公开(公告)号：US20140187442A1

公开(公告)日：2014-07-03

申请号：US14134754

申请日：2013-12-19

Applicant: Larry A. Sklar ,  Bruce Edwards ,  Frederick Kuckuck

Inventor： Larry A. Sklar ,  Bruce Edwards ,  Frederick Kuckuck

IPC: G01N21/64

CPC classification number: G01N15/1436 ,  B01L3/5085 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6428 ,  G01N21/6486 ,  G01N35/0099 ,  G01N35/085 ,  G01N35/1095 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1413 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2201/06113 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.

Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流动流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析用于颗粒的多个样品中的每一个的装置。 本发明还提供了使用这种装置的流式细胞术方法。

公开(公告)号：US20140170130A1

公开(公告)日：2014-06-19

申请号：US13823856

申请日：2011-09-15

Applicant: Surojit Paul

Inventor： Surojit Paul

IPC: C12N9/16

CPC classification number: C12N9/16 ,  A61K38/00 ,  A61K38/465 ,  C12Y301/03048

Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and/or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.

Abstract translation: 显示和描述了作为神经元特异性酪氨酸磷酸酶的修饰衍生物的新型肽序列。 具体来说，新肽序列是纹状体富含酪氨酸磷酸酶的修饰衍生物（STEP）。 肽序列已被修饰，以便能够改善和治疗由过量的谷氨酸释放和/或氧化应激引起的脑损伤。 目前公开的肽序列可用于治疗的脑损伤类型的实例包括由中风或创伤性脑损伤引起的急性脑损伤和慢性疾病如亨廷顿氏舞蹈症和精神分裂症。 此外，目前描述的肽序列还可用于治疗和改善与恐惧记忆相关的疾病，例如创伤后应激障碍。

公开(公告)号：US08712180B2

公开(公告)日：2014-04-29

申请号：US13980230

申请日：2012-01-17

Applicant: Pradeep Sen ,  Aliakbar Darabi

Inventor： Pradeep Sen ,  Aliakbar Darabi

IPC: G06K9/40 ,  G06T5/00

CPC classification number: G06T5/001 ,  G06T5/00 ,  G06T5/50 ,  G06T15/503 ,  G06T2200/12 ,  G06T2207/20221

Abstract: The invention produces a higher quality image from a rendering system based on a relationship between the output of a rendering system and the parameters used to compute them. Specifically, noise is removed in rendering by estimating the functional dependency between sample features and the random inputs to the system. Mutual information is applied to a local neighborhood of samples in each part of the image. This dependency is then used to reduce the importance of certain scene features in a cross-bilateral filter, which preserves scene detail. The results produced by the invention are computed in a few minutes thereby making it reasonably robust for use in production environments.

Abstract translation: 本发明基于渲染系统的输出与用于计算它们的参数之间的关系从渲染系统产生更高质量的图像。 具体来说，通过估计样本特征与系统的随机输入之间的功能依赖性，在渲染中消除噪声。 相互信息被应用于图像的每个部分中的样本的局部邻域。 然后，这种依赖关系用于减少跨双边筛选器中某些场景特征的重要性，这保留了场景细节。 本发明产生的结果在几分钟内计算，从而使其在生产环境中的使用相当稳健。

公开(公告)号：US08709791B2

公开(公告)日：2014-04-29

申请号：US12069284

申请日：2008-02-08

Applicant: Richard S Larson ,  Brian Hjelle ,  Pam R Hall ,  David C Brown ,  Marco Bisoffi ,  Susan M Brozik ,  Darren W Branch ,  Thayne L Edwards ,  David Wheeler

Inventor： Richard S Larson ,  Brian Hjelle ,  Pam R Hall ,  David C Brown ,  Marco Bisoffi ,  Susan M Brozik ,  Darren W Branch ,  Thayne L Edwards ,  David Wheeler

IPC: G01N33/543

CPC classification number: G01N33/54373 ,  C12Q1/6825 ,  G01N29/032 ,  G01N33/553 ,  G01N2291/0422

Abstract: A biosensor combining the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In a preferred embodiment, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV). Rapid detection of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, and the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1 The biosensor was able to delect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS).

Abstract translation: 将在325MHz频率产生的表面声波（SAW）的灵敏度与由抗体和其他配体提供的特异性检测病毒剂的灵敏度组合的生物传感器。 在优选实施例中，使用具有三个测试和一个参考延迟线的具有二氧化硅波导传感器平台的基于钽酸锂的SAW换能器来吸附针对柯萨奇病毒B4或负链A类生物剂Sin Nombre病毒（SNV）的抗体。 病毒颗粒增加浓度的快速检测在两种病毒的数量级范围内是线性的，并且传感器对其靶标的选择性没有被混合的单纯疱疹病毒1型的存在所影响。生物传感器能够以剂量剔除SNV 低于患有汉坦病毒心肺综合征（HCPS）的人类患者中通常发现的病毒的负载。

公开(公告)号：US08663742B2

公开(公告)日：2014-03-04

申请号：US13121150

申请日：2009-06-30

Applicant: David J. Kissel ,  Charles Jeffrey Brinker

Inventor： David J. Kissel ,  Charles Jeffrey Brinker

IPC: B05D5/00

CPC classification number: C09D7/1225 ,  A01N55/00 ,  C08K3/36 ,  C08K9/06 ,  C09D5/006 ,  C09D5/14 ,  C09D5/165 ,  C09D5/1681 ,  C09D7/62 ,  C09D133/12 ,  D06N3/0043 ,  D06N3/0063 ,  D10B2401/10 ,  D10B2401/13 ,  Y10T428/249953 ,  Y10T428/249972 ,  Y10T428/24999 ,  Y10T428/249991 ,  Y10T442/20

Abstract: Provided are polymer-aerogel composite coatings, devices and articles including polymer-aerogel composite coatings, and methods for preparing the polymer-aerogel composite. The exemplary article can include a surface, wherein the surface includes at least one region and a polymer-aerogel composite coating disposed over the at least one region, wherein the polymer-aerogel composite coating has a water contact angle of at least about 140° and a contact angle hysteresis of less than about 1°. The polymer-aerogel composite coating can include a polymer and an ultra high water content catalyzed polysilicate aerogel, the polysilicate aerogel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.

Abstract translation: 提供聚合物 - 气凝胶复合涂层，装置和制品，包括聚合物 - 气凝胶复合涂层，以及制备聚合物 - 气凝胶复合材料的方法。 示例性制品可以包括表面，其中表面包括至少一个区域和设置在至少一个区域上的聚合物 - 气凝胶复合涂层，其中聚合物 - 气凝胶复合涂层具有至少约140°的水接触角和 接触角滞后小于约1°。 聚合物 - 气凝胶复合涂层可以包括聚合物和超高含水量催化的聚硅酸盐气凝胶，所述聚硅酸盐气凝胶包括具有由甲硅烷基化剂衍生的表面官能团和多个孔的二氧化硅颗粒的三维网络。

公开(公告)号：US08654923B2

公开(公告)日：2014-02-18

申请号：US12990338

申请日：2009-05-04

Applicant: Shuang Luan ,  Nathan Swanson ,  Lijun Ma

Inventor： Shuang Luan ,  Nathan Swanson ,  Lijun Ma

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61B34/10 ,  A61B90/10 ,  A61B2090/101 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1084

Abstract: The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of “dose-painting” to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical “paintbrush”, and treatment planning is reduced to finding the best route of this “paintbrush” to “paint” a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

Abstract translation: 本发明是基于“剂量绘画”的概念，利用伽玛刀C和Perfexion单元上的机器人患者定位系统开发伽玛刀放射外科手术的动态方案和系统。 由伽玛刀单元创建的球形高剂量体积将被视为3D球形“画笔”，并且减少治疗计划以找到该“画笔”最佳路线来“绘制”3D肿瘤体积。 在剂量绘画概念下，伽玛刀放射外科手术变得动态，病人在机器人定位系统下连续移动。

公开(公告)号：US08649607B1

公开(公告)日：2014-02-11

申请号：US13013744

申请日：2011-01-25

Applicant: Majeed M. Hayat ,  Sanjay Krishna ,  Biliana Stefanova Paskaleva

Inventor： Majeed M. Hayat ,  Sanjay Krishna ,  Biliana Stefanova Paskaleva

IPC: G06K9/00 ,  G06K9/46

CPC classification number: G06K9/6289 ,  G06T7/12 ,  G06T2207/10036 ,  G06T2207/30184

Abstract: Apparatus, systems, and methods integrating spectral information with spatial feature extraction of image data, providing simultaneous spatial and spectral feature selection of the image data, can be used in a variety of applications. In various embodiments, an edge signature for the edge between two materials can be defined using ratios of identified spectral bands, where the edge signature can be combined with a spatial mask to obtain a joint spatio-spectral mask. Additional apparatus, systems, and methods are disclosed.

Abstract translation: 将光谱信息与图像数据的空间特征提取集成在一起的设备，系统和方法，可提供图像数据的同时空间和光谱特征选择，可用于各种应用。 在各种实施例中，可以使用所识别的光谱带的比率来定义两个材料之间的边缘的边缘签名，其中边缘签名可以与空间掩码组合以获得联合空间 - 频谱掩模。 公开了附加装置，系统和方法。

公开(公告)号：US08623470B2

公开(公告)日：2014-01-07

申请号：US12143398

申请日：2008-06-20

Applicant: Claudia Luhrs ,  Jonathan Phillips ,  Monique N. Richard

Inventor： Claudia Luhrs ,  Jonathan Phillips ,  Monique N. Richard

IPC: H05H1/24 ,  B05D7/00

CPC classification number: B22F9/12 ,  B01J2/006 ,  B01J2/04 ,  B01J13/04 ,  B22F1/02 ,  B22F2999/00 ,  B22F2202/13

Abstract: Disclosed is a process for making a composite material that contains core-shell structured nanoparticles. The process includes providing a precursor in the form of a powder a liquid and/or a vapor of a liquid that contains a core material and a shell material, and suspending the precursor in an aerosol gas to produce an aerosol containing the precursor. In addition, the process includes providing a plasma that has a hot zone and passing the aerosol through the hot zone of the plasma. As the aerosol passes through the hot zone of the plasma, at least part of the core material and at least part of the shell material in the aerosol is vaporized. Vapor that contains the core material and the shell material that has been vaporized is removed from the hot zone of the plasma and allowed to condense into core-shell structured nanoparticles.

Abstract translation: 公开了一种制备包含核 - 壳结构纳米颗粒的复合材料的方法。 该方法包括提供粉末形式的前体，液体和/或含有芯材料和壳材料的液体蒸气，并将前体悬浮在气溶胶气体中以产生含有前体的气溶胶。 此外，该方法包括提供具有热区并使气溶胶通过等离子体的热区的等离子体。 当气溶胶通过等离子体的热区时，核心材料的至少一部分和气溶胶中的壳材料的至少一部分被蒸发。 含有已被蒸发的芯材料和壳材料的蒸气从等离子体的热区中除去并使其冷凝成核 - 壳结构的纳米颗粒。

公开(公告)号：US08598053B2

公开(公告)日：2013-12-03

申请号：US13503067

申请日：2010-10-12

Applicant: David G. Whitten ,  Linnea K. Ista ,  Thomas S. Corbitt ,  Motokatsu Ogawa ,  Kirk S. Schanze ,  Gabriel P. Lopez ,  Ramanathan Nagarajan

Inventor： David G. Whitten ,  Linnea K. Ista ,  Thomas S. Corbitt ,  Motokatsu Ogawa ,  Kirk S. Schanze ,  Gabriel P. Lopez ,  Ramanathan Nagarajan

IPC: B32B5/02

CPC classification number: A01N43/90 ,  D06M13/513 ,  D06M14/02 ,  D06M14/04 ,  D06M14/06 ,  D06M14/08 ,  D06M15/227 ,  D06M16/00 ,  D06M23/005 ,  D06M2400/01 ,  Y10T442/20 ,  Y10T442/2525 ,  A01N25/10 ,  A01N25/34

Abstract: The present disclosure describes the manufacture and use of soft surfaces such as fabrics bearing surface-grafted antimicrobial polymers.

Abstract translation: 本公开描述了软表面的制造和使用，例如带有表面接枝的抗微生物聚合物的织物。

公开(公告)号：US20130299720A1

公开(公告)日：2013-11-14

申请号：US13986039

申请日：2013-03-26

Applicant: Marek A. Osinski ,  Nathan J. Withers ,  Brian A. Akins ,  Gennady A. Smolyakov ,  Krishnaprasad Sankar

Inventor： Marek A. Osinski ,  Nathan J. Withers ,  Brian A. Akins ,  Gennady A. Smolyakov ,  Krishnaprasad Sankar

IPC: C09K11/77 ,  G01T1/20

CPC classification number: C09K11/7773 ,  C09K11/664 ,  C09K11/7772 ,  G01T1/20 ,  G01T1/202 ,  Y10T428/256 ,  Y10T428/2982

Abstract: A heterogeneous scintillator material is provided comprising core/shell nanoparticles having a highly hygroscopic or deliquescent halide-based core activated with trivalent Ln3+ or divalent Ln2+ lanthanide ions (Ln=La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) and a stable non-hygroscopic shell thereon. The heterogeneous nanoparticles can comprise highly hygroscopic lanthanide halide (LaBr3, LuI3) cores protected with stable non-hygroscopic LaF3 shells. The heterogeneous nanoparticles can comprise deliquescent alkaline earth halide (SrI2, BaI2) cores protected with stable non-hygroscopic (SrF2, BaF2) shells.

Abstract translation: 提供了一种异质闪烁体材料，其包括具有由三价Ln3 +或二价Ln2 +镧系元素离子（Ln = La，Ce，Pr，Nd，Pm，Sm，Eu，Gd，Tb）活化的高吸湿性或潮解性卤化物基核心的核/壳纳米颗粒 ，Dy，Ho，Er，Tm，Yb，Lu）和稳定的非吸湿性外壳。 非均相纳米颗粒可以包含用稳定的非吸湿性LaF 3壳保护的高吸湿性镧系元素卤化物（LaBr 3，LuI 3）。 非均相纳米颗粒可以包含用稳定的非吸湿性（SrF 2，BaF 2）壳保护的潮解性碱土卤​​化物（SrI 2，BaI 2）。