摘要:
A dual-pawl ratchet wrench mechanism is disclosed having a stop mechanism for limiting over-travel of a reversing lever for selecting drive directions. The stop mechanism is formed on a disc is selectively engageable with first and second pawls to move the pawls into and out of engagement with a ratchet gear to determine a torque drive direction, the ratchet gear capable of providing torque to a working piece in the selected drive direction. The design simplifies manufacturing. Additionally, the reversing lever is assembled with the mechanism in a manner to improve sealing.
摘要:
A mounting system is provided for mounting an air conditioner on the exterior of a building adjacent to a window with an opening defined by a window frame having a lower sill and a height to an upper horizontal frame member. The air conditioner includes a main cabinet and a removable air duct. The mounting system includes two mounting arms, each arm being attached at a first point to a wall of the main cabinet and at a second point being engaged to the frame of the window. The main cabinet is suspended from the two mounting arms such that when mounted, a top surface of the main cabinet is positioned at a height of no more than 10% of the height of the window opening above the sill. The mounting system may provide support for the air conditioner at three points, namely, the sill of the window, an inside casing of the window and an exterior surface of the building, without requiring any fasteners to be driven into any of these points.
摘要:
An apparatus and method for treating sleep apnea and/or snoring is provided. The apparatus includes an appliance sized and structured to be placed in the pharyngeal region of a human or animal and being effective in treating sleep apnea and/or snoring, for example in maintaining openness of an oropharyngeal region of a human or animal during natural sleep, advantageously while not interfering with normal functioning of the epiglottis. The appliance may be made of a super elastic material, for example, Nitinol, and may be submucossally implanted in the pharyngeal walls.
摘要:
Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: In the compounds of Formula I, B or R2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a —CH2—.
摘要翻译:具有式I结构的化合物,包括化合物的药学上可接受的盐,是CETP抑制剂,可用于升高HDL-胆固醇,降低LDL-胆固醇,以及用于治疗或预防动脉粥样硬化。在式I化合物中,B或 R 2是具有邻芳基,杂环,苯并杂环或苯并环烷基取代基的苯基,并且在5元环上的另一个位置具有直接连接的芳族,杂环,环烷基,苯并杂环或苯并环烷基取代基 通过-CH 2 - 2连接到环上或连接到环上。
摘要:
An apparatus and method for treating sleep apnea and/or snoring is provided. The apparatus includes an appliance sized and structured to be placed in the pharyngeal region of a human or animal and being effective in treating sleep apnea and/or snoring, for example in maintaining openness of an oropharyngeal region of a human or animal during natural sleep, advantageously while not interfering with normal functioning of the epiglottis. Preferably, the appliance is non-circumferential in form and includes rounded, spaced apart end portions.
摘要:
A glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, in which each dash represents a covalent bond; wherein A1 comprises a modified or unmodified α-amino acid residue, alkyl, aryl, aralkyl, alkanoyl, aroyl, aralkanoyl, heterocyclic, heterocyclic-carbonyl, heterocyclic-alkyl, heterocyclic-alkyl-carbonyl, alkylsulfonyl, arylsulfonyl, guanidinyl, carbamoyl, or xanthyl; wherein each of A2 to A7 comprises a modified or unmodified α-amino acid residue, whereby (i) A1 is linked to an amino group on A2, (ii) each of A2, A4 and A6 bears an aromatic side chain, which aromatic side chains are cross-linked together by two or more covalent bonds, and (iii) A7 bears a terminal carboxyl, ester, amide, or N-substituted amide group; and wherein one or more of A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, at least one of the sugar residues bearing one or more substituents of the formula YXR, N+(R1)═CR2R3, N═PR1R2R3, N+R1R2R3 or P+R1R2R3 in which Y is a single bond, O, NR1 or S; X is O, NR1, S, SO2, C(O)O, C(O)S, C(S)O, C(S)S, C(NR1)O, C(O)NR1, or halo (in which case Y and R are absent). A chemical library comprising a plurality of the glycopeptides of the invention. A method for preparing a glycopeptide by glycosylation of an aglycone derived from a glycopeptide antibiotic. A method for preparing a glycopeptide by preparing a pseudoaglycone from a glycopeptide antibiotic and glycosylating the pseudoaglycone.
摘要:
A knowledge management system according to the invention uses print cover sheets to connect users to knowledge relevant both to the user and the communities to which they belong by making use of the declaration of relevance implicit in the print process. The cover sheet becomes an input, output and surrogate document mechanism enabling access to both document repositories and associated knowledge management services, such as for example, document related services and a recommender service.
摘要:
The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.