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    DEVICES AND METHODS FOR TREATING RECTOVAGINAL AND OTHER FISTULAE
    51.
    发明申请
    DEVICES AND METHODS FOR TREATING RECTOVAGINAL AND OTHER FISTULAE 审中-公开
    用于治疗重建和其他造影剂的装置和方法

    公开(公告)号：US20110060362A1

    公开(公告)日：2011-03-10

    申请号：US12948177

    申请日：2010-11-17

    申请人： Umesh H. Patel ,  F. Joseph Obermiller

    发明人： Umesh H. Patel ,  F. Joseph Obermiller

    IPC分类号： A61B17/03

    CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00641

    摘要： Provided by certain aspects of the invention are methods for treating fistulae and various fistula graft assemblages useful in this regard. Illustratively, some inventive methods are useful in treating fistulae having at least a first fistula opening, a second fistula opening and a fistula tract extending therebetween. In one step, a first capping member is positioned over the first fistula opening such that a first pulling member, which extends from the first capping member, passes through the fistula tract. In another step, a second capping member is positioned over the second fistula opening such that a second pulling member, which extends from the second capping member, passes through the fistula tract. A first pulling force is applied to the first pulling member, and a second pulling force is applied to the second pulling member, for maintaining the first capping member over the first fistula opening and for maintaining the second capping member over the second fistula opening, respectively.

    摘要翻译： 由本发明的某些方面提供的是用于治疗瘘管和各种瘘移植物组合物的方法。 说明性地，一些本发明的方法可用于治疗具有至少第一瘘开口，第二瘘开口和在其间延伸的瘘管道的瘘。 在一个步骤中，第一封盖构件定位在第一瘘开口上方，使得从第一封盖构件延伸的第一牵引构件穿过瘘管道。 在另一步骤中，第二封盖构件定位在第二瘘开口上方，使得从第二封盖构件延伸的第二牵引构件穿过瘘管道。 第一拉力被施加到第一牵引构件，并且第二拉力施加到第二牵引构件，用于将第一封盖构件保持在第一瘘开口上方并且用于将第二封盖构件分别保持在第二瘘开口上方 。

    TISSUE AUGMENTATION DEVICES AND METHODS
    52.
    发明申请
    TISSUE AUGMENTATION DEVICES AND METHODS 有权
    组织补充装置及方法

    公开(公告)号：US20110046576A1

    公开(公告)日：2011-02-24

    申请号：US12939636

    申请日：2010-11-04

    申请人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    发明人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    IPC分类号： A61M5/00

    CPC分类号： A61F2/0059

    摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.

    摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。

    Quilted implantable graft
    53.
    发明授权
    Quilted implantable graft 有权

    公开(公告)号：US10688219B2

    公开(公告)日：2020-06-23

    申请号：US12482002

    申请日：2009-06-10

    申请人： Umesh H. Patel ,  Jeffrey Miller

    发明人： Umesh H. Patel ,  Jeffrey Miller

    IPC分类号： A61L27/36 ,  A61L27/50 ,  A61L27/38 ,  A61L27/56 ,  A61L27/14 ,  B32B5/26 ,  B32B5/06 ,  B32B7/08

    摘要： Described are embodiments of a multilaminate or multiple layer implantable surgical graft comprising remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.

    Quilted implantable graft
    54.
    发明授权
    Quilted implantable graft 有权
    绗缝植入式移植物

    公开(公告)号：US09295757B2

    公开(公告)日：2016-03-29

    申请号：US12965205

    申请日：2010-12-10

    申请人： Umesh H. Patel ,  Jeffrey Miller ,  Neal E. Fearnot ,  Mark W. Bleyer

    发明人： Umesh H. Patel ,  Jeffrey Miller ,  Neal E. Fearnot ,  Mark W. Bleyer

    IPC分类号： A61F2/02 ,  A61L27/36 ,  A61L27/50 ,  A61L31/00

    CPC分类号： A61L27/3633 ,  A61F2/0063 ,  A61F2/0077 ,  A61F2/02 ,  A61L27/3625 ,  A61L27/3629 ,  A61L27/50 ,  A61L31/005

    摘要： Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.

    摘要翻译： 描述了具有包含可重塑胶原片材料的说明性移植物的多层或多层可植入手术移植物的实施方案，所述移植物包括一个或多个交织构件以将移植物缝合在一起以帮助防止层在处理期间分层或分离，并且初始 重塑阶段。 交织构件可以包括以期望的图案编织穿过生物材料层的缝合线，线，单个线迹，材料条等。 在一个实施方案中，交织构件包含药理学活性物质，例如药物，生长因子等，以在宿主组织中引发所需的生物反应。 在另一个实施方案中，移植物还包括在可重塑生物材料层内的增强材料，例如合成网，并由一个或多个交织构件缝合在一起。

    Frameless vascular valve
    58.
    发明授权
    Frameless vascular valve 有权
    无框血管瓣膜

    公开(公告)号：US08556960B2

    公开(公告)日：2013-10-15

    申请号：US12613326

    申请日：2009-11-05

    申请人： Charles W. Agnew ,  Umesh H. Patel

    发明人： Charles W. Agnew ,  Umesh H. Patel

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2412 ,  A61F2/2415 ,  A61F2/2475 ,  A61F2220/0016 ,  A61L27/3604 ,  A61L27/3633 ,  A61L27/507

    摘要： Prosthetic valve devices, as well as systems and methods for the delivery thereof, are disclosed. A device includes one or more leaflets disposed within a frameless conduit, wherein the conduit is adapted for attachment to walls of a vascular vessel, and the leaflets are adapted for attachment to walls of the conduit. The leaflets are configured to selectively restrict blood flow through the conduit, and the conduit can include wall-engaging adaptations, for example, barbs or an adhesive. The conduit and the leaflets are formed with a flexible material, which may comprise a remodelable material and/or a synthetic polymer.

    摘要翻译： 公开了假体瓣膜装置，以及用于其传送的系统和方法。 装置包括设置在无框导管内的一个或多个小叶，其中所述导管适于附着到血管容器的壁上，并且所述小叶适于附接到所述导管的壁。 传单构造成选择性地限制通过导管的血液流动，并且导管可以包括壁接合适配，例如倒钩或粘合剂。 导管和小叶形成有柔性材料，其可以包含可重塑材料和/或合成聚合物。

    Tissue augmentation devices and methods
    60.
    发明授权
    Tissue augmentation devices and methods 有权
    组织增强装置和方法

    公开(公告)号：US08470356B2

    公开(公告)日：2013-06-25

    申请号：US12939636

    申请日：2010-11-04

    申请人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    发明人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    IPC分类号： A61M5/158 ,  C12N5/00 ,  A61F2/00 ,  A61M31/00 ,  A61M5/178 ,  A61B17/34 ,  A61B17/04 ,  A61B17/06 ,  C12M1/00

    CPC分类号： A61F2/0059

    摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.

    摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。