image current detection determining the centroids of at least some of the peaks which have a sufficient signal-to-noise (S/N) ratio so that the variation of the centroid of each such peak from the plurality of mass spectra is significantly lower than the full-width at half-maximum, dM, of the peak in the m/z domain; and generating a histogram of the centroids determined from the plurality of acquired mass spectra thereby forming a composite mass spectrum. The resultant composite mass spectrum comprises peaks having full-width at half-maximum, dMC, significantly narrower than the peak width, dM, of the corresponding peaks in the plurality of acquired mass spectra.
Abstract translation: 公开了用于产生质谱的方法，例如 用于傅立叶变换质谱，具有改进的分辨能力。 该方法包括以下步骤：使用图像电流检测从质谱仪获取多个质谱，确定具有足够的信噪比（S / N）比的至少一些峰的质心，使得 来自多个质谱的每个这样的峰的质心显着低于m / z域中的峰的半峰最大值dM的全宽; 以及生成由所述多个获取的质谱确定的质心的直方图，从而形成复合质谱。 所得到的复合质谱包括半峰全宽，dMC，比多个获取质谱中相应峰的峰宽dM明显窄的峰。
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公开(公告)号：US07888633B2
公开(公告)日：2011-02-15
申请号：US12037506
申请日：2008-02-26
Applicant: Jochen Franzen , Karsten Michelmann
Inventor： Jochen Franzen , Karsten Michelmann
IPC: B01D59/44
CPC classification number: H01J49/42 , H01J49/0036 , H01J49/027
Abstract: The invention relates to mass spectrometers in which ion clouds are stored in two spatial directions by radial forces while oscillating largely harmonically at a mass-specific frequency in a third spatial direction perpendicular to the other two, in a potential minimum, the shape of which is as close to a parabola as possible. Analysis of the oscillation frequencies of these ion clouds, preferably by a Fourier analysis, leads via a frequency spectrum to a mass spectrum. The frequency spectrum is analyzed to identify false signals in the frequency spectrum as harmonics and eliminating them where necessary.
Abstract translation: 本发明涉及质谱仪，其中离子云通过径向力在两个空间方向上存储，同时以与另外两个垂直的第三空间方向上的质量特定频率大量谐波地振荡，其形状为 尽可能接近抛物线。 这些离子云的振荡频率的分析优选通过傅立叶分析，经由频谱到达质谱。 分析频谱以将频谱中的伪信号作为谐波识别，并在必要时消除它们。
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公开(公告)号：US07615766B2
公开(公告)日：2009-11-10
申请号：US11723347
申请日：2007-03-19
Applicant: Masaki Nakano
Inventor： Masaki Nakano
IPC: G01J1/18
CPC classification number: H01J49/162 , H01J49/027 , H01J49/16 , H05G2/001
Abstract: A target supplier accelerates a target material injected from a nozzle such that a velocity of the target material after accelerated is kept within a predetermined range. The target supplier includes: a target nozzle that injects a target material in a liquid droplet state or solid particle state; an electric charge supplying unit that supplies electric charge to the target material; a charge amount measuring unit that measures an amount of the electric charge supplied to the target material by the electric charge supplying unit; a control unit that controls the electric charge supplying unit in a feedback manner based on a measurement result obtained by the charge amount measuring unit; and an accelerator that accelerates the target material supplied with the electric charge by the electric charge supplying unit.
Abstract translation: 目标供应商加速从喷嘴喷射的目标材料，使得加速后的目标材料的速度保持在预定范围内。 目标供应商包括：将目标材料注入液滴状态或固体颗粒状态的目标喷嘴; 向目标材料供给电荷的电荷供给单元; 电荷量测量单元，其测量由所述电荷供应单元供应到所述目标材料的电荷的量; 控制单元，其基于由所述计费量测量单元获得的测量结果以反馈方式控制所述电荷供给单元; 以及加速器，其加速由电荷供给单元供给的电荷的目标材料。
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公开(公告)号：US07078679B2
公开(公告)日：2006-07-18
申请号：US10723462
申请日：2003-11-26
Applicant: Michael S. Westphall , Lloyd M. Smith
Inventor： Michael S. Westphall , Lloyd M. Smith
CPC classification number: H01J49/06 , H01J49/027
Abstract: The invention provides devices, device configurations and methods for improved sensitivity, resolution and efficiency in mass spectrometry, particularly as applied to biological molecules, including biological polymers, such as proteins and nucleic acids. More particularly, the invention provides methods and devices for analyzing and detecting electrically charged particles, especially suitable for gas phase ions generated from high molecular weight compounds. In one aspect, the invention provides devices and methods for determining the velocity, charged state or both of electrically charged particles and packets of electrically charged particles. In another aspect, the invention provides methods and devices for the time-of-flight analysis of electrically charged particles comprising spatially collimated sources. In another aspect, the invention relates to multiple detection using inductive detectors, improved methods of signal averaging and charged particle detection in coincidence.
Abstract translation: 本发明提供了用于提高质谱法的灵敏度，分辨率和效率的装置，装置配置和方法，特别是适用于包括生物聚合物如蛋白质和核酸在内的生物分子。 更具体地，本发明提供用于分析和检测带电粒子的方法和装置，特别适用于由高分子量化合物产生的气相离子。 一方面，本发明提供用于确定带电粒子和带电粒子的包的速度，带电状态或两者的装置和方法。 在另一方面，本发明提供了用于包括空间准直源的带电粒子的飞行时间分析的方法和装置。 另一方面，本发明涉及使用感应检测器的多重检测，符合信号平均和带电粒子检测的改进方法。
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公开(公告)号：US5880466A
公开(公告)日：1999-03-09
申请号：US869282
申请日：1997-06-02
Applicant: W. Henry Benner
Inventor： W. Henry Benner
CPC classification number: H01J49/4245 , H01J49/027 , H01J49/04
Abstract: The design and operation of a new type of charged-particle trap provides simultaneous measurements of mass, charge, and velocity of large electrospray ions. The trap consists of a detector tube mounted between two sets of center-bored trapping plates. Voltages applied to the trapping plates define symmetrically-opposing potential valleys which guide axially-injected ions to cycle back and forth through the charge-detection tube. A low noise charge-sensitive amplifier, connected to the tube, reproduces the image charge of individual ions as they pass through the detector tube. Ion mass is calculated from measurement of ion charge and velocity following each passage through the detector.
Abstract translation: 新型带电粒子陷阱的设计和操作可以同时测量大型电喷雾离子的质量，电荷和速度。 陷阱由安装在两组中心钻孔捕集板之间的探测器管组成。 施加到捕获板的电压限定对称的相对的电位谷，其引导轴向注入的离子来循环通过电荷检测管。 连接到管的低噪声电荷敏感放大器在通过检测器管时再现各离子的图像电荷。 每次通过检测器后，离子电荷和速度的测量计算出离子质量。
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Patent Agency Ranking
公开(公告)号：US20240290597A1
公开(公告)日：2024-08-29
申请号：US18567194
申请日：2021-06-15
Applicant: SHIMADZU CORPORATION
Inventor： Sergey SMIRNOV , Li DING , Aleksandr RUSINOV
CPC classification number: H01J49/0036 , H01J49/0004 , H01J49/027 , H01J49/425
Abstract: A method of processing an image-charge/current signal representative of one or more ions undergoing oscillatory motion within an ion analyser apparatus, the method comprising obtaining a recording of the image-charge/current signal generated by the ion analyser apparatus in the time domain. By a signal processing unit, the method includes selecting N (where N is an integer>1) separate values (OPn, where n=1 to N; N≥M) of the frequency-domain spectrum of the image-charge/current signal each from amongst a plurality of spectral peaks which include a harmonic peak associated with a target ion. By solving a system of equations:
OP
n
=
∑
m
=
1
N
α
n
m
×
TP
m
,
for
n
=
1
to
N
;
N
≥
M
where αnm are coefficients and TPm are corrected values of the spectrum, the charge of the target ion is determined based on a magnitude of a corrected value(s) (TPm) associated with that ion.-
公开(公告)号：US20240136167A1
公开(公告)日：2024-04-25
申请号：US18554024
申请日：2022-04-07
Applicant: HGSG LTD
Inventor： John Brian HOYES
CPC classification number: H01J49/027 , H01J49/0045 , H01J49/4245 , H01J49/067
Abstract: A charge detection mass spectrometer, CDMS, is described. The CDMS comprises: an electrostatic sector field ion trap and an inductive charge detector, wherein the electrostatic sector field ion trap is configured to define, at least in part, an ion path via the inductive charge detector; and a fragmentation device. A method is also described.
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公开(公告)号：US11742192B2
公开(公告)日：2023-08-29
申请号：US16573686
申请日：2019-09-17
Applicant: LECO Corporation
Inventor： Anatoly N. Verenchikov
CPC classification number: H01J49/0031 , H01J49/06 , H01J49/4245 , H05K3/027 , H01J49/027 , H01J49/406 , H01J49/4205 , H01J49/4255 , H05K2201/0154 , H05K2203/092 , H05K2203/095
Abstract: A method of mass spectral analysis in an analytical electrostatic trap (14) is disclosed. The electrostatic trap (14) defines an electrostatic field volume and includes trap electrodes having static and non-ramped potentials. The method comprises injecting a continuous ion beam into the electrostatic field volume.
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公开(公告)号：US20170032950A1
公开(公告)日：2017-02-02
申请号：US15303226
申请日：2015-04-14
Inventor： Yury Tsybin , Anton Kozhinov , Konstantin Nagornov
CPC classification number: H01J49/38 , H01J49/0031 , H01J49/027
Abstract: The present invention relates to a method and device for measuring m/z ratios of ions in ion cyclotron resonance (ICR) mass spectrometry. The described ion traps for ICR mass spectrometry are distinct from the previous configurations by having one or many narrow aperture (flat) detection electrodes that could be moved radially inward the ICR trap, for example on the plane where radiofrequency excitation potential is minimal, closer to the post-excitation ion trajectories.
Abstract translation: 本发明涉及一种用于测量离子回旋共振（ICR）质谱中离子的m / z比的方法和装置。 所描述的用于ICR质谱的离子阱不同于先前的配置，通过具有一个或许多窄孔径（平坦的）检测电极，其可以在ICR陷阱的径向向内移动，例如在射频激发电位最小的平面上，更接近 后激发离子轨迹。
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公开(公告)号：US20160104609A1
公开(公告)日：2016-04-14
申请号：US14877593
申请日：2015-10-07
Applicant: SHIMADZU CORPORATION
Inventor： Li DING , Mikhail SUDAKOV , Sumio KUMASHIRO
CPC classification number: H01J49/027 , H01J49/0031 , H01J49/061 , H01J49/406 , H01J49/408 , H01J49/4245
Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.
Abstract translation: 用于质量分析的静电离子阱包括第一电极阵列和与第一电极阵列间隔开的第二电极阵列。 第一和第二电极阵列可以是由平行条形电极或同心圆形或部分圆形导电环形成的平面阵列。 阵列的电极被提供有基本上相同的电压模式，由此阵列之间的空间中的电位分布使得在飞行方向上等离子地反射离子，使得它们在空间中经历周期性的振荡运动 基本上位于阵列之间。 放大器电路用于检测具有与经历周期性振荡运动的离子的质荷比相关的频率分量的图像电流。
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