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公开(公告)号：US09821017B2
公开(公告)日：2017-11-21
申请号：US14665538
申请日：2015-03-23
Applicant: JIN XIN BIOTECHNOLOGY CO., LTD. , ACADEMIA SINICA
Inventor： Kun-Hsuan Huang , Tza-Zen Chaung , Pei-Wen Hsiao , Chia-Jui Tsai
IPC: A61K36/11 , A61K36/185 , A61K36/12 , A61K31/231 , A61K31/232 , A61K31/409 , A61K31/23 , A23L33/105
CPC classification number: A61K36/12 , A23L33/105 , A23V2002/00 , A61K31/23 , A61K31/231 , A61K31/232 , A61K31/409 , A23V2200/30
Abstract: An extract of Asplenium nidus L. includes pyropheophorbide a methyl ester (C34H36N4O3), pheophorbide a methyl ester (C35H36N4O5), 1-linleoyl-3-linolenoyl-glycerol (C39H66O5), 1-linleoyl-2,3-dipalmitoyl-rac-glycerol (C53H98O6) and 1,3-dipalmitoyl-sn-glycerol (C35H68O5). The extract of Asplenium nidus L. is obtained by using a method including steps of: solvent extraction, using an solvent to extract an Asplenium nidus L. sample and to obtain an extract, with a w/v ratio between the solvent and the Asplenium nidus L. sample being 50˜60 mg/ml; and column chromatography, fractionating the extract with water and ethanol as eluent to obtain several fractions including fraction a to fraction i, and further evaporating and lyophilizing fraction b, c, d or their combination to obtain an extract of Asplenium nidus L.
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公开(公告)号：US09799479B2
公开(公告)日：2017-10-24
申请号：US14612393
申请日：2015-02-03
Applicant: Academia Sinica
Inventor： Yeu-Kuang Hwu , Tsung-Tse Li , Yu-Tai Ching
CPC classification number: H01J35/08 , A61B6/40 , A61B6/5205 , G01N23/04 , G01N23/20075 , G06T11/006 , H01J35/30 , H01J2235/086
Abstract: The present invention relates to a method, a system, and a light source for penetrating radiation imaging, and more particularly, to a method, a system, and a light source for X-ray imaging. The system for X-ray phase contrast and high resolution imaging of the present invention comprises an X-ray source comprising a plurality of X-ray micro-light sources, an X-ray sensor configured to receive X-rays penetrating an object, and a computer configured to receive and compute raw image data from the X-ray sensor so as to obtain a clear image of the object.
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公开(公告)号：US09797015B2
公开(公告)日：2017-10-24
申请号：US14764448
申请日：2014-01-29
Applicant: Academia Sinica
Inventor： Andrew Tai-Ann Cheng , Yuan-Tsong Chen , Chien-Hsiun Chen , Chau-Shoun Lee , Ming Ta Michael Lee
CPC classification number: C12Q1/6883 , A61K33/00 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
Abstract: Described herein is a method of determining lithium responsiveness in a bipolar disorder patient. The method includes obtaining a sample from a patient having bipolar disorder, and assaying the sample for the presence or absence of one or more glutamate decarboxylase-like 1 (GADL1) gene variants selected from the group consisting of a T allele of the single nucleotide polymorphism (SNP) rs17026688, a G allele of the SNP rs17026651, and GADL1 1VS8+48delG. The presence of one or more of the GADL1 gene variants indicates that the patient is responsive to lithium treatment.
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公开(公告)号：US09796778B1
公开(公告)日：2017-10-24
申请号：US15516015
申请日：2015-09-15
Applicant: Academia Sinica
Inventor： Yun-Ru Chen
CPC classification number: C07K16/18 , C07K2317/76 , G01N33/6896 , G01N2800/2821
Abstract: Disclosed herein are novel pathological form of TDP-43, monoclonal antibodies against such pathological form of TDP-43, and uses thereof. The novel pathological form of TDP-43 is characterized in having a spherical particle size of about 2 to 400 nm in diameter.
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585.发明授权公开(公告)号：US09770485B2
公开(公告)日：2017-09-26
申请号：US12510387
申请日：2009-07-28
Applicant: Che-Kun James Shen , Kuen-jer Tsai
Inventor： Che-Kun James Shen , Kuen-jer Tsai
CPC classification number: A61K38/193 , A01K2207/10 , A01K2267/0312 , A61K35/28
Abstract: A method for treating a progressive neurodegenerative disorder with bone marrow stem cells and a G-CSF receptor agonist.
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Patent Agency Ranking
公开(公告)号：US09754328B2
公开(公告)日：2017-09-05
申请号：US14455384
申请日：2014-08-08
Applicant: ACADEMIA SINICA
Inventor： De-Nian Yang , Chih-Ya Shen , Hong-Han Shuai , Ming-Syan Chen
CPC classification number: G06Q50/01 , G06Q10/109
Abstract: A social activity planning method includes the following operation. A database storing multiple candidate invitees with their geographical locations and interest scores towards a topic, and a social graph including vertices representing the candidate invitees and edges connecting two vertices representing mutual acquaintance of the associated candidate invitees is accessed. A social activity request including an invitation number, information about a social activity, and a familiarity condition for the social activity request is received. At least one feasible solution including the invitation number of the candidate invitees and meeting the familiarity condition is generated. A group of selected invitees are found based on the feasible solution and the information about the social activity.
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公开(公告)号：US09750844B2
公开(公告)日：2017-09-05
申请号：US14857189
申请日：2015-09-17
Applicant: ACADEMIA SINICA , NATIONAL TAIWAN OCEAN UNIVERSITY
Inventor： Jyh-Yih Chen , Chang-Jer Wu , Han-Ning Huang
CPC classification number: A61L26/0047 , A61L15/32 , A61L15/325 , A61L15/46 , A61L26/0033 , A61L26/0066 , A61L2300/252 , A61L2300/404 , A61L2300/412
Abstract: The preset invention relates to a new method for wound healing, particularly in burns, comprising Epinecidin-1 (Epi-1) or Pardaxin (GE33), optionally in the incorporation into collagen.
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588.发明申请公开(公告)号：US20170229703A1
公开(公告)日：2017-08-10
申请号：US15501634
申请日：2014-08-07
Applicant: ACADEMIA SINICA
Inventor： Chih-Wei CHU , Lain-Jong LI , Kumar PUSHPENDRA , Lung-Hao HU
CPC classification number: H01M4/0419 , H01M4/133 , H01M4/136 , H01M4/1393 , H01M4/1397 , H01M4/364 , H01M4/38 , H01M4/505 , H01M4/5815 , H01M4/587 , H01M4/623 , H01M4/661 , H01M4/663 , H01M10/052 , Y02T10/7011
Abstract: The present invention provides a method of preparing a battery electrode, comprising: (a) providing electroactive particles; (b) mixing the electroactive particles with a graphene-based material to form a composite; and (c) spray coating the composite onto a substrate to form the battery electrode; wherein the percentage of the electroactive particles to the graphene-based material is 40-95 wt %. Furthermore, the present invention provides a high performance battery electrode and lithium sulfur battery or Lithium Metal Oxide-Sulfur battery.
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公开(公告)号：US20170219593A1
公开(公告)日：2017-08-03
申请号：US14781165
申请日：2015-04-01
Applicant: ACADEMIA SINICA
Inventor： Ying Chih CHANG
IPC: G01N33/574 , B01L3/00 , G01N33/543
CPC classification number: G01N33/57492 , B01L3/502769 , B01L2200/0673 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , B01L2400/0487 , G01N33/54366
Abstract: The disclosure provides for compositions and methods of making and using a foam composition and its utility in clinical applications.
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公开(公告)号：US09695463B2
公开(公告)日：2017-07-04
申请号：US14647816
申请日：2013-12-10
Applicant: Academia Sinica
Inventor： Che-Kun James Shen , Chun-Chang Chen
CPC classification number: C12Q1/48 , C12Q1/68 , C12Q1/6897 , G01N2333/91011 , G01N2500/04 , C12Q2521/331 , C12Q2525/143
Abstract: Methods for identifying a test agent as a modulator of the active DNA demethylation activity of a DNA methyltransferase are disclosed. The method comprises: a) providing a methylated DNA; b) providing the DNA methyltransferase; c) allowing the methylated DNA to react with the DNA methyltransferase for a sufficient time to perform a demethylation reaction and generate a demethylated DNA product in the presence or absence of a test agent; d) analyzing the extent of demethylation; and d) comparing the extents of the demethylation in the presence and absence of the test agent, and thereby identify the test agent as a modulator of the DNA demethylation activity of the DNA methyltransferase.
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