利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

182 records (took 0.049 seconds)

    VARIANT NUCLEIC ACID LIBRARIES FOR ADENOSINE RECEPTORS
    52.
    发明申请
    VARIANT NUCLEIC ACID LIBRARIES FOR ADENOSINE RECEPTORS 有权

    公开(公告)号：US20210179724A1

    公开(公告)日：2021-06-17

    申请号：US17116939

    申请日：2020-12-09

    Applicant: Twist Bioscience Corporation

    Inventor： Aaron SATO ,  Ray TABIBIAZAR ,  Pankaj GARG ,  Qiang LIU

    IPC: C07K16/28 ,  C12N15/10

    Abstract: Provided herein are methods and compositions relating to adenosine A2A receptor libraries having nucleic acids encoding for a scaffold comprising an adenosine A2A binding domain. adenosine A2A receptor libraries described herein encode for immunoglobulins including antibodies and single domain antibodies. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

    VARIANT NUCLEIC ACID LIBRARIES FOR SINGLE DOMAIN ANTIBODIES
    53.
    发明申请
    VARIANT NUCLEIC ACID LIBRARIES FOR SINGLE DOMAIN ANTIBODIES 有权

    公开(公告)号：US20210102195A1

    公开(公告)日：2021-04-08

    申请号：US17030232

    申请日：2020-09-23

    Applicant: Twist Bioscience Corporation

    Inventor： Aaron SATO ,  Pankaj GARG ,  Qiang LIU ,  Tom YUAN

    IPC: C12N15/10 ,  C07K16/28

    Abstract: Provided herein are methods and compositions relating to variant nucleic acid libraries encoding for antibodies including single domain antibodies. Libraries generated using methods described herein have improved characteristics including improved binding affinity. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

    Variant libraries of the immunological synapse and synthesis thereof
    55.
    发明授权
    Variant libraries of the immunological synapse and synthesis thereof 有权

    公开(公告)号：US10894959B2

    公开(公告)日：2021-01-19

    申请号：US15921537

    申请日：2018-03-14

    Applicant: TWIST BIOSCIENCE CORPORATION

    Inventor： Anthony Cox ,  Siyuan Chen

    IPC: C12N15/10 ,  C12Q1/6806

    Abstract: Disclosed herein are methods for the generation of highly accurate nucleic acid libraries encoding for predetermined variants of a nucleic acid sequence. The nucleic acid sequence may encode for all or part of a reference domain of a CAR. The degree of variation may be complete, resulting in a saturated variant library, or less than complete, resulting in a non-saturating library of variants. The variant nucleic acid libraries described herein may be designed for further processing by transcription or translation. The variant nucleic acid libraries described herein may be designed to generate variant RNA, DNA and/or protein populations. Further provided herein are method for identifying variant species with increased or decreased activities, with applications in regulating biological functions and the design of therapeutics for treatment or reduction of a disease, such as cancer.

Patent Agency Ranking