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    Method for Producing Antibodies
    51.
    发明申请
    Method for Producing Antibodies 审中-公开

    公开(公告)号：US20190031752A1

    公开(公告)日：2019-01-31

    申请号：US15898286

    申请日：2018-02-16

    Applicant: UCB PHARMA S.A.

    Inventor： Paul Edward Stephens ,  Michael John Wright

    IPC: C07K16/24

    Abstract: This invention provides a method for obtaining a recombinant antibody with a desired function, comprising: (a) providing a population of anti-body-forming cells suspected of containing at least one cell capable of producing an antibody exhibiting the desired function; (b) generating one or more transcriptionally active recombinant linear polynucleotides from the antibody-forming cells obtained in step (a) wherein each transcriptionally active recombinant linear polynucleotide comprises a polynucleotide sequence encoding a variable domain of an antibody produced by an antibody-forming cell obtained in step (a) and one or more transcription regulatory elements; (c) expressing a recombinant antibody using one or more of the transcriptionally active recombinant linear polynucleotides generated in step (b); (d) screening the recombinant antibody produced by step (c) for the desired function; and (e) optionally repeating steps (b), (c) and (d) to identify a recombinant antibody exhibiting the desired function.

    Sequence asymmetric modified IgG4 bispecific antibodies
    52.
    发明授权
    Sequence asymmetric modified IgG4 bispecific antibodies 有权

    公开(公告)号：US09902768B2

    公开(公告)日：2018-02-27

    申请号：US14380310

    申请日：2013-02-22

    Applicant: UCB Pharma S.A.

    Inventor： David Paul Humphreys ,  Shirley Jane Peters

    IPC: C07K16/24 ,  C07K16/00 ,  C07K16/46

    CPC classification number: C07K16/24 ,  C07K16/00 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/94

    Abstract: The present disclosure provides an asymmetric mixed antibody comprising two heavy chains or heavy chain fragments each comprising at least a variable region, a hinge region and a CH1 domain, wherein a first heavy chain or fragment thereof is a class IgG4 and has: a the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, and wherein the second heavy chain or fragment thereof is characterized in that part or all of the chain has a different amino acid sequence to said first heavy chain in at least the region outside the variable region (for example the constant region), formulations comprising the same, therapeutic used of both of the above, and processes for preparing the antibodies and formulation.

    Bacterial host strain
    55.
    发明授权
    Bacterial host strain 有权
    细菌宿主菌株

    公开(公告)号：US09550973B2

    公开(公告)日：2017-01-24

    申请号：US15083446

    申请日：2016-03-29

    Applicant: UCB PHARMA, S.A.

    Inventor： Mark Ellis ,  David Paul Humphreys

    IPC: C12P21/02 ,  C12N1/20 ,  C12R1/19 ,  C07K16/24 ,  C12N9/52 ,  C12N15/70

    CPC classification number: C12N1/20 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/55 ,  C12N9/52 ,  C12N15/70 ,  C12P21/02 ,  C12R1/19 ,  Y02P20/52

    Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated DegP gene and optionally a polynucleotide sequence encoding a protein of interest.

    Abstract translation: 包含一个或多个以下突变蛋白酶基因的重组革兰氏阴性细菌细胞：a）突变的Tsp基因，其中突变的Tsp基因编码具有降低的蛋白酶活性的Tsp蛋白或是敲除突变的Tsp基因; b）突变的ptr基因，其中突变的ptr基因编码具有降低的蛋白酶活性的蛋白酶III蛋白质或是敲除突变的ptr基因; 和c）编码具有伴侣活性和降低的蛋白酶活性的DegP蛋白的突变DegP基因; 其中所述细胞与野生型细菌细胞是同基因的，除了突变的Tsp基因和/或突变的ptr基因和/或突变的DegP基因和任选的编码目的蛋白质的多核苷酸序列。

    Compounds for Enhancing the Cognitive Function
    58.
    发明申请
    Compounds for Enhancing the Cognitive Function 有权
    用于增强认知功能的化合物

    公开(公告)号：US20160185761A1

    公开(公告)日：2016-06-30

    申请号：US14909246

    申请日：2014-07-28

    Applicant: UCB PHARMA, S.A.

    Inventor： Florian Montel ,  Eric Jnoff

    IPC: C07D403/06

    CPC classification number: C07D403/06

    Abstract: The invention relates to 2-oxo-1-pyrrolidinyl triazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for enhancing the cognitive function or to counteract cognitive decline.

    Abstract translation: 本发明涉及2-氧代-1-吡咯烷基三唑衍生物，其制备方法，含有它们的药物组合物及其作为用于增强认知功能或抵抗认知衰退的药物的用途。

    BACTERIAL HOST STRAIN
    60.
    发明申请
    BACTERIAL HOST STRAIN 有权
    细菌宿主菌株

    公开(公告)号：US20150344840A1

    公开(公告)日：2015-12-03

    申请号：US14827408

    申请日：2015-08-17

    Applicant: UCB PHARMA, S.A.

    Inventor： MARK ELLIS ,  DAVID PAUL HUMPHREYS

    IPC: C12N1/20 ,  C12R1/19

    CPC classification number: C12N1/20 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/55 ,  C12N9/52 ,  C12N15/70 ,  C12P21/02 ,  C12R1/19 ,  Y02P20/52

    Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated DegP gene and optionally a polynucleotide sequence encoding a protein of interest.

    Abstract translation: 包含一个或多个以下突变蛋白酶基因的重组革兰氏阴性细菌细胞：a）突变的Tsp基因，其中突变的Tsp基因编码具有降低的蛋白酶活性的Tsp蛋白或是敲除突变的Tsp基因; b）突变的ptr基因，其中突变的ptr基因编码具有降低的蛋白酶活性的蛋白酶III蛋白质或是敲除突变的ptr基因; 和c）编码具有伴侣活性和降低的蛋白酶活性的DegP蛋白的突变DegP基因; 其中所述细胞与野生型细菌细胞是同基因的，除了突变的Tsp基因和/或突变的ptr基因和/或突变的DegP基因和任选的编码目的蛋白质的多核苷酸序列。

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