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51.发明申请RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) 审中-公开使用短干扰核酸（siNA）的RNA干扰介导的多梳组蛋白EZH2基因表达的抑制公开(公告)号：US20050159382A1
公开(公告)日：2005-07-21
申请号：US10923580
申请日：2004-08-19
IPC分类号： A61K38/00 , A61K47/48 , C12N15/11 , C12N15/113 , C12N15/115 , C12N15/87 , A61K48/00 , C07H21/02
CPC分类号： A61K49/0008 , A61K38/00 , C12N15/111 , C12N15/113 , C12N15/1132 , C12N15/1137 , C12N15/1138 , C12N15/115 , C12N15/87 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/53 , C12N2320/32 , C12N2330/30 , C12Y103/01022 , C12Y104/03003 , C12Y114/19001 , C12Y207/07049 , C12Y207/11001 , C12Y207/11013 , C12Y301/03048 , C12Y604/01002 , C12N2310/3521
摘要： This invention relates to compounds, compositions, and methods useful for modulating polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of polycomb group protein EZH2 gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of polycomb group protein EZH2 genes, such as EZH2.
摘要翻译： 本发明涉及可用于使用短干扰核酸（siNA）分子调节多梳组蛋白EZH2基因表达的化合物，组合物和方法。 本发明还涉及使用小核酸分子调节参与多梳组蛋白EZH2基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（mRNA）和短发夹RNA（shRNA） ）分子和方法用于调节多组蛋白EZH2基因的表达，如EZH2。
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52.发明申请RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) 审中-公开RNA干扰介导的使用短干扰核酸（siNA）抑制血管内皮生长因子和血管内皮生长因子受体基因表达公开(公告)号：US20050148530A1
公开(公告)日：2005-07-07
申请号：US10831620
申请日：2004-04-23
申请人： James McSwiggen , Leonid Beigelman , Pamela Pavco
发明人： James McSwiggen , Leonid Beigelman , Pamela Pavco
CPC分类号： C12N15/111 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/51 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要： The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor (e.g., VEGFR1, VEGFR2 and/or VEGFr3) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against VEGF and/or VEGFr gene expression and/or activity. The small nucleic acid molecules are useful in the diagnosis and treatment of cancer, proliferative diseases, and any other disease or condition that responds to modulation of VEGF and/or VEGFr expression or activity.
摘要翻译： 本发明涉及可用于调节血管内皮生长因子（VEGF，VEGF-A，VEGF-B，VEGF-C，VEGF-D）和/或血管内皮生长因子受体（例如VEGFR1，VEGFR2和/或 VEGFr3）基因在各种应用中的表达，包括用于治疗，诊断，靶标验证和基因组发现应用。 具体地，本发明涉及小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（mRNA）和短发夹RNA（shRNA） 能够介导针对VEGF和/或VEGFr基因表达和/或活性的RNA干扰（RNAi）的分子。 小核酸分子可用于诊断和治疗癌症，增殖性疾病以及对VEGF和/或VEGFr表达或活性的调节作出响应的任何其它疾病或病症。
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53.发明申请RNA interference mediated treatment of Parkinson disease using short interfering nucleic acid (siNA) 审中-公开使用短干扰核酸（siNA）的RNA干扰介导的帕金森病治疗公开(公告)号：US20050137155A1
公开(公告)日：2005-06-23
申请号：US10861060
申请日：2004-06-03
IPC分类号： A61K38/00 , A61K47/48 , C12N15/113 , C12N15/87 , H01L21/331 , H01L29/08 , H01L29/161 , H01L29/45 , H01L29/737 , A61K48/00 , C07H21/02
CPC分类号： H01L29/7371 , A61K38/00 , A61K49/0008 , C12N15/113 , C12N15/87 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/53 , H01L29/0817 , H01L29/161 , H01L29/452 , H01L29/66318 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating Parkinson genes, for example, PARK1 (SNCA), PARK2, PARK7, and/or PARK5 gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against SNCA gene expression and/or activity. The small nucleic acid molecules are useful in the diagnosis and treatment of Parkinson Disease (PD), and any other disease or condition that responds to modulation of PARK1 (SNCA), PARK2, PARK7, and/or PARK5 expression or activity.
摘要翻译： 本发明涉及用于调节帕金森病基因（例如PARK1（SNCA）），PARK2，PARK7和/或PARK5基因在各种应用中的表达的方法和试剂，包括用于治疗，诊断，靶标验证和基因组发现 应用程序。 具体而言，本发明涉及小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） 能够介导针对SNCA基因表达和/或活性的RNA干扰（RNAi）的分子。 小的核酸分子可用于帕金森病（PD）的诊断和治疗以及对PARK1（SNCA），PARK2，PARK7和/或PARK5表达或活性的调节作出反应的任何其它疾病或病症。
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54.发明申请RNA interference mediated inhibtion of tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) 审中-公开使用短干扰核酸（siNA）的RNA干扰介导的酪氨酸磷酸酶-1B（PTP-1B）基因表达的抑制公开(公告)号：US20050070497A1
公开(公告)日：2005-03-31
申请号：US10894475
申请日：2004-07-19
申请人： James McSwiggen , Leonid Beigelman , Nassim Usman
发明人： James McSwiggen , Leonid Beigelman , Nassim Usman
CPC分类号： C12N15/1137 , A61K38/00 , A61K49/0008 , C12N15/87 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/53 , C12Y301/03048 , C12N2310/3521
摘要： This invention relates to compounds, compositions, and methods useful for modulating protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of PTP-1B gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of PTP-1B genes.
摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节蛋白酪氨酸磷酸酶-1B（PTP-1B）基因表达的化合物，组合物和方法。 本发明还涉及使用小核酸分子调节涉及PTP-1B基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节PTP-1B基因表达的方法。
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55.发明授权Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor 有权用于治疗与血管内皮生长因子受体水平相关的疾病或病症的方法和试剂公开(公告)号：US06818447B1
公开(公告)日：2004-11-16
申请号：US09685664
申请日：2000-10-10
IPC分类号： C12N502
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： The present invention relates to nucleic acid molecules which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor.
摘要翻译： 本发明涉及调节编码血管内皮生长因子的一种或多种受体的mRNA的合成，表达和/或稳定性的核酸分子。
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56.发明授权Nucleic acid molecules with novel chemical compositions capable of modulating gene expression 有权具有能够调节基因表达的新化学成分的核酸分子公开(公告)号：US06673611B2
公开(公告)日：2004-01-06
申请号：US09866316
申请日：2001-05-25
申请人： James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
发明人： James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1138 , C12N2310/15 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3521 , C12N2310/3527
摘要： This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
摘要翻译： 本发明涉及具有特异性结构的新化学修饰的核酸分子，其表现出对核酸酶的增加的抗性和增加的对靶核酸分子的结合亲和力。 本发明还涉及使用新的化学修饰的核酸分子调节基因表达的方法，以及包含所述分子的组合物和细胞。
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57.发明授权Ribozyme treatment of diseases or conditions related to levels of NF-&kgr;B 失效与NF-κB水平相关的疾病或病症的核酶治疗公开(公告)号：US06410224B1
公开(公告)日：2002-06-25
申请号：US08777916
申请日：1996-12-23
IPC分类号： C07H2104
CPC分类号： C12N15/101 , A61K38/00 , A61K48/00 , C07K14/4702 , C12N9/6491 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3517 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535 , C12N2310/3521
摘要： Enzymatic RNA molecules which cleave rel A mRNA.
摘要翻译： 分解相关A mRNA的酶RNA分子
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公开(公告)号：US06194150B1
公开(公告)日：2001-02-27
申请号：US09038073
申请日：1998-03-11
申请人： Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
发明人： Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
IPC分类号： C07H2104
CPC分类号： C07H19/16 , C07H19/06 , C07H19/10 , C07H19/20 , C07H21/00 , C12N9/6491 , C12N15/113 , C12N15/1138 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/3521
摘要： Nucleic acid molecule which blocks synthesis and/or expression of an mRNA encoding B7-1, B7-2, B7-3 and/or CD40.
摘要翻译： 阻断编码B7-1，B7-2，B7-3和/或CD40的mRNA的合成和/或表达的核酸分子。
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公开(公告)号：US5972704A
公开(公告)日：1999-10-26
申请号：US910408
申请日：1997-08-13
IPC分类号： A61K38/00 , C07K14/08 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/70 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/85 , C12N15/86 , C12Q1/701 , C12Q1/703 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2740/16022
摘要： An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
摘要翻译： 在病毒复制所需的基因中切割免疫缺陷病毒RNA的酶学核酸分子，例如nef或tat基因区域。
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公开(公告)号：US5879938A
公开(公告)日：1999-03-09
申请号：US435398
申请日：1995-05-05
IPC分类号： A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/08 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/70 , C07H21/04 , C12N15/00
CPC分类号： C12N15/1137 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/005 , C12N15/1138 , C12N15/85 , C12N15/86 , C12Y304/24017 , A61K38/00 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/346 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2760/10122
摘要： Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
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