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77 条记录 (耗时 0.032 秒)

    Condensed heterocyclic compounds, their production and use
    52.
    发明授权
    Condensed heterocyclic compounds, their production and use 失效
    稠合杂环化合物，其生产和使用

    公开(公告)号：US5459129A

    公开(公告)日：1995-10-17

    申请号：US112795

    申请日：1993-08-27

    申请人： Hiroshi Akimoto ,  Kazuyoshi Aso ,  Koichiro Ootsu

    发明人： Hiroshi Akimoto ,  Kazuyoshi Aso ,  Koichiro Ootsu

    IPC分类号： C07D487/04 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08

    CPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04

    摘要： A novel compound of the formula: ##STR1## wherein a ring A stands for an optionally substituted 5-membered ring; B stands for an optionally substituted divalent cyclic or chain group; either one of Q.sup.1 and Q.sup.2 stands for N and the other stands for N or CH; X stands for an amino group, hydroxyl group or mercapto group; Y stands for H, halogen atom or a group bonded through C, N, 0 or S; Z stands for a straight-chain divalent group having 2 to 5 atoms constituted of optionally substituted carbon atoms or constituted of optionally substituted carbon atoms and one optionally substituted hetero-atom; COOR.sup.1 and COOR.sup.2 independently stand for an optionally esterified carboxyl group; n denotes an integer of 2 to 6; and R.sup.1 may be different in each of n repeating units, or their salts and it is useful as a therapeutic drug for tumor in mammals.

    摘要翻译： 下式的新化合物：其中环A代表任选取代的5元环; B代表任选取代的二价环状或链状基团; Q1和Q2之一代表N，另一个代表N或CH; X代表氨基，羟基或巯基; Y代表H，卤素原子或通过C，N，O或S键合的基团; Z表示由任选取代的碳原子构成或由任选取代的碳原子和一个任选取代的杂原子构成的具有2至5个原子的直链二价基团; COOR1和COOR2独立地代表任选酯化的羧基; n表示2〜6的整数， 并且R 1可以在n个重复单元或其盐中的每一个中不同，并且其可用作哺乳动物肿瘤的治疗药物。

    Pyrrolopyrimidine derivatives, their production and use
    54.
    发明授权
    Pyrrolopyrimidine derivatives, their production and use 失效
    吡咯并嘧啶衍生物，其生产和使用

    公开(公告)号：US4997838A

    公开(公告)日：1991-03-05

    申请号：US326901

    申请日：1989-03-21

    申请人： Hiroshi Akimoto ,  Takenori Hitaka ,  Tetsuo Miwa

    发明人： Hiroshi Akimoto ,  Takenori Hitaka ,  Tetsuo Miwa

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： A compound of the formula ##STR1## wherein the ring .circle.A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.

    Maytansinoids, their use and pharmaceutical compositions thereof
    55.
    发明授权
    Maytansinoids, their use and pharmaceutical compositions thereof 失效
    美登木素类，它们的用途和药物组合物

    公开(公告)号：US4317821A

    公开(公告)日：1982-03-02

    申请号：US152392

    申请日：1980-05-22

    申请人： Osamu Miyashita ,  Hiroshi Akimoto

    发明人： Osamu Miyashita ,  Hiroshi Akimoto

    IPC分类号： A61K31/535 ,  A61P35/00 ,  C07D498/18

    CPC分类号： C07D498/18

    摘要： Novel maytansinoids of the formula: ##STR1## wherein Y is H or Cl, and R is C.sub.2-15 alkyl, phenyl-C.sub.1-4 alkyl, pyridyl-C.sub.1-4 alkyl, imidazolyl-C.sub.1-4 alkyl, indolyl-C.sub.1-4 alkyl, furyl-C.sub.1-4 alkyl or thienyl-C.sub.1-4 alkyl, said R group being substituted by hydroxyl, halogen or C.sub.1-5 alkanoyloxy at its .alpha.- and/or .beta.-position, have antimitotic, antitumor and antimicrobial activities.

    摘要翻译： 新型美登木素素，其分子式如下：其中Y是H或Cl，R是C 2-15烷基，苯基-C 1-4烷基，吡啶基-C 1-4烷基，咪唑基C 1-4烷基，吲哚基-C 1-4烷基，呋喃基-C1 -4-烷基或噻吩基-C 1-4烷基，所述R基团在其α-和/或β-位置被羟基，卤素或C 1-5烷酰氧基取代，具有抗有丝分裂，抗肿瘤和抗微生物活性。

    Maytansinoids
    56.
    发明授权
    Maytansinoids 失效
    美登木素生物碱

    公开(公告)号：US4309428A

    公开(公告)日：1982-01-05

    申请号：US171459

    申请日：1980-07-23

    申请人： Osamu Miyashita ,  Hiroshi Akimoto

    发明人： Osamu Miyashita ,  Hiroshi Akimoto

    IPC分类号： C07D498/18 ,  A61K31/535 ,  C07D498/16

    CPC分类号： C07D498/18

    摘要： Novel maytansinoids of the formula: ##STR1## wherein X is hydrogen or chlorine,R.sup.1 is C.sub.2-4 alkyl,R.sup.2 is C.sub.2-8 alkyl which may be substituted or methyl which is substituted,have antimicrobial, antimitotic and antitumor activities.

    摘要翻译： 新型美登木素素，其分子式如下：其中X为氢或氯，R1为C2-4烷基，R2为可被取代的C2-8烷基或被取代的甲基，具有抗微生物，抗有丝分裂和抗肿瘤活性。

    Ozonizer
    57.
    发明授权
    Ozonizer 失效
    臭氧发生器

    公开(公告)号：US4307433A

    公开(公告)日：1981-12-22

    申请号：US141658

    申请日：1980-04-18

    申请人： Taichi Takechi ,  Hideomi Takahashi ,  Hiroshi Akimoto ,  Hiroshi Tomiki

    发明人： Taichi Takechi ,  Hideomi Takahashi ,  Hiroshi Akimoto ,  Hiroshi Tomiki

    IPC分类号： C01B13/11 ,  H01J9/18 ,  F24F3/16

    CPC分类号： C01B13/11 ,  C01B2201/10 ,  C01B2201/20 ,  C01B2201/24 ,  C01B2201/30 ,  C01B2201/34 ,  Y10T29/49218 ,  Y10T29/4922

    摘要： An ozonizer which comprises a flat hollow metal grounded electrode and a discharge electrode plate spaced apart therefrom by a discharge space. The discharge electrode plate includes a flat hollow dielectric member, a high voltage electrode formed on the inner surface of the dielectric member, a spacer material provided within and held in a clamped state by the dielectric member, a lead conductor provided within and held in a clamped state by the spacer material and a connector connecting the lead conductor and high voltage electrode.

    摘要翻译： 一种臭氧发生器，其包括平坦的中空金属接地电极和通过放电空间与其隔开的放电电极板。 放电电极板包括平坦的中空电介质构件，形成在电介质构件的内表面上的高电压电极，设置在电介质构件内并由钳位状态保持的隔离材料， 通过间隔材料夹持状态，连接引线导体和高压电极的连接器。