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公开(公告)号：US20210147913A1
公开(公告)日：2021-05-20
申请号：US17000209
申请日：2020-08-21
发明人： Mansour Samadpour
IPC分类号： C12Q1/689 , C12Q1/04 , G01N33/569 , C12Q1/06 , C12Q1/70
摘要： Aspects of the present invention provide novel multi-targeted microbiological screening and monitoring methods having substantial utility for monitoring and control of microbial growth and contaminants, microbiological processes, predictive microbiology, and for exposure and risk assessment. Microbial markers shared by both target and index microbes are used in novel methods for microbial monitoring, monitoring of microbial performance potential, trend analysis, and statistical process control (SPC) in processes or systems that are receptive to a plurality of genetically distinct microbes.
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公开(公告)号：US20210116373A1
公开(公告)日：2021-04-22
申请号：US16629326
申请日：2018-04-10
摘要： A sample observation device includes an imaging unit that images observation light generated due to irradiation with the planar light that is transmitted through a membrane filter and outputs fluorescent light image data, a partial image generation unit that specifies a first area corresponding to a first sample holding space and a second area corresponding to a second sample holding space in the fluorescent light image data, and generates first partial image data corresponding to the first area and second partial image data corresponding to the second area, an observation image generation unit that generates first observation image data and second observation image data on the basis of the partial image data, and an analysis unit that analyzes a sample on the basis of the first observation image data and the second observation image data.
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公开(公告)号：US20210109099A1
公开(公告)日：2021-04-15
申请号：US17075520
申请日：2020-10-20
申请人： Genentech, Inc.
发明人： Felix CHU , Oded FOREMAN , James ZIAI
IPC分类号： G01N33/569 , G01N33/574 , A61K38/17 , C07K16/28 , C12Q1/06 , G01N33/58
摘要： The present disclosure provides methods for measuring the number of CD4+ OX40+ Foxp3+ lymphocytes in a sample containing cancer cells and lymphocytes obtained from a subject by labeling lymphocytes that show CD4 expression in the sample, then labeling lymphocytes that show OX40 expression in the sample, then labeling lymphocytes that show Foxp3 expression in the sample, then measuring the number of CD4+ OX40+ Foxp3+ lymphocytes in the sample. Further provided are methods for determining the prognosis of a subject, predicting responsiveness of a subject having cancer to an OX40 agonist treatment, and methods for treating or delaying progression of cancer based on the number of CD4+ OX40+ Foxp3+ lymphocytes in a sample.
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公开(公告)号：US10920261B2
公开(公告)日：2021-02-16
申请号：US14882742
申请日：2015-10-14
摘要： Provided herein are methods of culturing a microorganism. The method includes providing a container comprising one or more microorganisms and medium, wherein the microorganisms and medium form a start volume. The microorganisms and medium are cultured until the culture reaches a threshold indicator, wherein culturing comprises feeding one or more carbon sources to the culture and wherein the culture is at a threshold volume when the threshold indicator is reached. The method also includes harvesting a portion of the threshold volume to leave a residual volume that is 40% or less of the start volume and adding fresh medium to the container in an amount to return the volume of the culture to the start volume.
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公开(公告)号：US20200347431A1
公开(公告)日：2020-11-05
申请号：US16763902
申请日：2018-11-14
申请人： Chapman University
IPC分类号： C12Q1/06 , G01N33/569
摘要： A rapid assay for determining the presence of bacteria in a sample, such as a contaminated food sample, is disclosed. The assay comprises contacting the sample with a bacteria-specific ligand associated with a substrate, wherein bacteria present in the sample bind the ligand; contacting the bound bacteria with a detection agent; detecting the presence of bacteria in the sample by measuring the quantity of detection agent associated with the sample.
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公开(公告)号：US20200319180A1
公开(公告)日：2020-10-08
申请号：US16906669
申请日：2020-06-19
IPC分类号： G01N33/566 , C12Q1/02 , G01N33/74 , G01N33/50 , C12Q1/00 , C12Q1/06 , G01N33/569
摘要： The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.
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公开(公告)号：US20200263121A1
公开(公告)日：2020-08-20
申请号：US16651357
申请日：2018-06-04
申请人： JNC CORPORATION
发明人： Hajime TERAMURA , Aoi FUJIWARA
摘要： Provided is a method for simply and accurately counting the number of microorganisms in an analyte containing carbonate ion or bicarbonate ion in a dialysis fluid or the like. A counting method for the number of microorganisms includes: a step of adding the analyte to a composition for preparing a medium for counting the number of microorganisms, and containing (a) polyacrylic acid and/or a salt thereof, (b) hydroxide of alkaline earth metal and (c) a nutritional ingredient, and mixing the resulting mixture; a step of culturing microorganisms contained in the analyte; and a step of counting the number of colonies of the microorganisms.
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48.发明授权公开(公告)号：US10738343B2
公开(公告)日：2020-08-11
申请号：US16250466
申请日：2019-01-17
申请人： The Trustees of Indiana University , The United States Government as represented by the Department of Veterans Affairs
摘要： Methods and compositions are provided for detecting and/or determining a patient's risk of developing hyperglycemia or type 1 diabetes. The methods are directed to analyzing the miRNA content of extracellular vesicles recovered from said patient.
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公开(公告)号：US10725036B2
公开(公告)日：2020-07-28
申请号：US15596837
申请日：2017-05-16
IPC分类号： G01N33/566 , C12Q1/02 , C12Q1/00 , C12Q1/06 , G01N33/569 , G01N33/74 , G01N33/50
摘要： The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.
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公开(公告)号：US20200224240A1
公开(公告)日：2020-07-16
申请号：US16797249
申请日：2020-02-21
申请人： NCH Corporation
IPC分类号： C12Q1/06
摘要： A system and method for monitoring or detecting a level of biofilm growth in a fluid system and controlling operating parameters of the fluid system based a measured level of growth. The monitoring system and method comprises a dye injection system for periodically injecting dye into a portion of fluid from the fluid system, passing the portion of fluid though a narrow lumen tube to achieve laminar flow and using a light source and optical sensor to detect a transmission or emission indicating a level of biofilm growth in the tube corresponding to a level of growth on components in the fluid system. Information based upon the measurements or calculations made by the monitoring system may be used to manually or automatically alter various operating parameters to control the fluid system and aid in maintaining stable operation of the fluid system within preferred specifications.
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