公开(公告)号：US20230194482A1

公开(公告)日：2023-06-22

申请号：US17557698

申请日：2021-12-21

申请人： DIONEX CORPORATION

发明人： Brandon Howard Robson ,  Xuefei Sun ,  Carla Marie Medlin ,  Shane Bechler

IPC分类号： G01N30/72 ,  G01N30/60 ,  H01J49/16 ,  H01J49/04

CPC分类号： G01N30/7266 ,  G01N30/6047 ,  G01N30/6004 ,  H01J49/167 ,  H01J49/0445

摘要： An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.

公开(公告)号：US20230162961A1

公开(公告)日：2023-05-25

申请号：US17919951

申请日：2020-04-24

申请人： SHIMADZU CORPORATION

发明人： Yohei TOJI

IPC分类号： H01J49/04 ,  H01J49/16

CPC分类号： H01J49/045 ,  H01J49/167 ,  H01J49/0468

摘要： An ionizer including: an ionization chamber 2; a sample nozzle 60 configured to cause a liquid sample to flow out into the ionization chamber 2; an assist gas passage 61 configured to supply, to the ionization chamber 2, an assist gas that promotes desolvation of the liquid sample; a heater 62 disposed inside the assist gas passage 61; and a heat transfer member 64 disposed in the assist gas passage 61 in contact with the heater 62. The heat transfer member 64 can be disposed, for example, inside the heater 62 including a spirally wound heater wire and between the heater 62 and an inner wall surface of the assist gas passage 61.

公开(公告)号：US20230154740A1

公开(公告)日：2023-05-18

申请号：US17916929

申请日：2021-03-26

申请人： Micromass UK Limited

发明人： Emrys Jones ,  Richard Denny ,  Emmy Hoyes ,  Keith George Richardson

IPC分类号： H01J49/16 ,  H01J49/00

CPC分类号： H01J49/165 ,  H01J49/0036 ,  H01J49/0004 ,  H01J49/0045 ,  H01J49/164 ,  H01J49/0031

摘要： A method of analysing a sample comprises analysing a sample in a first mode of operation so as to produce a spatially resolved data set representative of the sample, and analysing the data set so as to identify one or more regions of the sample. For each of one or more identified regions of the sample, a tandem mass spectrometry (MS/MS) data set is produced for that region by determining a path through the region, and analysing the sample along the path using Desorption Electrospray Ionisation (“DESI”) in a tandem mass spectrometry (MS/MS) mode of operation.

公开(公告)号：US11651945B2

公开(公告)日：2023-05-16

申请号：US17480094

申请日：2021-09-20

申请人： UT-Battelle, LLC

发明人： Vilmos Kertesz ,  John F. Cahill

IPC分类号： H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  H01J49/14 ,  H01J49/10

CPC分类号： H01J49/0445 ,  H01J49/0031 ,  H01J49/105 ,  H01J49/145 ,  H01J49/161 ,  H01J49/165

摘要： A system for the mass spectrometry analysis of an analyte includes a droplet ejection device, a spray head comprising a spray tip for ejecting the solvent as a spray, and a solvent delivery conduit for delivering solvent to the spray tip. The spray head includes a droplet inlet opening communicating with the surrounding atmosphere for receiving liquid droplets comprising the analyte. The droplet ejection device selectively ejects a liquid analyte droplet comprising the analyte through a surrounding atmosphere and the droplet inlet opening into a solvent flowing through the solvent delivery conduit. A method for the mass spectrometry analysis of an analyte is also disclosed.

公开(公告)号：US11635415B2

公开(公告)日：2023-04-25

申请号：US17395909

申请日：2021-08-06

申请人： Purdue Research Foundation

发明人： Robert Graham Cooks ,  Zheng Ouyang

IPC分类号： H01J49/00 ,  G01N30/95 ,  H01J49/16 ,  H01J49/04 ,  G01N30/91 ,  G01N33/49

摘要： The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

公开(公告)号：US11635407B2

公开(公告)日：2023-04-25

申请号：US16983265

申请日：2020-08-03

申请人： The University of North Carolina at Chapel Hill

发明人： John Scott Mellors ,  Erin Anne Redman ,  John Michael Ramsey

IPC分类号： G01N27/447 ,  H01J49/16 ,  G01N30/16 ,  B01L3/00 ,  G01N30/72 ,  B05B5/00

摘要： Methods, systems and devices that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer.

公开(公告)号：US11610767B2

公开(公告)日：2023-03-21

申请号：US17345070

申请日：2021-06-11

申请人： PHARMACADENCE ANALYTICAL SERVICES, LLC

发明人： Richard C. King, III ,  William J. Metzler, IV

IPC分类号： H01J49/00 ,  G01N27/623 ,  H01J49/02 ,  H01J49/16 ,  H01J49/30 ,  G01R19/00 ,  H01J49/10

摘要： The present invention comprises novel methods of continuously monitoring the performance of an atmospheric pressure ionization (API) system. The methods of the invention allow for improved quality monitoring of the processes that leads to the formation of ions at atmospheric pressure. The methods of the invention further allow for continuously monitoring for the quality of the ion formation process in API without the addition of extraneous material (such as labelled compounds or control known compounds) to the system being monitored.

公开(公告)号：US11600481B2

公开(公告)日：2023-03-07

申请号：US16927936

申请日：2020-07-13

申请人： West Virginia University

发明人： Peng Li ,  Xiaojun Li ,  Stephen J. Valentine ,  Lisa Holland

IPC分类号： H01J49/16 ,  H01J49/00

摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to a vibrating sharp edge spray ionization (VSSI) method suitable for coupling with a mass spectrometer, a VSSI method modified with a capillary suitable for use with continuous-flow separation methods such as liquid chromatography, and a VSSI method suitable for coupling with a capillary electrophoresis (CE) device in order to introduce the CE sample flow into a mass spectrometer. Also disclosed herein are devices for carrying out these methods and methods of making the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20230050396A1

公开(公告)日：2023-02-16

申请号：US17975104

申请日：2022-10-27

申请人： MS Pen Technologies, Incorporated ,  Board of Regents, The University of Texas System

发明人： Livia Schiavinato Eberlin ,  Shannon D. Green ,  Kyana Garza ,  Sydney Cordano Povilaitis ,  Michael Keating ,  Jialing Zhang ,  James Suliburk

IPC分类号： H01J49/04 ,  G01N33/483 ,  H01J49/00 ,  H01J49/16

摘要： In a general aspect, a swab sample is analyzed, for example, to test for disease. In some examples, a swab head of a swab sample is inserted through an opening into an internal reservoir of a sampling device. The sampling device includes the opening, an inlet channel, an outlet channel, and the internal reservoir. The internal reservoir is in fluid communication with the inlet channel, the outlet channel, and the opening. A liquid solvent is supplied to the swab head in the internal reservoir via the inlet channel of the sampling device. The swab head is held in the liquid solvent for a period of time to form an analyte in the internal reservoir. The analyte is extracted from the internal reservoir via the outlet channel of the sampling device. The analyte is transferred to and processed by a mass spectrometer to obtain mass spectrometry data.

公开(公告)号：US11581178B2

公开(公告)日：2023-02-14

申请号：US17453683

申请日：2021-11-05

申请人： Roche Diagnostics Operations, Inc.

发明人： Robert Lang ,  Stefan Quint ,  Gabriele Punzmann

IPC分类号： H01J49/00 ,  H01J49/04 ,  G01N30/72 ,  H01J49/02 ,  H01J49/16

摘要： A mass spectrometry (MS) apparatus is provided. The MS apparatus includes a mass spectrometer, an ionization source coupled to the mass spectrometer, and a flow injection system (FIS) coupled to the ionization source. The ionization source is configured to provide an ionized gas flow of an analyte towards an entrance of the mass spectrometer. The ionization source is further configured to provide a second gas flow of a second gas. The MS apparatus is configured to measure a mass spectrometer (MS) signal of the analyte. The MS apparatus is further configured to analyze a dependency of the MS signal of the analyte versus a parameter of the second gas flow or a state of the second gas flow and to determine a condition of the apparatus based on the analyzed dependency.