公开(公告)号：US07959672B2

公开(公告)日：2011-06-14

申请号：US10911059

申请日：2004-08-03

申请人： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider

发明人： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078 ,  A61F2250/0069

摘要： Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve; expanding the anchor to a deployed configuration; and locking the anchor in the deployed configuration.

摘要翻译： 用于血管内替换患者心脏瓣膜的装置，包括：适于被血管内递送至心脏瓣膜附近的置换瓣膜; 可膨胀的锚固件适于被血管内递送到心脏瓣膜附近; 以及锁定机构，其构造成保持最小量的锚固膨胀。 本发明还包括一种用于血管内替换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：将置换瓣膜和可扩张锚固件血管内输送到心脏瓣膜附近; 将锚扩展到部署配置; 并将锚定器锁定在部署的配置中。

公开(公告)号：US20090054969A1

公开(公告)日：2009-02-26

申请号：US12264082

申请日：2008-11-03

申请人： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider ,  Jeff Krolik

发明人： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider ,  Jeff Krolik

IPC分类号： A61F2/06 ,  A61B19/00 ,  A61F2/24

CPC分类号： A61F2/2409 ,  A61F2/013 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/0036 ,  A61F2250/0039

摘要： A method for percutaneously replacing a heart valve of a patient. In some embodiments the method includes the steps of percutaneously delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; expanding the anchor to a deployed configuration in which the anchor contacts tissue at a first anchor site; repositioning the anchor to a second anchor site; and deploying the anchor at the second anchor site.

摘要翻译： 一种用于经皮置换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以未膨胀构型经皮递送置换瓣膜和可扩张锚定至心脏瓣膜附近的步骤; 将锚扩展到展开构型，其中锚固件在第一锚固部位接触组织; 将锚重新定位到第二锚点; 并在第二锚点部署锚。

公开(公告)号：US07022284B2

公开(公告)日：2006-04-04

申请号：US10434887

申请日：2003-05-09

申请人： Ben F. Brian ,  John Thomas Buckley ,  Jean-Pierre Dueri ,  Mehrdad Farhangnia ,  Steven K. Stringer

发明人： Ben F. Brian ,  John Thomas Buckley ,  Jean-Pierre Dueri ,  Mehrdad Farhangnia ,  Steven K. Stringer

IPC分类号： A61M1/34 ,  A61M1/36 ,  A61M37/00

CPC分类号： A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2209/084 ,  B01D19/0031 ,  Y10S128/03 ,  Y10S261/28

摘要： Apparatus for oxygenating and pumping blood includes a housing defining a blood flow path including, in series, a gas collection plenum, a pump space and a blood oxygenation element. A pump disposed in the pump space is configured to draw blood from the gas collection plenum and propel blood from the pump space through a heat exchanger and the blood oxygenation element. The heat exchanger includes a heat exchange plate and a coolant space.

公开(公告)号：US06689315B2

公开(公告)日：2004-02-10

申请号：US10117964

申请日：2002-04-05

申请人： Fred I. Linker ,  Jean-Pierre Dueri ,  Paul LaRoy Edwards ,  Ronald Cambron ,  Ben F. Brian, III

发明人： Fred I. Linker ,  Jean-Pierre Dueri ,  Paul LaRoy Edwards ,  Ronald Cambron ,  Ben F. Brian, III

IPC分类号： A61M136

CPC分类号： A61M1/3626 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/262 ,  A61M1/267 ,  A61M1/3606 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3666 ,  Y10S128/03 ,  Y10S261/28 ,  Y10S417/902

摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system and a pump impeller with a single piece metal insert. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.

摘要翻译： 提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统和具有单件金属插入件的泵叶轮。 提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。 气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。

公开(公告)号：US20060177343A1

公开(公告)日：2006-08-10

申请号：US11397423

申请日：2006-04-03

申请人： Ben Brian ,  John Buckley ,  Jean-Pierre Dueri ,  Mehrdad Farhangnia ,  Steven Stringer

发明人： Ben Brian ,  John Buckley ,  Jean-Pierre Dueri ,  Mehrdad Farhangnia ,  Steven Stringer

IPC分类号： A61M1/36

CPC分类号： A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2209/084 ,  B01D19/0031 ,  Y10S128/03 ,  Y10S261/28

摘要： Apparatus for oxygenating and pumping blood includes a housing defining a blood flow path including, in series, a gas collection plenum, a pump space and a blood oxygenation element. A pump disposed in the pump space is configured to draw blood from the gas collection plenum and propel blood from the pump space through a heat exchanger and the blood oxygenation element. The heat exchanger includes a heat exchange plate and a coolant space.

摘要翻译： 用于对血液进行充氧和抽血的装置包括限定血流路径的壳体，其包括串联的气体收集气室，泵空间和血氧元件。 设置在泵空间中的泵构造成从气体收集室抽取血液，并且通过热交换器和血氧元件推动来自泵空间的血液。 热交换器包括热交换板和冷却剂空间。

公开(公告)号：US06224829B1

公开(公告)日：2001-05-01

申请号：US09223423

申请日：1998-12-30

申请人： Alec A. Piplani ,  Anthony Makarewicz ,  Jean-Pierre Dueri ,  Thomas A. Afzal

发明人： Alec A. Piplani ,  Anthony Makarewicz ,  Jean-Pierre Dueri ,  Thomas A. Afzal

IPC分类号： A61M114

CPC分类号： A61M1/267 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M2205/366

摘要： Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. A plurality of vanes arranged along a central shaft of the device increase pressure near the center of the fiber bundle to prevent microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to minimize flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements. Blood trauma may be further reduced by contouring the vanes and other components of the device.

摘要翻译： 具有提供含氧化合物和泵血液的旋转中空纤维束组件的集成血液泵/充氧器的改进。 沿着装置的中心轴布置的多个叶片增加了纤维束中心附近的压力，以防止微泡产生和血液创伤。 施加在纤维束的纤维元件上的剪切载荷通过添加加强结构而减少，而气体流动路径被配置为最小化由于纤维元件的偶尔破裂引起的淹没和氧合效率的损失。 通过对设备的叶片和其它部件进行轮廓化可以进一步减少血液创伤。

公开(公告)号：US06428747B1

公开(公告)日：2002-08-06

申请号：US09430219

申请日：1999-10-29

申请人： Jean-Pierre Dueri ,  Robert Jochim ,  Alex Leynov

发明人： Jean-Pierre Dueri ,  Robert Jochim ,  Alex Leynov

IPC分类号： A61M3700

CPC分类号： F28F21/062 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1029 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/366

摘要： An integrated blood pump, oxygenator and heat exchanger is provided having a rotating hollow fiber bundle assembly. A plurality of vanes arranged along a central shaft of the device increase pressure near the center of the fiber bundle to develop sufficient pressure head to pump the blood through the heat exchanger. In alternative embodiments, the heat exchanger comprises a pleated metal wall, a bundle of non-permeable hollow fibers, or a coiled tub disposed between the rotating hollow fiber bundle and an interior wall of the housing.

摘要翻译： 提供具有旋转的中空纤维束组件的集成血液泵，充氧器和热交换器。 沿着装置的中心轴布置的多个叶片增加了靠近纤维束中心的压力，以形成足够的压力头，以通过热交换器泵送血液。 在替代实施例中，热交换器包括折叠的金属壁，一束不可渗透的中空纤维或设置在旋转的中空纤维束和壳体的内壁之间的盘管。

公开(公告)号：US06379618B1

公开(公告)日：2002-04-30

申请号：US09223676

申请日：1998-12-30

申请人： Alec A. Piplani ,  Anthony Makarewicz ,  Jean-Pierre Dueri ,  Thomas A. Afzal

发明人： Alec A. Piplani ,  Anthony Makarewicz ,  Jean-Pierre Dueri ,  Thomas A. Afzal

IPC分类号： A61M114

CPC分类号： F28F21/062 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/366

摘要： Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. A plurality of vanes arranged along a central shaft of the device increase pressure near the center of the fiber bundle to prevent microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to minimize flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements. Blood trauma may be further reduced by contouring the vanes and other components of the device.

摘要翻译： 具有提供含氧化合物和泵血液的旋转中空纤维束组件的集成血液泵/充氧器的改进。 沿着装置的中心轴布置的多个叶片增加了纤维束中心附近的压力，以防止微泡产生和血液创伤。 施加在纤维束的纤维元件上的剪切载荷通过添加加强结构而减少，而气体流动路径被配置为最小化由于纤维元件的偶尔破裂引起的淹没和氧合效率的损失。 通过对设备的叶片和其它部件进行轮廓化可以进一步减少血液创伤。

公开(公告)号：US06960322B2

公开(公告)日：2005-11-01

申请号：US10616116

申请日：2003-07-08

申请人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Ben F. Brian, III ,  Fred I. Linker ,  James M. Culp ,  Jean-Pierre Dueri ,  Thomas A. Afzal

发明人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Ben F. Brian, III ,  Fred I. Linker ,  James M. Culp ,  Jean-Pierre Dueri ,  Thomas A. Afzal

IPC分类号： A61M1/14 ,  A61M1/10 ,  A61M1/36 ,  A61M37/00 ,  B01D47/08 ,  B01D53/22 ,  C02F1/44

CPC分类号： A61M1/3626 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/262 ,  A61M1/267 ,  A61M1/3606 ,  A61M1/3627 ,  A61M1/3666 ,  Y10S261/28

摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.

摘要翻译： 提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统。 提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。 气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。

公开(公告)号：US06503450B1

公开(公告)日：2003-01-07

申请号：US09475467

申请日：1999-12-30

申请人： Thomas A. Afzal ,  Jean-Pierre Dueri ,  Alex Leynov ,  Anthony Makarewicz ,  Alec A. Piplani ,  Greg Potts

发明人： Thomas A. Afzal ,  Jean-Pierre Dueri ,  Alex Leynov ,  Anthony Makarewicz ,  Alec A. Piplani ,  Greg Potts

IPC分类号： A61M114

CPC分类号： F28F21/062 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1029 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/366

摘要： Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. An inner member arranged along a central axis of the device accelerates blood entering the fiber bundle to reduce microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to reduce flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements.

摘要翻译： 具有提供含氧化合物和泵血液的旋转中空纤维束组件的集成血液泵/充氧器的改进。 沿着装置的中心轴布置的内部构件加速进入纤维束的血液，以减少微泡产生和血液创伤。 施加在纤维束的纤维元件上的剪切载荷通过添加加强结构而减少，而气体流动路径被配置为减少由于纤维元件的偶尔破裂引起的淹水和氧合效率的损失。