公开(公告)号：US20130114076A1

公开(公告)日：2013-05-09

申请号：US13809304

申请日：2011-07-05

申请人： Johannes Joseph Hubertina Barbara Schleipen ,  Albert Hendrik Jan Immink ,  Menno William Jose Prins ,  Derk Jan Wilfred Klunder

发明人： Johannes Joseph Hubertina Barbara Schleipen ,  Albert Hendrik Jan Immink ,  Menno William Jose Prins ,  Derk Jan Wilfred Klunder

IPC分类号： G01N21/01

CPC分类号： G01N21/01 ,  A61B5/0059 ,  B01L3/508 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0822 ,  B01L2300/0887 ,  B01L2400/043 ,  G01N21/552 ,  G01N21/648 ,  G01N21/7703

摘要： The invention relates to a cartridge (110) and an examination apparatus (100) for optical examinations of a sample. The cartridge (110) comprises a transparent bottom layer (113) that is of substantially uniform thickness and a top layer (111, 112) comprising a sample chamber (SC). The bottom layer and the top layer are preferably laminated onto each other, for example in a C roll-to-roll process. The bottom layer (113) is provided with structures like gratings (115) that allow the incoupling or outcoupling of light.

摘要翻译： 本发明涉及用于样品光学检查的盒（110）和检查装置（100）。 盒（110）包括具有基本均匀厚度的透明底层（113）和包括样品室（SC）的顶层（111,112）。 底层和顶层优选层压在彼此上，例如以C卷对卷方法。 底层（113）设置有允许光耦合或耦合的光栅（115）的结构。

公开(公告)号：US20120107961A1

公开(公告)日：2012-05-03

申请号：US13381115

申请日：2010-06-24

申请人： Wendy Uyen Dittmer ,  Femke Karina De Theije ,  Albert Hendrik Jan Immink ,  Jeroen Hans Nieuwenhuis ,  Petrus Johannes Wilhelmus Van Lankvelt

发明人： Wendy Uyen Dittmer ,  Femke Karina De Theije ,  Albert Hendrik Jan Immink ,  Jeroen Hans Nieuwenhuis ,  Petrus Johannes Wilhelmus Van Lankvelt

IPC分类号： G01N33/566 ,  G01N30/00

CPC分类号： G01N33/54326 ,  G01N21/552 ,  G01N27/745 ,  G01N33/54366 ,  G01N33/54386

摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.

摘要翻译： 公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。 所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括 用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。 所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生来自所述第一检测信号 在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值 当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。 还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。

公开(公告)号：US20110188030A1

公开(公告)日：2011-08-04

申请号：US12671735

申请日：2008-07-17

申请人： Coen Adrianus Verschuren ,  Menno Willem Jose Prins ,  Albert Hendrik Jan Immink

发明人： Coen Adrianus Verschuren ,  Menno Willem Jose Prins ,  Albert Hendrik Jan Immink

IPC分类号： G01N21/41

CPC分类号： G01N21/552 ,  G01N21/41 ,  G01N2021/4153 ,  G01N2021/434 ,  G01N2021/437

摘要： The invention relates to a microelectronic sensor device with a light source (21) for emitting an input light beam (L1) into a transparent carrier (11) such that it is totally internally reflected at a contact surface (12) as an output light beam (L2), which is detected by a light detector (31). Frustration of the total internal reflection at the contact surface (12) can then for example be used to determine the amount of target particles (1) present at this surface. The sensor device further comprises a refractive index measurement unit (100, 200, 300) for measuring the refractive index (nB) of the sample medium, and an evaluation unit (50) for evaluating the measurement of the light detector (31) taking the measured refractive index (nB) into account and/or for changing the conditions of total internal reflection of the input light beam (L1). The refractive index measurement unit may particularly be designed to infer the refractive index (nB) from the deflection of a test-light beam (L3) that is transmitted through the sample medium, or from a reflection of a test-light beam (L1) at an interface (12) to the sample medium. In the latter case, it is possible to determine the critical angle of total internal reflection and/or to measure the reflectivity of the interface.

摘要翻译： 本发明涉及一种具有用于将输入光束（L1）发射到透明载体（11）中的光源（21）的微电子传感器装置，使得其在接触表面（12）处作为输出光束被全内反射 （L2），其由光检测器（31）检测。 接触表面（12）处的全内反射的挫折可以例如用于确定存在于该表面的目标颗粒（1）的量。 传感器装置还包括用于测量样品介质的折射率（nB）的折射率测量单元（100,200,300），以及用于评估光检测器（31）的测量的评估单元（50） 测量的折射率（nB）和/或用于改变输入光束（L1）的全内反射的条件。 折射率测量单元可以特别地被设计为从透射通过样品介质的测试光束（L3）的偏转或从测试光束（L1）的反射推断折射率（nB） 在样品介质的界面（12）处。 在后一种情况下，可以确定全内反射的临界角和/或测量界面的反射率。

公开(公告)号：US07955558B2

公开(公告)日：2011-06-07

申请号：US12092840

申请日：2006-10-30

申请人： Johannes Wilhelmus Weekamp ,  Menno Willem Jose Prins ,  Albert Hendrik Jan Immink

发明人： Johannes Wilhelmus Weekamp ,  Menno Willem Jose Prins ,  Albert Hendrik Jan Immink

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N27/00 ,  G01N31/22 ,  G01N33/52 ,  B01L3/00

CPC分类号： B01L3/5029 ,  A61B10/0051 ,  A61B2010/0009 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2300/0654 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L2400/065

摘要： A device for testing a fluid including an elongated carrier; two foam members for absorbing the fluid, which are arranged at an end of the carrier; a positioning member having a sleeve which is slidably arranged on the carrier; and a diagnostic device, which is arranged in the positioning member having a sensor die adapted to detecting at least one property of the fluid and means for supplying the fluid to a sensor surface of the sensor die. After the fluid has been supplied to the foam members, the positioning member is moved towards the end of the carrier where the foam members are located. When the diagnostic device comes into contact with one of the foam members, the fluid is squeezed from the foam member and supplied to the sensor surface of the sensor die through the fluid supplying means of the diagnostic device.

摘要翻译： 一种用于测试包括细长载体的流体的装置; 用于吸收流体的两个泡沫构件，其布置在载体的端部; 定位构件，其具有可滑动地布置在所述载体上的套筒; 以及诊断装置，其布置在所述定位构件中，所述诊断装置具有适于检测所述流体的至少一个性质的传感器管芯和用于将所述流体供应到所述传感器管芯的传感器表面的装置。 在将流体供应到泡沫构件之后，定位构件朝向泡沫构件所在的载体的端部移动。 当诊断装置与其中一个泡沫构件接触时，流体被从泡沫构件挤压并通过诊断装置的流体供给装置供应到传感器模头的传感器表面。

公开(公告)号：US20100248383A1

公开(公告)日：2010-09-30

申请号：US12743833

申请日：2008-11-18

申请人： Albert Hendrik Jan Immink ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson ,  Murray Fulton Gillies

发明人： Albert Hendrik Jan Immink ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson ,  Murray Fulton Gillies

IPC分类号： G01N21/55 ,  G01N21/05 ,  H05K13/00

CPC分类号： G01N21/552 ,  Y10T29/49002

摘要： A sensor cartridge has a cartridge substrate comprising an optical substrate for optical detection of a target moiety in a sample fluid based on frustrated totalinternal reflection and at least one electric structure. This way, optical read-out and electrical functions, e.g. read-out, are combined in a single substrate, in a simple and cheap manner. Also a method of fabricating such sensor cartridge is provided.

摘要翻译： 传感器盒具有包括光学基板的盒基板，该光学基板用于基于挫败的总内反射和至少一个电结构来光学检测样品流体中的目标部分。 这样，光学读出和电功能，例如， 读出，以简单和便宜的方式组合在单个基板中。 还提供了一种制造这种传感器盒的方法。

公开(公告)号：US20100233824A1

公开(公告)日：2010-09-16

申请号：US12669213

申请日：2008-07-11

申请人： Godefridus Johannes Verhoeckx ,  Henkrik Sibolt Van Damme ,  Jeroen Hans Nieuwenhuis ,  Sergei Shulepov ,  Johannes Wilhelmus Weekamp ,  Mara Johanna Jacoba Sijbers ,  Harold Johannes Antonius Brans ,  Femke Karina De Theije ,  Albert Hendrik Jan Immink

发明人： Godefridus Johannes Verhoeckx ,  Henkrik Sibolt Van Damme ,  Jeroen Hans Nieuwenhuis ,  Sergei Shulepov ,  Johannes Wilhelmus Weekamp ,  Mara Johanna Jacoba Sijbers ,  Harold Johannes Antonius Brans ,  Femke Karina De Theije ,  Albert Hendrik Jan Immink

IPC分类号： G01N33/53 ,  G01N33/00 ,  B23P17/04

CPC分类号： B01L3/502715 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0487 ,  Y10T29/49826

摘要： A microfluidic reactor arrangement (100) for use in detecting an analyte in a fluid sample (106) is described. The reactor arrangement is provided with a reagent providing means such that the reagent can be introduced after assembly of the reactor arrangement. The latter can be performed by introducing the reagent in the form of a solution or a dispersion and fixing it on a holding means (118) by removal of the liquid, i.e. by drying, the holding means comprising the reagent in a solid version in the detector chamber. Prior to the introduction of the reagent, components of the reactor arrangement already present, such as the sample inlet can be hydrophilised by a wetting hydrophilising technique. The invention relates to a manufacturing technique as well as to the resulting product. The invention furthermore relates to functionalizing of the reactor arrangement with a particular reagent for particular applications. The latter can be performed well after fabrication and assembly of the major reactor arrangement components.

摘要翻译： 描述了用于检测流体样品（106）中的分析物的微流体反应器装置（100）。 反应器装置设置有试剂提供装置，使得可以在组装反应器装置之后引入试剂。 后者可以通过将试剂以溶液或分散体的形式引入并通过除去液体将其固定在保持装置（118）上来进行，即通过干燥包含试剂的固定装置以固体形式在 检测器室。 在引入试剂之前，已经存在的反应器装置的组分（例如样品入口）可以通过润湿亲水化技术亲水化。 本发明涉及制造技术以及所得到的产品。 本发明还涉及用于特定应用的具有特定试剂的反应器装置的功能化。 后者可以在主要反应器布置部件的制造和组装之后很好地进行。

公开(公告)号：US07706234B2

公开(公告)日：2010-04-27

申请号：US11718921

申请日：2005-11-11

申请人： Andrei Mijiritskii ,  Sjoerd Stallinga ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper ,  Albert Hendrik Jan Immink ,  Teunis Willem Tukker ,  Coen Theodorus Hubertus Fran Liedenbaum

发明人： Andrei Mijiritskii ,  Sjoerd Stallinga ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper ,  Albert Hendrik Jan Immink ,  Teunis Willem Tukker ,  Coen Theodorus Hubertus Fran Liedenbaum

IPC分类号： G11B7/00

CPC分类号： G11B7/1353 ,  G02B3/14 ,  G02B26/005 ,  G11B7/1369 ,  G11B7/1378

摘要： In an optical scanning device (10) capable of scanning an information plane of an optical record carrier (5) of different types such as BD, DVD and CD, the diameter of the radiation spot on the detector (7) is dependent on the numerical aperture of the objective system (4) that is used for scanning the record carrier An optimal design of the optical detection system for scanning a BD, result in a small radiation spot for the other types such as DVD and CD. By implementing an optical element (13) that increases the diameter of the radiation spot in the situation a DVD or CD is scanned, the influence of stray light is reduced and the tracking signals are improved

摘要翻译： 在能够扫描诸如BD，DVD和CD的不同类型的光学记录载体（5）的信息平面的光学扫描装置（10）中，检测器（7）上的辐射点的直径取决于数字 用于扫描记录载体的物镜系统（4）的孔径用于扫描BD的光学检测系统的最佳设计导致诸如DVD和CD的其它类型的小的辐射点。 通过实现在DVD或CD被扫描的情况下增加辐射点的直径的光学元件（13），杂散光的影响减小并且跟踪信号得到改善

公开(公告)号：US20090181464A1

公开(公告)日：2009-07-16

申请号：US12299775

申请日：2007-04-24

申请人： Femke Karina De Theije ,  Albert Hendrik Jan Immink

发明人： Femke Karina De Theije ,  Albert Hendrik Jan Immink

IPC分类号： G01N27/00

CPC分类号： G01N33/54333 ,  B82Y25/00 ,  G01N27/745 ,  H01F1/0054

摘要： A method is provided for determining the concentration of target in a fluid sample using a magnetic label and a magnetic sensor for detection. It was surprisingly found that efficient and accurate measurements can be carried out by determination of a signal as soon as the signal has reached a specified threshold level. In an alternative embodiment, a displacement step is used as soon as the signal has reached a pre-defined threshold level.

摘要翻译： 提供了一种用于使用磁性标签和用于检测的磁性传感器来确定流体样品中的靶的浓度的方法。 令人惊讶地发现，一旦信号达到指定的阈值水平，就可以通过确定信号来执行有效和准确的测量。 在替代实施例中，一旦信号达到预定义的阈值水平，就使用位移步骤。

公开(公告)号：US20080318339A1

公开(公告)日：2008-12-25

申请号：US12158555

申请日：2006-12-22

申请人： Erik Robbert Vossenaar ,  Albert Hendrik Jan Immink

发明人： Erik Robbert Vossenaar ,  Albert Hendrik Jan Immink

IPC分类号： G01N33/53 ,  C07K16/00 ,  B01J19/00

CPC分类号： G01N33/54326 ,  G01N33/54373 ,  G01N33/686 ,  G01N35/0098

摘要： A sensing device is provided which has a universal sensor surface. This allows easy modification of the detection properties without the need for investigation of the binding properties of a new target to the sensor surface. The device comprises a sensor surface, which has attached thereto a primary capture molecule. The invention further relates to a method for measurement of a target wherein this device is used.

摘要翻译： 提供了一种具有通用传感器表面的感测装置。 这允许容易地修改检测性能，而不需要研究新的靶标与传感器表面的结合特性。 该装置包括传感器表面，其附接有主要捕获分子。 本发明还涉及一种用于测量其中使用该装置的目标的方法。

公开(公告)号：US20080305969A1

公开(公告)日：2008-12-11

申请号：US12095133

申请日：2006-11-23

申请人： Johan Frederik Dijksman ,  Anke Pierik ,  Antonius Johannes Jo Wismans ,  Leonardus Johannes Cornelius Van Den Besselaar ,  Martin Maurice Vernhout ,  Adrianus Theodorus Anthonius Maria Raaijmakers ,  Richard Joseph Marinus Schroeders ,  Albert Hendrik Jan Immink ,  Roy Gerardus Franciscus Antonius Verbeek

发明人： Johan Frederik Dijksman ,  Anke Pierik ,  Antonius Johannes Jo Wismans ,  Leonardus Johannes Cornelius Van Den Besselaar ,  Martin Maurice Vernhout ,  Adrianus Theodorus Anthonius Maria Raaijmakers ,  Richard Joseph Marinus Schroeders ,  Albert Hendrik Jan Immink ,  Roy Gerardus Franciscus Antonius Verbeek

IPC分类号： C40B50/14 ,  C40B60/14

CPC分类号： B01L3/0268 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00693 ,  B01L9/523 ,  B01L13/02 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2400/0439 ,  G01N35/00663 ,  G01N35/1002 ,  G01N2035/1006 ,  G01N2035/1041

摘要： The invention provides an ink jet device (10) for producing a biological assay-substrate by releasing a plurality of substances onto the substrate, the device comprising printing means (20), detection means (30,32,45,45′), filling means and cleaning means (120), and wherein the ink jet device further comprises control means for an automated production such that the production of the biological assay substrate is error tolerant for a multitude of error sources.

摘要翻译： 本发明提供了一种用于通过将多种物质释放到基底上产生生物测定基板的喷墨装置（10），该装置包括印刷装置（20），检测装置（30,32,45,45'），填充物 装置和清洁装置（120），并且其中所述喷墨装置还包括用于自动化生产的控制装置，使得所述生物测定基板的生产对于许多误差源是错误的。