公开(公告)号：US20140255932A1

公开(公告)日：2014-09-11

申请号：US14261775

申请日：2014-04-25

申请人： TMG - TROPICAL MELHORAMENTO E GENETICA LTDA.

发明人： Arlindo Harada ,  Eberson Sanches Calvo ,  Romeu Afonso de Souza Kiihl ,  Alexandre Garcia

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6895 ,  A01H1/04 ,  A01H5/10 ,  C12Q2600/156

摘要： The present invention relates to screening methods for rust resistance or tolerance, in particular, Asian soybean rust (ASR—Phakopsora pachyrhizi). In addition, the present invention relates to the use of molecular markers for the Glycine genus, in particular, for the Glycine max species. The present invention further relates to a method for identifying loci with quantitative and/or qualitative traits associated with rust resistance or tolerance in plants by means of molecular markers. Said markers can be used for assisted screening in improvement programs directed to selecting disease-resistant or -tolerant plants. The present invention also relates to gene pyramiding related to rust resistance. The markers of the present invention are also useful for the positional cloning of rust-resistant or -tolerant genes. Also disclosed are a method for obtaining disease-resistant or -tolerant cultivars, a process for obtaining a plant population and a method for controlling diseases in a plant population. Another object of the present invention is the use of species from the Glycine genus as a source of resistance for obtaining ASR-resistant or tolerant cultivars.

摘要翻译： 本发明涉及耐锈性或耐受性的筛选方法，特别是亚洲大豆锈病（ASR- Phakopsora pachyrhizi）。 此外，本发明涉及分子标记用于甘氨酸属的用途，尤其涉及大豆种类。 本发明还涉及通过分子标记鉴定具有与植物抗锈性或耐受性有关的定量和/或定性性状的基因座的方法。 所述标记物可用于辅助筛选，用于选择抗病性或耐受性植物的改良方案。 本发明还涉及与抗锈性相关的基因金字塔。 本发明的标记物也可用于防锈或耐受基因的定位克隆。 还公开了获得抗病性或耐性品种的方法，获得植物群体的方法和控制植物群体中的疾病的方法。 本发明的另一个目的是使用来自甘氨酸属的物质作为获得抗ASR抗性或耐受品种的抗性来源。

公开(公告)号：US08729226B2

公开(公告)日：2014-05-20

申请号：US13700286

申请日：2011-05-31

申请人： Maribel Guerra Vallespi ,  Julio Raúl Fernández Massó ,  Alexis Musacchio Lasa ,  Jeovanis Gil Valdés ,  Osvaldo Reyes Acosta ,  Brizaida Maylin Oliva Argüelles

发明人： Maribel Guerra Vallespi ,  Julio Raúl Fernández Massó ,  Alexis Musacchio Lasa ,  Jeovanis Gil Valdés ,  Osvaldo Reyes Acosta ,  Brizaida Maylin Oliva Argüelles

IPC分类号： A61K38/00

CPC分类号： C12N15/11 ,  A61K31/505 ,  A61K31/513 ,  A61K33/24 ,  A61K38/10 ,  A61K38/1767 ,  A61K45/06 ,  A61K48/00 ,  C07K7/08 ,  G01N33/574 ,  A61K2300/00

摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.

摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。

公开(公告)号：US08674063B2

公开(公告)日：2014-03-18

申请号：US12513085

申请日：2007-10-30

申请人： Glay Chinea Santiago ,  Vivian Huerta Galindo ,  Alejandro Miguel Martin Dunn ,  Noralvis Fleitas Salazar ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Mónica Sarría Núñez ,  Alexis Musacchio Lasa ,  Olvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Anìa Cabrales Rico

发明人： Glay Chinea Santiago ,  Vivian Huerta Galindo ,  Alejandro Miguel Martin Dunn ,  Noralvis Fleitas Salazar ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Mónica Sarría Núñez ,  Alexis Musacchio Lasa ,  Olvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Anìa Cabrales Rico

IPC分类号： C07K14/00

CPC分类号： A61K47/48315 ,  A61K38/00 ,  A61K47/645 ,  C07K14/005 ,  C07K2319/04 ,  C07K2319/10 ,  C12N2770/24022 ,  C12N2770/24122 ,  C12N2770/24222 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/393 ,  Y02A50/395

摘要： The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.

摘要翻译： 本发明是相对于嵌合肽，其主要结构保持至少一个片段，其抑制来自黄病毒科的病毒的NS3蛋白酶的活化，它们还含有细胞穿透片段，并且它们能够抑制或减弱病毒 感染。 本发明还涉及含有这些嵌合肽用于预防和/或治疗由黄病毒科病毒引起的感染的药物化合物。

公开(公告)号：US08410057B2

公开(公告)日：2013-04-02

申请号：US13142471

申请日：2009-12-29

申请人： Ariana Barbera Betancourt ,  Maria del Carmen Dominguez Horta ,  Norailys Lorenzo Perez ,  Gabriel Ramon Padron Palomares ,  Viviana Falcon Cama ,  Ivon Menendez Valdes

发明人： Ariana Barbera Betancourt ,  Maria del Carmen Dominguez Horta ,  Norailys Lorenzo Perez ,  Gabriel Ramon Padron Palomares ,  Viviana Falcon Cama ,  Ivon Menendez Valdes

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61P43/00 ,  A61P3/10 ,  A61P7/12 ,  A61P1/04

CPC分类号： A61K38/1709

摘要： The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of Crohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohn's disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1.

摘要翻译： 本发明涉及药物领域，特别是使用衍生自60kDa人热激蛋白的APL肽或其类似物用于制备用于治疗克罗恩病，溃疡性结肠炎的药物组合物 和1型糖尿病。该肽生物分布到胃肠道中，并且还促进克罗恩病患者的活化的肠固定层和外周血T细胞的凋亡诱导。 此外，该肽在1型糖尿病患者的单核细胞中诱导凋亡。

公开(公告)号：US08383771B2

公开(公告)日：2013-02-26

申请号：US11663603

申请日：2005-09-22

申请人： Maria del Carmen Dominguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marin ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Diaz ,  Nelson J. Merino Garcia ,  Ariel Vázquez Bonachea ,  José Suárez Alba

发明人： Maria del Carmen Dominguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marin ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Diaz ,  Nelson J. Merino Garcia ,  Ariel Vázquez Bonachea ,  José Suárez Alba

IPC分类号： C07K14/47 ,  A61K38/16

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

摘要： Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.

摘要翻译： 构成T细胞表位的人类热休克蛋白的肽，以及它们衍生的肽，在与MHC分子的接触位点被修饰，可用于诱导外周耐受机制，特别是无反应机制 或由风湿性关节炎患者的调节性T细胞的克隆介导。 本发明还涉及包含这些肽用于治疗类风湿关节炎的药物组合物。

公开(公告)号：US08283324B2

公开(公告)日：2012-10-09

申请号：US12278990

申请日：2007-02-23

申请人： Maribel Guerra Vallespi ,  Isis del Carmen Torréns Madrazo ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Gerardo Enrique Guillén Nieto ,  Boris Ernesto Acevedo Castro ,  Raimundo Ubieta Gómez

发明人： Maribel Guerra Vallespi ,  Isis del Carmen Torréns Madrazo ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Gerardo Enrique Guillén Nieto ,  Boris Ernesto Acevedo Castro ,  Raimundo Ubieta Gómez

IPC分类号： A61K38/16 ,  C07K14/00

CPC分类号： C07K14/43509 ,  A61K38/00

摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.

摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKYKGKFW（SEQ ID NO：13）的肽的开发，显示氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。

公开(公告)号：US20110064718A1

公开(公告)日：2011-03-17

申请号：US12857194

申请日：2010-08-16

申请人： Jesus Mena Campos ,  Eulogio Pimentel Vazquez ,  Armando Tomas Hernadez Garcia ,  Liuven Veloz Gonzalez ,  Marieta Marin Bruzos ,  Oscar Compte Alberto ,  Marilin Domingo Puente ,  Licette Leon Barreras ,  Merardo Pujol Ferrero ,  Juan Diego Mencho Ponce ,  Carlos Borroto Nordelo

发明人： Jesus Mena Campos ,  Eulogio Pimentel Vazquez ,  Armando Tomas Hernadez Garcia ,  Liuven Veloz Gonzalez ,  Marieta Marin Bruzos ,  Oscar Compte Alberto ,  Marilin Domingo Puente ,  Licette Leon Barreras ,  Merardo Pujol Ferrero ,  Juan Diego Mencho Ponce ,  Carlos Borroto Nordelo

IPC分类号： A61K38/47 ,  A01N59/02 ,  A01P5/00 ,  A61P33/00

CPC分类号： A01N63/00 ,  A01N63/02 ,  A01N2300/00

摘要： This invention relates to pesticide and antiparasitic compositions for the control of pests, diseases and parasites attacking plants and animals. The compositions include, at least one chitinolytic agent or a chitinolytic activity-inducing agent, and sulfide or a sulfide-producing agent from microorganisms or chemical compounds, wherein the chitinolytic agent or the chitinolytic activity-inducing agent and sulfur or a sulfur-producing agent obtaining from microorganisms or chemical compounds are concurrently applied at a range significantly lower than any of the above-mentioned compounds, when they are individually to attain effective control.

摘要翻译： 本发明涉及用于防治害虫，疾病和寄生虫攻击植物和动物的农药和抗寄生虫剂组合物。 所述组合物包括至少一种chitinotictic试剂或chitinolytic活性诱导剂，以及来自微生物或化学化合物的硫化物或硫化物生成剂，其中所述chitinolytic试剂或所述chitinolytic活性诱导剂和硫或硫产生剂 当微生物或化合物单独获得有效控制时，从微生物或化合物获得的同时应用于显着低于任何上述化合物的范围。

公开(公告)号：US07790173B2

公开(公告)日：2010-09-07

申请号：US12067129

申请日：2006-09-18

申请人： Laura Lazo Vázquez ,  Lisset Hermida Cruz ,  Carlos López Abarrategui ,  Beatriz de la Caridad Sierra Vázquez ,  Susana Vázquez Ramundo ,  Iris Valdez Prado ,  Gerardo Enrique Guillen Nieto ,  Maria Guadalupe Guzmán Tirado ,  Aida Zulueta Morales

发明人： Laura Lazo Vázquez ,  Lisset Hermida Cruz ,  Carlos López Abarrategui ,  Beatriz de la Caridad Sierra Vázquez ,  Susana Vázquez Ramundo ,  Iris Valdez Prado ,  Gerardo Enrique Guillen Nieto ,  Maria Guadalupe Guzmán Tirado ,  Aida Zulueta Morales

IPC分类号： A61K39/00 ,  A61K39/12

CPC分类号： A61K39/12 ,  A61K2039/55505 ,  A61K2039/55566 ,  C07K14/005 ,  C12N2770/24122 ,  C12N2770/24134 ,  Y02A50/386

摘要： This invention describes a pharmaceutical compound which has the capsid protein of Dengue virus and which is capable of inducing, in the receptor, a protective immune response before the viral challenge, without inducing the Ab-dependent enhancement phenomenon.

摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的能够在病毒攻击之前在受体中诱导保护性免疫应答而不诱导依赖于Ab的增强现象的药物化合物。

公开(公告)号：US20100166777A1

公开(公告)日：2010-07-01

申请号：US12601474

申请日：2008-05-27

申请人： Sergio Abrignani ,  Mariacristina Crosti ,  Monica Moro

发明人： Sergio Abrignani ,  Mariacristina Crosti ,  Monica Moro

IPC分类号： A61K35/14 ,  C12N5/078 ,  C12Q1/02 ,  C07K14/42 ,  C07K16/40 ,  A61K38/16 ,  A61K39/395 ,  A61P35/02

CPC分类号： C12N5/0647 ,  A61K35/12 ,  A61K38/1709 ,  C12N5/0634 ,  C12N5/0645

摘要： The present invention relates to ex-vivo cells belonging to the hematopoietic system, characterized by the presence of MOSC-1 protein on cell surface, methods for isolating them and uses thereof.

摘要翻译： 本发明涉及属于造血系统的离体细胞，其特征在于细胞表面存在MOSC-1蛋白，分离它们的方法及其用途。

公开(公告)号：US07736638B2

公开(公告)日：2010-06-15

申请号：US11662844

申请日：2005-09-16

申请人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

发明人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

IPC分类号： A61K38/20 ,  C12N15/06 ,  C07K14/54 ,  C12N5/02 ,  C12P21/02

CPC分类号： C07K14/5443 ,  A61K38/00 ,  A61K39/00 ,  C07K16/244

摘要： Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.

摘要翻译： 本发明涉及分子药理学分支，特别是涉及能够抑制IL-15生物活性，类似物或模拟这些肽的白细胞介素-15序列（IL-15）的肽。 在本发明中，显示肽结合IL15受体a亚基（IL15Rα）和TNFα介导的细胞凋亡后，抑制IL-15诱导的T细胞增殖。 此外，本发明涉及该肽用于治疗其中异常IL-15或IL-15Rα表达与疾病进展相关的几种病症的用途。