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    DELTA-8 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS
    51.
    发明申请
    DELTA-8 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS 审中-公开
    DELTA-8去饱和酶及其在制备多糖脂肪酸中的用途

    公开(公告)号：US20110184200A1

    公开(公告)日：2011-07-28

    申请号：US13080279

    申请日：2011-04-05

    申请人： Howard Glenn DAMUDE ,  Quinn Qun Zhu

    发明人： Howard Glenn DAMUDE ,  Quinn Qun Zhu

    IPC分类号： C07F9/02

    CPC分类号： C12N15/8247 ,  C12N9/0083

    摘要： Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast are disclosed.

    摘要翻译： 公开了分离的核酸片段和重组构建体，其包含编码Δ-8去饱和酶的片段以及使用该植物中的δ-8去饱和酶和油性酵母制备长链多不饱和脂肪酸（PUFA）的方法。

    DELTA-8 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS
    53.
    发明申请
    DELTA-8 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 有权
    DELTA-8苦味及其在制备多脂肪脂肪酸中的应用

    公开(公告)号：US20100267099A1

    公开(公告)日：2010-10-21

    申请号：US12825537

    申请日：2010-06-29

    申请人： Howard Glenn Damude ,  Quinn Qun Zhu

    发明人： Howard Glenn Damude ,  Quinn Qun Zhu

    IPC分类号： C12P7/64 ,  C12N1/00 ,  C12N1/21 ,  C12N1/19 ,  C12N1/15 ,  C12N1/13 ,  C07H21/00

    CPC分类号： C12P7/6427 ,  C12N9/0083 ,  C12N15/8247

    摘要： The present invention relates to Δ8 desaturase genes, which have the ability to convert eicosadienoic acid (EDA; 20:2 ω-6) to dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) and/or eicosatrienoic acid (ETrA; 20:3 ω-3) to eicosatetraenoic acid (ETA; (20:3 ω-3). Isolated nucleic acid fragments and recombinant DNA constructs comprising such fragments encoding Δ8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ8 desaturases in oleaginous yeast are disclosed.

    摘要翻译： 本发明涉及具有将二十碳二烯酸（EDA; 20：2ω-6）转化为二高-γ-亚麻酸（DGLA; 20：3ω-6）和/或二十碳三烯酸的能力的Dgr .8去饱和酶基因 分离的核酸片段和重组DNA构建体，其包含编码“Dgr。8”去饱和酶的片段，以及一种制备长链多糖的方法， 公开了在含油酵母中使用这些＆Dgr。8去饱和酶的链多不饱和脂肪酸（PUFA）。

    Δ-9 elongases and their use in making polyunsaturated fatty acids
    55.
    发明授权
    Δ-9 elongases and their use in making polyunsaturated fatty acids 有权
    ＆Dgr; -9延伸酶及其在制备多不饱和脂肪酸中的应用

    公开(公告)号：US07794701B2

    公开(公告)日：2010-09-14

    申请号：US12102879

    申请日：2008-04-15

    申请人： Howard Glenn Damude ,  Quinn Qun Zhu

    发明人： Howard Glenn Damude ,  Quinn Qun Zhu

    IPC分类号： A01N63/00 ,  A01K48/00 ,  C07H21/04

    CPC分类号： C12N9/1029 ,  A23D9/00 ,  A23D9/007 ,  A23K20/158 ,  A23L33/12 ,  A23V2002/00 ,  A23V2250/1862 ,  A23V2250/187 ,  A23V2250/1868

    摘要： The present invention relates to Δ9 elongases, which have the ability to convert linoleic acid (LA; 18:2 ω-6) to eicosadienoic acid (EDA; 20:2 ω-6) and/or α-linolenic acid (ALA; 18:3 ω-3) to eicosatrienoic acid (ETrA; 20:3 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ9 elongases in oleaginous yeast are disclosed.

    摘要翻译： 本发明涉及具有将亚油酸（LA; 18：2ω-6）转化成二十碳烯酸（EDA;20:2ω-6）和/或α-亚麻酸（ALA）的能力的Dgr。 ; 18：3ω-3）至二十碳三烯酸（ETrA; 20：3ω-3）。 公开了分离的核酸片段和重组构建体，其包含编码'Dgr。9延伸酶的这种片段以及在含油酵母中使用这些＆Dgr.9延伸酶制备长链多不饱和脂肪酸（PUFA）的方法。

    REDUCING BYPRODUCTION OF MALONATES IN A FERMENTATION PROCESS
    56.
    发明申请
    REDUCING BYPRODUCTION OF MALONATES IN A FERMENTATION PROCESS 有权
    在发酵过程中减少丙二醛的引入

    公开(公告)号：US20100159558A1

    公开(公告)日：2010-06-24

    申请号：US12637877

    申请日：2009-12-15

    申请人： Quinn Qun Zhu ,  Zhixiong Xue

    发明人： Quinn Qun Zhu ,  Zhixiong Xue

    IPC分类号： C12N9/00 ,  C12N1/21 ,  C12N1/15 ,  C12N1/19 ,  C12N1/13

    CPC分类号： C12P7/6427 ,  C12N9/93 ,  C12P7/6472

    摘要： Described are methods of reducing the amount of byproduct organic acids during fermentation of an organism, based on expression of a heterologous malonyl-CoA synthetase. A polyunsaturated fatty acid [“PUFA”]-producing strain of the oleaginous yeast Yarrowia lipolytica was engineered to express a heterologous malonyl-CoA synthetase gene. The expression did not effect the production of PUFAs, but did result in a reduced amount of malonates when compared to the amount of malonates produced in the parental strain not expressing malonyl-CoA synthetase.

    摘要翻译： 描述了基于异源丙二酰辅酶A合成酶的表达减少生物体发酵期间副产物有机酸的量的方法。 将多油不饱和脂肪酸[“PUFA”]生产菌株的油质酵母解脂耶氏酵母解脂工程化以表达异源丙二酰辅酶A合成酶基因。 该表达不影响PUFA的产生，但与不表达丙二酰辅酶A合成酶的亲本菌株中产生的丙二酸的量相比，确实导致了丙二酸的量减少。

    DELTA 17 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS
    59.
    发明申请
    DELTA 17 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS 有权
    DELTA 17去饱和及其在制备聚氨酯脂肪酸中的应用

    公开(公告)号：US20090280996A1

    公开(公告)日：2009-11-12

    申请号：US12469208

    申请日：2009-05-20

    申请人： Narendra S. Yadav ,  Zhixiong Xue ,  Quinn Qun Zhu

    发明人： Narendra S. Yadav ,  Zhixiong Xue ,  Quinn Qun Zhu

    IPC分类号： C40B30/04 ,  C12N15/11 ,  C12N9/00 ,  C12Q1/68

    CPC分类号： C12P7/6427 ,  C12N9/0083 ,  C12P7/6472

    摘要： The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to eicosapentaenoic acid [20:5, EPA]). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ17 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ17 desaturases in oleaginous yeast are disclosed.

    摘要翻译： 本发明涉及具有将ω-6脂肪酸转化成其ω-3对应物的能力的Delta17去饱和酶（即将花生四烯酸[20：4，ARA]转化为二十碳五烯酸[20：5，EPA]） 。 公开了分离的核酸片段和包含编码Δ17去饱和酶的片段的重组构建物以及使用这些Delta17去饱和酶在含油酵母中制备长链多不饱和脂肪酸（PUFA）的方法。