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    Triazene compounds for the treatment of cancer
    52.
    发明授权
    Triazene compounds for the treatment of cancer 失效
    用于治疗癌症的三氮烯化合物

    公开(公告)号：US08426390B2

    公开(公告)日：2013-04-23

    申请号：US13205831

    申请日：2011-08-09

    申请人： Rudolf Reiter ,  Jochen Kalbe ,  Heinz Forster

    发明人： Rudolf Reiter ,  Jochen Kalbe ,  Heinz Forster

    IPC分类号： A61K31/655

    CPC分类号： C07C245/24 ,  C07C309/15 ,  C07D233/64

    摘要： The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.

    摘要翻译： 本发明涉及新的三氮烯化合物，其制备方法，包含它们的药物组合物及其在治疗人类癌症疾病中的用途。 与已知的三氮烯化合物相比，新的三氮烯化合物通过改善活性而同时具有降低的毒性，也就是说副作用较少。

    Trifluoromethyl-phenoxy-phenyl-silicon derivatives, processes for their preparation, and their use as herbicides and plant-growth regulators
    59.
    发明授权
    Trifluoromethyl-phenoxy-phenyl-silicon derivatives, processes for their preparation, and their use as herbicides and plant-growth regulators 失效

    公开(公告)号：US4481365A

    公开(公告)日：1984-11-06

    申请号：US433923

    申请日：1982-10-12

    申请人： Heinz Forster ,  Ludwig Eue ,  Robert Schmidt ,  Klaus Lurssen

    发明人： Heinz Forster ,  Ludwig Eue ,  Robert Schmidt ,  Klaus Lurssen

    IPC分类号： A01N55/00 ,  A01N55/10 ,  C07F7/08 ,  C07F7/10 ,  C07F7/12 ,  C07F7/18 ,  E05B65/00 ,  E05B63/00

    CPC分类号： A01N55/00 ,  C07F7/0818 ,  C07F7/10 ,  C07F7/12 ,  C07F7/1844

    摘要： A trifluoromethyl-phenoxy-phenyl-silicon compound is disclosed of the general formula ##STR1## in which X.sup.1 and X.sup.2 independently of each other represent a hydrogen, fluorine, chlorine, bromine or iodine atom,Y represents a hydrogen or halogen atom or a cyano or nitro group,n is 0 or 1,m is 0, 1, 2 or 3,p is 0, 1, 2 or 3,X.sup.3 and X.sup.4 independently of each other represent oxygen or a --CO--O-- group,R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently of one another represent a hydrogen atom or a C.sub.1 to C.sub.5 alkyl group,R.sup.5 and R.sup.6 independently of each other represent a C.sub.1 to C.sub.5 alkyl group, andR.sup.7 represents a C.sub.1 to C.sub.5 alkyl or hydroxyl group, a chlorine, bromine, or iodine atom or a C.sub.2 to C.sub.5 alkenoxy, C.sub.2 to C.sub.5 alkinoxy,C.sub.1 to C.sub.5 alkylthio, C.sub.2 to C.sub.5 alkenyl-thio or C.sub.2 to C.sub.5 alkinyl-thio group or a C.sub.1 to C.sub.5 alkoxy group which is straight-chain or branched and optionally substituted by fluorine, chlorine, bromine, iodine, C.sub.1 to C.sub.5 alkoxy and/or C.sub.1 to C.sub.5 alkylthio, or represents a radical of the general formula ##STR2## wherein R.sup.8 and R.sup.9 independently of each other represent a phenyl radical which is optionally substituted by fluorine, bromine, and/or iodine, or represent a straight-chain or branched C.sub.1 to C.sub.5 alkyl, C.sub.2 to C.sub.5 alkenyl or C.sub.2 to C.sub.5 alkinyl group,or whereinR.sup.8 and R.sup.9, together with the nitrogen atom to which they are bonded, represent a pyrrolidyl radical which is optionally substituted by methyl and/or ethyl, represent a morpholinyl radical which is optionally substituted by methyl, or represent an azacycloheptyl, piperidyl, 3-methyl-piperidyl, 4-methyl-piperidyl, 2-ethyl-piperidyl, 4-ethyl-piperidyl, 2,3-dimethyl-piperidyl, 2,4-dimethyl-piperidyl, 2,5-dimethyl-piperidyl, or 3,5-dimethyl-piperidyl radical.The trifluoromethyl-phenoxy-phenyl-silicon compounds are useful as herbicides and plant growth regulators. Disclosed are compositions containing the same and methods for their preparation.