公开(公告)号：US20130332100A1

公开(公告)日：2013-12-12

申请号：US13989383

申请日：2011-11-23

申请人： Christopher David Young ,  Daniel Paul Carlson ,  Lucas Paul Keranen ,  Jeffrey P. Schirer

发明人： Christopher David Young ,  Daniel Paul Carlson ,  Lucas Paul Keranen ,  Jeffrey P. Schirer

IPC分类号： G01D18/00

CPC分类号： G01D18/008 ,  B82Y35/00 ,  G01B5/28 ,  G01B21/042 ,  G01N1/42 ,  G01N2203/0206 ,  G01N2203/021 ,  G01Q30/04 ,  G01Q40/00 ,  G01Q60/366

摘要： A method of calibrating a mechanical instrument assembly includes reading a memory device coupled with a mechanical testing instrument, the mechanical testing instrument having one or more mechanical characteristics with values unique to the mechanical testing instrument, and reading includes reading of one or more calibration values based on the one or more mechanical characteristic values. The method further includes calibrating the mechanical instrument assembly according to the one or more calibration values. The mechanical testing instrument is coupled with the mechanical instrument assembly.

摘要翻译： 校准机械仪器组件的方法包括读取与机械测试仪器耦合的存储器件，所述机械测试仪器具有具有机械测试仪器独有的值的一个或多个机械特性，并且读取包括读取一个或多个校准值 关于一个或多个机械特性值。 该方法还包括根据一个或多个校准值校准机械仪器组件。 机械测试仪器与机械仪器组件相结合。

公开(公告)号：US20130266665A1

公开(公告)日：2013-10-10

申请号：US13802080

申请日：2013-03-13

申请人： Oliver DORIG ,  James Gimzewski ,  Jianyu Rao ,  Shivani Sharma ,  Chintda Santiskulvong

发明人： Oliver DORIG ,  James Gimzewski ,  Jianyu Rao ,  Shivani Sharma ,  Chintda Santiskulvong

IPC分类号： G01N33/50

CPC分类号： G01N33/5044 ,  G01N2800/52 ,  G01Q60/366

摘要： A method of treating a patient having cancer includes: (1) providing a biological sample from the patient, the biological sample including multiple cells; (2) detecting a response of the biological sample to a probing element; (3) based on the response, determining test values for the biological sample, the test values being indicative of a nanomechanical characteristic of the cells; (4) deriving a test nanomechanical profile characterizing a distribution of the test values; and (5) based on the test nanomechanical profile, selecting a therapeutic agent to treat the patient.

摘要翻译： 治疗患有癌症的患者的方法包括：（1）从患者提供生物样品，所述生物样品包括多个细胞; （2）检测生物样品对探测元件的响应; （3）基于响应，确定生物样品的测试值，测试值表示细胞的纳米机械特征; （4）导出表征测试值分布的测试纳米机械轮廓; 和（5）基于测试纳米机械特征，选择治疗剂治疗患者。

公开(公告)号：US20120266666A1

公开(公告)日：2012-10-25

申请号：US13454823

申请日：2012-04-24

申请人： Yunje Oh ,  Syed Amanula Syed Asif ,  Oden Warren

发明人： Yunje Oh ,  Syed Amanula Syed Asif ,  Oden Warren

IPC分类号： G01N3/40

CPC分类号： G01N3/40 ,  G01B7/34 ,  G01N3/42 ,  G01N19/00 ,  G01N2203/0051 ,  G01N2203/0286 ,  G01N2203/0617 ,  G01Q60/366 ,  Y10S977/956

摘要： A microelectromechanical nanoindenter including a body, a probe moveable relative to the body, an indenter tip coupled to an end of the moveable probe, and a micromachined comb drive. The micromachined comb drive includes an electrostatic actuator capacitor configured to drive the probe, along with the indenter tip. The micromachined comb drive includes a plurality of sensing capacitors forming a differential capacitive displacement sensor, each sensing capacitor comprising a plurality of comb capacitors and each configured to provide capacitance levels which, together, are representative of a position of the probe, wherein each of the comb capacitors of the actuator capacitor and the sensing capacitors includes a fixed electrode comb coupled to the body and a moveable electrode comb coupled to the probe.

摘要翻译： 包括主体，可相对于主体移动的探针，连接到可移动探针的端部的压头，以及微加工梳状驱动器的微机电纳米压痕机。 微加工梳状驱动器包括静电致动器电容器，其构造成与压头尖端一起驱动探针。 微加工梳状驱动器包括形成差分电容位移传感器的多个感测电容器，每个感测电容器包括多个梳状电容器，并且每个感测电容器被配置为提供一起代表探头位置的电容电平，其中， 致动器电容器和感测电容器的梳状电容器包括耦合到主体的固定电极梳和耦合到探针的可移动电极梳。

公开(公告)号：US08196458B2

公开(公告)日：2012-06-12

申请号：US12729339

申请日：2010-03-23

申请人： Flavio Alejandro Bonilla ,  Roger Proksch ,  Jason Cleveland ,  Tim Sauter

发明人： Flavio Alejandro Bonilla ,  Roger Proksch ,  Jason Cleveland ,  Tim Sauter

IPC分类号： G01B5/28 ,  G01N3/40

CPC分类号： G01N3/317 ,  B82Y35/00 ,  G01N2203/0078 ,  G01Q60/366

摘要： A new type of indenter is described. This device combines certain sensing and structural elements of atomic force microscopy with a module designed for the use of indentation probes, conventional diamond and otherwise, as well as unconventional designs, to produce high resolution and otherwise superior indentation measurements.

公开(公告)号：US20110070604A1

公开(公告)日：2011-03-24

申请号：US12993826

申请日：2008-12-01

申请人： James K. Gimzewski ,  Sarah E. Cross ,  Yusheng Jin ,  Jianyu Rao

发明人： James K. Gimzewski ,  Sarah E. Cross ,  Yusheng Jin ,  Jianyu Rao

IPC分类号： C12Q1/02 ,  C12M1/34 ,  B82Y15/00 ,  B82Y5/00

CPC分类号： G01Q30/025 ,  B82Y15/00 ,  B82Y35/00 ,  G01Q20/00 ,  G01Q30/14 ,  G01Q60/366 ,  Y10S977/92

摘要： Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that are administered with a therapeutic agent, changes in local nanomechanical characteristics of ex vivo cells collected from the patients can correlate with effectiveness of the therapeutic agent in terms of impeding or reversing progression of the disease. By exploiting this correlation, systems and related methods can be advantageously implemented for disease state detection and therapeutic agent selection and monitoring.

摘要翻译： 这里描述的是细胞的纳米机械特性的分析。 特别地，离体人细胞的某些局部纳米机械特征的变化可以与人类疾病如癌症的存在以及疾病进展的特定阶段相关联。 此外，对于施用治疗剂的人类患者，从患者收集的离体细胞的局部纳米机械特征的变化可以与治疗剂在阻碍或逆转疾病进展方面的有效性相关。 通过利用这种相关性，系统和相关方法可以有利地实现用于疾病状态检测和治疗剂选择和监测。

公开(公告)号：US07849731B2

公开(公告)日：2010-12-14

申请号：US12251136

申请日：2008-10-14

申请人： Richard L. Bradshaw ,  Bernd W. Gotsmann ,  Urs T. Duerig

发明人： Richard L. Bradshaw ,  Bernd W. Gotsmann ,  Urs T. Duerig

IPC分类号： G01N3/42

CPC分类号： G01Q60/366 ,  G01Q60/58 ,  G01Q70/06

摘要： The present invention provides a novel method for determining the mechanical properties of the surfaces of materials including thin films. Generally, the method is comprised of laterally scanning the surface of the film with an array of cantilever tips varying temperature, load and time to obtain a measurement of mechanical properties, such as hardness and glass transition temperature. The method can be used to obtain mechanical properties of films that would otherwise be unobtainable using standard methods.

摘要翻译： 本发明提供一种用于确定包括薄膜的材料的表面的机械性能的新方法。 通常，该方法包括用悬臂尖端阵列横向扫描薄膜的表面，该阵列具有温度，载荷和时间，从而获得诸如硬度和玻璃化转变温度的机械性能的测量。 该方法可以用于获得否则将使用标准方法无法获得的膜的机械性能。

公开(公告)号：US07845214B2

公开(公告)日：2010-12-07

申请号：US12230340

申请日：2008-08-28

申请人： Jiong-Shiun Hsu ,  Hui-Ching Lu ,  Chung-Lin Wu ,  Sheng-Jui Chen

发明人： Jiong-Shiun Hsu ,  Hui-Ching Lu ,  Chung-Lin Wu ,  Sheng-Jui Chen

IPC分类号： G01N3/48

CPC分类号： G01N3/405 ,  G01N2203/0286 ,  G01N2203/0641 ,  G01Q60/366

摘要： This invention relates to a device and method for optical nanoindentation measurement, according to which respective measurement results are obtained by having an indenter tip apply load to a fixed portion of a thin film, having an indenter tip apply load to a non-fixed portion of a thin film, and having a vibrating component transmit the dynamic properties of the vibration to the thin film. By combining the above measurement results in calculations, the Young's modulus, the Poisson's ratio, and the density of the thin film can be obtained.

摘要翻译： 本发明涉及一种用于光学纳米压痕测量的装置和方法，根据该装置和方法，通过将压头施加载荷施加到薄膜的固定部分上，获得各自的测量结果，该固定部分具有压头施加载荷到非固定部分 并且具有振动分量的薄膜将振动的动态特性传递给薄膜。 通过在计算中结合上述测量结果，可以获得杨氏模量，泊松比和薄膜的密度。

公开(公告)号：US20100132441A1

公开(公告)日：2010-06-03

申请号：US12497834

申请日：2009-07-06

申请人： Yunje Oh ,  Syed Amanula Syed Asif ,  Oden Warren

发明人： Yunje Oh ,  Syed Amanula Syed Asif ,  Oden Warren

IPC分类号： G01N3/42

CPC分类号： G01N3/40 ,  G01B7/34 ,  G01N3/42 ,  G01N19/00 ,  G01N2203/0051 ,  G01N2203/0286 ,  G01N2203/0617 ,  G01Q60/366 ,  Y10S977/956

摘要： A microelectromechanical (MEMS) nanoindenter transducer including a body, a probe moveable relative to the body, an indenter tip coupled to an end of the moveable probe, the indenter tip moveable together with the probe, and a micromachined comb drive. The micromachined comb drive includes an electrostatic actuator capacitor comprising a plurality of comb capacitors configured to drive the probe, together with the indenter tip, along a displacement axis, including in an indentation direction, upon application of a bias voltage to the actuation capacitor. The micromachined comb drive further includes a plurality of sensing capacitors forming a differential capacitive displacement sensor, each sensing capacitor comprising a plurality of comb capacitors and each configured to provide capacitance levels which, together, are representative of a position of the probe, wherein each of the comb capacitors of the actuator capacitor and the sensing capacitors includes a fixed electrode comb coupled to the body and a moveable electrode comb coupled to the probe.

摘要翻译： 微机电（MEMS）纳米压头换能器，包括主体，可相对于主体移动的探针，连接到可移动探针的端部的压头，可与探针一起移动的压头以及微机械梳状驱动器。 微加工梳状驱动器包括静电致动器电容器，该静电致动器电容器包括多个梳状电容器，该多个梳状电容器被配置为在施加偏置电压到致动电容器时沿包括压痕方向的位移轴沿着位移轴驱动探头。 微加工梳状驱动器还包括形成差分电容位移传感器的多个感测电容器，每个感测电容器包括多个梳状电容器，并且每个感测电容器被配置为提供一起代表探针位置的电容电平，其中， 致动器电容器和感测电容器的梳状电容器包括耦合到主体的固定电极梳和耦合到探针的可移动电极梳。

公开(公告)号：US20100036636A1

公开(公告)日：2010-02-11

申请号：US12498238

申请日：2009-07-06

申请人： Yunje Oh ,  Matthew R. Wilson ,  Ryan Charles Major ,  Syed Amanula Syed Asif ,  Oden L. Warren

发明人： Yunje Oh ,  Matthew R. Wilson ,  Ryan Charles Major ,  Syed Amanula Syed Asif ,  Oden L. Warren

IPC分类号： G06F19/00 ,  G01M17/00

CPC分类号： G01Q60/366 ,  G01N3/42 ,  G01N2203/0234 ,  G01N2203/0286 ,  G01Q10/065

摘要： A method of damping control for a nanomechanical test system, the method including providing an input signal, providing an output signal representative of movement of a displaceable probe along an axis in response to the input signal, performing a frequency-dependent phase shift of the output signal to provide a phase-shifted signal, adjusting the phase-shifted signal by a gain value to provide a feedback signal, and adjusting the input signal by incorporating the feedback signal with the input signal.

摘要翻译： 一种用于纳米机械测试系统的阻尼控制的方法，所述方法包括提供输入信号，响应于所述输入信号提供表示可移动探针沿着轴移动的输出信号，执行所述输出的频率相关相移 信号以提供相移信号，通过增益值调整相移信号以提供反馈信号，以及通过将反馈信号与输入信号相结合来调整输入信号。

公开(公告)号：US06755075B2

公开(公告)日：2004-06-29

申请号：US09958477

申请日：2001-11-21

申请人： Nobuo Nagashima ,  Kensuke Miyahara ,  Saburo Matsuoka

发明人： Nobuo Nagashima ,  Kensuke Miyahara ,  Saburo Matsuoka

IPC分类号： G01N348

CPC分类号： G01Q60/366 ,  G01N3/42 ,  G01N2203/0286 ,  G01N2203/0647 ,  Y10S977/852

摘要： An ultra micro indentation testing apparatus comprises: a lever stand provided with a center lever having a silicon probe and a diamond indenter disposed therein; a moving mechanism for moving the lever stand in a triaxial direction; in indentation mechanism for pushing the diamond indenter in a sample; a displacement gage for measuring a displacement of the silicon probe or the diamond indenter; and an optical picture device for positioning the silicon probe or the diamond indenter and observing the surface of the sample. The apparatus has, in combination, a hardness measuring function based on the measurement of the force and depth of the diamond indenter pushed in the surface of the sample, an atomic force microscopic function of acquiring the shape of the surface of the sample based on a displacement of the diamond indenter or the silicon probe, and an optical microscopic function of observing the surface of the sample by the optical picture device. Furthermore, the testing apparatus is equipped with both the function of measuring the hardness of the surface of material in a ultra micro region and the surface observing function with high accuracy.

摘要翻译： 超微压痕测试装置包括：杆架，设置有具有硅探针和设置在其中的金刚石压头的中心杆; 用于使杆架沿三轴方向移动的移动机构; 用于将金刚石压头推入样品的压痕机构; 用于测量硅探针或金刚石压头的位移的位移计; 以及用于定位硅探针或金刚石压头并观察样品表面的光学图像装置。 该装置组合地具有基于在样品表面推动的金刚石压头的力和深度的测量的硬度测量功能，基于样品的表面获取样品的形状的原子力显微镜功能 金刚石压头或硅探针的位移，以及通过光学图像装置观察样品表面的光学显微镜功能。 此外，测试装置既具有测量超微区域中的材料表面的硬度和高精度的表面观察功能的功能。