Prokaryotic collagen-like proteins and uses thereof
    52.
    发明申请
    Prokaryotic collagen-like proteins and uses thereof 有权
    原核胶原蛋白及其用途

    公开(公告)号:US20090258390A1

    公开(公告)日:2009-10-15

    申请号:US12455840

    申请日:2009-06-08

    CPC分类号: C07K14/78

    摘要: The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.

    摘要翻译: 本发明提供重组三螺旋蛋白或胶原样蛋白,其包含原核蛋白或原核蛋白的一个或多个结构域,其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外,提供针对重组胶原样蛋白的抗体,其优选结合整联蛋白。 此外,筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。

    Backlight module with polarizer film, liquid crystal display using same, and method for assembling liquid crystal display
    55.
    发明申请
    Backlight module with polarizer film, liquid crystal display using same, and method for assembling liquid crystal display 审中-公开
    具有偏光膜的背光模块,使用其的液晶显示器以及用于组装液晶显示器的方法

    公开(公告)号:US20080088773A1

    公开(公告)日:2008-04-17

    申请号:US11974847

    申请日:2007-10-16

    申请人: Ye-Jun Tang Yi Xu

    发明人: Ye-Jun Tang Yi Xu

    IPC分类号: G02F1/1335 F21V7/04 H01L21/02

    CPC分类号: G02F1/13362 G02F1/133615

    摘要: An exemplary liquid crystal display (2) includes a liquid crystal panel (21) and a backlight module (22). The liquid crystal panel includes a first substrate (212), a second substrate (214) opposite to the first substrate, a liquid crystal layer disposed between the substrates, and a first polarizer film (210) provided at an outside of the first substrate. The backlight module includes a light guide plate (222), a light source (230), a second polarizer film (220) and an optical film assembly (224) adjacent to the liquid crystal panel, which has a plurality of optical films. The polarizer film is disposed adjacent to at least one of the optical films. The light guide plate is disposed below the optical film assembly. The light source is positioned for providing light rays to the light guide plate such that the backlight module is capable of providing a planar source of polarized light rays.

    摘要翻译: 示例性液晶显示器(2)包括液晶面板(21)和背光模块(22)。 液晶面板包括第一基板(212),与第一基板相对的第二基板(214),设置在基板之间的液晶层和设置在第一基板的外侧的第一偏光膜(210)。 背光模块包括具有多个光学膜的导光板(222),光源(230),第二偏光膜(220)和与液晶面板相邻的光学膜组件(224)。 偏振膜设置成与至少一个光学膜相邻。 导光板设置在光学膜组件的下方。 定位光源以将光线提供给导光板,使得背光模块能够提供平面的偏振光源。

    IMAGE DATA COMPRESSION METHOD AND APPARATUSES, IMAGE DISPLAY METHOD AND APPARATUSES
    56.
    发明申请
    IMAGE DATA COMPRESSION METHOD AND APPARATUSES, IMAGE DISPLAY METHOD AND APPARATUSES 失效
    图像数据压缩方法和装置,图像显示方法和装置

    公开(公告)号:US20080080778A1

    公开(公告)日:2008-04-03

    申请号:US11861770

    申请日:2007-09-26

    IPC分类号: G06K9/36 G06T1/20

    摘要: The image data compression method involves the performing of steps: a block dividing step for dividing a computer processor pipeline statistic image to be displayed into a plurality of blocks with predetermined block width and block height; a block list creating step for creating a block list for indexed blocks containing meaningful pixels in said divided blocks such that said indexed blocks are associated with each other, wherein said meaningful pixels are pixels corresponding to the computer processor pipeline raw trace data; and a pixel information compressing step for compressing original pixel information on the meaningful pixels in said indexed blocks and storing it in said block list. Apparatus for performing the method is also provided.

    摘要翻译: 图像数据压缩方法包括执行步骤:块分割步骤,用于将要显示的计算机处理器流水线统计图像划分成具有预定块宽度和块高度的多个块; 块列表创建步骤,用于在所述分割块中创建包含有意义像素的索引块的块列表,使得所述索引块相互关联,其中所述有意义的像素是与计算机处理器管线原始跟踪数据相对应的像素; 以及像素信息压缩步骤,用于压缩所述索引块中有意义的像素上的原始像素信息并将其存储在所述块列表中。 还提供了用于执行该方法的装置。

    CROSS-REACTIVE DISPLACING ANTIBODIES FROM COLLAGEN-BINDING PROTEINS AND METHOD OF IDENTIFICATION AND USE
    57.
    发明申请
    CROSS-REACTIVE DISPLACING ANTIBODIES FROM COLLAGEN-BINDING PROTEINS AND METHOD OF IDENTIFICATION AND USE 有权
    来自胶原蛋白结合蛋白的交叉反应位移抗体及其鉴定和使用方法

    公开(公告)号:US20070122416A1

    公开(公告)日:2007-05-31

    申请号:US09810428

    申请日:2001-03-19

    摘要: Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermidis bacteria and which can thus be used in the prevention and treatment of infections caused by both of these types of bacteria. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the proteins are advantageous because they are cross-reactive and may thus be administered to patients so as to reduce or prevent severe infection by staphylococcal bacteria of more than one species. Antibodies generated in this manner have also been shown to exhibit displacement activity and can thus be utilized advantageously in methods wherein these antibodies will be administered to patients having pre-existing staphylococcal infections because of the ability to displace bacterial proteins from binding sites on the extracellular matrix. Finally, a method of identifying, isolating and utilizing displacing antibodies is also provided.

    摘要翻译: 提供了对CNA蛋白和来自胶原结合结构域的其他区域(包括结构域CNA19)的抗体,并且以这种方式产生的抗体已显示与金黄色葡萄球菌和表皮葡萄球菌交叉反应,因此可以用于 预防和治疗由这两种细菌引起的感染。 此外,可以使用本发明的抗体治疗医疗器械,以便减少或消除它们被感染或进一步扩散感染的可能性。 特别地,蛋白质是有利的,因为它们是交叉反应性的,并且因此可以施用于患者,以便减少或预防多于一种物种的葡萄球菌细菌的严重感染。 以这种方式产生的抗体也已显示出显示置换活性,因此可有利地用于其中将这些抗体施用于具有预先存在的葡萄球菌感染的患者的方法,因为能够从细胞外基质上的结合位点置换细菌蛋白质 。 最后,还提供了鉴定,分离和利用置换抗体的方法。

    Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
    59.
    发明授权
    Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them 有权
    来自具有高度保守基序的革兰氏阳性细菌的表面蛋白和识别它们的抗体

    公开(公告)号:US06790448B2

    公开(公告)日:2004-09-14

    申请号:US10140372

    申请日:2002-05-08

    IPC分类号: A01N6300

    摘要: Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface proteins of Gram-positive bacteria, and these consensus sequences include amino acid sequences such as LPXTG (SEQ ID NO:13), ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:14), VEGAWEKPVAEAYLKQN (SEQ ID NO:15), and EYAGVDIDLAKKIAK (SEQ ID NO:16). By virtue of the highly conserved regions, the sequences and the proteins including these sequences can be utilized to generate antibodies which can recognize these highly conserved motifs and the proteins containing them and thus be useful in the treatment or prevention of a wide range of infections caused by Gram-positive bacteria.

    摘要翻译: 提供了含有这些序列的分离的肽序列和蛋白质,其可用于预防和治疗由革兰氏阳性菌引起的感染。 已经显示肽序列在革兰氏阳性细菌的表面蛋白中是高度保守的基序,并且这些共有序列包括氨基酸序列如LPXTG(SEQ ID NO:13),ALKTGKIDIIISGMTSTPERKK(SEQ ID NO:14),VEGAWEKPVAEAYLKQN (SEQ ID NO:15)和EYAGVDIDLAKKIAK(SEQ ID NO:16)。 由于高度保守的区域,包括这些序列的序列和蛋白质可用于产生能识别这些高度保守的基序和含有它们的蛋白质的抗体,因此可用于治疗或预防引起的广泛感染 通过革兰氏阳性菌。

    Damascene structure with reduced capacitance using a boron carbon nitride passivation layer, etch stop layer, and/or cap layer
    60.
    发明授权
    Damascene structure with reduced capacitance using a boron carbon nitride passivation layer, etch stop layer, and/or cap layer 有权
    使用氮化硼钝化层,蚀刻停止层和/或盖层的具有降低的电容的镶嵌结构

    公开(公告)号:US06690091B1

    公开(公告)日:2004-02-10

    申请号:US09666316

    申请日:2000-09-21

    IPC分类号: H01L2348

    摘要: A damascene structure with reduced capacitance dielectric stacking comprise a passivation, a first dielectric, an etch stop, a second dielectric and a cap layer over a first conductive layer formed on a semiconductor. The passivation, the etch stop, and the cap layers comprise low dielectric constant materials carbon nitride, boron nitride, or boron carbon nitride. The stack is patterned to form a via opening to the first conductive layer. A trench opening is formed stopping on the etch stop layer. A barrier layer of TaN, WN, TaSiN or Ta and a second conductive material is applied to the openings. Passivation, etch stop, or cap layers can be formed with carbon nitride by magnetron sputtering from a graphite target in a nitrogen atmosphere; boron carbon nitride by magnetron sputtering from a graphite target in a nitrogen and B2H6 atmosphere; or boron nitride by PECVD using B2H6, ammonia, and nitrogen.

    摘要翻译: 具有减小的电容电介质堆叠的镶嵌结构包括在半导体上形成的第一导电层上的钝化,第一电介质,蚀刻停止层,第二介电层和覆盖层。 钝化,蚀刻停止和盖层包括低介电常数材料碳氮化物,氮化硼或氮碳化硼。 图案化堆叠以形成到第一导电层的通孔。 形成停止在蚀刻停止层上的沟槽开口。 将TaN,WN,TaSiN或Ta和第二导电材料的阻挡层施加到开口。 钝化,蚀刻停止或盖层可以通过在氮气气氛中的石墨靶磁控溅射由碳氮化物形成; 硼氮化物通过磁控溅射从石墨靶在氮气和B2H6气氛中; 或使用B2H6,氨和氮的PECVD的氮化硼。