公开(公告)号：US20090047722A1

公开(公告)日：2009-02-19

申请号：US12045618

申请日：2008-03-10

申请人： Brian D. Wilkerson ,  James C. Chen ,  John Pulse ,  Andrei Guschin ,  Michael Weaver

发明人： Brian D. Wilkerson ,  James C. Chen ,  John Pulse ,  Andrei Guschin ,  Michael Weaver

IPC分类号： C12N13/00 ,  C12M1/00 ,  C12N1/12

CPC分类号： C12N1/12 ,  C12M21/02 ,  C12M31/10 ,  C12M33/00

摘要： Systems, devices, and methods for releasing one or more cell components from a photosynthetic organism. A bioreactor system is operable for growing photosynthetic organisms. Some of the methods include contacting the photosynthetic organism with an energy-activatable sensitizer, and activating the energy-activatable sensitizer, thereby releasing a cellular component from at least one of, for example, a membrane structure, tubule, vesicle, cisterna, organelle, cell compartment, plastid, or mitochondrion, associated with the photosynthetic organisms.

摘要翻译： 用于从光合生物释放一种或多种细胞组分的系统，装置和方法。 生物反应器系统可用于生长光合生物。 一些方法包括使光合生物与能量激活的敏化剂接触，并激活能量可激活的敏化剂，从而从例如膜结构，小管，囊泡，细胞器，细胞器，细胞器中的至少一种释放细胞成分， 与光合生物相关的细胞室，质体或线粒体。

公开(公告)号：US07320786B2

公开(公告)日：2008-01-22

申请号：US11297880

申请日：2005-12-07

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61K9/00 ,  A61K39/395 ,  A01N43/38

CPC分类号： A61K41/0057 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/62 ,  A61K47/6843 ,  A61K47/6847 ,  Y10S514/912

摘要： This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light of specific wavelength sufficient to photoactivate photosensitizing agent. The photosensitizing agent is bound to a composition that mediates site specific delivery to a neovasculature target tissue of a therapeutically effective amount of a photosensitizing agent that is activated by a relatively low fluence rate of light over a prolonged period of time. Diseases treatable under this invention, include: diabetic retinopathy; macular degeneration; and malignant uveal melanomas.

摘要翻译： 本发明公开了通过施用靶向光敏剂并随后暴露于足以光敏化剂的特定波长的光来治疗眼睛新生血管疾病的方法，试剂盒和说明书。 光敏剂与一种组合物结合，该组合物介导在新的脉管系统靶组织中治疗有效量的光敏剂的部位特异性递送，所述光敏剂在较长的时间内被相对较低的光通量光激活。 本发明可治疗的疾病包括：糖尿病性视网膜病变; 黄斑变性; 和恶性葡萄膜黑素瘤。

公开(公告)号：US07288106B2

公开(公告)日：2007-10-30

申请号：US10677645

申请日：2003-10-02

申请人： Gregory L. Heacock ,  Darrin Huston ,  James C. Chen ,  Steven R. Daly

发明人： Gregory L. Heacock ,  Darrin Huston ,  James C. Chen ,  Steven R. Daly

IPC分类号： A61N5/06

CPC分类号： A61F9/008 ,  A61F9/009 ,  A61F2009/00844 ,  A61F2009/00863 ,  A61F2009/00868 ,  A61F2009/00891 ,  A61N5/062 ,  A61N2005/0652

摘要： A system and method for excitation of photosensitizers is configured to provide desired illumination on targeted eye tissue. The excitation system includes an optical module that generates illumination and a controller to power the optical module and control the shape, intensity or energy level, and duration of the illumination. The optical module includes a contact portion for interfacing with the eye, a treatment beam portion including a light emitter array to generate shaped light patterns and optics to focus the light patterns onto the eye, and a visualization portion to provide visual feedback of treatment through a visualization interface coupled with a microscope. A typical treatment involves the optical module being placed on a diseased eye of a patient by a clinician to project illumination on a diseased portion of the eye. The clinician typically views the eye through the microscope and the optical module during treatment.

摘要翻译： 用于激发光敏剂的系统和方法被配置为在目标眼睛组织上提供期望的照明。 励磁系统包括产生照明的光学模块和用于为光学模块供电并控制形状，强度或能量水平以及照明持续时间的控制器。 光学模块包括用于与眼睛接口的接触部分，包括光发射器阵列以产生成形光图案的光束部分和用于将光图案聚焦到眼睛上的光学元件，以及可视化部分，以通过以下方式提供治疗的视觉反馈： 可视化界面与显微镜相结合。 典型的治疗包括光学模块被临床医生放置在患者的患病眼睛上以在眼睛的患病部分上投影照明。 临床医生通常在治疗期间通过显微镜和光学模块观察眼睛。

公开(公告)号：US07197663B2

公开(公告)日：2007-03-27

申请号：US10719388

申请日：2003-11-20

申请人： Frederick J. Carberry ,  Rufus J. Twito ,  James C. Chen ,  Richard A. Schaeffer ,  Kaukab Uddin

发明人： Frederick J. Carberry ,  Rufus J. Twito ,  James C. Chen ,  Richard A. Schaeffer ,  Kaukab Uddin

IPC分类号： G06F11/00

CPC分类号： G06F3/065 ,  G06F3/0617 ,  G06F3/067

摘要： A method of error management in a data storage system having a target device, with the target device receiving commands from a first initiator and the target device concurrently receiving commands from a second initiator. The target device is typically a storage device operating as a PPRC secondary. A first initiator is a device which communicates with the target device through small computer systems interface (SCSI) protocol. The first initiator is typically a host computer or server. The second initiator communicates with the target device through peer-to-peer remote copy PPRC initiator mode commands. The second initiator is typically a separate storage device in a peer-to-peer remote copy (PPRC) relationship with the target device. The method consists of managing errors associated with a command sent to the target device from the first initiator independently from the management of errors associated with a command sent to the target device from the second initiator.

摘要翻译： 一种具有目标设备的数据存储系统中的错误管理方法，其中目标设备从第一启动器接收命令，并且目标设备同时从第二启动器接收命令。 目标设备通常是作为PPRC辅助设备运行的存储设备。 第一启动器是通过小型计算机系统接口（SCSI）协议与目标设备通信的设备。 第一个启动器通常是主机或服务器。 第二个启动器通过对等远程复制PPRC启动器模式命令与目标设备进行通信。 第二个启动器通常是与目标设备的对等远程复制（PPRC）关系中的单独的存储设备。 该方法包括管理与从第一启动器发送到目标设备的命令相关联的错误，独立于从与第二启动器发送到目标设备的命令相关联的错误的管理。

公开(公告)号：US06520669B1

公开(公告)日：2003-02-18

申请号：US09597931

申请日：2000-06-19

申请人： James C. Chen ,  Darrin Huston

发明人： James C. Chen ,  Darrin Huston

IPC分类号： F21W10114

CPC分类号： G09F9/301 ,  B60Q1/2696 ,  F21S41/143 ,  F21S43/14 ,  F21S43/315 ,  F21V7/0091 ,  F21Y2115/10 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/48228 ,  H01L2224/73265 ,  H01L2224/85801 ,  H01L2224/8585 ,  Y10S362/80 ,  H01L2924/00014

摘要： Exterior lighting assemblies for use on vehicles include a flexible substrate on which are mounted a plurality of solid-state light emitting devices. Preferably, light emitting diodes (LEDs) are used for the solid-state light emitting devices, although other types of devices can alternatively be employed. The light emitting devices are connected to flexible conductive traces provided on the flexible substrate and leads are provided to connect to the power supply on the vehicle so that electrical current can be selectively supplied to energize the light emitting devices. The flexible substrate is adapted to be mounted on the exterior surface of a vehicle, for example, as a tail lamp assembly, or as a headlamp. Light emitting devices that emit different colored light can be used to provide red light to indicate slowing of the vehicle due to braking, amber light for turn signal indication, and white light to illuminate the surface over which the vehicle is traveling. A flexible optically transparent cover protects the light emitting devices. Due to their flexibility, the light assemblies can be conformed around a curved exterior surface of a vehicle.

摘要翻译： 用于车辆的外部照明组件包括柔性基板，其上安装有多个固态发光装置。 优选地，发光二极管（LED）用于固态发光器件，但是也可以采用其他类型的器件。 发光器件连接到设置在柔性基板上的柔性导电迹线，并且提供引线以连接到车辆上的电源，使得可以选择性地提供电流以激励发光器件。 柔性基板适于安装在车辆的外表面上，例如，作为尾灯组件或头灯。 可以使用发射不同颜色的光的发光装置来提供红光，以指示由于制动而导致的车辆减速，用于转向信号指示的琥珀色光，以及照亮车辆行驶的表面的白光。 柔性光学透明盖保护发光器件。 由于它们的灵活性，灯组件可以围绕车辆的弯曲外表面。

公开(公告)号：US6112277A

公开(公告)日：2000-08-29

申请号：US937423

申请日：1997-09-25

申请人： Thao B. Bui ,  James C. Chen ,  Chan Y. Ng

发明人： Thao B. Bui ,  James C. Chen ,  Chan Y. Ng

IPC分类号： G06F3/06 ,  G06F12/08 ,  G06F12/00

CPC分类号： G06F3/061 ,  G06F12/0866 ,  G06F3/0638 ,  G06F3/0689 ,  G06F3/065

摘要： A staging method and means for both device read and update write operations in which messages and commands between a storage subsystem and a fixed-block formatted RAID array emulating a variable-length record (CKD) formatted device for both read and write operations are evaluated to ascertain whether the record addressing was random and truly in record mode. If they are in that mode, then partial track staging by the RAID array control from the fixed-block formatted HDDs to a subsystem cache or the like would reduce device contention by reading and staging less than full track.

公开(公告)号：US6080160A

公开(公告)日：2000-06-27

申请号：US760057

申请日：1996-12-04

申请人： James C. Chen ,  Brent Wiscombe

发明人： James C. Chen ,  Brent Wiscombe

IPC分类号： A61B17/00 ,  A61B17/34 ,  A61B19/00 ,  A61M25/04 ,  A61N5/06

CPC分类号： A61M25/04 ,  A61B17/3468 ,  A61N5/0601 ,  A61B2017/00867 ,  A61B2090/306 ,  A61B90/39

摘要： A method and apparatus for selectively engaging and disengaging an anchor to fix a medical device at a selected site within a patient's body. A shape memory alloy (SMA) such as Nitinol is used to fabricate one or more anchors for the medical device. The shape memory effect exhibited by the SMA is thermally activated. One embodiment of the anchor has a substantially circular shape when at its martensite temperature and reverts to an elliptical shape at its austenite temperature. Another embodiment is a substantially straight strip at its martensite temperature and has an end that curls to engage tissue when at its austenite temperature. Still another embodiment includes a pair of anchors that extend outwardly from each side of an elongate probe at their austenite temperature and retract inwardly against the sides of the probe at their martensite temperature. The change in the shape of the SMA elements tends to anchor the medical device or probe at the treatment site. To change the temperature of the SMA elements, an electrical current is selectively energized to provide heat, or thermal conduction between the SMA and a heat source or a heat sink is employed.

摘要翻译： 一种用于选择性地接合和分离锚定器以将医疗装置固定在患者体内的选定部位的方法和装置。 使用诸如镍钛诺的形状记忆合金（SMA）来制造用于医疗装置的一个或多个锚固件。 SMA表现出的形状记忆效应被热激活。 锚固件的一个实施例在其马氏体温度下具有大致圆形形状并且在其奥氏体温度下回复到椭圆形状。 另一个实施方案是其马氏体温度下的基本上直的条带，并且具有在其奥氏体温度时卷曲以接合组织的端部。 另一个实施例包括一对锚定件，其在其奥氏体温度下从细长探针的每侧向外延伸并且在其马氏体温度下向内靠近探针的侧部。 SMA元件的形状变化倾向于将医疗器械或探针固定在治疗部位。 为了改变SMA元件的温度，选择性地通电电流以提供热量，或者使用SMA与热源或散热器之间的热传导。

公开(公告)号：US5957960A

公开(公告)日：1999-09-28

申请号：US850909

申请日：1997-05-05

申请人： James C. Chen ,  Brent Wiscombe

发明人： James C. Chen ,  Brent Wiscombe

IPC分类号： A61K41/00 ,  A61K45/00 ,  A61N5/06 ,  A61P43/00

CPC分类号： A61N5/062 ,  A61K41/008 ,  A61N5/0601 ,  A61N2005/0645 ,  A61N2005/0652

摘要： A plurality of light sources that emit light having a long wavelength are energized for an extended period of time to increase the likelihood of two photon absorption by cells that have preferentially absorbed a photoreactive agent such as psoralen. The cells are preferably microscopic metastatic cancer cells that are diffusely distributed throughout a treatment site, for example, within an organ. The plurality of light sources are arranged in a spaced-apart array, mounted on a support plate that includes a plurality of conductive traces. A plurality of such arrays are preferably mounted to a flexible sheet that can conform to an outer surface of an organ being treated. Because the light emitted by the light sources is in the infrared or near infrared waveband, it penetrates deeply into the tissue at the treatment site. The duration of the treatment and the number of light sources employed for administering the therapy increases the likelihood of two photon absorption by the metastatic cancer cells, which has been shown to activate the photoreactive agent to destroy cancer cells in a tumor, even though the characteristic light absorption waveband of the photoreactive agent is in the ultraviolet waveband.

摘要翻译： 发射长波长的光的多个光源被激励一段较长的时间，以增加优先吸收光活性剂如补骨脂素的细胞的双光子吸收的可能性。 细胞优选是扩散分布在整个治疗部位，例如器官内的微观转移癌细胞。 多个光源被布置成间隔开的阵列，安装在包括多个导电迹线的支撑板上。 多个这样的阵列优选地安装到柔性片材上，该柔性片材可以符合被处理器官的外表面。 由于光源发出的光线处于红外线或近红外线波段，所以在治疗部位深入到组织中。 用于治疗的持续时间和用于治疗该治疗的光源的数量增加了转移癌细胞的两个光子吸收的可能性，已经显示活化光反应剂以破坏肿瘤中的癌细胞，即使特征 光反应剂的光吸收波段处于紫外波段。

公开(公告)号：US5876427A

公开(公告)日：1999-03-02

申请号：US787775

申请日：1997-01-29

申请人： James C. Chen ,  Brent Wiscombe

发明人： James C. Chen ,  Brent Wiscombe

IPC分类号： A61N5/06 ,  H01L25/075 ,  H05K1/18 ,  A61N21/00

CPC分类号： A61N5/0601 ,  A61N5/062 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/48465 ,  H01L2224/73265 ,  H01L25/0756 ,  H05K1/189

摘要： A flexible probe constructed using a flexible circuit having a small cross-sectional profile. In the various disclosed embodiments of the flexible circuit, a flexible substrate includes a plurality of conductive traces that extend along opposite surfaces of the substrate. Light emitting devices (or other electronic devices) are mounted at spaced-apart intervals along the length of the conductive traces using a conductive adhesive/solder. A conductor couples a terminal on the outwardly facing side of each of the light emitting devices to the conductive trace that is disposed on the opposite side of the substrate. In one embodiment, this conductor comprises a short conductive bar that extends between the terminals of pairs of the light emitting devices that are mounted on opposite sides of the flexible substrate so that the pair of light emitting devices are connected in series. In another embodiment, the flexible substrate includes an outwardly extending arm of the conductive trace that wraps around the edge of the flexible substrate to connect to the light emitting device mounted on the opposite side thereof. In each embodiment, a substantially smaller cross-sectional profile is achieved compared to a previous approach in which the conductive traces providing power to a light emitting device were located on the same side of the flexible substrate and fly wires were used to connect the light emitting devices to the conductive traces.

摘要翻译： 使用具有小横截面轮廓的柔性电路构成的柔性探头。 在柔性电路的各种公开的实施例中，柔性衬底包括沿衬底的相对表面延伸的多个导电迹线。 发光器件（或其他电子器件）使用导电粘合剂/焊料沿着导电迹线的长度以间隔的间隔安装。 导体将每个发光器件的面向外侧的端子连接到设置在衬底的相对侧上的导电迹线。 在一个实施例中，该导体包括短导电棒，其在安装在柔性基板的相对侧上的成对的发光器件的端子之间延伸，使得该对发光器件串联连接。 在另一个实施例中，柔性基板包括导电迹线的向外延伸的臂，其围绕柔性基板的边缘缠绕以连接到安装在其相对侧上的发光器件。 在每个实施例中，与先前的方法相比，实现了基本上较小的横截面轮廓，其中向发光器件提供功率的导电迹线位于柔性基板的相同侧上，并且使用飞线将发光 器件到导电迹线。

公开(公告)号：US5766234A

公开(公告)日：1998-06-16

申请号：US633171

申请日：1996-04-16

申请人： James C. Chen ,  Brent Wiscombe

发明人： James C. Chen ,  Brent Wiscombe

IPC分类号： A61B5/04 ,  A61B17/00 ,  A61B17/04 ,  A61B19/00 ,  A61N1/00 ,  A61N5/06 ,  A61N7/00

CPC分类号： A61B17/00234 ,  A61N5/0601 ,  A61N5/062 ,  A61B2017/00243 ,  A61B2017/00274 ,  A61B2017/0404 ,  A61B2017/0458 ,  A61B2018/00547 ,  A61N2005/061 ,  A61N2005/0645 ,  A61N2005/0652

摘要： A plurality of embodiments for a flexible probe used to provide photodynamic therapy (PDT) and to effect other medical procedures at an internal treatment site inside a patient's body. Each of the embodiments of the flexible probe (100, 108, 130, 158, 182, 190, 220, 280, 370, 390, 440, 460, 520) includes a flexible substrate (102, 184, 196, 222, 250, 282, 412, 462, 482, 502, 522) on which are disposed conductive traces (414, 466, 468, 488, 490, 504, 506, 524, 526) electrically connected to leads through which electrical current and signals are conveyed. A plurality of light sources (104, 192, 256, 286, 418, 436, 470, 492, 508, 542) or other micro-electronic circuits are connected to the conductive traces and mounted on the flexible substrate. Each of the embodiments of the flexible probes is enclosed within a transparent, biocompatible polymer envelope (106, 110, 464, 522). Due to the characteristic elastic properties of the flexible substrate, the flexible probe can readily be bent, folded, or rolled while being disposed at the internal treatment site. Thus, for example, a curved surgical needle (650) can be used to implant a flexible probe at the treatment site by drawing the flexible probe through tissue along a curved path to a desired position; one or more disk-shaped buttons (660, 670) that are attached to the ends of the flexible probe can be used to secure the flexible probe so that it does not move from the desired position.

摘要翻译： 用于提供光动力治疗（PDT）的柔性探针的多个实施例，并且在患者体内的内部治疗部位进行其它医疗程序。 柔性探针（100,108,130,158,182,190,220,280,370,390,440,460,520）的每个实施例包括柔性基底（102,184,196,222,250， 282,412,462,482,502,522），其上设置有电连接到通过其传送电流和信号的引线的导电迹线（414,466,468,48,490,504,506,524,526）。 多个光源（104,192,256,286,418,436,470,492,504,542）或其它微电子电路连接到导电迹线并且安装在柔性基板上。 柔性探针的每个实施例被封装在透明的生物相容性聚合物封套（106,110,464,522）内。 由于柔性基板的特征弹性特性，柔性探针可以容易地弯曲，折叠或卷起，同时处于内部处理部位。 因此，例如，弯曲外科手术针（650）可以用于通过将柔性探针通过组织沿弯曲路径拉伸到期望位置来在治疗部位植入柔性探针; 可以使用附接到柔性探针的端部的一个或多个盘形按钮（660,670）来固定柔性探针，使得其不会从期望的位置移动。