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公开(公告)号：US08088350B2
公开(公告)日：2012-01-03
申请号：US12028582
申请日：2008-02-08
CPC分类号： B01J20/28026 , B01J20/08 , B01J20/103 , B01J20/20 , B01J20/26 , B01J20/28004 , B01J20/2803 , B01J20/28033 , B01J20/28035 , B01J20/28042 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/281 , B01J20/3223 , B01J20/3293 , B01J2220/46 , B01J2220/54 , B01J2220/64 , B01J2220/86 , C03C12/00 , C03C25/47 , C08G77/62 , C08L83/16 , Y10T428/1321 , Y10T428/1393 , Y10T428/2933 , Y10T428/31663 , C08L83/00
摘要： This invention relates to an amorphous non-glassy ceramic composition that may be prepared by curing, calcining and/or pyrolyzing a precursor material comprising silicon, a Group III metal, a Group IVA metal, and/or a Group IVB metal.
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公开(公告)号：US20240279713A1
公开(公告)日：2024-08-22
申请号：US18470565
申请日：2023-09-20
发明人： Brian Ward , Kenneth Heuermann
IPC分类号： C12Q1/6806 , C12N15/10 , C12Q1/6853 , C12Q1/6876
CPC分类号： C12Q1/6806 , C12N15/1093 , C12Q1/6853 , C12Q1/6876 , C12Q2525/179
摘要： The present invention provides a plurality of oligonucleotides comprising a semi-random sequence, wherein the semi-random sequence comprises degenerate nucleotides that are substantially non-complementary. Also provided are methods for using the plurality of oligonucleotides to amplify a population of target nucleic acids.
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公开(公告)号：US20240247007A1
公开(公告)日：2024-07-25
申请号：US18558693
申请日：2022-05-04
CPC分类号： C07F5/04 , A61K47/54 , A61K47/545 , C07F5/025
摘要： Nuclear targeting tags having a phenylboronate targeting moiety, a linker, a chemically linkable end group suitable for linking the targeting moiety to a molecule of interest, and optionally a spacer between the linker and chemically linkable end group. Also provided are compounds including the nuclear targeting tag covalently bonded to a molecule of interest, such as a drug, probe, dye, peptide, protein, drug candidate, or natural product. Also provided are methods of introducing a molecule of interest into a nucleus of a cell using the nuclear targeting tag. Also provided are methods for preparing the nuclear targeting tags.
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公开(公告)号：US11806693B2
公开(公告)日：2023-11-07
申请号：US17349562
申请日：2021-06-16
发明人： William R. Betz , Michael J. Keeler , Curtis W. Frantz , Jay M. Jones , William Maule , Kenneth G. Espenschied , Cory E. Muraco , Clinton Corman , Maochun Ye
IPC分类号： B01J20/282 , B01J20/20 , B01J20/28 , B01J20/30 , C01B32/205
CPC分类号： B01J20/282 , B01J20/20 , B01J20/28004 , B01J20/2808 , B01J20/28021 , B01J20/28052 , B01J20/28071 , B01J20/28073 , B01J20/28083 , B01J20/3057 , B01J20/3071 , B01J20/3078 , B01J20/3085 , C01B32/205 , B01J2220/54 , C01P2004/03 , C01P2004/34 , C01P2004/61 , C01P2006/14 , C01P2006/16
摘要： Methods for producing porous graphic carbon microspheres having improved separation properties over conventional porous graphitic carbons. The methods include dispersing a monovinyl aromatic monomer, a polyvinyl aromatic monomer, and an initiator in a solvent, contacting porous silica microspheres with the monomer dispersion for a time sufficient for the monomers to coat the porous silica microspheres, polymerizing the monomers to form copolymer coated microspheres, sulfonating the copolymer, pyrolyzing the sulfonated copolymer, digesting the carbon microspheres to dissolve the silica leaving porous carbon microspheres, pyrolyzing the porous carbon microspheres, and graphitizing the porous carbon microspheres to form porous graphitic carbon microspheres. Further provided are improved porous graphitic carbon microspheres and chromatography columns including the improved porous graphitic carbon microspheres described herein.
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55.发明申请公开(公告)号：US20230129674A1
公开(公告)日：2023-04-27
申请号：US17905907
申请日：2021-03-09
发明人： David Goeddel , James Walker , Emilia Groso , Ross Bemowski , Logan Berg
IPC分类号： C07K5/02 , C07D207/08 , C07C229/22 , C07C271/22
摘要： Methods for making a dolastatin, auristatin or related compounds comprising the steps of providing a universal dolastatin core of Formula (I) reacting the C-terminal carboxylic acid group with an amine (A) to form an amide bond and reacting the N-terminal amine with a carboxylic acid (CA) to form an amide bond, wherein the steps can be performed in either order. Also provided are an isolated salt of the universal dolastatin core for use in preparation of dolastatins, auristatins and related compounds. Also provided are a number of intermediates and process steps which are useful for the preparation of high purity dolastatin core and high purity dolastatin and auristatin compounds.
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公开(公告)号：US20230058352A1
公开(公告)日：2023-02-23
申请号：US17790392
申请日：2021-03-11
发明人： Fuqiang Chen
摘要： Engineered Cas9 protein variants and systems, nucleic acids encoding said protein variants and systems, and methods of making and using said protein variants and systems for genome modification.
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公开(公告)号：USD970517S1
公开(公告)日：2022-11-22
申请号：US29758166
申请日：2020-11-12
设计人： Sarah Trice , Lindsey Rickershauser , Xiang Wu , Churl Oh , Nadia Brugger , Emma Gardener
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公开(公告)号：USD962282S1
公开(公告)日：2022-08-30
申请号：US29758161
申请日：2020-11-12
设计人： Sarah Trice , Lindsey Rickershauser , Xiang Wu , Churl Oh , Nadia Brugger , Emma Gardener
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公开(公告)号：US20220195465A1
公开(公告)日：2022-06-23
申请号：US17604332
申请日：2020-04-20
摘要： Methods for integrating exogenous sequences in genomic loci, wherein the integration is stable and the exogenous sequence can function predictably and reliably.
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公开(公告)号：US20210388396A1
公开(公告)日：2021-12-16
申请号：US17398648
申请日：2021-08-10
发明人： Fuqiang Chen , Gregory D. Davis
IPC分类号： C12N15/90 , C12N9/22 , C12N15/63 , C12N15/10 , C12N15/85 , C07K7/06 , C12N15/11 , C12N7/00 , C12N15/67 , C12N15/86 , C07K14/46 , C12N9/96
摘要： The present invention provides RNA-guided endonucleases, which are engineered for expression in eukaryotic cells or embryos, and methods of using the RNA-guided endonuclease for targeted genome modification in in eukaryotic cells or embryos. Also provided are fusion proteins, wherein each fusion protein comprises a CRISPR/Cas-like protein or fragment thereof and an effector domain. The effector domain can be a cleavage domain, an epigenetic modification domain, a transcriptional activation domain, or a transcriptional repressor domain. Also provided are methods for using the fusion proteins to modify a chromosomal sequence or regulate expression of a chromosomal sequence.
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